ATE224725T1 - Stabilisierung von interferonen in wässriger lösung durch gummiarabikum - Google Patents

Stabilisierung von interferonen in wässriger lösung durch gummiarabikum

Info

Publication number
ATE224725T1
ATE224725T1 AT97919596T AT97919596T ATE224725T1 AT E224725 T1 ATE224725 T1 AT E224725T1 AT 97919596 T AT97919596 T AT 97919596T AT 97919596 T AT97919596 T AT 97919596T AT E224725 T1 ATE224725 T1 AT E224725T1
Authority
AT
Austria
Prior art keywords
interferons
stabilization
aqueous solution
rubber arabic
arabic
Prior art date
Application number
AT97919596T
Other languages
English (en)
Inventor
Peter R Rothschild
Original Assignee
Feronpatent Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Feronpatent Ltd filed Critical Feronpatent Ltd
Application granted granted Critical
Publication of ATE224725T1 publication Critical patent/ATE224725T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT97919596T 1996-05-09 1997-05-09 Stabilisierung von interferonen in wässriger lösung durch gummiarabikum ATE224725T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB9600433 1996-05-09
PCT/IB1997/000531 WO1997041885A1 (en) 1996-05-09 1997-05-09 Stabilization of interferons in aqueous solution for manufacture of sublingually administered tablets

Publications (1)

Publication Number Publication Date
ATE224725T1 true ATE224725T1 (de) 2002-10-15

Family

ID=11004429

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97919596T ATE224725T1 (de) 1996-05-09 1997-05-09 Stabilisierung von interferonen in wässriger lösung durch gummiarabikum

Country Status (8)

Country Link
EP (1) EP0920329B1 (de)
AP (1) AP1168A (de)
AT (1) ATE224725T1 (de)
AU (1) AU2401197A (de)
DE (1) DE69715883T2 (de)
DK (1) DK0920329T3 (de)
ES (1) ES2184084T3 (de)
WO (1) WO1997041885A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0920329T3 (da) * 1996-05-09 2003-01-27 Feronpatent Ltd Stabilisering af interferoner i vandig opløsning med gummiarabicum
EP1007083A1 (de) * 1997-05-09 2000-06-14 Feronpatent Limited Stabilisierung von wässrigen interferon-lösungen zur herstellung von sublingualen tabletten
US6391296B1 (en) 1997-08-01 2002-05-21 Toray Industries, Inc. Method of stabilizing useful protein and useful protein compositions
FR2836379B1 (fr) * 2002-02-28 2007-06-01 Dit Bon Michel Betend Formes galeniques solides de medicaments homeopathiques, dont les allergenes ou antigenes, en dilutions homeopathiques pour preparation extemporanee pour un seul individu pour administration sublinguale
EP1749018B1 (de) * 2004-04-23 2014-10-22 Expedeon Limited Verfahren und kits zur stabilisierung, zum schutz und zur solubilisierung von proteinen
JP2008501639A (ja) * 2004-04-23 2008-01-24 ノベシン リミテッド タンパク質を安定化、保護及び可溶化させるための方法及びキット

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH156609A (de) * 1931-01-27 1932-08-15 Chem Pharm Lab Bika V Poehlman Verfahren zur Herstellung eines trockenen, homöopathischen Heilmittels.
EP0123291A2 (de) * 1983-04-20 1984-10-31 Kyowa Hakko Kogyo Co., Ltd. Verfahren zur Stabilisierung von Interferon
DE3484374D1 (de) * 1983-08-04 1991-05-08 Green Cross Corp Gamma-interferonzusammensetzung.
ZA878295B (en) * 1986-11-06 1988-05-03 Amarillo Cell Culture Co. Inc. Treatment of immuno-resistant disease
FR2619714B1 (fr) * 1987-09-02 1991-07-12 Medibrevex Nouvelles formes galeniques de theophylline pour administration par voie per- et sublinguale
CA2024046A1 (en) * 1989-09-28 1991-03-29 Alberto Ferro Stabilized leukocyte-interferons
US5298261A (en) * 1992-04-20 1994-03-29 Oregon Freeze Dry, Inc. Rapidly distintegrating tablet
DK0920329T3 (da) * 1996-05-09 2003-01-27 Feronpatent Ltd Stabilisering af interferoner i vandig opløsning med gummiarabicum

Also Published As

Publication number Publication date
DE69715883D1 (de) 2002-10-31
ES2184084T3 (es) 2003-04-01
AU2401197A (en) 1997-11-26
DK0920329T3 (da) 2003-01-27
DE69715883T2 (de) 2003-07-31
EP0920329A1 (de) 1999-06-09
EP0920329B1 (de) 2002-09-25
AP1168A (en) 2003-06-30
AP9901682A0 (en) 1999-12-31
WO1997041885A1 (en) 1997-11-13

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