ATE223058T1 - Verfahren zur messung der assoziation von teilstrukturen pathologischer proteinablagerungen - Google Patents

Verfahren zur messung der assoziation von teilstrukturen pathologischer proteinablagerungen

Info

Publication number
ATE223058T1
ATE223058T1 AT98948990T AT98948990T ATE223058T1 AT E223058 T1 ATE223058 T1 AT E223058T1 AT 98948990 T AT98948990 T AT 98948990T AT 98948990 T AT98948990 T AT 98948990T AT E223058 T1 ATE223058 T1 AT E223058T1
Authority
AT
Austria
Prior art keywords
pathological protein
depositions
association
protein depositions
pathological
Prior art date
Application number
AT98948990T
Other languages
German (de)
English (en)
Inventor
Detlev Riesner
Karin Post
Oliver Schaefer
Martin Pitschke
Manfred Eigen
Jan Bieschke
Original Assignee
Evotec Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1997152712 external-priority patent/DE19752712C2/de
Application filed by Evotec Ag filed Critical Evotec Ag
Application granted granted Critical
Publication of ATE223058T1 publication Critical patent/ATE223058T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AT98948990T 1997-09-19 1998-09-18 Verfahren zur messung der assoziation von teilstrukturen pathologischer proteinablagerungen ATE223058T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19741486 1997-09-19
DE1997152712 DE19752712C2 (de) 1997-11-28 1997-11-28 Verfahren zur Messung der Assoziation von Teilstrukturen pathologischer Proteinablagerungen
DE19818917 1998-04-28
PCT/EP1998/005958 WO1999015903A1 (de) 1997-09-19 1998-09-18 Verfahren zur messung der assoziation von teilstrukturen pathologischer proteinablagerungen

Publications (1)

Publication Number Publication Date
ATE223058T1 true ATE223058T1 (de) 2002-09-15

Family

ID=27217757

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98948990T ATE223058T1 (de) 1997-09-19 1998-09-18 Verfahren zur messung der assoziation von teilstrukturen pathologischer proteinablagerungen

Country Status (7)

Country Link
US (1) US6498017B2 (enExample)
EP (1) EP1015888B1 (enExample)
JP (1) JP4223681B2 (enExample)
AT (1) ATE223058T1 (enExample)
AU (1) AU9541398A (enExample)
DE (1) DE59805338D1 (enExample)
WO (1) WO1999015903A1 (enExample)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001023894A1 (de) * 1999-09-28 2001-04-05 Evotec Oai Ag Quantitative analyse und typisierung subzellulärer partikel
DE19952955A1 (de) 1999-11-03 2001-05-17 Acgt Progenomics Ag Verfahren zur Charakterisierung und zur Auftrennung von molekularen Assoziaten
DE10013854A1 (de) * 2000-03-17 2001-09-20 Zeiss Carl Jena Gmbh Anordnung und Verfahren zur Untersuchung von Wirkstoffen zur Beeinflussung intrazellulärer Vorgänge
WO2003090599A2 (en) * 2002-04-25 2003-11-06 Brainsgate Ltd. Methods and apparatus for modifying properties of the bbb and cerebral circulation by using the neuroexcitatory and/or neuroinhibitory effects of odorants on nerves in the head
US7640062B2 (en) 2000-05-08 2009-12-29 Brainsgate Ltd. Methods and systems for management of alzheimer's disease
US7146209B2 (en) * 2000-05-08 2006-12-05 Brainsgate, Ltd. Stimulation for treating eye pathologies
US6603546B1 (en) * 2000-07-21 2003-08-05 I.S.S. (Usa) Inc. Rapid high throughput spectrometer and method
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
MXPA03011000A (es) 2001-05-31 2004-02-27 Arete Associates Metodo de sensor de proteinas deformadas.
EP1321771A1 (de) * 2001-12-21 2003-06-25 Evotec Analytical Systems GmbH Verfahren zur qualitativen und/oder quantitativen Bestimmung von Aggregaten
EP1572937B1 (en) * 2002-04-09 2012-02-08 The Scripps Research Institute Motif-grafted hybrid polypeptides and uses thereof
WO2004043218A2 (en) * 2002-11-14 2004-05-27 Brainsgate Ltd. Surgical tools and techniques for stimulation
US7684859B2 (en) * 2002-04-25 2010-03-23 Brainsgate Ltd. Stimulation of the OTIC ganglion for treating medical conditions
WO2005008212A2 (en) * 2003-06-20 2005-01-27 The Regents Of The University Of California Modulated excitation fluorescence analysis
US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
EP1600774A1 (de) * 2004-03-12 2005-11-30 Ludwig-Maximilians-Universität München Verfahren zur Identifizierung von Substanzen zur Beeinflussung der Aggregationen von Proteinen
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation
US8055347B2 (en) 2005-08-19 2011-11-08 Brainsgate Ltd. Stimulation for treating brain events and other conditions
US8010189B2 (en) * 2004-02-20 2011-08-30 Brainsgate Ltd. SPG stimulation for treating complications of subarachnoid hemorrhage
JP4338590B2 (ja) 2004-06-03 2009-10-07 独立行政法人科学技術振興機構 蛍光相関分光法による抗原の迅速検出及び／又は測定法。
US20090299418A1 (en) * 2004-08-23 2009-12-03 Brainsgate Ltd. Concurrent bilateral spg modulation
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
WO2006076683A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Isolation and detection of pathogenic prions
CA2594840A1 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Elisa assays using prion-specific peptide reagents
CA2597912C (en) * 2005-02-15 2013-06-04 Adlyfe, Inc. Method for detecting misfolded proteins and prions
US20090253217A1 (en) 2005-09-12 2009-10-08 Japan Science And Technology Agency Method of Quickly Detecting Antigen Using Fluorescence Correlation Spectroscopy or Fluorescence Cross-Correlation Spectroscopy
ES2323725T3 (es) * 2006-07-28 2009-07-23 Vista Ventures Gmbh Procedimiento para la deteccion de oligomeros de amiloide beta en fluidos corporales.
MX2009001079A (es) * 2006-07-28 2009-02-10 Adlyfe Inc Sondas de peptido para diagnosis y terapeutica.
WO2008022035A2 (en) * 2006-08-10 2008-02-21 The Scripps Research Institute Methods for identifying cellular modulators of disaggregation activity or aggregation activity in an animal
US20090210026A1 (en) * 2006-08-17 2009-08-20 Brainsgate Ltd. Spg stimulation for enhancing neurogenesis and brain metabolism
JP2010043865A (ja) * 2006-12-12 2010-02-25 Olympus Corp 異常型プリオンの検出方法
US7860569B2 (en) 2007-10-18 2010-12-28 Brainsgate, Ltd. Long-term SPG stimulation therapy for prevention of vascular dementia
CN102083450A (zh) * 2008-04-30 2011-06-01 诺华有限公司 致病性构象异构体的分析
US20110174064A1 (en) * 2008-10-02 2011-07-21 Ramot At Tel-Aviv University Ltd. Method and system for emitting light
US20100129290A1 (en) * 2008-11-26 2010-05-27 I.S.T. Corporation Smart contrast agent and detection method for detecting transition metal ions
US20100227794A1 (en) * 2008-11-26 2010-09-09 I.S.T. Corporation Smart contrast agent and method for detecting transition metal ions and treating related disorders
US10512794B2 (en) 2016-12-16 2019-12-24 Brainsonix Corporation Stereotactic frame
US9061133B2 (en) 2012-12-27 2015-06-23 Brainsonix Corporation Focused ultrasonic transducer navigation system
US10974078B2 (en) 2012-12-27 2021-04-13 Brainsonix Corporation Treating degenerative dementia with low intensity focused ultrasound pulsation (LIFUP) device
US9675796B2 (en) 2013-11-10 2017-06-13 Brainsgate Ltd. Implant and delivery system for neural stimulator
US10271907B2 (en) 2015-05-13 2019-04-30 Brainsgate Ltd. Implant and delivery system for neural stimulator
AU2017378419A1 (en) * 2016-12-15 2019-07-04 Brainsonix Corporation Treating degenerative dementia using low intensity focused ultrasound pulsation (lifup) device
GB201805466D0 (en) * 2018-04-03 2018-05-16 Vukojevic Vladana Methods
US11759661B2 (en) 2020-05-20 2023-09-19 Brainsonix Corporation Ultrasonic transducer treatment device
US12257446B2 (en) 2020-08-24 2025-03-25 Brainsonix Corporation Systems and methods for neuromodulation of neuronal circuits using transcranial focused microwave pulses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016628A1 (en) * 1990-04-24 1991-10-31 The Regents Of The University Of California Purification, detection and methods of use of protease nexin-2
WO1993023432A1 (en) * 1992-05-15 1993-11-25 New York University Soluble prion polypeptides, and methods for detecting and purifying thereof
EP1416280A3 (en) 1995-09-14 2005-08-10 The Regents of the University of California Antibodies specific for native PrPsc
DK0862653T3 (da) * 1995-10-26 2002-03-11 Ernst Ludwig Prof Winnacker Nukleinsyremolekyler, som er i stand til at skelne mellem PrPc- og PrPSc-isoformerne af prionproteiner og fremgangsmåder til fremstilling deraf

Also Published As

Publication number Publication date
JP2001517800A (ja) 2001-10-09
JP4223681B2 (ja) 2009-02-12
US20020042121A1 (en) 2002-04-11
DE59805338D1 (de) 2002-10-02
EP1015888A1 (de) 2000-07-05
WO1999015903A1 (de) 1999-04-01
EP1015888B1 (de) 2002-08-28
AU9541398A (en) 1999-04-12
US6498017B2 (en) 2002-12-24

Similar Documents

Publication Publication Date Title
ATE223058T1 (de) Verfahren zur messung der assoziation von teilstrukturen pathologischer proteinablagerungen
US5820561A (en) Analysis and measurement of temporal tissue velocity information
DE69010506D1 (de) Bestimmungsverfahren für biologische zielkomplexe auf der oberfläche eines biosensors.
DE69015195D1 (de) Telemetrische Sensor zur Detektion mechanischer Deformation eines Gegenstandes mittels Messung der Veränderungen von Magnetfeldstärke.
WO2004063753A3 (en) A serum marker for measuring liver fibrosis
CY1115366T1 (el) Δεικτες ογκου
DE69114314D1 (de) Diagnostisches Verfahren zur Messung der Blutströmung.
NO20001126D0 (no) Et ikke-angripende transdermalt system for Õ detektere analytter
ATE502119T1 (de) Verfahren zur bewertung pathologischer krankheitszustände unter verwendung extrazellulärer rna
DE69723319D1 (de) Verfahren und vorrichtung zum stützen eines körpers, insbesondere eines patienten mit einer vorgewählten einsinktiefe
ATE52621T1 (de) Verfahren zur bestimmung der grenzen von unterirdischen erdgas-lagerstaetten.
RU94027293A (ru) Способ измерения электропроводности жидкостей организма и измерительный зонд для осуществления этого способа
DK0968421T3 (da) Diagnose af tidlig gastrisk cancer
ATE368229T1 (de) Diagnostischer test zur bestimmung der konzentration einer transienten proteolytischen aktivität in zusammengesetzten biologischen medien
Gawne et al. Estimating left ventricular offset volume using dual-frequency conductance catheters
ATE303098T1 (de) Kalibrierung eines doppler-geschwindigkeitmessers zur bestimmung von schlagvolumen
DE69414871D1 (de) Verfahren zur bestimmung der quantität extrazellulärer bpi in körperflüssigkeiten
Schattner et al. Comparison of (2′-5′) oligo-adenylate synthetase and interferon blood-levels in mice early after viral infection
DE69621837D1 (de) Methoden zur feststellung von alzheimerscher krankheit
BR9612475A (pt) Método de determinação do estado hepático de uma pessoa incluíndo um beneficiário para transplante de figado
ATE534037T1 (de) Verwendung des proteins asc als marker für brustkrebs
WO2022241292A3 (en) Use of markers in the diagnosis and treatment of parkinson's disease
DE58901295D1 (de) Sensor zur beruehrungsfreien erfassung der innenkontur von metallischen bauteilen.
ATE222371T1 (de) Verfahren zur bestimmung einer bewegungsrichtung
Akbay et al. Serum dipeptidylpeptidase activity and tissue polypeptide specific antigen in patients with advanced cirrhosis: preliminary results

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee