ATE2191T1 - Rosmarinsaeure-phospholipid komplexe, verfahren zur ihrer herstellung und sie enthaltende arzneimittel. - Google Patents
Rosmarinsaeure-phospholipid komplexe, verfahren zur ihrer herstellung und sie enthaltende arzneimittel.Info
- Publication number
- ATE2191T1 ATE2191T1 AT80107751T AT80107751T ATE2191T1 AT E2191 T1 ATE2191 T1 AT E2191T1 AT 80107751 T AT80107751 T AT 80107751T AT 80107751 T AT80107751 T AT 80107751T AT E2191 T1 ATE2191 T1 AT E2191T1
- Authority
- AT
- Austria
- Prior art keywords
- processes
- preparation
- medicines containing
- phospholipid complexes
- rosemary acid
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 241001529742 Rosmarinus Species 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- DOUMFZQKYFQNTF-WUTVXBCWSA-N (R)-rosmarinic acid Chemical compound C([C@H](C(=O)O)OC(=O)\C=C\C=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-WUTVXBCWSA-N 0.000 abstract 2
- DOUMFZQKYFQNTF-MRXNPFEDSA-N rosemarinic acid Natural products C([C@H](C(=O)O)OC(=O)C=CC=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-MRXNPFEDSA-N 0.000 abstract 2
- ZZAFFYPNLYCDEP-HNNXBMFYSA-N Rosmarinsaeure Natural products OC(=O)[C@H](Cc1cccc(O)c1O)OC(=O)C=Cc2ccc(O)c(O)c2 ZZAFFYPNLYCDEP-HNNXBMFYSA-N 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- TVHVQJFBWRLYOD-UHFFFAOYSA-N rosmarinic acid Natural products OC(=O)C(Cc1ccc(O)c(O)c1)OC(=Cc2ccc(O)c(O)c2)C=O TVHVQJFBWRLYOD-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
- C07F9/106—Adducts, complexes, salts of phosphatides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fats And Perfumes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2952115A DE2952115C2 (de) | 1979-12-22 | 1979-12-22 | Rosmarinsäure-Phospholipid-Komplex |
| EP80107751A EP0032556B1 (de) | 1979-12-22 | 1980-12-09 | Rosmarinsäure-Phospholipid Komplexe, Verfahren zur ihrer Herstellung und sie enthaltende Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE2191T1 true ATE2191T1 (de) | 1983-01-15 |
Family
ID=6089504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT80107751T ATE2191T1 (de) | 1979-12-22 | 1980-12-09 | Rosmarinsaeure-phospholipid komplexe, verfahren zur ihrer herstellung und sie enthaltende arzneimittel. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4358442A (de) |
| EP (1) | EP0032556B1 (de) |
| JP (1) | JPS5699442A (de) |
| AT (1) | ATE2191T1 (de) |
| DE (1) | DE2952115C2 (de) |
| DK (1) | DK148202C (de) |
| IE (1) | IE50913B1 (de) |
| ZA (1) | ZA807927B (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1237670A (en) * | 1983-05-26 | 1988-06-07 | Andrew S. Janoff | Drug preparations of reduced toxicity |
| US5059591B1 (en) * | 1983-05-26 | 2000-04-25 | Liposome Co Inc | Drug preparations of reduced toxicity |
| PT78628B (en) * | 1984-05-02 | 1986-06-18 | Liposome Co Inc | Pharmaceutical composition with reduced toxicity |
| EP0187022B1 (de) * | 1984-12-28 | 1991-05-29 | TECHNICON INSTRUMENTS CORPORATION(a Delaware corporation) | Phospholipidkonjugate und deren Herstellung |
| IT1215291B (it) * | 1985-07-17 | 1990-01-31 | Inverni Della Beffa Spa | Complessi di flavanolignani con fosfolipidi, loro preparazione e relative composizioni farmaceutiche. |
| IT1201151B (it) * | 1987-01-14 | 1989-01-27 | Indena Spa | Complessi fosfolipidici con estratti da vitis vinifera,procedimento per la loro preparazione e composizioni che li cntengono |
| IT1201149B (it) * | 1987-01-14 | 1989-01-27 | Indena Spa | Complessi di bioflavonoidi con fosfolipidi,loro preparazione,uso e composizioni farmaceutici e cosmetiche |
| US6406713B1 (en) | 1987-03-05 | 2002-06-18 | The Liposome Company, Inc. | Methods of preparing low-toxicity drug-lipid complexes |
| US5616334A (en) * | 1987-03-05 | 1997-04-01 | The Liposome Company, Inc. | Low toxicity drug-lipid systems |
| IT1223290B (it) * | 1987-07-27 | 1990-09-19 | Indena Spa | Acidi poliinsaturi ad azione vasocinetica e relative formulazioni farmaceutiche e cosmetiche |
| CA2140053C (en) * | 1994-02-09 | 2000-04-04 | Joel S. Rosenblatt | Collagen-based injectable drug delivery system and its use |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| US6309623B1 (en) | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| US5989558A (en) * | 1997-12-05 | 1999-11-23 | Lopes; Carlos Alberto Correia | Method of using rosmarinus officinalis for treating various diseases |
| DE69930619T2 (de) * | 1998-05-16 | 2006-12-28 | Mogam Biotechnology Research Institute, Yongin | Verwendung von rosmarinsäure und deren derivate als immunsuppressor oder als inhibitor von sh-2 vermittelten prozessen |
| US6824789B2 (en) | 1998-05-20 | 2004-11-30 | Kemin Industries, Inc. | Method of extracting antioxidants from lamiaceae species and the extract products thereof |
| US6855349B2 (en) | 1998-12-07 | 2005-02-15 | Kemin Industries, Inc. | Method for simultaneous extraction of essential oils and antioxidants from Labiatae species and the extract products thereof |
| WO2000039248A1 (en) * | 1998-12-24 | 2000-07-06 | Rad Natural Technologies Ltd. | Method for protecting a substance liable to oxidative deterioration |
| US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| TWI290473B (en) | 2000-05-10 | 2007-12-01 | Alliance Pharma | Phospholipid-based powders for drug delivery |
| US6450935B1 (en) | 2000-10-13 | 2002-09-17 | Kemin Industries, Inc. | Method for removing essential oils and antioxidants from extract products of lamiaceae species using rolled film evaporation |
| PT1458360E (pt) | 2001-12-19 | 2011-07-13 | Novartis Ag | Derivados de indole como agonistas do recetor s1p1 |
| ITMI20061883A1 (it) * | 2006-09-29 | 2008-03-30 | Monteres S R L | Formulazioni orodispersibili, gastroprotettive e taste- masking contenenti almeno un principio attivo gastrolesivo |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2856333C2 (de) * | 1978-12-27 | 1983-09-22 | A. Nattermann & Cie GmbH, 5000 Köln | Oral einnehmbare Arzneimittel mit entzündungshemmender Wirkung |
| GR73668B (de) * | 1978-11-21 | 1984-03-28 | Hoffmann La Roche |
-
1979
- 1979-12-22 DE DE2952115A patent/DE2952115C2/de not_active Expired
-
1980
- 1980-12-09 AT AT80107751T patent/ATE2191T1/de not_active IP Right Cessation
- 1980-12-09 EP EP80107751A patent/EP0032556B1/de not_active Expired
- 1980-12-10 IE IE2588/80A patent/IE50913B1/en unknown
- 1980-12-11 US US06/215,425 patent/US4358442A/en not_active Expired - Lifetime
- 1980-12-18 ZA ZA00807927A patent/ZA807927B/xx unknown
- 1980-12-22 JP JP18058180A patent/JPS5699442A/ja active Pending
- 1980-12-22 DK DK548980A patent/DK148202C/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IE50913B1 (en) | 1986-08-20 |
| EP0032556B1 (de) | 1983-01-12 |
| DE2952115C2 (de) | 1982-05-06 |
| EP0032556A1 (de) | 1981-07-29 |
| IE802588L (en) | 1981-06-22 |
| JPS5699442A (en) | 1981-08-10 |
| DK148202B (da) | 1985-04-29 |
| US4358442A (en) | 1982-11-09 |
| DE2952115B1 (de) | 1981-07-23 |
| DK548980A (da) | 1981-06-23 |
| DK148202C (da) | 1986-04-01 |
| ZA807927B (en) | 1982-01-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |