ATE216708T1 - TC OR RE RADIOM LABELED SOMASTOSTATIN ANALOGUE - Google Patents

TC OR RE RADIOM LABELED SOMASTOSTATIN ANALOGUE

Info

Publication number
ATE216708T1
ATE216708T1 AT95933284T AT95933284T ATE216708T1 AT E216708 T1 ATE216708 T1 AT E216708T1 AT 95933284 T AT95933284 T AT 95933284T AT 95933284 T AT95933284 T AT 95933284T AT E216708 T1 ATE216708 T1 AT E216708T1
Authority
AT
Austria
Prior art keywords
radiom
labeled
somastostatin analogue
useful
chelate
Prior art date
Application number
AT95933284T
Other languages
German (de)
Inventor
Richard J Flanagan
Jean-Marc Dufour
Keith T Hogan
Original Assignee
Merck Frosst Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc
Application granted granted Critical
Publication of ATE216708T1 publication Critical patent/ATE216708T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides

Abstract

Technetium or rhenium radionuclide labelled chelate-hexapeptide complexes are useful for the selective detection or treatment of tumors with somatostatin receptors. In particular, compounds of formula: <IMAGE> (wherein R, R1, R3 and A are as defined herein) incorporating an N3S2 chelate may be labelled with a radionuclide. The resulting complexes are useful as radioimaging agents or as radiopharmaceuticals for the treatment of certain tumors.
AT95933284T 1994-10-13 1995-10-11 TC OR RE RADIOM LABELED SOMASTOSTATIN ANALOGUE ATE216708T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/322,880 US5556939A (en) 1994-10-13 1994-10-13 TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
PCT/CA1995/000573 WO1996011954A1 (en) 1994-10-13 1995-10-11 Tc or re radiolabelled somatostatin analogs

Publications (1)

Publication Number Publication Date
ATE216708T1 true ATE216708T1 (en) 2002-05-15

Family

ID=23256849

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95933284T ATE216708T1 (en) 1994-10-13 1995-10-11 TC OR RE RADIOM LABELED SOMASTOSTATIN ANALOGUE

Country Status (7)

Country Link
US (1) US5556939A (en)
EP (1) EP0785951B1 (en)
JP (1) JP3630239B2 (en)
AT (1) ATE216708T1 (en)
AU (1) AU3602795A (en)
DE (1) DE69526515T2 (en)
WO (1) WO1996011954A1 (en)

Families Citing this family (33)

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US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US7238340B1 (en) * 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
DE69738353T2 (en) * 1996-07-12 2009-09-24 Immunomedics, Inc. RADIOMETALL-BINDING PEPTIDE ANALOG
US6548663B1 (en) 1998-03-31 2003-04-15 Bristol-Myers Squibb Pharma Company Benzodiazepine vitronectin receptor antagonist pharmaceuticals
US6537520B1 (en) 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
US6524553B2 (en) 1998-03-31 2003-02-25 Bristol-Myers Squibb Pharma Company Quinolone vitronectin receptor antagonist pharmaceuticals
US6794518B1 (en) * 1998-12-18 2004-09-21 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
US6569402B1 (en) 1998-12-18 2003-05-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
CA2349333A1 (en) 1998-12-18 2000-06-22 Du Pont Pharmaceuticals Company Vitronectin receptor antagonist pharmaceuticals
US6511649B1 (en) * 1998-12-18 2003-01-28 Thomas D. Harris Vitronectin receptor antagonist pharmaceuticals
EP1140204A2 (en) 1998-12-18 2001-10-10 Du Pont Pharmaceuticals Company Vitronectin receptor antagonist pharmaceuticals
US6989139B2 (en) * 2000-02-15 2006-01-24 Bristol-Myers Squibb Pharma Company Matrix metalloproteinase inhibitors
AU2002218075A1 (en) 2000-11-08 2002-05-21 K.U. Leuven Research And Development Substituted bis-indole derivatives useful as contrast agents, pharmaceutical compositions containing them and intermediates for producing them
WO2002055111A2 (en) 2000-11-27 2002-07-18 Bristol Myers Squibb Medical I Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
US6623721B2 (en) * 2000-12-18 2003-09-23 Draximage, Inc. Bifunctional chelating compounds containing hydroxamic acid residues
AU2002331042B2 (en) * 2001-08-08 2007-10-25 Bristol-Myers Squibb Pharma Company Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
US6838074B2 (en) 2001-08-08 2005-01-04 Bristol-Myers Squibb Company Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
JP2006514915A (en) 2002-03-01 2006-05-18 ダイアックス、コープ KDR and VEGF / KDR binding peptides and their use in diagnosis and therapy
US7794693B2 (en) * 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
EP1587944A4 (en) 2002-03-01 2007-03-21 Dyax Corp Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
SI2949658T1 (en) 2003-03-03 2018-10-30 Dyax Corp. Peptides that specifically bind HGF receptor (cMet) and uses thereof
US7785565B2 (en) * 2004-08-10 2010-08-31 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Metal chelators and methods of their use
WO2006114324A1 (en) * 2005-04-28 2006-11-02 Schering Ag Compounds comprising cyclized somatostatin receptor binding peptides
EP1717247A1 (en) * 2005-04-28 2006-11-02 Schering AG Cyclic peptides binding to the somatostatin receptor
WO2020145977A1 (en) * 2019-01-10 2020-07-16 Andarix Pharmaceuticals, Inc. Radiotherapeutic combination therapy for the treatment of cancer

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3780015A (en) * 1971-12-30 1973-12-18 Merck & Co Inc Process for preparing lysine containing peptides
US4707352A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
HUT42101A (en) * 1985-01-07 1987-06-29 Sandoz Ag Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
DE3522638A1 (en) * 1985-06-25 1987-01-08 Diamalt Ag NEW SOMATOSTATIN DERIVATIVES
AU593611B2 (en) * 1986-02-14 1990-02-15 Nihon Medi-Physics Co., Ltd. High molecular compounds having amino groups, and their utilization
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
HU906341D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Process for producing peptonic derivatives modified with sugar and pharmaceutical preparatives containing these compounds as active substance
CH679045A5 (en) * 1987-06-29 1991-12-13 Sandoz Ag
MY106120A (en) * 1988-12-05 1995-03-31 Novartis Ag Peptide derivatives.
US5101041A (en) * 1989-04-26 1992-03-31 The Curators Of The University Of Missouri Triamines and their derivatives as bifunctional chelating agents
US5382654A (en) * 1992-02-05 1995-01-17 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
IL108308A0 (en) * 1993-01-12 1994-04-12 Sandoz Ag Polypeptides, their production and pharmaceutical compositions containing them
SG93839A1 (en) * 1993-07-15 2003-01-21 Diatide Inc Radiolabeled peptides

Also Published As

Publication number Publication date
EP0785951A1 (en) 1997-07-30
JP3630239B2 (en) 2005-03-16
DE69526515T2 (en) 2002-11-28
JPH10507180A (en) 1998-07-14
WO1996011954A1 (en) 1996-04-25
DE69526515D1 (en) 2002-05-29
AU3602795A (en) 1996-05-06
US5556939A (en) 1996-09-17
EP0785951B1 (en) 2002-04-24

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Legal Events

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