ATE216245T1 - Zusammensetzungen zur inhibition von retroviraler verbreitung, die 2',3'-dideoxy-inosin und hydroxyharnstoff enthalten - Google Patents

Zusammensetzungen zur inhibition von retroviraler verbreitung, die 2',3'-dideoxy-inosin und hydroxyharnstoff enthalten

Info

Publication number
ATE216245T1
ATE216245T1 AT95909917T AT95909917T ATE216245T1 AT E216245 T1 ATE216245 T1 AT E216245T1 AT 95909917 T AT95909917 T AT 95909917T AT 95909917 T AT95909917 T AT 95909917T AT E216245 T1 ATE216245 T1 AT E216245T1
Authority
AT
Austria
Prior art keywords
dideoxy
hydroxyurea
inosine
compositions
distribution containing
Prior art date
Application number
AT95909917T
Other languages
German (de)
English (en)
Inventor
Serge D Malley
Raul Jorge Vila
Original Assignee
Us Gov Health & Human Serv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv
Application granted granted Critical
Publication of ATE216245T1 publication Critical patent/ATE216245T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT95909917T 1993-12-20 1994-12-20 Zusammensetzungen zur inhibition von retroviraler verbreitung, die 2',3'-dideoxy-inosin und hydroxyharnstoff enthalten ATE216245T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/169,253 US5521161A (en) 1993-12-20 1993-12-20 Method of treating HIV in humans by administration of ddI and hydroxycarbamide
PCT/IB1995/000153 WO1995017899A2 (en) 1993-12-20 1994-12-20 Mixtures of dideoxy-nucleosides and hydroxycarbamide for inhibiting retroviral spread

Publications (1)

Publication Number Publication Date
ATE216245T1 true ATE216245T1 (de) 2002-05-15

Family

ID=22614846

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95909917T ATE216245T1 (de) 1993-12-20 1994-12-20 Zusammensetzungen zur inhibition von retroviraler verbreitung, die 2',3'-dideoxy-inosin und hydroxyharnstoff enthalten

Country Status (13)

Country Link
US (2) US5521161A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0735890B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE216245T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU1821295A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2179627C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE69430440T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK0735890T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2173948T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
OA (1) OA10721A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT735890E (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW283645B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1995017899A2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA949219B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
US6346627B1 (en) * 1990-02-01 2002-02-12 Emory University Intermediates in the synthesis of 1,3-oxathiolane nucleoside enantiomers
SE9003151D0 (sv) * 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
WO1993012782A1 (en) 1991-10-31 1993-07-08 Elford Howard L Method of treating viral diseases
CA2163456C (en) * 1993-05-21 2009-06-23 Franco Lori New procedure to block the replication of reverse transcriptase dependent viruses by the use of inhibitors of deoxynucleotides synthesis
US6677310B1 (en) * 1999-04-21 2004-01-13 Nabi Ring-expanded nucleosides and nucleotides
US6093702A (en) * 1993-12-20 2000-07-25 The United States Of America As Represented By The Department Of Health And Human Services Mixtures of dideoxy-nucleosides and hydroxycarbamide for inhibiting retroviral spread
US5521161A (en) * 1993-12-20 1996-05-28 Compagnie De Developpment Aguettant S.A. Method of treating HIV in humans by administration of ddI and hydroxycarbamide
IL114520A0 (en) * 1994-07-15 1995-11-27 Lepetit Spa Dinucleoside-5',5',-pyrophosphates
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5703058A (en) * 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US6511848B2 (en) * 1996-04-17 2003-01-28 Winfried Albert Process for producing and multiplying lymphocytes
US5719132A (en) * 1996-06-27 1998-02-17 Bristol-Myers Squibb Company Compositions and methods of treating HIV with d4T, 5-fluorouracil/tegafur, and uracil
US5886165A (en) * 1996-09-24 1999-03-23 Hybridon, Inc. Mixed backbone antisense oligonucleotides containing 2'-5'-ribonucleotide- and 3'-5'-deoxyribonucleotides segments
US5932570A (en) * 1996-11-08 1999-08-03 Dupont Pharmaceuticals Company 1-(3-aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as HIV protease inhibitors
US6218386B1 (en) 1996-11-08 2001-04-17 Dupont Pharmaceuticals A1-(3-aminoindazol-5-yl)-3 butyl-cyclic urea useful as a HIV protease inhibitor
US6686462B2 (en) * 1997-02-28 2004-02-03 The Regents Of The University Of California Antiviral compounds and methods of administration
US6114312A (en) * 1997-03-07 2000-09-05 Research Institute For Genetic And Human Therapy (R.I.G.H.T.) Method of inhibiting human immunodeficiency virus by combined use of hydroxyurea, a nucleoside analog, and a protease inhibitor
JP2001521548A (ja) * 1997-03-20 2001-11-06 コンパニー デ デベロップマー アーギュタント 特にレトロウイルス伝播を阻害するための、少なくとも２種の逆転写酵素阻害剤とヒドロキシカルバミドとの混合物
AU7273598A (en) * 1997-05-05 1998-11-27 Regents Of The University Of California, The Naphthols useful in antiviral methods
ATE413881T1 (de) 1997-08-08 2008-11-15 Celmed Oncology Usa Inc Verfahren und zubereitungen um resistenz gegen biologische oder chemische therapien zu überwinden
US20020022034A1 (en) * 1997-09-15 2002-02-21 Julianna Lisziewicz Therapeutic DNA vaccination
KR100286373B1 (ko) * 1997-10-17 2001-04-16 윤종용 적외선 데이터 통신을 위한 휴대용 컴퓨터
US7462605B2 (en) * 1998-01-23 2008-12-09 Celmed Oncology (Usa), Inc. Phosphoramidate compounds and methods of use
DE69900841T2 (de) 1998-01-23 2002-10-02 Newbiotics Inc., San Diego Durch enzymkatalyse erhaltene therapeutische substanzen.
US6015796A (en) * 1998-03-11 2000-01-18 Zeria Pharmaceutical Co., Ltd. Method for treating AIDS
US6251874B1 (en) * 1998-03-26 2001-06-26 Research Institute For Genetic And Human Therapy (R.I.G.H.T.) Method of inhibiting human immunodeficiency virus using hydroxurea and a reverse transcriptase inhibitor in vivo
JP2002518452A (ja) * 1998-06-24 2002-06-25 エモリ ユニバーシティ Ｈｉｖの治療薬物の製造のための他の抗ｈｉｖ薬と組み合わせた３’−アジド−２’，３’−ジデオキシウリジンの使用
EP1146904A4 (en) * 1999-02-03 2004-09-15 Franco Lori USE OF HYDROXY URINE AND AN INHIBITOR OF REVERSE TRANSCRIPTASE FOR INDUCING AUTOVACCATION BY AUTOLOGICAL HIV
US6020325A (en) * 1999-03-09 2000-02-01 Zeria Pharmaceutical Co., Ltd. Method for inhibiting replication of HIV
MXPA02000762A (es) 1999-07-22 2002-08-20 Newbiotics Inc Metodos para tratar tumores resistentes a terapia.
US6683061B1 (en) * 1999-07-22 2004-01-27 Newbiotics, Inc. Enzyme catalyzed therapeutic activation
US6479466B1 (en) 1999-08-13 2002-11-12 University Of Maryland Compositions for treating viral infections, and methods therefor
NL1012825C2 (nl) * 1999-08-13 2001-02-23 Faculteit Geneeskunde Universi Farmaceuticum voor de behandeling van virale infecties in het bijzonder van het humane immunodeficiency virus (HIV).
AU2002241911B9 (en) * 2001-01-19 2007-01-25 Celmed Oncology (Usa), Inc. Methods to treat autoimmune and inflammatory conditions
US20050250728A1 (en) * 2002-05-23 2005-11-10 Shanta Bantia Enhancing the efficacy of reverse transcriptase and dna polymerase inhibitors (nucleoside analogs) using pnp inhibitors and/or 2'-deoxyguanosine and/or prodrug thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8324800D0 (en) * 1983-09-15 1983-10-19 Pasteur Institut Antigens
DE3689976T2 (de) * 1985-05-15 1995-03-16 Wellcome Found Therapeutische Nucleoside und deren Herstellung.
WO1987001284A1 (en) * 1985-08-26 1987-03-12 United States Of America, Represented By The Unite Inhibition of in vitro infectivity and cytopathic effect of htlv-iii/lav by 2',3'-dideoxynosine, 2',3'-dideoxyguanosine, or 2',3'-dideoxyadenosine
US5110600A (en) * 1988-01-25 1992-05-05 The Regents Of The University Of California Method of treating viral infections with amino acid analogs
US5026687A (en) * 1990-01-03 1991-06-25 The United States Of America As Represented By The Department Of Health And Human Services Treatment of human retroviral infections with 2',3'-dideoxyinosine alone and in combination with other antiviral compounds
US5300059A (en) * 1991-11-19 1994-04-05 Hydro Slip Technologies Inc. Bloodbag and method of making same
CA2163456C (en) * 1993-05-21 2009-06-23 Franco Lori New procedure to block the replication of reverse transcriptase dependent viruses by the use of inhibitors of deoxynucleotides synthesis
US5521161A (en) * 1993-12-20 1996-05-28 Compagnie De Developpment Aguettant S.A. Method of treating HIV in humans by administration of ddI and hydroxycarbamide

Also Published As

Publication number Publication date
EP0735890B1 (en) 2002-04-17
US5521161A (en) 1996-05-28
TW283645B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1996-08-21
EP0735890A1 (en) 1996-10-09
DE69430440T2 (de) 2002-11-14
US5736527A (en) 1998-04-07
DK0735890T3 (da) 2002-08-05
DE69430440D1 (de) 2002-05-23
WO1995017899A2 (en) 1995-07-06
ES2173948T3 (es) 2002-11-01
OA10721A (en) 2002-12-09
CA2179627C (en) 2000-02-22
ZA949219B (en) 1995-08-01
CA2179627A1 (en) 1995-07-06
PT735890E (pt) 2002-09-30
WO1995017899A3 (en) 1995-08-10
AU1821295A (en) 1995-07-17

Similar Documents

Publication Publication Date Title
ATE216245T1 (de) Zusammensetzungen zur inhibition von retroviraler verbreitung, die 2&#39;,3&#39;-dideoxy-inosin und hydroxyharnstoff enthalten
SI0725779T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE69326776D1 (de) Verwendung von n-arylmethylen ethylendiamintriacetate, n-arylmethylen iminodiacetat oder n,n&#39;-diarylmethylen ethylendiamindiacetat gegen oxidativen stress
ATE269066T1 (de) Kombinationstherapie zur prophylaxe und/oder behandlung von gutartiger prostatischer hyperplasie
GR3007385T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ATE206916T1 (de) Zusammensetzungen zur erhöhung der konzentration und/oder beweglichkeit von samenzellen in menschen
EA199700032A1 (ru) Дезинфицирующий состав &#34;велтолен&#34;
HUT40330A (en) Composition for treating acne and process for producing them
DE69311541D1 (de) Kosmetische oder pharmazeutische zusammensetzungen zur topischen anwendung die deacylierten glycerophospholipide enthalten
GR3029370T3 (en) Compounds and methods for inhibition of hiv and related viruses
ATE152628T1 (de) Verwendung von parathormone, seinen biologisch aktiven fragmenten oder von verwandten peptiden zur behandlung von schwangerschaft
EP0695184A4 (en) HIV PROTEASE INHIBITORS
ATE158947T1 (de) Hautregenerierende kosmetische zusammensetzung
DE69424679D1 (de) Zusammensetzung zur behandlung oder vorbeugung von herpes
DE3576154D1 (de) 5-cyanopyridine-2-diazohydroxide, basische salze und verfahren zu ihrer herstellung und anwendung.
WO1995017875A3 (en) MIXTURES OF DIDEOXYNUCLEOSIDES AND D-ASPARTIC ACID β-HYDROXAMATE FOR INHIBITING RETROVIRAL SPREAD
AU576473B2 (en) Spiro(2h-1,4-benzodioxepin-3(5h)4&#39;-piperidine and 3&#39;- pyrrolidino) compounds
ATE226818T1 (de) Zubereitungen zur behandlung von verbrennungen und externen ulcera sowie verfahren zu deren herstellung
DE69408664D1 (de) Zusammensetzungen zur behandlung von geernteter pflanzenmaterial
ATE55252T1 (de) Zusammensetzungen zur milderung, behandlung und bestimmungung von arthritschen krankheiten und aehnlichen zustaenden.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee