ATE215948T1 - Verfahren zur herstellung von mequitazin und zwischenprodukt der synthese - Google Patents
Verfahren zur herstellung von mequitazin und zwischenprodukt der syntheseInfo
- Publication number
- ATE215948T1 ATE215948T1 AT98958961T AT98958961T ATE215948T1 AT E215948 T1 ATE215948 T1 AT E215948T1 AT 98958961 T AT98958961 T AT 98958961T AT 98958961 T AT98958961 T AT 98958961T AT E215948 T1 ATE215948 T1 AT E215948T1
- Authority
- AT
- Austria
- Prior art keywords
- mequitazine
- producing
- synthesis intermediate
- laevo
- gyrate
- Prior art date
Links
- HOKDBMAJZXIPGC-UHFFFAOYSA-N Mequitazine Chemical compound C12=CC=CC=C2SC2=CC=CC=C2N1CC1C(CC2)CCN2C1 HOKDBMAJZXIPGC-UHFFFAOYSA-N 0.000 title abstract 2
- 229960005042 mequitazine Drugs 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 abstract 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
- 150000002990 phenothiazines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9715479A FR2772029B1 (fr) | 1997-12-08 | 1997-12-08 | Procede de preparation de la mequitazine et nouvel intermediaire de synthese |
| PCT/FR1998/002638 WO1999029692A1 (fr) | 1997-12-08 | 1998-12-07 | Procede de preparation de la mequitazine et nouvel intermediaire de synthese |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE215948T1 true ATE215948T1 (de) | 2002-04-15 |
Family
ID=9514296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98958961T ATE215948T1 (de) | 1997-12-08 | 1998-12-07 | Verfahren zur herstellung von mequitazin und zwischenprodukt der synthese |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1037891B1 (de) |
| AT (1) | ATE215948T1 (de) |
| DE (1) | DE69804853T2 (de) |
| ES (1) | ES2175823T3 (de) |
| FR (1) | FR2772029B1 (de) |
| WO (1) | WO1999029692A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6433168B1 (en) | 1999-07-26 | 2002-08-13 | Sumika Fine Chemicals Co., Ltd. | Highly pure phenothiazine compound, production method thereof, production method of intermediate therefor, and hydrate and novel crystal as starting materials for the intermediate |
| ES2257968B1 (es) * | 2005-01-28 | 2007-07-01 | Universidad De Sevilla | Procedimiento y dispositivo para la obtencion de particulas de tamaño micro y nanometrico. |
| FR2896690B1 (fr) * | 2006-01-30 | 2008-05-02 | Pierre Fabre Medicament Sa | Utilisation de l'enantiomere(s) de la mequitazine pour la preparation d'un medicament, tout en limitant la toxicite genomique |
| FR2911606B1 (fr) * | 2007-01-18 | 2009-04-17 | Pierre Fabre Medicament Sa | Nouveau derive de la quinuclidine utile dans la preparation de la mequitazine |
| FR2916142A1 (fr) * | 2007-05-15 | 2008-11-21 | Pierre Fabre Medicament Sa | Forme pharmaceutique comprenant du (10-[(3s)-1-azabicyclo [2.2.2]oct-3-ylmethyl]-10h-phenothiazine se presentant sous une forme appropriee pour l'administration d'unde dose journaliere comprise entre 1 et 3 mg |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1250534A (de) * | 1969-03-03 | 1971-10-20 | ||
| JPS57175181A (en) * | 1981-04-20 | 1982-10-28 | Daicel Chem Ind Ltd | Novel phenothiazine derivative |
| FR2522660A1 (fr) * | 1982-03-05 | 1983-09-09 | Pharmuka Lab | Isomere levogyre de la mequitazine, son procede de preparation et medicaments le contenant |
| JP2835413B2 (ja) * | 1990-10-30 | 1998-12-14 | 住化ファインケム株式会社 | フェノチアジン誘導体およびその製造方法 |
| JP2979358B2 (ja) * | 1991-11-22 | 1999-11-15 | 住化ファインケム株式会社 | フェノチアジン誘導体 |
-
1997
- 1997-12-08 FR FR9715479A patent/FR2772029B1/fr not_active Expired - Fee Related
-
1998
- 1998-12-07 DE DE69804853T patent/DE69804853T2/de not_active Expired - Lifetime
- 1998-12-07 WO PCT/FR1998/002638 patent/WO1999029692A1/fr not_active Ceased
- 1998-12-07 AT AT98958961T patent/ATE215948T1/de not_active IP Right Cessation
- 1998-12-07 EP EP98958961A patent/EP1037891B1/de not_active Expired - Lifetime
- 1998-12-07 ES ES98958961T patent/ES2175823T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999029692A1 (fr) | 1999-06-17 |
| DE69804853T2 (de) | 2002-11-14 |
| ES2175823T3 (es) | 2002-11-16 |
| EP1037891B1 (de) | 2002-04-10 |
| EP1037891A1 (de) | 2000-09-27 |
| DE69804853D1 (de) | 2002-05-16 |
| FR2772029B1 (fr) | 2000-02-25 |
| FR2772029A1 (fr) | 1999-06-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |