ATE201212T1 - Verfahren zur herstellung von sulfierte oligonukleotid-analoge - Google Patents
Verfahren zur herstellung von sulfierte oligonukleotid-analogeInfo
- Publication number
- ATE201212T1 ATE201212T1 AT92918677T AT92918677T ATE201212T1 AT E201212 T1 ATE201212 T1 AT E201212T1 AT 92918677 T AT92918677 T AT 92918677T AT 92918677 T AT92918677 T AT 92918677T AT E201212 T1 ATE201212 T1 AT E201212T1
- Authority
- AT
- Austria
- Prior art keywords
- sulfufated
- producing
- oligonucleotide analogues
- analogs
- phosphorthioamidite
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000543 intermediate Substances 0.000 abstract 2
- CSNJTIWCTNEOSW-UHFFFAOYSA-N carbamothioylsulfanyl carbamodithioate Chemical compound NC(=S)SSC(N)=S CSNJTIWCTNEOSW-UHFFFAOYSA-N 0.000 abstract 1
- NAGJZTKCGNOGPW-UHFFFAOYSA-N dithiophosphoric acid Chemical class OP(O)(S)=S NAGJZTKCGNOGPW-UHFFFAOYSA-N 0.000 abstract 1
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 abstract 1
- 150000008300 phosphoramidites Chemical class 0.000 abstract 1
- BIIUNHCUZONUSM-UHFFFAOYSA-N sulfanylphosphonamidous acid Chemical compound NP(O)S BIIUNHCUZONUSM-UHFFFAOYSA-N 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1991/001008 WO1992014742A1 (en) | 1991-02-14 | 1991-02-14 | Method of synthesizing sulfurized oligonucleotide analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE201212T1 true ATE201212T1 (de) | 2001-06-15 |
Family
ID=22225344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92918677T ATE201212T1 (de) | 1991-02-14 | 1991-02-14 | Verfahren zur herstellung von sulfierte oligonukleotid-analoge |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0643721B1 (de) |
| JP (1) | JP3087181B2 (de) |
| AT (1) | ATE201212T1 (de) |
| DE (1) | DE69132611T2 (de) |
| WO (1) | WO1992014742A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0540789U (ja) * | 1991-10-28 | 1993-06-01 | 株式会社ヨシノ | 冷蔵庫用テーブル |
| US5852168A (en) * | 1996-04-30 | 1998-12-22 | Regents Of The University Of Minesota | Sulfurization of phosphorus-containing compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3730379A1 (de) | 1987-09-10 | 1989-03-30 | Kernforschungsz Karlsruhe | Verfahren zur herstellung eines halbzeugs oder endproduktes aus einphasigem, hochlegiertem martensitischem chromstahl durch warm- und/oder kaltverformung |
| US5194599A (en) * | 1988-09-23 | 1993-03-16 | Gilead Sciences, Inc. | Hydrogen phosphonodithioate compositions |
-
1991
- 1991-02-14 EP EP92918677A patent/EP0643721B1/de not_active Expired - Lifetime
- 1991-02-14 JP JP03508564A patent/JP3087181B2/ja not_active Expired - Fee Related
- 1991-02-14 DE DE69132611T patent/DE69132611T2/de not_active Expired - Fee Related
- 1991-02-14 AT AT92918677T patent/ATE201212T1/de not_active IP Right Cessation
- 1991-02-14 WO PCT/US1991/001008 patent/WO1992014742A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0643721A1 (de) | 1995-03-22 |
| DE69132611T2 (de) | 2002-04-18 |
| EP0643721B1 (de) | 2001-05-16 |
| EP0643721A4 (de) | 1994-06-06 |
| DE69132611D1 (de) | 2001-06-21 |
| WO1992014742A1 (en) | 1992-09-03 |
| JP3087181B2 (ja) | 2000-09-11 |
| JPH06504982A (ja) | 1994-06-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties | ||
| REN | Ceased due to non-payment of the annual fee |