ATE197156T1 - Verfahren zum nachweis von verbindungen einer konbinatorischen bibliothek. - Google Patents

Verfahren zum nachweis von verbindungen einer konbinatorischen bibliothek.

Info

Publication number
ATE197156T1
ATE197156T1 AT95915384T AT95915384T ATE197156T1 AT E197156 T1 ATE197156 T1 AT E197156T1 AT 95915384 T AT95915384 T AT 95915384T AT 95915384 T AT95915384 T AT 95915384T AT E197156 T1 ATE197156 T1 AT E197156T1
Authority
AT
Austria
Prior art keywords
pct
tof
bead
sec
grid
Prior art date
Application number
AT95915384T
Other languages
English (en)
Inventor
Stephen J Benkovic
Nicholas Winograd
Christopher L Brummel
Irene N W Lee
Original Assignee
Penn State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Penn State Res Found filed Critical Penn State Res Found
Application granted granted Critical
Publication of ATE197156T1 publication Critical patent/ATE197156T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Indexing, Searching, Synchronizing, And The Amount Of Synchronization Travel Of Record Carriers (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT95915384T 1994-03-23 1995-03-23 Verfahren zum nachweis von verbindungen einer konbinatorischen bibliothek. ATE197156T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21704694A 1994-03-23 1994-03-23
PCT/US1995/003355 WO1995025737A1 (en) 1994-03-23 1995-03-23 Method for identifying members of combinatorial libraries

Publications (1)

Publication Number Publication Date
ATE197156T1 true ATE197156T1 (de) 2000-11-15

Family

ID=22809467

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95915384T ATE197156T1 (de) 1994-03-23 1995-03-23 Verfahren zum nachweis von verbindungen einer konbinatorischen bibliothek.

Country Status (8)

Country Link
US (1) US5834195A (de)
EP (1) EP0751950B1 (de)
JP (1) JPH09510711A (de)
AT (1) ATE197156T1 (de)
DE (1) DE69519225T2 (de)
DK (1) DK0751950T3 (de)
ES (1) ES2151057T3 (de)
WO (1) WO1995025737A1 (de)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6654505B2 (en) 1994-10-13 2003-11-25 Lynx Therapeutics, Inc. System and apparatus for sequential processing of analytes
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
WO1998053300A2 (en) 1997-05-23 1998-11-26 Lynx Therapeutics, Inc. System and apparaus for sequential processing of analytes
US5891742A (en) * 1995-01-19 1999-04-06 Chiron Corporation Affinity selection of ligands by mass spectroscopy
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
WO1997012897A1 (en) * 1995-10-03 1997-04-10 The Penn State Research Foundation Method to identify a surface-bound molecule
EP0992511B1 (de) * 1996-01-23 2009-03-11 Operon Biotechnologies, Inc. Verfahren und Zusammensetzungen zur Bestimmung von Sequenzen von Nukleinsäure-Molekülen
US6312893B1 (en) 1996-01-23 2001-11-06 Qiagen Genomics, Inc. Methods and compositions for determining the sequence of nucleic acid molecules
US6613508B1 (en) 1996-01-23 2003-09-02 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
CN1163619C (zh) * 1996-01-23 2004-08-25 佳根基因组学公司 测定核酸分子序列的方法和组合物
US6027890A (en) 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
US6063633A (en) 1996-02-28 2000-05-16 The University Of Houston Catalyst testing process and apparatus
AU2889097A (en) * 1996-05-10 1997-12-05 Novartis Ag Identification of members of combinatorial libraries by mass spectrometry
DE69735411T2 (de) * 1996-10-09 2006-09-07 Symyx Technologies, Inc., Santa Clara Infrarot-spektroskopie und abbildung von bibliotheken
CA2270132A1 (en) 1996-11-06 1998-05-14 Sequenom, Inc. Dna diagnostics based on mass spectrometry
DE19649359C1 (de) * 1996-11-28 1998-02-12 Thomas Prof Dr Peters Verfahren zum Nachweis biologisch aktiver Substanzen in Substanzbibliotheken
WO1998026095A1 (en) 1996-12-10 1998-06-18 Genetrace Systems Inc. Releasable nonvolatile mass-label molecules
GB9710582D0 (en) * 1997-05-22 1997-07-16 Oxford Glycosciences Uk Ltd A method for de novo peptide sequence determination
US6969488B2 (en) * 1998-05-22 2005-11-29 Solexa, Inc. System and apparatus for sequential processing of analytes
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
AU738237B2 (en) * 1997-07-22 2001-09-13 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
AU8414798A (en) * 1997-07-23 1999-02-16 Millennium Pharmaceuticals, Inc. Multiple target screening of molecular libraries by mass spectrometry
US6207370B1 (en) * 1997-09-02 2001-03-27 Sequenom, Inc. Diagnostics based on mass spectrometric detection of translated target polypeptides
EP0974054A1 (de) * 1997-11-07 2000-01-26 The Penn State Research Foundation Kombinatorisches chemiesystem und methode zur benutzung
US6428956B1 (en) * 1998-03-02 2002-08-06 Isis Pharmaceuticals, Inc. Mass spectrometric methods for biomolecular screening
CA2240325A1 (en) 1998-03-27 1998-11-14 Synsorb Biotech, Inc. Methods for screening compound libraries
US6613575B1 (en) 1998-03-27 2003-09-02 Ole Hindsgaul Methods for screening compound libraries
US6720190B1 (en) 1998-03-27 2004-04-13 Ole Hindsgaul Methods for screening compound libraries
US6054047A (en) * 1998-03-27 2000-04-25 Synsorb Biotech, Inc. Apparatus for screening compound libraries
US6191418B1 (en) 1998-03-27 2001-02-20 Synsorb Biotech, Inc. Device for delivery of multiple liquid sample streams to a mass spectrometer
US6998233B2 (en) 1998-06-26 2006-02-14 Sunesis Pharmaceuticals, Inc. Methods for ligand discovery
US6919178B2 (en) 2000-11-21 2005-07-19 Sunesis Pharmaceuticals, Inc. Extended tethering approach for rapid identification of ligands
US6288390B1 (en) 1999-03-09 2001-09-11 Scripps Research Institute Desorption/ionization of analytes from porous light-absorbing semiconductor
WO2001034291A2 (en) 1999-11-09 2001-05-17 Sri International High-throughput synthesis, screening and characterization of combinatorial libraries
US7033840B1 (en) 1999-11-09 2006-04-25 Sri International Reaction calorimeter and differential scanning calorimeter for the high-throughput synthesis, screening and characterization of combinatorial libraries
US6864091B1 (en) 2000-08-31 2005-03-08 Symyx Technologies, Inc. Sampling probe
AU2001296846B2 (en) 2000-10-12 2007-07-05 University Of Rochester Compositions that inhibit proliferation of cancer cells
US7074570B2 (en) * 2001-05-23 2006-07-11 Ge Healthcare Bio-Sciences Ab Peptide fragmentation
US6800449B1 (en) * 2001-07-13 2004-10-05 Syngenta Participations Ag High throughput functional proteomics
US7202030B2 (en) * 2001-11-01 2007-04-10 Rensselaer Polytechnic Institute Solid-phase array-based biocatalytic transformations
KR20040096554A (ko) 2002-02-06 2004-11-16 비코르 테크놀로지스 인코포레이티드 경색방지 분자
JP2004024203A (ja) * 2002-06-28 2004-01-29 Canon Inc 飛行時間型二次イオン質量分析法によるｒｎａの分析方法
US20040137491A1 (en) * 2002-06-28 2004-07-15 Tadashi Okamoto Method of analyzing probe carrier using time-of-flight secondary ion mass spectrometry
CA2495478A1 (en) 2002-08-05 2004-02-12 University Of Rochester Protein transducing domain/deaminase chimeric proteins, related compounds, and uses thereof
US7074318B1 (en) 2002-08-20 2006-07-11 The United States Of America As Represented By The Secretary Of The Army Movable ionic conductive wire and method of forming an electrochemical cell
EP1701784A1 (de) 2003-12-22 2006-09-20 VersaMatrix A/S Identifikation von kodierten kügelchen
CA2550902C (en) 2003-12-22 2013-06-25 Versamatrix A/S Apparatus and methods for analysis and sorting of particles such as polymer beads
US6958480B1 (en) 2004-06-25 2005-10-25 The Regents Of The University Of California Sample desorption/ionization from mesoporous silica
JP5129119B2 (ja) 2005-04-05 2013-01-23 コーニング インコーポレイテッド 標識フリーバイオセンサおよび細胞
ES2431315T3 (es) 2005-05-19 2013-11-26 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Epítopos funcionales del antígeno PsaA de Streptococcus pneumoniae y usos de los mismos
EP2392646A1 (de) 2005-10-14 2011-12-07 MUSC Foundation For Research Development Targeting von PAX2 zur Induktion der DEFB1-vermittelten Tumorimmunität und Krebstherapie
US8080534B2 (en) 2005-10-14 2011-12-20 Phigenix, Inc Targeting PAX2 for the treatment of breast cancer
US7695601B2 (en) * 2006-05-09 2010-04-13 The United States Of America As Represented By The Secretary Of The Army Electrochemical test apparatus and method for its use
CA2664189C (en) 2006-09-21 2017-11-21 University Of Rochester Compositions and methods related to protein displacement therapy for myotonic dystrophy
EP2104516B1 (de) 2006-11-01 2015-01-07 University of Rochester Verfahren und zusammensetzungen in zusammenhang mit der struktur und funktion von apobec3g
US9381226B2 (en) 2007-02-08 2016-07-05 University Of Utah Research Foundation Methods and compositions related to inhibition of viral entry
GB0714301D0 (en) * 2007-07-21 2007-08-29 Ionoptika Ltd Secondary ion mass spectrometry and secondary neutral mass spectrometry using a multiple-plate buncher
ES2325724B1 (es) 2008-03-11 2010-05-31 FUNDACION DE LA COMUNIDAD VALENCIANA "CENTRO DE INVESTIGACIONES PRINCIPE FELIPE" Composicion farmaceutica para inhibir el factor de transcripcion inducible por hipoxia. moduladores de procesos patologicos de angiogenesis, oncogenesis, inflamacion, apoptosis y terapia celular.
AU2009281732A1 (en) 2008-08-15 2010-02-18 Georgetown University Na channels, disease, and related assays and compositions
EP2370080A1 (de) 2008-12-02 2011-10-05 University of Utah Research Foundation Pde1 als zieltherapeutikum bei herzkrankheiten
US20120149663A1 (en) 2009-08-18 2012-06-14 Georgetown University Boronic acid compositions and methods related to cancer
WO2011043980A1 (en) 2009-10-07 2011-04-14 Sanford Burnham Medical Research Institute Methods and compositions related to clot-binding lipid compounds
CA2784145A1 (en) 2009-12-18 2011-06-23 Sanford-Burnham Medical Research Institute Methods and compositions related to clot-binding compounds
EP2691105B1 (de) 2011-03-28 2018-07-11 University of Utah Research Foundation Verfahren und zusammensetzungen zur viruseindringungshemmung
WO2019055618A1 (en) 2017-09-15 2019-03-21 Arizona Board Of Regents On Behalf Of Arizona State University METHODS OF CLASSIFYING RESPONSES TO ANTICANCER IMMUNOTHERAPY
WO2021067550A1 (en) 2019-10-02 2021-04-08 Arizona Board Of Regents On Behalf Of Arizona State University Methods and compositions for identifying neoantigens for use in treating and preventing cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4988879A (en) * 1987-02-24 1991-01-29 The Board Of Trustees Of The Leland Stanford Junior College Apparatus and method for laser desorption of molecules for quantitation
US5010175A (en) * 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5272338A (en) * 1992-05-21 1993-12-21 The Pennsylvania Research Corporation Molecular imaging system

Also Published As

Publication number Publication date
DE69519225T2 (de) 2001-03-29
DK0751950T3 (da) 2001-01-29
WO1995025737A1 (en) 1995-09-28
DE69519225D1 (de) 2000-11-30
EP0751950B1 (de) 2000-10-25
US5834195A (en) 1998-11-10
EP0751950A1 (de) 1997-01-08
JPH09510711A (ja) 1997-10-28
ES2151057T3 (es) 2000-12-16

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee