ATE186741T1 - Polyarylate, die derivate der natürlichen aminosäure l-tyrosin enthalten - Google Patents

Polyarylate, die derivate der natürlichen aminosäure l-tyrosin enthalten

Info

Publication number
ATE186741T1
ATE186741T1 AT93920079T AT93920079T ATE186741T1 AT E186741 T1 ATE186741 T1 AT E186741T1 AT 93920079 T AT93920079 T AT 93920079T AT 93920079 T AT93920079 T AT 93920079T AT E186741 T1 ATE186741 T1 AT E186741T1
Authority
AT
Austria
Prior art keywords
amino acid
natural amino
tyrosine
containing derivatives
polyarylate containing
Prior art date
Application number
AT93920079T
Other languages
English (en)
Inventor
Joachim B Kohn
James J Fiordeliso
Original Assignee
Univ Rutgers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rutgers filed Critical Univ Rutgers
Application granted granted Critical
Publication of ATE186741T1 publication Critical patent/ATE186741T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
    • C08G64/04—Aromatic polycarbonates
    • C08G64/06—Aromatic polycarbonates not containing aliphatic unsaturation
    • C08G64/08—Aromatic polycarbonates not containing aliphatic unsaturation containing atoms other than carbon, hydrogen or oxygen
    • C08G64/12—Aromatic polycarbonates not containing aliphatic unsaturation containing atoms other than carbon, hydrogen or oxygen containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/68—Polyesters containing atoms other than carbon, hydrogen and oxygen
    • C08G63/685—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen
    • C08G63/6854—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen derived from polycarboxylic acids and polyhydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/44—Polyester-amides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Polyamides (AREA)
  • Materials For Medical Uses (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
AT93920079T 1992-08-13 1993-08-13 Polyarylate, die derivate der natürlichen aminosäure l-tyrosin enthalten ATE186741T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/930,146 US5216115A (en) 1990-06-12 1992-08-13 Polyarylate containing derivatives of the natural amino acid L-tyrosine

Publications (1)

Publication Number Publication Date
ATE186741T1 true ATE186741T1 (de) 1999-12-15

Family

ID=25458979

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93920079T ATE186741T1 (de) 1992-08-13 1993-08-13 Polyarylate, die derivate der natürlichen aminosäure l-tyrosin enthalten

Country Status (8)

Country Link
US (1) US5216115A (de)
EP (1) EP0656026B1 (de)
JP (1) JP3255365B2 (de)
AT (1) ATE186741T1 (de)
AU (1) AU670821B2 (de)
CA (1) CA2140255C (de)
DE (1) DE69327057T2 (de)
WO (1) WO1994004593A1 (de)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE37160E1 (en) * 1990-06-12 2001-05-01 Rutgers, The State University Synthesis of tyrosine derived diphenol monomers
US5587507A (en) * 1995-03-31 1996-12-24 Rutgers, The State University Synthesis of tyrosine derived diphenol monomers
US6515009B1 (en) * 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) * 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5658995A (en) * 1995-11-27 1997-08-19 Rutgers, The State University Copolymers of tyrosine-based polycarbonate and poly(alkylene oxide)
US6120491A (en) * 1997-11-07 2000-09-19 The State University Rutgers Biodegradable, anionic polymers derived from the amino acid L-tyrosine
US6048521A (en) * 1997-11-07 2000-04-11 Rutgers, The State University Copolymers of tyrosine-based polyarlates and poly(alkylene oxides)
AU729552B2 (en) * 1997-02-18 2001-02-01 Rutgers, The State University Monomers derived from hydroxy acids and polymers prepared therefrom
DE69842217D1 (de) * 1997-11-07 2011-05-19 State University Röntgendichte polymerische Biomateriale
US6602497B1 (en) 1997-11-07 2003-08-05 Rutgers, The State University Strictly alternating poly(alkylene oxide ether) copolymers
US6623521B2 (en) 1998-02-17 2003-09-23 Md3, Inc. Expandable stent with sliding and locking radial elements
EP1073688B1 (de) 1998-04-13 2015-03-04 Rutgers, The State University Herstellung von copolymerbibliotheken
US8133421B2 (en) * 1999-02-23 2012-03-13 Warsaw Orthopedic, Inc. Methods of making shaped load-bearing osteoimplant
US20070233272A1 (en) * 1999-02-23 2007-10-04 Boyce Todd M Shaped load-bearing osteoimplant and methods of making same
US6103255A (en) * 1999-04-16 2000-08-15 Rutgers, The State University Porous polymer scaffolds for tissue engineering
CA2370810C (en) * 1999-04-16 2007-06-19 Rutgers, The State University Porous polymer scaffolds for tissue engineering
US6899137B2 (en) * 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US20030170285A1 (en) * 2001-11-13 2003-09-11 Veazey William S. Delivery of tissue engineering media
CA2822457C (en) 2001-12-14 2016-03-08 The University Of Wyoming Methods and compositions for controlled resease of drugs
AU2003234231A1 (en) * 2002-04-24 2003-11-10 Rutgers New polyarylates for drug delivery and tissue engineering
US20060182752A1 (en) * 2003-05-15 2006-08-17 Rutgers, The State University Tri-block polymers for nanosphere-based drug or gene delivery
US8591951B2 (en) * 2002-05-15 2013-11-26 Joachim B. Kohn Tri-block copolymers for nanosphere-based drug delivery
US6916868B2 (en) * 2003-01-23 2005-07-12 Integra Lifesciences Corporation Selective modification of pendent functionalities of polymers
US8685367B2 (en) 2003-09-25 2014-04-01 Rutgers, The State University of of New Jersey Inherently radiopaque polymeric products for embolotherapy
US7368169B2 (en) * 2003-12-01 2008-05-06 Rutgers, The State University Of New Jersey Hydrazide compounds with angiogenic activity
US7763065B2 (en) 2004-07-21 2010-07-27 Reva Medical, Inc. Balloon expandable crush-recoverable stent device
US20060034891A1 (en) * 2004-08-12 2006-02-16 Laurie Lawin Biodegradable controlled release bioactive agent delivery device
WO2006020616A1 (en) * 2004-08-13 2006-02-23 Reva Medical, Inc. Inherently radiopaque bioresorbable polymers for multiple uses
US20060034769A1 (en) * 2004-08-13 2006-02-16 Rutgers, The State University Radiopaque polymeric stents
US8292944B2 (en) 2004-12-17 2012-10-23 Reva Medical, Inc. Slide-and-lock stent
US7914574B2 (en) 2005-08-02 2011-03-29 Reva Medical, Inc. Axially nested slide and lock expandable device
US9149378B2 (en) 2005-08-02 2015-10-06 Reva Medical, Inc. Axially nested slide and lock expandable device
US8153837B2 (en) 2005-11-03 2012-04-10 Tyrx, Inc. Resorbable phenolic polymers
US8287914B2 (en) 2006-01-12 2012-10-16 Rutgers, The State University Of New Jersey Biomimetic hydroxyapatite synthesis
US8591531B2 (en) * 2006-02-08 2013-11-26 Tyrx, Inc. Mesh pouches for implantable medical devices
JP5367692B2 (ja) 2006-02-08 2013-12-11 タイレックス・インコーポレイテッド 一時的補剛メッシュ補綴具
US8315700B2 (en) * 2006-02-08 2012-11-20 Tyrx, Inc. Preventing biofilm formation on implantable medical devices
WO2007115368A1 (en) * 2006-04-07 2007-10-18 The University Of Queensland Porous polymer structures
EP2010597B1 (de) * 2006-04-07 2015-06-17 The University of Queensland Poröse polymerblendstrukturen
US8034365B2 (en) * 2006-10-17 2011-10-11 Reva Medical, Inc. N-substituted monomers and polymers
EP2079416A4 (de) * 2006-10-30 2012-06-27 Univ Rutgers Elektrospinn-matrizen zur ausgabe hydrophiler und lipophiler verbindungen
US9023114B2 (en) 2006-11-06 2015-05-05 Tyrx, Inc. Resorbable pouches for implantable medical devices
JP2010508915A (ja) 2006-11-06 2010-03-25 タイレックス・ファーマ・インコーポレイテッド 埋込型医療機器のためのメッシュパウチ
EP2079389B1 (de) * 2006-11-06 2018-01-10 Tyrx, Inc. Resorbierbare beutel für implantierbare medizinische vorrichtungen
WO2008066902A2 (en) 2006-11-30 2008-06-05 Nektar Therapeutics Al, Corporation Method for preparing a polymer conjugate
US7704275B2 (en) 2007-01-26 2010-04-27 Reva Medical, Inc. Circumferentially nested expandable device
CN101668512A (zh) 2007-01-31 2010-03-10 新泽西鲁特格斯州立大学 皮肤中活性物质的控制释放
EP2129339B1 (de) * 2007-03-29 2015-03-04 Tyrx, Inc. Biologisch abbaubare polymerabdeckungen für brustimplantate
MX2009011785A (es) * 2007-05-02 2010-03-04 Tyrx Pharma Inc Polimeros de dihidroxibenzoato y usos de los mismos.
JP6046331B2 (ja) 2007-06-21 2016-12-14 タイレックス・インコーポレイテッドTyrx Inc. ポリマーの吸収性を高めるためのフェニルエステル側鎖
WO2009070180A1 (en) 2007-11-30 2009-06-04 Reva Medical, Inc. Axially-radially nested expandable device
WO2009149093A1 (en) 2008-06-02 2009-12-10 University Of Medicine And Dentistry Of New Jersey Tissue engineered fibrocartilage replacement
US8617607B2 (en) * 2008-07-10 2013-12-31 Tyrx, Inc. Sustained release formulations of psychoactive drugs
WO2010006046A1 (en) * 2008-07-10 2010-01-14 Tyrx Pharma, Inc. Nsaid delivery from polyarylates
EP2334712A4 (de) * 2008-09-16 2013-10-23 Univ Rutgers Aus monomeranaloga natürlicher metaboliten synthetisierte bioresorbierbare polymere
WO2010033995A1 (en) 2008-09-22 2010-03-25 Tyrx Pharma, Inc. Linear polyesteramides from aminophenolic esters
CN103948460B (zh) 2008-10-10 2016-05-25 雷瓦医药公司 可扩展的滑动和锁定支架
EP2349213B1 (de) 2008-10-11 2025-06-18 Rutgers, The State University of New Jersey Phasengetrennte biokompatible polymerzusammensetzungen zur verwendung in der medizin
US20100215716A1 (en) * 2009-02-23 2010-08-26 Biomet Manufacturing Corp. Compositions and methods for coating orthopedic implants
US9839628B2 (en) 2009-06-01 2017-12-12 Tyrx, Inc. Compositions and methods for preventing sternal wound infections
JP5847706B2 (ja) 2009-06-01 2016-01-27 タイレックス・インコーポレイテッドTyrx Inc. 胸骨創感染症を予防するための組成物および方法
US9080015B2 (en) 2009-07-31 2015-07-14 Rutgers, The State University Of New Jersey Biocompatible polymers for medical devices
US8409279B2 (en) 2009-10-01 2013-04-02 Lipose Corporation Breast implant implantation method and apparatus
AU2010303170B2 (en) 2009-10-11 2015-02-26 Rutgers, The State University Of New Jersey Biocompatible polymers for medical devices
CA2795292A1 (en) 2010-04-10 2011-10-13 Reva Medical, Inc. Expandable slide and lock stent
JP6031033B2 (ja) * 2010-08-25 2016-11-24 タイレックス・インコーポレイテッドTyrx Inc. 医療デバイスの新規なコーティング
US8883861B2 (en) 2010-11-01 2014-11-11 Rutgers, The State University Of New Jersey Iminic monomers and polymers thereof
WO2012064963A1 (en) 2010-11-12 2012-05-18 Tyrx, Inc. Anchorage devices comprising an active pharmaceutical ingredient
US8961948B2 (en) 2011-01-17 2015-02-24 Rutgers, The State University Of New Jersey Molecular surface design of tyrosine-derived polycarbonates for attachment of biomolecules
AU2012283875B2 (en) 2011-07-20 2016-05-12 Medtronic, Inc. Drug eluting mesh to prevent infection of indwelling transdermal devices
US11472918B2 (en) 2012-02-03 2022-10-18 Rutgers, The State University Of New Jersey Polymeric biomaterials derived from phenolic monomers and their medical uses
US9416090B2 (en) 2012-02-03 2016-08-16 Rutgers, The State University Of New Jersey Polymeric biomaterials derived from phenolic monomers and their medical uses
KR101417305B1 (ko) 2012-07-23 2014-07-08 포항공과대학교 산학협력단 이온성 액체가 화학적으로 결합된 고분자 전해질막 및 이를 이용한 연료전지
WO2014137454A1 (en) 2013-03-07 2014-09-12 Tyrx, Inc. Methods and compositions to inhibit the assemblage of microbial cells irreversibly associated with surfaces of medical devices
KR102210895B1 (ko) 2013-03-08 2021-02-02 폴리액티바 피티와이 리미티드 생리활성 물질의 전달을 위한 폴리머 결합체
WO2014159337A1 (en) 2013-03-14 2014-10-02 Reva Medical, Inc. Reduced - profile slide and lock stent
WO2015021254A1 (en) 2013-08-07 2015-02-12 Rutgers, The State Universtity Of New Jersey Polymeric biomaterials derived from monomers comprising hydroxyacids and phenol compounds and their medical uses
WO2015069305A1 (en) 2013-11-08 2015-05-14 Tyrx, Inc. Antimicrobial compositions and methods for preventing infection in surgical incision sites
US10774030B2 (en) 2014-12-23 2020-09-15 Rutgers, The State University Of New Jersey Polymeric biomaterials derived from phenolic monomers and their medical uses
EP3237487B1 (de) 2014-12-23 2021-02-17 Rutgers, the State University of New Jersey Biokompatible iodierte diphenolmonomere und polymere
US11129711B2 (en) 2015-02-27 2021-09-28 University of Pittsburgh—of the Commonwealth System of Higher Education Double component mandrel for electrospun stentless, multi-leaflet valve fabrication
EP3579790A4 (de) 2017-02-13 2020-12-23 Rutgers, The State University of New Jersey Polymerfilamentverstärktes gerüst zur partiellen meniskusregeneration
WO2018156856A1 (en) 2017-02-23 2018-08-30 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Stentless biopolymer heart valve replacement capable of living tissue regeneration
US11680341B2 (en) 2017-03-20 2023-06-20 University of Pittsburgh—of the Commonwealth System of Higher Education Mandrel-less electrospinning processing method and system, and uses therefor
WO2019094734A1 (en) 2017-11-09 2019-05-16 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Decellularization and functionalization of extracellular matrix biomaterials
EP3999675A4 (de) 2019-07-15 2024-04-17 University of Pittsburgh - of the Commonwealth System of Higher Education Verarbeitungsverfahren und vorrichtung für mikrostrukturiertes seilförmiges material
WO2024073481A2 (en) 2022-09-28 2024-04-04 Rutgers, The State University Of New Jersey Microdevices for use in cell seeding onto two- and three-dimensional biocompatible constructs

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2891929A (en) * 1954-03-31 1959-06-23 Eastman Kodak Co Polyesters of a glycol, a dicarboxylic acid and an aminoacid
NL295096A (de) * 1962-07-09
BE689347A (de) * 1965-12-09 1967-04-14 Madan Ag
US4356166A (en) * 1978-12-08 1982-10-26 University Of Utah Time-release chemical delivery system
MX158102A (es) * 1980-03-24 1989-01-09 Sun Chemical Corp Procedimiento mejorado para la obtencion de una resina de eteres de poliamida
US4579866A (en) * 1984-05-29 1986-04-01 Usv Pharmaceutical Corp. Phenylacetamides as anti-allergy, anti-asthma and anti-inflammatory agents
US4868277A (en) * 1988-08-18 1989-09-19 The Dow Chemical Company Polyamide resins with good toughness properties
US4999417A (en) * 1989-03-30 1991-03-12 Nova Pharmaceutical Corporation Biodegradable polymer compositions
FR2649713B1 (fr) * 1989-07-12 1991-10-18 Atochem Copolyesteramides semialiphatiques thermotropes et leur procede de preparation
US5015476A (en) * 1989-08-11 1991-05-14 Paravax, Inc. Immunization implant and method
US5099060A (en) 1990-06-12 1992-03-24 Rutgers, The State University Of New Jersey Synthesis of amino acid-derived bioerodible polymers

Also Published As

Publication number Publication date
CA2140255A1 (en) 1994-03-03
EP0656026A1 (de) 1995-06-07
JPH08500387A (ja) 1996-01-16
EP0656026B1 (de) 1999-11-17
WO1994004593A1 (en) 1994-03-03
US5216115A (en) 1993-06-01
AU670821B2 (en) 1996-08-01
CA2140255C (en) 1999-04-06
DE69327057T2 (de) 2000-04-13
EP0656026A4 (de) 1996-01-10
AU5013293A (en) 1994-03-15
DE69327057D1 (de) 1999-12-23
JP3255365B2 (ja) 2002-02-12

Similar Documents

Publication Publication Date Title
DE69327057D1 (de) Polyarylate, die derivate der natürlichen aminosäure l-tyrosin enthalten
ES2031806T3 (es) Factor de permeabilidad vascular humano.
ATE104348T1 (de) O-glycosyliertes ifn-alpha.
ATE217884T1 (de) Pentapeptid-methylester, die menschliche krebs hemmen
FI945912A0 (fi) Proteinoidikantajat ja menetelmät niiden valmistamiseksi sekä niiden käyttö
DE69212879D1 (de) Magensaftstabile pharmazeutische Formulierungen zur Oral Verbreichung von Gallensäuren
FI964253A0 (fi) Kollageenivalmiste vaikuttavien aineiden säädellyksi vapauttamiseksi
DE68928993D1 (de) Arzneimittelzubereitung
IT1244548B (it) Derivati della 5-oxo-l-prolina e loro applicazioni farmaceutiche
HUP9800049A3 (en) Amino acid compositions and use thereof in clinical nutrition, and use of the said amino acids for preparing pharmaceutical compns. for the diminution of tnf
ES2193272T3 (es) Conjugados peptidicos, su utilizacion como medicamento y composiciones que los contienen.
ES2196187T3 (es) Conjugados peptidicos derivados de las hormonas timicas, su utilizacion a titulo de medicamento y composiciones que los contienen.
NO883261D0 (no) Fremgangsmaate for fremstilling av et farmasoeytisk preparat
DE69106892D1 (de) Probucol enthaltendes arzneimittel mit gesteigerter bioverfügbarkeit.
ATE146673T1 (de) Kosmetika und pharmazeutika enthaltend extensin
DE69218193D1 (de) Verfahren zur Synthese von Peptiden, Derivate von Aminosäuren zur Verwendung bei dem obengenannten Verfahren und Methoden zu deren Herstellung.
TR199600583A2 (tr) Farmasötik aktiviteye sahip -amino asitlerin tolere edilebilirliginin arttirilmasi.
FR2569111B1 (fr) Nouveaux medicaments contenant des tripeptides
DE69002881D1 (de) Peptide und deren Benutzung.
ITMI910658A0 (it) N-(4,5-diidrossi-e 4,5,8-triidrossi-9,10-diidro-9,10-diosso-2- antracen-il)carbonil) amminoacidi utilizzabili nella terapia delle affezioni osteoarticolari
BG103905A (en) New bpc peptide salts with organoprotective activity, method for their preparation and application in medicine
ATE133960T1 (de) Peptide mit bradykinin-antagonistischer wirkung
NO942323D0 (no) Soyaprotein eller hydrolysater i farmasöytiske preparater for beskyttelse av bioaktive peptider mot enzymatisk inaktivering
EP0490383A3 (en) Peptides of the hiv-gag protein, their preparation and use
IT8821046A0 (it) Poliammide biodegradabile pellicole e prodotti ottenuti da detta poliammide e procedimento per lasua preparazione.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification