ATE18226T1 - Pyrrolo(2,3-d)carbazolderivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung. - Google Patents

Pyrrolo(2,3-d)carbazolderivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung.

Info

Publication number
ATE18226T1
ATE18226T1 AT82200513T AT82200513T ATE18226T1 AT E18226 T1 ATE18226 T1 AT E18226T1 AT 82200513 T AT82200513 T AT 82200513T AT 82200513 T AT82200513 T AT 82200513T AT E18226 T1 ATE18226 T1 AT E18226T1
Authority
AT
Austria
Prior art keywords
pyrrolo
processes
production
therapeutic use
same
Prior art date
Application number
AT82200513T
Other languages
German (de)
English (en)
Inventor
Martin Eric Kuehne
Original Assignee
Omnichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omnichem Sa filed Critical Omnichem Sa
Application granted granted Critical
Publication of ATE18226T1 publication Critical patent/ATE18226T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT82200513T 1981-05-04 1982-05-01 Pyrrolo(2,3-d)carbazolderivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung. ATE18226T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/260,415 US4362739A (en) 1981-05-04 1981-05-04 Pyrrolo(2,3-d)carbazole derivatives, compositions and use
EP82200513A EP0064317B1 (en) 1981-05-04 1982-05-01 Pyrrolo(2,3-d)carbazole derivatives, preparation thereof and their therapeutical use

Publications (1)

Publication Number Publication Date
ATE18226T1 true ATE18226T1 (de) 1986-03-15

Family

ID=22989067

Family Applications (1)

Application Number Title Priority Date Filing Date
AT82200513T ATE18226T1 (de) 1981-05-04 1982-05-01 Pyrrolo(2,3-d)carbazolderivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung.

Country Status (6)

Country Link
US (1) US4362739A (en, 2012)
EP (1) EP0064317B1 (en, 2012)
JP (1) JPS57206686A (en, 2012)
AT (1) ATE18226T1 (en, 2012)
CA (1) CA1185605A (en, 2012)
DE (1) DE3269309D1 (en, 2012)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU84664A1 (fr) * 1983-02-25 1984-11-08 Onmichem S A Alkyl-4-indolonaphtyridines et leur application therapeutique
JPS62502684A (ja) * 1985-03-12 1987-10-15 ザ・ユニバ−シテイ・オブ・バ−モント・アンド・ステイト・アグリカルチユラル・カレツジ ビンブラスチン及びビンクリスチン型化合物の合成
US4841045A (en) * 1985-03-12 1989-06-20 University Of Vermont & State Agricultural College Synthesis of vinblastine and vincristine type compounds
LU85894A1 (fr) * 1985-05-10 1986-12-05 Omnichem Sa Derives de 1,2,3,4,5,6-hexahydro-azepino (4,5-b) indole leur preparation,composes intermediaires,et leur application en therapeutique
GB9401921D0 (en) * 1994-02-01 1994-03-30 Wellcome Found Heterocyclic compounds
US7595311B2 (en) * 2002-05-24 2009-09-29 Exelixis, Inc. Azepinoindole derivatives as pharmaceutical agents
TWI329111B (en) * 2002-05-24 2010-08-21 X Ceptor Therapeutics Inc Azepinoindole and pyridoindole derivatives as pharmaceutical agents
JP4679517B2 (ja) * 2003-07-23 2011-04-27 エグゼリクシス， インコーポレイテッド 薬剤としてのアゼピン誘導体
US20130178618A1 (en) 2012-01-10 2013-07-11 William Allen Boulanger Novel pharmaceutical intermediates and methods for preparing the same
CN110437238B (zh) * 2019-08-15 2020-10-23 广州大学 一种多环螺吲哚啉化合物及其制备方法和应用
US12116372B1 (en) 2023-12-14 2024-10-15 William Allen Boulanger Process for preparing methyl 3-bromo-2-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)propanoate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3015661A (en) * 1958-09-04 1962-01-02 Georgian Vlasios Decahydroisoquinoline derivatives
US4154943A (en) * 1977-12-29 1979-05-15 University Of Vermont Preparation of vincadifformine

Also Published As

Publication number Publication date
US4362739A (en) 1982-12-07
CA1185605A (en) 1985-04-16
EP0064317B1 (en) 1986-02-26
JPH0322390B2 (en, 2012) 1991-03-26
EP0064317A3 (en) 1983-04-27
DE3269309D1 (en) 1986-04-03
JPS57206686A (en) 1982-12-18
EP0064317A2 (en) 1982-11-10

Similar Documents

Publication Publication Date Title
ATE58534T1 (de) 2-pyrimidinyl-l-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
ES2044836T3 (es) Derivado de la piperidina, su utilizacion y compuesto farmaceutico que lo contiene.
ATE13056T1 (de) Indanderivate, verfahren zu ihrer herstellung und sie enthaltende zusammensetzungen.
DE3581566D1 (de) Oxindol-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte.
IE842930L (en) Furopyridines
ATE45153T1 (de) Benzisoselenazolthione, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische produkte.
ATE63913T1 (de) Pyrazolo(3,4-b)pyridinderivate und verfahren zu ihrer herstellung.
ATE18226T1 (de) Pyrrolo(2,3-d)carbazolderivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung.
ATE19773T1 (de) Nitroaliphatische verbindungen, verfahren zu deren herstellung und deren verwendung.
ATE56707T1 (de) Imidazolverbindungen, verfahren zu deren herstellung und deren pharmazeutische zusammensetzungen.
ATE69444T1 (de) N-substituierte-n-nitroso-aminoacetonitrile, verfahren zu ihrer herstellung und ihre verwendung.
BG44203A3 (en) Method for preparing of 2- oxyindol- 1- carboxamides
DE3781879D1 (de) Anthracyclinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
ATE31928T1 (de) Acylamino-4-aza-1-adamantane, verfahren zu ihrer herstellung und ihre anwendung in der therapeutik.
ATE2794T1 (de) 1-n-alkylsisomicin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
ATE12643T1 (de) 2-0- und 5-0-substituierte 1.4;3.6-dianhydrohexit-mononitrate, verfahren zu ihrer herstellung und pharmazeutische zubereitung.
ATE59637T1 (de) Neue basisch substituierte pyridinverbindungen, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung.
ES8504122A1 (es) Procedimiento para la obtencion de pirrolidinonas
ATE34740T1 (de) (bis(hydroxymethyl)methyl)-isochinolinderivate, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die sie enthalten.
ATE23528T1 (de) +/- 2-((3,4-methylenedioxy)phenethyl)-5-((3carboxamido-4-hydroxy)-alpha-hydroxybenzyl)pyrrolidine, pharmazeutische zusammenstellungen die sie enthalten, verfahren zur herstellung und deren zwischenprodukte.
ATE25517T1 (de) Delta-1-pyrrolin-thiolactimaether und verfahren zu ihrer herstellung.
DE3851697D1 (de) 2-Amino-1,2,3,4-tetrahydroisochinolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel.
ATE67206T1 (de) 6h-isoxazolo(3,4-d>pyrazolo(3,4-b>pyridine, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel.
ATE2173T1 (de) Die blutplaettchenaggregation inhibierende derivate der 1-benzyl-1,2,5,6-tetrahydropyridin-3-carbonsaeur und ihre salze, diese verbindungen enthaltende pharmazeutische zusammensetzungen und verfahren zu ihrer herstellung.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee