ATE1799T1 - Aufloesbare thymidin-zusammensetzung und verfahren zu deren herstellung. - Google Patents
Aufloesbare thymidin-zusammensetzung und verfahren zu deren herstellung.Info
- Publication number
- ATE1799T1 ATE1799T1 AT80300103T AT80300103T ATE1799T1 AT E1799 T1 ATE1799 T1 AT E1799T1 AT 80300103 T AT80300103 T AT 80300103T AT 80300103 T AT80300103 T AT 80300103T AT E1799 T1 ATE1799 T1 AT E1799T1
- Authority
- AT
- Austria
- Prior art keywords
- thymidine
- composition
- production
- solubilizing agent
- soluble
- Prior art date
Links
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 title abstract 8
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 title abstract 4
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 title abstract 4
- 229940104230 thymidine Drugs 0.000 title abstract 4
- 239000002904 solvent Substances 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- -1 methyleneamino Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003873 salicylate salts Chemical class 0.000 abstract 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7900893 | 1979-01-10 | ||
| EP80300103A EP0013625B1 (de) | 1979-01-10 | 1980-01-10 | Auflösbare Thymidin-Zusammensetzung und Verfahren zu deren Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE1799T1 true ATE1799T1 (de) | 1982-12-15 |
Family
ID=10502427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT80300103T ATE1799T1 (de) | 1979-01-10 | 1980-01-10 | Aufloesbare thymidin-zusammensetzung und verfahren zu deren herstellung. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4368138A (de) |
| EP (1) | EP0013625B1 (de) |
| AT (1) | ATE1799T1 (de) |
| CA (1) | CA1136550A (de) |
| DE (1) | DE3061077D1 (de) |
| IL (1) | IL59083A (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4405488A (en) * | 1980-10-09 | 1983-09-20 | Chisso Corporation | Liquid-crystalline halogenobenzene derivatives |
| DE3100478A1 (de) * | 1981-01-09 | 1982-08-12 | Dr. Thilo & Co GmbH, 8021 Sauerlach | 5'ester von pyrimidinnucleosiden mit antiviraler wirksamkeit, verfahren zur herstellung und daraus hergestellte arzneimittel |
| GB0213904D0 (en) * | 2002-06-17 | 2002-07-31 | Univ Sheffield | Products useful in the treatment of MMR deficient tumours |
| US20030125283A1 (en) * | 2002-09-16 | 2003-07-03 | Gatenby Robert A. | Therapy of proliferative disorders by direct irradiation of cell nuclei with tritiated nuclear targetting agents |
| CA2539914A1 (en) * | 2003-09-22 | 2005-04-07 | Acidophil Llc | Small molecule compositions and methods for increasing drug efficiency using compositions thereof |
| US20050148534A1 (en) * | 2003-09-22 | 2005-07-07 | Castellino Angelo J. | Small molecule compositions and methods for increasing drug efficiency using compositions thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL62992C (de) * | 1946-05-27 | |||
| DE947424C (de) * | 1951-04-24 | 1956-08-16 | Byk Gulden Lomberg Chem Fab | Verfahren zur Herstellung von Loesungen substituierter Xanthine |
| US2949449A (en) * | 1959-01-14 | 1960-08-16 | Hoffmann La Roche | Synthesis of 3, 5-diaroyl-2-deoxy-d-ribofuranosyl ureas |
| DE1132925B (de) * | 1960-02-19 | 1962-07-12 | Bayer Ag | Loesungsvermittler fuer wasserschwerloesliche organische Verbindungen |
| US3320236A (en) * | 1963-03-07 | 1967-05-16 | Miles Lab | Reaction products of polymeric dialdehyde polysaccharides with p-aminosalicylates |
| FR1468708A (fr) * | 1964-05-28 | 1967-02-10 | Schwarz Biores | Compositions contenant du sulfoxyde de diméthyle comme agent solubilisant |
| US3579453A (en) * | 1968-11-12 | 1971-05-18 | Rohm & Haas | Alkali-soluble surfactant consisting of substituted succinic acid-nonionic ethoxylate blends |
| US3906043A (en) * | 1969-06-12 | 1975-09-16 | Israel Marcus | Water-soluble tetracyclines |
| CA920124A (en) * | 1969-06-12 | 1973-01-30 | Marcus Israel | Water-soluble tetracyclines |
| DE2147094A1 (de) * | 1971-09-21 | 1973-04-05 | Robugen Gmbh | Virostatisch wirksames arzneimittel |
| DE2658406C2 (de) * | 1975-12-31 | 1984-04-26 | Asahi Kasei Kogyo K.K., Osaka | Verfahren zur Herstellung wasserlöslicher Arzneimittelzubereitungen, enthaltend N↑4↑-Acylcytosin-arabinosid |
| GB2000025A (en) * | 1977-05-14 | 1979-01-04 | Pfizer Ltd | Nitroimidazole formulations |
| GB2016921B (en) * | 1978-03-27 | 1982-08-18 | Taiho Pharmaceutical Co Ltd | Anti cancer compositions containing uracil derivatives |
-
1980
- 1980-01-07 IL IL59083A patent/IL59083A/xx unknown
- 1980-01-08 US US06/110,397 patent/US4368138A/en not_active Expired - Lifetime
- 1980-01-09 CA CA000343347A patent/CA1136550A/en not_active Expired
- 1980-01-10 DE DE8080300103T patent/DE3061077D1/de not_active Expired
- 1980-01-10 EP EP80300103A patent/EP0013625B1/de not_active Expired
- 1980-01-10 AT AT80300103T patent/ATE1799T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0013625B1 (de) | 1982-11-17 |
| IL59083A0 (en) | 1980-05-30 |
| EP0013625A2 (de) | 1980-07-23 |
| EP0013625A3 (en) | 1980-10-15 |
| CA1136550A (en) | 1982-11-30 |
| US4368138A (en) | 1983-01-11 |
| DE3061077D1 (en) | 1982-12-23 |
| IL59083A (en) | 1983-12-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |