ATE176673T1 - Spezifisch vernetztes hämoglobin mit freier funktionalität - Google Patents
Spezifisch vernetztes hämoglobin mit freier funktionalitätInfo
- Publication number
- ATE176673T1 ATE176673T1 AT93924476T AT93924476T ATE176673T1 AT E176673 T1 ATE176673 T1 AT E176673T1 AT 93924476 T AT93924476 T AT 93924476T AT 93924476 T AT93924476 T AT 93924476T AT E176673 T1 ATE176673 T1 AT E176673T1
- Authority
- AT
- Austria
- Prior art keywords
- reaction
- hemoglobin
- crosslinking
- effects
- reagent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6445—Haemoglobin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/978,418 US5399671A (en) | 1992-11-18 | 1992-11-18 | Specifically crosslinked hemoglobin with free functionality |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE176673T1 true ATE176673T1 (de) | 1999-02-15 |
Family
ID=25526077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93924476T ATE176673T1 (de) | 1992-11-18 | 1993-11-12 | Spezifisch vernetztes hämoglobin mit freier funktionalität |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5399671A (de) |
| EP (1) | EP0669940B1 (de) |
| JP (1) | JPH08503456A (de) |
| AT (1) | ATE176673T1 (de) |
| AU (1) | AU683029B2 (de) |
| CA (1) | CA2149132A1 (de) |
| CZ (1) | CZ128695A3 (de) |
| DE (1) | DE69323497T2 (de) |
| HU (1) | HUT70740A (de) |
| MX (1) | MX9307175A (de) |
| NZ (1) | NZ257513A (de) |
| PL (1) | PL309032A1 (de) |
| RU (1) | RU95112535A (de) |
| SK (1) | SK64195A3 (de) |
| WO (1) | WO1994011399A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK145092D0 (de) * | 1992-12-03 | 1992-12-03 | Novo Nordisk As | |
| NZ262349A (en) * | 1993-03-16 | 1996-05-28 | Hemosol Inc | Chemically modifying haemoglobin by crosslinking with a polyaldehyde produced by ring opening oxidation of a saccharide; for use in a blood substitute |
| JPH10509983A (ja) * | 1995-06-16 | 1998-09-29 | クルーガー，ロナルド | ヘモグロビンのための多官能性架橋剤および架橋ヘモグロビン複合体 |
| US5917020A (en) * | 1997-01-15 | 1999-06-29 | Kluger; Ronald H. | Bis-tetrameric hemoglobin and reagents for its production |
| GB2346144A (en) * | 1997-11-03 | 2000-08-02 | Univ Toronto | Hemoglobin with chemically introduced disulfide cross-links and preparation thereof |
| AU750387B2 (en) * | 1997-11-07 | 2002-07-18 | Conjuchem Biotechnologies Inc. | Novel conjugates of opioids and endogenous carriers |
| CA2236344A1 (en) * | 1998-04-30 | 1999-10-30 | Hemosol Inc. | Hemoglobin-haptoglobin complexes |
| WO2004100995A1 (en) * | 2003-05-15 | 2004-11-25 | Hemosol Lp | Targeted delivery of anti-viral compounds through hemoglobin bioconjugation |
| US7875293B2 (en) * | 2003-05-21 | 2011-01-25 | Dexcom, Inc. | Biointerface membranes incorporating bioactive agents |
| CA2731546C (en) * | 2008-07-23 | 2013-11-19 | Hanmi Holdings Co., Ltd. | A polypeptide complex comprising non-peptidyl polymer having three functional ends |
| US7989593B1 (en) * | 2010-05-27 | 2011-08-02 | Bing Lou Wong | Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof |
| US8642744B2 (en) * | 2010-10-28 | 2014-02-04 | Agilent Technologies, Inc. | Crosslinking reagent for analysis of protein-protein interaction |
| WO2017197499A1 (en) * | 2016-04-25 | 2017-11-23 | The Governing Council Of The University Of Toronto | Stabilized hemoglobin-avidin assembly and method of preparation |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4529719A (en) * | 1983-05-04 | 1985-07-16 | Tye Ross W | Modified crosslinked stroma-free tetrameric hemoglobin |
| US4598064A (en) * | 1984-06-27 | 1986-07-01 | University Of Iowa Research Foundation | Alpha-alpha cross-linked hemoglobins |
| US4584130A (en) * | 1985-03-29 | 1986-04-22 | University Of Maryland | Intramolecularly cross-linked hemoglobin and method of preparation |
| GB8710598D0 (en) * | 1987-05-05 | 1987-06-10 | Star Medical Diagnostics Ltd | Hemoglobin based blood substitute |
| US5250665A (en) * | 1991-05-31 | 1993-10-05 | The University Of Toronto Innovations Foundation | Specifically β-β cross-linked hemoglobins and method of preparation |
-
1992
- 1992-11-18 US US07/978,418 patent/US5399671A/en not_active Expired - Lifetime
-
1993
- 1993-11-12 WO PCT/CA1993/000480 patent/WO1994011399A1/en not_active Application Discontinuation
- 1993-11-12 JP JP6511549A patent/JPH08503456A/ja active Pending
- 1993-11-12 DE DE69323497T patent/DE69323497T2/de not_active Expired - Fee Related
- 1993-11-12 NZ NZ257513A patent/NZ257513A/en unknown
- 1993-11-12 AU AU54153/94A patent/AU683029B2/en not_active Ceased
- 1993-11-12 HU HU9501448A patent/HUT70740A/hu unknown
- 1993-11-12 SK SK641-95A patent/SK64195A3/sk unknown
- 1993-11-12 RU RU95112535/04A patent/RU95112535A/ru unknown
- 1993-11-12 PL PL93309032A patent/PL309032A1/xx unknown
- 1993-11-12 AT AT93924476T patent/ATE176673T1/de active
- 1993-11-12 CA CA002149132A patent/CA2149132A1/en not_active Abandoned
- 1993-11-12 EP EP93924476A patent/EP0669940B1/de not_active Expired - Lifetime
- 1993-11-12 CZ CZ951286A patent/CZ128695A3/cs unknown
- 1993-11-17 MX MX9307175A patent/MX9307175A/es not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU683029B2 (en) | 1997-10-30 |
| RU95112535A (ru) | 1997-03-20 |
| MX9307175A (es) | 1994-08-31 |
| HUT70740A (en) | 1995-10-30 |
| AU5415394A (en) | 1994-06-08 |
| JPH08503456A (ja) | 1996-04-16 |
| HU9501448D0 (en) | 1995-06-28 |
| DE69323497D1 (de) | 1999-03-25 |
| US5399671A (en) | 1995-03-21 |
| CA2149132A1 (en) | 1994-05-26 |
| SK64195A3 (en) | 1995-09-13 |
| WO1994011399A1 (en) | 1994-05-26 |
| NZ257513A (en) | 1997-02-24 |
| PL309032A1 (en) | 1995-09-18 |
| EP0669940B1 (de) | 1999-02-10 |
| DE69323497T2 (de) | 1999-09-16 |
| CZ128695A3 (en) | 1996-01-17 |
| EP0669940A1 (de) | 1995-09-06 |
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