MX9307175A - Hemoglobina especificamente reticulada con funcionalidad libre. - Google Patents
Hemoglobina especificamente reticulada con funcionalidad libre.Info
- Publication number
- MX9307175A MX9307175A MX9307175A MX9307175A MX9307175A MX 9307175 A MX9307175 A MX 9307175A MX 9307175 A MX9307175 A MX 9307175A MX 9307175 A MX9307175 A MX 9307175A MX 9307175 A MX9307175 A MX 9307175A
- Authority
- MX
- Mexico
- Prior art keywords
- reaction
- crosslinking
- hemoglobin
- effects
- reagent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6445—Haemoglobin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Abstract
La hemoglobina se retícula específicamente en el sitio en su forma tetramérica, mediante su reacción con un reagente presuncional que combina efectos electrostáticos, efectos estéricos y la presencia de grupos funcionales, de tal manera que dos de los grupos funcionales reaccionan con sitios específicos sobre la hemoglobina, mientras que el tercer sitio se deja libre para reaccionar con compuestos nucleofílicos endógenos. Un ejemplo específico de este reagente reticulante es tris(3, 5-dibromosalicilato) de trimesoílo, TTDS, que efectúa la reticulación específica entre los grupos amino de lisina-82 sobre cada subunidad ß respectiva. Mientras que el reagente reticulante TTDS tiene tres grupos carboxilo disponibles para la reacción de reticulación, solamente dos reaccionan de esta manera, dejando un carboxilo libre para la reacción con los nucleófilos exógenos, por ejemplo, para hacer al producto de hemoglobina útil como un portador para compuestos nucleofílicos a través del sistema circulatorio del cuerpo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/978,418 US5399671A (en) | 1992-11-18 | 1992-11-18 | Specifically crosslinked hemoglobin with free functionality |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9307175A true MX9307175A (es) | 1994-08-31 |
Family
ID=25526077
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9307175A MX9307175A (es) | 1992-11-18 | 1993-11-17 | Hemoglobina especificamente reticulada con funcionalidad libre. |
Country Status (15)
Country | Link |
---|---|
US (1) | US5399671A (es) |
EP (1) | EP0669940B1 (es) |
JP (1) | JPH08503456A (es) |
AT (1) | ATE176673T1 (es) |
AU (1) | AU683029B2 (es) |
CA (1) | CA2149132A1 (es) |
CZ (1) | CZ128695A3 (es) |
DE (1) | DE69323497T2 (es) |
HU (1) | HUT70740A (es) |
MX (1) | MX9307175A (es) |
NZ (1) | NZ257513A (es) |
PL (1) | PL309032A1 (es) |
RU (1) | RU95112535A (es) |
SK (1) | SK64195A3 (es) |
WO (1) | WO1994011399A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK145092D0 (es) * | 1992-12-03 | 1992-12-03 | Novo Nordisk As | |
AU668294B2 (en) * | 1993-03-16 | 1996-04-26 | Hemosol Inc. | Selective crosslinking of hemoglobins by oxidized, ring-opened saccharides |
DE69608406D1 (de) * | 1995-06-16 | 2000-06-21 | Ronald Kluger | Multifunktionelle vernetzungsreagenzien für haemoglobin und vernetzte haemoglobinconjugate |
US5917020A (en) * | 1997-01-15 | 1999-06-29 | Kluger; Ronald H. | Bis-tetrameric hemoglobin and reagents for its production |
CA2308277A1 (en) * | 1997-11-03 | 1999-05-14 | Ronald H. Kluger | Hemoglobin with chemically introduced disulfide cross-links and preparation thereof |
JP2001522863A (ja) * | 1997-11-07 | 2001-11-20 | コンジュケム,インコーポレーテッド | Rgd含有ペプチドおよび内因性担体の新規コンジュゲート |
CA2236344A1 (en) * | 1998-04-30 | 1999-10-30 | Hemosol Inc. | Hemoglobin-haptoglobin complexes |
EP1660133B1 (en) * | 2003-05-15 | 2018-04-18 | Therapure Biopharma Inc. | Targeted delivery of anti-viral compounds through hemoglobin bioconjugation |
US7875293B2 (en) * | 2003-05-21 | 2011-01-25 | Dexcom, Inc. | Biointerface membranes incorporating bioactive agents |
WO2010011096A2 (en) | 2008-07-23 | 2010-01-28 | Hanmi Pharmaceutical Co., Ltd. | A polypeptide complex comprising non-peptidyl polymer having three functional ends |
US7989593B1 (en) * | 2010-05-27 | 2011-08-02 | Bing Lou Wong | Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof |
US8642744B2 (en) * | 2010-10-28 | 2014-02-04 | Agilent Technologies, Inc. | Crosslinking reagent for analysis of protein-protein interaction |
WO2017197499A1 (en) * | 2016-04-25 | 2017-11-23 | The Governing Council Of The University Of Toronto | Stabilized hemoglobin-avidin assembly and method of preparation |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4529719A (en) * | 1983-05-04 | 1985-07-16 | Tye Ross W | Modified crosslinked stroma-free tetrameric hemoglobin |
US4598064A (en) * | 1984-06-27 | 1986-07-01 | University Of Iowa Research Foundation | Alpha-alpha cross-linked hemoglobins |
US4584130A (en) * | 1985-03-29 | 1986-04-22 | University Of Maryland | Intramolecularly cross-linked hemoglobin and method of preparation |
GB8710598D0 (en) * | 1987-05-05 | 1987-06-10 | Star Medical Diagnostics Ltd | Hemoglobin based blood substitute |
US5250665A (en) * | 1991-05-31 | 1993-10-05 | The University Of Toronto Innovations Foundation | Specifically β-β cross-linked hemoglobins and method of preparation |
-
1992
- 1992-11-18 US US07/978,418 patent/US5399671A/en not_active Expired - Lifetime
-
1993
- 1993-11-12 AU AU54153/94A patent/AU683029B2/en not_active Ceased
- 1993-11-12 NZ NZ257513A patent/NZ257513A/en unknown
- 1993-11-12 CZ CZ951286A patent/CZ128695A3/cs unknown
- 1993-11-12 RU RU95112535/04A patent/RU95112535A/ru unknown
- 1993-11-12 HU HU9501448A patent/HUT70740A/hu unknown
- 1993-11-12 SK SK641-95A patent/SK64195A3/sk unknown
- 1993-11-12 EP EP93924476A patent/EP0669940B1/en not_active Expired - Lifetime
- 1993-11-12 JP JP6511549A patent/JPH08503456A/ja active Pending
- 1993-11-12 CA CA002149132A patent/CA2149132A1/en not_active Abandoned
- 1993-11-12 DE DE69323497T patent/DE69323497T2/de not_active Expired - Fee Related
- 1993-11-12 WO PCT/CA1993/000480 patent/WO1994011399A1/en not_active Application Discontinuation
- 1993-11-12 PL PL93309032A patent/PL309032A1/xx unknown
- 1993-11-12 AT AT93924476T patent/ATE176673T1/de active
- 1993-11-17 MX MX9307175A patent/MX9307175A/es not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CZ128695A3 (en) | 1996-01-17 |
DE69323497D1 (de) | 1999-03-25 |
RU95112535A (ru) | 1997-03-20 |
JPH08503456A (ja) | 1996-04-16 |
ATE176673T1 (de) | 1999-02-15 |
NZ257513A (en) | 1997-02-24 |
PL309032A1 (en) | 1995-09-18 |
AU5415394A (en) | 1994-06-08 |
SK64195A3 (en) | 1995-09-13 |
WO1994011399A1 (en) | 1994-05-26 |
AU683029B2 (en) | 1997-10-30 |
HU9501448D0 (en) | 1995-06-28 |
DE69323497T2 (de) | 1999-09-16 |
US5399671A (en) | 1995-03-21 |
HUT70740A (en) | 1995-10-30 |
EP0669940B1 (en) | 1999-02-10 |
EP0669940A1 (en) | 1995-09-06 |
CA2149132A1 (en) | 1994-05-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
MM | Annulment or lapse due to non-payment of fees |