ATE167192T1 - Produktion von gereinigtem, biologisch aktivem, bakteriell hergestelltem human-csf-1 - Google Patents

Produktion von gereinigtem, biologisch aktivem, bakteriell hergestelltem human-csf-1

Info

Publication number
ATE167192T1
ATE167192T1 AT88904086T AT88904086T ATE167192T1 AT E167192 T1 ATE167192 T1 AT E167192T1 AT 88904086 T AT88904086 T AT 88904086T AT 88904086 T AT88904086 T AT 88904086T AT E167192 T1 ATE167192 T1 AT E167192T1
Authority
AT
Austria
Prior art keywords
biologically active
human csf
purified
production
produced human
Prior art date
Application number
AT88904086T
Other languages
English (en)
Inventor
Robert F Halenbeck
Kirston E Koths
Cynthia Cowgill
Walter J Laird
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Application granted granted Critical
Publication of ATE167192T1 publication Critical patent/ATE167192T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT88904086T 1987-04-16 1988-04-18 Produktion von gereinigtem, biologisch aktivem, bakteriell hergestelltem human-csf-1 ATE167192T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4017487A 1987-04-16 1987-04-16
US11400187A 1987-10-27 1987-10-27

Publications (1)

Publication Number Publication Date
ATE167192T1 true ATE167192T1 (de) 1998-06-15

Family

ID=26716797

Family Applications (2)

Application Number Title Priority Date Filing Date
AT88904086T ATE167192T1 (de) 1987-04-16 1988-04-18 Produktion von gereinigtem, biologisch aktivem, bakteriell hergestelltem human-csf-1
AT97202737T ATE301133T1 (de) 1987-04-16 1988-04-18 Gereinigter, biologisch aktiver, bakteriell produzierter, rekombinanter humaner csf-1.

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT97202737T ATE301133T1 (de) 1987-04-16 1988-04-18 Gereinigter, biologisch aktiver, bakteriell produzierter, rekombinanter humaner csf-1.

Country Status (10)

Country Link
EP (2) EP0309569B1 (de)
JP (1) JP2656964B2 (de)
AT (2) ATE167192T1 (de)
AU (1) AU610182B2 (de)
BG (1) BG49827A3 (de)
DE (2) DE3856203T2 (de)
FI (1) FI96872C (de)
IL (1) IL86090A (de)
NO (1) NO300067B1 (de)
WO (1) WO1988008003A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5650297A (en) * 1986-09-17 1997-07-22 Otsuka Pharmaceutical Co., Ltd. DNA encoding human colony-stimulating factors
US4931543A (en) * 1987-05-11 1990-06-05 Cetus Corporation Process for recovering microbially produced interleukin-2
AU629549B2 (en) * 1988-04-29 1992-10-08 Genetics Institute Inc. Homogeneous dimeric m-csf and storage stable formulations thereof
DE69026440T2 (de) * 1989-07-27 1996-10-17 Denki Kagaku Kogyo Kk Für M-CSF kodierendes Gen und dazu gehörende rekombinante Systeme
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
EP0545999B1 (de) * 1990-08-20 1997-06-04 Novo Nordisk A/S Prozess für die Herstellung von biologisch aktivem IGF-1 durch Verwendung von amino-terminal verlängertem IGF-1
ES2119779T3 (es) * 1990-09-05 1998-10-16 Southern Cross Biotech Pty Ltd Solubilizacion de proteinas en formas activas.
US5288931A (en) * 1991-12-06 1994-02-22 Genentech, Inc. Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
US5866114A (en) * 1992-06-09 1999-02-02 Chiron Corporation Crystallization of M-CSFα
AU661914B2 (en) * 1992-08-18 1995-08-10 Jean-Louis Odore Support structure for a shelter cover
US5661001A (en) * 1993-08-04 1997-08-26 Ciba-Geigy Corporation High molecular weight desulphatohirudin
US5407810A (en) * 1993-08-20 1995-04-18 Genentech, Inc. Aqueous multiple-phase isolation of polypeptide
US5663304A (en) * 1993-08-20 1997-09-02 Genentech, Inc. Refolding of misfolded insulin-like growth factor-I
TW517059B (en) 1994-07-25 2003-01-11 Ciba Geigy Ag New process for the production of biologically active protein
FR2796071B1 (fr) * 1999-07-08 2001-09-07 Hoechst Marion Roussel Inc Procede de purification de facteur de stimulation de colonies de granulocytes
US6808902B1 (en) * 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
DE102004041639A1 (de) * 2004-08-27 2006-03-02 Bioceuticals Arzneimittel Ag Verfahren zur Gewinnung von biologisch aktivem humanen G-CSF aus Inclusion Bodies
KR101741859B1 (ko) 2009-06-22 2017-06-15 암젠 인크 화학적으로 조절된 산화환원 상태를 사용한 단백질의 재폴딩
SI3660032T1 (sl) 2009-06-25 2026-02-27 Amgen Inc. Postopki zajemanja in čiščenja beljakovin, izraženih v nesesalskem sistemu
DE202009019091U1 (de) 2009-12-21 2016-05-23 Agilent Technologies, Inc. - A Delaware Corporation - Fittingelement mit frontseitiger Einlage

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79124B (de) * 1982-12-22 1984-10-02 Genentech Inc
AU594045B2 (en) * 1985-02-05 1990-03-01 Chiron Corporation Recombinant colony stimulating factor-1
HU212277B (en) * 1986-05-06 1996-04-29 Genetics Inst Process for producing m-csf
DK54589A (da) * 1988-02-08 1989-08-09 Otsuka Pharma Co Ltd Humane kolonistmulerende faktorer

Also Published As

Publication number Publication date
NO300067B1 (no) 1997-04-01
IL86090A (en) 1993-03-15
JP2656964B2 (ja) 1997-09-24
AU610182B2 (en) 1991-05-16
FI96872B (fi) 1996-05-31
DE3856581D1 (de) 2005-09-29
EP0818466A2 (de) 1998-01-14
FI885807A0 (fi) 1988-12-15
JPH01503440A (ja) 1989-11-22
DE3856581T2 (de) 2006-05-24
EP0309569A1 (de) 1989-04-05
FI885807L (fi) 1988-12-15
EP0309569B1 (de) 1998-06-10
DE3856203T2 (de) 1998-10-08
WO1988008003A1 (en) 1988-10-20
ATE301133T1 (de) 2005-08-15
EP0818466B1 (de) 2005-08-03
NO885555D0 (no) 1988-12-14
BG49827A3 (bg) 1992-02-14
DE3856203D1 (de) 1998-07-16
IL86090A0 (en) 1988-09-30
FI96872C (fi) 1996-09-10
NO885555L (no) 1989-01-11
AU1712488A (en) 1988-11-04
EP0818466A3 (de) 1998-03-25

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time