ATE166392T1 - Verfahren zur modulierung der produktion von sekundären metaboliten - Google Patents

Verfahren zur modulierung der produktion von sekundären metaboliten

Info

Publication number
ATE166392T1
ATE166392T1 AT91200684T AT91200684T ATE166392T1 AT E166392 T1 ATE166392 T1 AT E166392T1 AT 91200684 T AT91200684 T AT 91200684T AT 91200684 T AT91200684 T AT 91200684T AT E166392 T1 ATE166392 T1 AT E166392T1
Authority
AT
Austria
Prior art keywords
modulating
production
secondary metabolites
organelles
microbodies
Prior art date
Application number
AT91200684T
Other languages
English (en)
Inventor
Der Voort Lucia Helena Mar Van
Roelof Ary Lans Bovenberg
Walraven Henry Muller
Adrianus Johannes Verkley
Original Assignee
Gist Brocades Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Nv filed Critical Gist Brocades Nv
Application granted granted Critical
Publication of ATE166392T1 publication Critical patent/ATE166392T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Hydrogenated Pyridines (AREA)
AT91200684T 1990-03-23 1991-03-25 Verfahren zur modulierung der produktion von sekundären metaboliten ATE166392T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90200695 1990-03-23

Publications (1)

Publication Number Publication Date
ATE166392T1 true ATE166392T1 (de) 1998-06-15

Family

ID=8204972

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91200684T ATE166392T1 (de) 1990-03-23 1991-03-25 Verfahren zur modulierung der produktion von sekundären metaboliten

Country Status (6)

Country Link
EP (1) EP0448180B1 (de)
JP (1) JPH05199897A (de)
AT (1) ATE166392T1 (de)
DE (1) DE69130122T2 (de)
IE (1) IE910956A1 (de)
PT (1) PT97116B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2139350C1 (ru) * 1993-07-30 1999-10-10 Гист-Брокейдс Б.В. Способ эффективного производства 7-адцк через 3-(карбоксиэтилтио)пропионил-7-адцк
ATE334203T1 (de) * 1994-09-28 2006-08-15 Novozymes As Verfahren zur herstellung von sekundären metaboliten
US5731165A (en) * 1995-06-02 1998-03-24 Gist-Brocades, B.V. Process for the production of 7-ADCA via expandase activity on penicillin G
AU1097297A (en) * 1995-11-27 1997-06-19 Gist-Brocades B.V. Improved process for the production of semi-synthetic cephalosporins via expandase activity on penicillin
AU7648898A (en) 1997-04-22 1998-11-13 Gist-Brocades B.V. Process for the fermentative production of deacylated cephalosporins
CN1145703C (zh) 1997-04-22 2004-04-14 吉斯特-布罗卡迪斯有限公司 去酰基化头孢菌素的发酵生产的方法
PL344863A1 (en) 1998-05-19 2001-11-19 Dsm Nv Improved in vivo
WO2000071579A2 (en) * 1999-05-21 2000-11-30 Dsm N.V. Regulating organelle homeostasis in a cell factory
ES2571865T3 (es) 2005-12-28 2016-05-27 Dsm Sinochem Pharm Nl Bv Acilasas de beta-lactama de tipo II mutantes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI104984B (fi) * 1988-08-11 2000-05-15 Dsm Nv Menetelmä biosynteettisten tai säätelygeenien identifioimiseksi ja käyttämiseksi sekundääristen metaboliittien tuoton parantamiseksi

Also Published As

Publication number Publication date
EP0448180B1 (de) 1998-05-20
DE69130122D1 (de) 1999-01-14
EP0448180A3 (en) 1992-07-08
DE69130122T2 (de) 1999-02-18
EP0448180A2 (de) 1991-09-25
PT97116B (pt) 1998-10-30
PT97116A (pt) 1991-12-31
IE910956A1 (en) 1991-09-25
JPH05199897A (ja) 1993-08-10

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Legal Events

Date Code Title Description
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee