ATE166343T1 - Cyanoguanidine als k-kanal-blocker - Google Patents
Cyanoguanidine als k-kanal-blockerInfo
- Publication number
- ATE166343T1 ATE166343T1 AT95907285T AT95907285T ATE166343T1 AT E166343 T1 ATE166343 T1 AT E166343T1 AT 95907285 T AT95907285 T AT 95907285T AT 95907285 T AT95907285 T AT 95907285T AT E166343 T1 ATE166343 T1 AT E166343T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- hydrogen
- c3alkyl
- sec
- compounds
- Prior art date
Links
- QGBSISYHAICWAH-UHFFFAOYSA-N dicyandiamide Chemical compound NC(N)=NC#N QGBSISYHAICWAH-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000003450 potassium channel blocker Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18896994A | 1994-01-28 | 1994-01-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE166343T1 true ATE166343T1 (de) | 1998-06-15 |
Family
ID=22695331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95907285T ATE166343T1 (de) | 1994-01-28 | 1995-01-09 | Cyanoguanidine als k-kanal-blocker |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5668157A (de) |
| EP (1) | EP0741708B1 (de) |
| JP (1) | JPH09508382A (de) |
| AT (1) | ATE166343T1 (de) |
| AU (1) | AU1556695A (de) |
| CA (1) | CA2179036A1 (de) |
| DE (1) | DE69502584T2 (de) |
| DK (1) | DK0741708T3 (de) |
| ES (1) | ES2116726T3 (de) |
| MX (1) | MX9603051A (de) |
| WO (1) | WO1995020579A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9711123D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711124D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711126D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Cyanoamidines |
| GB9711127D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711125D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| WO2000061561A1 (en) | 1999-04-09 | 2000-10-19 | Shionogi Bioresearch Corp. | Cyanoguanidine compounds |
| EP1276893A4 (de) | 2000-04-14 | 2005-05-04 | Univ Vanderbilt | Gereinigte und isolierte nukleinsäure für kalium-chlorid-kotransporter und polypeptide und ihr gebrauch in therapeutischen- und screening-verfahren |
| JP2004530650A (ja) * | 2001-02-07 | 2004-10-07 | アボット・ラボラトリーズ | カリウムチャンネル開口薬としてのアミナールジオン |
| EP1917244A2 (de) * | 2005-08-24 | 2008-05-07 | Abbott GmbH & Co. KG | Hetaryl substituierte guanidinverbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren |
| JP2022547083A (ja) * | 2019-09-03 | 2022-11-10 | ザルツマン グループ リミテッド | グアニジンを含むａｔｐ調節性カリウムチャネル開口薬及びその使用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2361052C2 (de) * | 1973-12-07 | 1982-12-30 | Ruhrchemie Ag, 4200 Oberhausen | Verfahren zur Polymerisation von α-Olefinen mit 2 bis 6 Kohlenstoffatomen |
| GB1489879A (en) * | 1974-12-20 | 1977-10-26 | Leo Pharm Prod Ltd | N'-cyano-n'-3-pyridylguanidines |
| US5006523A (en) * | 1989-10-26 | 1991-04-09 | E. R. Squibb & Sons, Inc. | Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers |
| JPH03166119A (ja) * | 1989-11-24 | 1991-07-18 | Showa Alum Corp | パイプの転送装置 |
| JPH05294935A (ja) * | 1991-03-15 | 1993-11-09 | Green Cross Corp:The | アミノピリジン系化合物 |
| WO1994004499A1 (en) * | 1992-08-13 | 1994-03-03 | The Upjohn Company | Cyanoguanidines as potassium channel blockers |
| US5401758A (en) * | 1993-10-07 | 1995-03-28 | Bristol-Myers Squibb Company | Pyridinyl cyanoguanidine compounds |
-
1995
- 1995-01-09 AT AT95907285T patent/ATE166343T1/de not_active IP Right Cessation
- 1995-01-09 DE DE69502584T patent/DE69502584T2/de not_active Expired - Fee Related
- 1995-01-09 WO PCT/US1995/000024 patent/WO1995020579A1/en not_active Ceased
- 1995-01-09 US US08/666,502 patent/US5668157A/en not_active Expired - Fee Related
- 1995-01-09 EP EP95907285A patent/EP0741708B1/de not_active Expired - Lifetime
- 1995-01-09 ES ES95907285T patent/ES2116726T3/es not_active Expired - Lifetime
- 1995-01-09 DK DK95907285T patent/DK0741708T3/da active
- 1995-01-09 AU AU15566/95A patent/AU1556695A/en not_active Abandoned
- 1995-01-09 CA CA002179036A patent/CA2179036A1/en not_active Abandoned
- 1995-01-09 MX MX9603051A patent/MX9603051A/es unknown
- 1995-01-09 JP JP7520050A patent/JPH09508382A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DK0741708T3 (da) | 1999-01-18 |
| DE69502584T2 (de) | 1998-11-26 |
| US5668157A (en) | 1997-09-16 |
| WO1995020579A1 (en) | 1995-08-03 |
| ES2116726T3 (es) | 1998-07-16 |
| MX9603051A (es) | 1997-06-28 |
| EP0741708A1 (de) | 1996-11-13 |
| EP0741708B1 (de) | 1998-05-20 |
| DE69502584D1 (de) | 1998-06-25 |
| AU1556695A (en) | 1995-08-15 |
| CA2179036A1 (en) | 1995-08-03 |
| JPH09508382A (ja) | 1997-08-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |