ATE159010T1 - Substituierte (5,6)- dihydronaphthalinylverbindungen mit retinoid- artiger wirkung - Google Patents
Substituierte (5,6)- dihydronaphthalinylverbindungen mit retinoid- artiger wirkungInfo
- Publication number
- ATE159010T1 ATE159010T1 AT95100033T AT95100033T ATE159010T1 AT E159010 T1 ATE159010 T1 AT E159010T1 AT 95100033 T AT95100033 T AT 95100033T AT 95100033 T AT95100033 T AT 95100033T AT E159010 T1 ATE159010 T1 AT E159010T1
- Authority
- AT
- Austria
- Prior art keywords
- 6alkyl
- formula
- independently hydrogen
- compound
- chem
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 8
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000003254 radicals Chemical class 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- -1 -CONHR<y> Chemical group 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
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- A61P17/00—Drugs for dermatological disorders
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- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/24—Anthracenes; Hydrogenated anthracenes
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17674694A | 1994-01-03 | 1994-01-03 | |
| US21674094A | 1994-03-23 | 1994-03-23 | |
| US30609294A | 1994-09-19 | 1994-09-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE159010T1 true ATE159010T1 (de) | 1997-10-15 |
Family
ID=27390716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95100033T ATE159010T1 (de) | 1994-01-03 | 1995-01-02 | Substituierte (5,6)- dihydronaphthalinylverbindungen mit retinoid- artiger wirkung |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0661259B1 (de) |
| JP (1) | JPH07242591A (de) |
| AT (1) | ATE159010T1 (de) |
| AU (1) | AU690598B2 (de) |
| CA (1) | CA2138000A1 (de) |
| CY (1) | CY2068A (de) |
| DE (1) | DE69500813T2 (de) |
| DK (1) | DK0661259T3 (de) |
| ES (1) | ES2107866T3 (de) |
| GR (1) | GR3024956T3 (de) |
| HK (1) | HK1001189A1 (de) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5264578A (en) | 1987-03-20 | 1993-11-23 | Allergan, Inc. | Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity |
| US5475022A (en) * | 1993-10-18 | 1995-12-12 | Allergan, Inc. | Phenyl or heteroaryl and tetrahydronaphthyl substituted diene compounds having retinoid like biological activity |
| US5618943A (en) * | 1994-12-29 | 1997-04-08 | Allergan | Acetylenes disubstituted with a 5 OXO substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity |
| US5543534A (en) * | 1994-12-29 | 1996-08-06 | Allergan | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl groups having retinoid-like biological activity |
| US5648514A (en) | 1994-12-29 | 1997-07-15 | Allergan | Substituted acetylenes having retinoid-like biological activity |
| US5514825A (en) * | 1994-12-29 | 1996-05-07 | Allergan, Inc. | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity |
| CA2208844A1 (en) * | 1994-12-29 | 1996-07-11 | Alan T. Johnson | Acetylenes disubstituted with a 5 or 8 substituted tetrahydronaphthyl or dihydronaphthyl group and with an aryl or heteroaryl groups having retinoid-like biological activity |
| US5534641A (en) * | 1994-12-29 | 1996-07-09 | Allergan | Acetylenes disubstituted with 2-tetrahydropyranoxyaryl and aryl or heteroaryl groups having retinoid-like biological activity |
| US5599967A (en) * | 1994-12-29 | 1997-02-04 | Allergan | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl of heteroaryl group having retinoid-like biological activity |
| US5559248A (en) * | 1995-04-05 | 1996-09-24 | Bristol-Myers Squibb Co. | Retinoid-like heterocycles |
| US5917082A (en) | 1995-06-06 | 1999-06-29 | Allergan Sales, Inc. | 2,4-pentadienoic acid derivatives having retinoid-like biological activity |
| US5675033A (en) | 1995-06-06 | 1997-10-07 | Allergan | 2,4-pentadienoic acid derivatives having retinoid-like biological activity |
| US5958954A (en) | 1995-09-01 | 1999-09-28 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
| US6008204A (en) | 1995-09-01 | 1999-12-28 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
| US6218128B1 (en) | 1997-09-12 | 2001-04-17 | Allergan Sales, Inc. | Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities |
| US5776699A (en) * | 1995-09-01 | 1998-07-07 | Allergan, Inc. | Method of identifying negative hormone and/or antagonist activities |
| US5952345A (en) | 1995-09-01 | 1999-09-14 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
| US6942980B1 (en) | 1995-09-01 | 2005-09-13 | Allergan, Inc. | Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities |
| AU7598596A (en) * | 1995-11-01 | 1997-05-22 | Allergan, Inc. | Sulfides, sulfoxides and sulfones disubstituted with a tetrahydronaphthalenyl, chromanyl, thiochromanyl or tetrahydroquinolinyl and substituted phenyl or heteroaryl group, having retinoid-like biological activity |
| US5663357A (en) | 1995-11-22 | 1997-09-02 | Allergan | Substituted heteroarylamides having retinoid-like biological activity |
| US5675024A (en) * | 1995-11-22 | 1997-10-07 | Allergan | Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4,-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity |
| US5965606A (en) | 1995-12-29 | 1999-10-12 | Allergan Sales, Inc. | Methods of treatment with compounds having RAR.sub.α receptor specific or selective activity |
| US5688957A (en) * | 1995-12-29 | 1997-11-18 | Allergan | (3"-thioxacyclohex-1"-enyl)!-but-3'-ene-1'-ynyl!aryl and (3"-thioxacyclohex-1"-enyl)!-but-3'-ene-1'-ynyl!heteroaryl carboxylic acids and esters having retinoid-like biological activity |
| US5877207A (en) * | 1996-03-11 | 1999-03-02 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
| US5808124A (en) * | 1996-06-21 | 1998-09-15 | Allergan | O- or S-substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
| US5741896A (en) | 1996-06-21 | 1998-04-21 | Allergan | O- or S- substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
| WO1997048672A2 (en) * | 1996-06-21 | 1997-12-24 | Allergan Sales, Inc. | Substituted tetrahydronaphthalene and dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
| US5747542A (en) * | 1996-06-21 | 1998-05-05 | Allergan | Oxo-substituted tetrahydronaphthalene derivatives having retinold and/or retinoid antagonist-like biological activity |
| US6555690B2 (en) | 1996-06-21 | 2003-04-29 | Allergan, Inc. | Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
| US5723666A (en) * | 1996-06-21 | 1998-03-03 | Allergan | Oxime substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
| US5763635A (en) | 1996-06-21 | 1998-06-09 | Allergan | Tetrahydronaphthalene derivatives substituted in the 8 position with alkyhidene groups having retinoid and/or retinoid antagonist-like biological activity |
| US5773594A (en) | 1996-06-21 | 1998-06-30 | Allergan | Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
| FR2753627B1 (fr) * | 1996-09-20 | 2003-02-21 | Galderma Rech Dermatologique | Utilisation des inhibiteurs de l'activite de l'acide retinoique pour favoriser la cicatrisation |
| US5739338A (en) * | 1996-11-05 | 1998-04-14 | Allergan | N-aryl substituted tetrahydroquinolines having retinoid agonist, retinoid antagonist or retinoid inverse agonist type biological activity |
| US5728846A (en) * | 1996-12-12 | 1998-03-17 | Allergan | Benzo 1,2-g!-chrom-3-ene and benzo 1,2-g!-thiochrom-3-ene derivatives |
| WO1998036746A1 (en) * | 1997-02-21 | 1998-08-27 | Bristol-Myers Squibb Company | Use of substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity to prevent or reduce ischemic injury |
| US5760276A (en) * | 1997-03-06 | 1998-06-02 | Allergan | Aryl-and heteroarylcyclohexenyl substituted alkenes having retinoid agonist, antagonist or inverse agonist type biological activity |
| AU6955898A (en) | 1997-04-11 | 1998-11-11 | Bristol-Myers Squibb Company | Retinoid antagonists and uses thereof |
| US6037488A (en) | 1997-04-19 | 2000-03-14 | Allergan Sales, Inc. | Trisubstituted phenyl derivatives having retinoid agonist, antagonist or inverse agonist type biological activity |
| US5919970A (en) | 1997-04-24 | 1999-07-06 | Allergan Sales, Inc. | Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity |
| ATE334673T1 (de) | 1997-11-12 | 2006-08-15 | Hoffmann La Roche | Behandlung von t-helfer zel typ 2 vermittelten immunkrankheiten mit retinoid antagonisten |
| EP1119350B1 (de) * | 1998-10-08 | 2005-02-23 | Allergan, Inc. | Rar-antagonisten zur verhütung für männer |
| US6043381A (en) * | 1999-05-07 | 2000-03-28 | Allergan Sales, Inc. | Process for preparing substituted benzo[1,2-g]-chrom-3-ene, benzo[1,2-g]-thiochrom-3-ene and benzo[1,2-g]-1,2-dihydroquinoline derivatives |
| US6613917B1 (en) | 2000-03-23 | 2003-09-02 | Allergan, Inc. | Amines substituted with a dihydronaphthalenyl, chromenyl, or thiochromenyl group, an aryl or heteroaryl group and an alkyl group, having retinoid-like biological activity |
| US6313107B1 (en) | 2000-08-29 | 2001-11-06 | Allergan Sales, Inc. | Methods of providing and using compounds having activity as inhibitors of cytochrome P450RAI |
| US6380256B1 (en) | 2000-08-29 | 2002-04-30 | Allergan Sales, Inc. | Compounds having activity as inhibitors of cytochrome P450RAI |
| US6369225B1 (en) | 2000-08-29 | 2002-04-09 | Allergan Sales, Inc. | Compounds having activity as inhibitors of cytochrome P450RAI |
| WO2002022113A2 (en) | 2000-09-13 | 2002-03-21 | Bristol-Myers Squibb Company | Retinoic acid receptor antagonists as promoters of angiogenesis |
| BR0307375A (pt) * | 2002-02-05 | 2004-12-07 | Wyeth Corp | Processo para a sìntese de ácidos n-acil-2-amino-4-alcóxi-5-nitro-benzóicos |
| US6620963B1 (en) | 2002-09-19 | 2003-09-16 | Allergan, Inc. | TRICYCLO[6.2.202,7]DODECA-2(7),3,5-TRIEN-4-CARBONYLAMINO-PHENYL AND TRICYCLO[6.2.202,7]DODECA-2(7),3,5-TRIEN-4-CARBONYLAMINO-HETEROARYL AND RELATED COMPOUNDS HAVING RARα RECEPTOR SELECTIVE BIOLOGICAL ACTIVITY |
| KR100704908B1 (ko) | 2005-12-27 | 2007-04-06 | 제일모직주식회사 | 테트라하이드로나프탈렌 구조의 측쇄를 가지는 디아민화합물 및 이를 이용한 액정 배향제 |
| WO2008137081A1 (en) * | 2007-05-02 | 2008-11-13 | The Trustees Of Columbia University In The City Of New York | Substituted ( 5, 6 ) -dihydronaphraalenyl compounds as reversible male contraceptives |
| US10940127B2 (en) | 2015-11-25 | 2021-03-09 | Io Therapeutics, Inc. | Use of CYP26-resistant RAR alpha selective agonists in the treatment of cancer |
| CN107176945B (zh) * | 2016-03-11 | 2021-06-08 | 中国科学院上海有机化学研究所 | 一种视黄酸类化合物、其制备方法、中间体及应用 |
| JP2019517557A (ja) | 2016-06-10 | 2019-06-24 | アイオー セラピューティクス インコーポレイテッド | 癌免疫療法のための受容体選択的レチノイドおよびレキシノイド化合物および免疫調節因子 |
| AU2018301810A1 (en) | 2017-07-13 | 2020-01-23 | Io Therapeutics, Inc. | Receptor subtype and function selective retinoid and rexinoid compounds in combination with immune modulators for cancer immunotherapy |
| US10363272B2 (en) | 2017-08-31 | 2019-07-30 | Io Therapeutics, Inc. | RAR selective agonists in combination with immune modulators for cancer immunotherapy |
| CN112479918B (zh) * | 2020-12-11 | 2023-07-14 | 成都大学 | 一种维甲酸类衍生物Am580的合成方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3973030A (en) * | 1973-10-29 | 1976-08-03 | Ciba-Geigy Corporation | Antiasthmatic 5,6-benzoisoindoline compositions |
| US4454341A (en) * | 1983-03-03 | 1984-06-12 | Sri International | Naphthyl or tetrahydronaphthyl-substituted naphthoic acid and derivatives |
| ATE195716T1 (de) * | 1992-04-22 | 2000-09-15 | Ligand Pharm Inc | Retinoid-x rezeptor selektive verbindungen |
-
1994
- 1994-12-13 CA CA002138000A patent/CA2138000A1/en not_active Abandoned
- 1994-12-27 JP JP6340886A patent/JPH07242591A/ja active Pending
- 1994-12-30 AU AU81781/94A patent/AU690598B2/en not_active Ceased
-
1995
- 1995-01-02 ES ES95100033T patent/ES2107866T3/es not_active Expired - Lifetime
- 1995-01-02 AT AT95100033T patent/ATE159010T1/de not_active IP Right Cessation
- 1995-01-02 EP EP95100033A patent/EP0661259B1/de not_active Expired - Lifetime
- 1995-01-02 DK DK95100033.0T patent/DK0661259T3/da active
- 1995-01-02 CY CY206895A patent/CY2068A/xx unknown
- 1995-01-02 DE DE69500813T patent/DE69500813T2/de not_active Expired - Fee Related
-
1997
- 1997-10-09 GR GR970402346T patent/GR3024956T3/el unknown
-
1998
- 1998-01-10 HK HK98100208A patent/HK1001189A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH07242591A (ja) | 1995-09-19 |
| EP0661259B1 (de) | 1997-10-08 |
| DK0661259T3 (da) | 1998-03-16 |
| AU690598B2 (en) | 1998-04-30 |
| AU8178194A (en) | 1995-07-13 |
| ES2107866T3 (es) | 1997-12-01 |
| DE69500813T2 (de) | 1998-05-20 |
| CA2138000A1 (en) | 1995-07-04 |
| DE69500813D1 (de) | 1997-11-13 |
| HK1001189A1 (en) | 1998-05-29 |
| GR3024956T3 (en) | 1998-01-30 |
| CY2068A (en) | 1995-01-02 |
| EP0661259A1 (de) | 1995-07-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |