ES2107866T3 - Compuestos de (5,6)-dihidronaftalenilo sustituidos con actividad retinoide. - Google Patents
Compuestos de (5,6)-dihidronaftalenilo sustituidos con actividad retinoide.Info
- Publication number
- ES2107866T3 ES2107866T3 ES95100033T ES95100033T ES2107866T3 ES 2107866 T3 ES2107866 T3 ES 2107866T3 ES 95100033 T ES95100033 T ES 95100033T ES 95100033 T ES95100033 T ES 95100033T ES 2107866 T3 ES2107866 T3 ES 2107866T3
- Authority
- ES
- Spain
- Prior art keywords
- 6alkyl
- formula
- independently hydrogen
- compound
- chem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/48—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to carbon atoms of six-membered aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07C17/00—Preparation of halogenated hydrocarbons
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- C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
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- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/58—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by halogen atoms
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- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions
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- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
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- C07C233/76—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
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- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
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- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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- C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
EL PRESENTE INVENTO SE REFIERE A UN COMPUESTO DE FORMULA I O A UNA SAL NO TOXICA ACEPTABLE FARMACEUTICAMENTE, UN ESTER FISIOLOGICAMENTE HIDROLIZABLE O UN SOLVATO DEL MISMO, EN EL QUE X ES - O -CO -, -NH - CO -, -CS - NH -, -CO - O -, - COS -, SCO -, SCH2 -, - CH2 -CH2 -, - C TRIPLE ENLACE C -, -CH2 - NH - , - COCH2 -, - NHCS -, - CH2S -, - CH2O -, -OCH2 -, O - CR5 = CR6 - ; RM Y RK SON INDEPENDIENTEMENTE HIDROGENO, HALOGENO, ALQUILO C1 - 6, HIDROXI, ALQUILOXI C1 - 6, O NITRO; N ES 0 O 1; R4 ES - (CH2)T - Y, ALQUILO C1 - 6, O CICLOALQUILO C3 - 6; R1 ES - CO2Z, ALQUILO C1 - 6, CH2OH, - CONHRY, O CHO; R2 Y R3 SON INDEPENDIENTEMENTE HIDROGENO O ALQUIL C1 - 6; RA Y RB SON INDEPENDIENTEMENTE HIDROGENO O ALQUIL C1 - 6; PERO CUANDO N ES 1, RA Y RB JUNTOS PUEDEN FORMAR UN RADICAL DE LA FORMULA; Y ES NAFTILO O FENILO, AMBOS RADICALES PUEDEN ESTAR OPCIONALMENTE SUSTITUIDOS CON UNO A TRES IGUALES O DIFERENTES ALQUILO C1 - 6 O HALOGENO; Z ES HIDROGENO O ALQUILO C1 - 6; R5, R6 Y RY SON INDEPENDIENTEMENTEHIDROGENO O ALQUILO C1 - 6 Y T ES 0 A 6. TAMBIEN SE PROPORCIONAN EN ESTE INVENTO METODOS PARA PREVENIR Y/O TRATAR TUMORES Y ENFERMEDADES NO MALIGNAS DE LA PIEL, QUE COMPRENDE LA ADMINISTRACION DE UN COMPUESTO DE LA FORMULA I A UN MAMIFERO. ADEMAS ESTA PREVISTO UNA FORMULACION FARMACEUTICA (COMPOSICION) QUE COMPRENDE UN COMPUESTO DE LA FORMULA I EN MEZCLA CON (A) EXCIPIENTES ACEPTABLES FARMACEUTICAMENTE.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17674694A | 1994-01-03 | 1994-01-03 | |
US21674094A | 1994-03-23 | 1994-03-23 | |
US30609294A | 1994-09-19 | 1994-09-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2107866T3 true ES2107866T3 (es) | 1997-12-01 |
Family
ID=27390716
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95100033T Expired - Lifetime ES2107866T3 (es) | 1994-01-03 | 1995-01-02 | Compuestos de (5,6)-dihidronaftalenilo sustituidos con actividad retinoide. |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0661259B1 (es) |
JP (1) | JPH07242591A (es) |
AT (1) | ATE159010T1 (es) |
AU (1) | AU690598B2 (es) |
CA (1) | CA2138000A1 (es) |
CY (1) | CY2068A (es) |
DE (1) | DE69500813T2 (es) |
DK (1) | DK0661259T3 (es) |
ES (1) | ES2107866T3 (es) |
GR (1) | GR3024956T3 (es) |
HK (1) | HK1001189A1 (es) |
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WO2008137081A1 (en) * | 2007-05-02 | 2008-11-13 | The Trustees Of Columbia University In The City Of New York | Substituted ( 5, 6 ) -dihydronaphraalenyl compounds as reversible male contraceptives |
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CN107176945B (zh) * | 2016-03-11 | 2021-06-08 | 中国科学院上海有机化学研究所 | 一种视黄酸类化合物、其制备方法、中间体及应用 |
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US3973030A (en) * | 1973-10-29 | 1976-08-03 | Ciba-Geigy Corporation | Antiasthmatic 5,6-benzoisoindoline compositions |
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-
1994
- 1994-12-13 CA CA002138000A patent/CA2138000A1/en not_active Abandoned
- 1994-12-27 JP JP6340886A patent/JPH07242591A/ja active Pending
- 1994-12-30 AU AU81781/94A patent/AU690598B2/en not_active Ceased
-
1995
- 1995-01-02 CY CY206895A patent/CY2068A/xx unknown
- 1995-01-02 DK DK95100033.0T patent/DK0661259T3/da active
- 1995-01-02 AT AT95100033T patent/ATE159010T1/de not_active IP Right Cessation
- 1995-01-02 EP EP95100033A patent/EP0661259B1/en not_active Expired - Lifetime
- 1995-01-02 DE DE69500813T patent/DE69500813T2/de not_active Expired - Fee Related
- 1995-01-02 ES ES95100033T patent/ES2107866T3/es not_active Expired - Lifetime
-
1997
- 1997-10-09 GR GR970402346T patent/GR3024956T3/el unknown
-
1998
- 1998-01-10 HK HK98100208A patent/HK1001189A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CY2068A (en) | 1995-01-02 |
AU8178194A (en) | 1995-07-13 |
AU690598B2 (en) | 1998-04-30 |
JPH07242591A (ja) | 1995-09-19 |
EP0661259B1 (en) | 1997-10-08 |
GR3024956T3 (en) | 1998-01-30 |
CA2138000A1 (en) | 1995-07-04 |
DK0661259T3 (da) | 1998-03-16 |
ATE159010T1 (de) | 1997-10-15 |
DE69500813T2 (de) | 1998-05-20 |
HK1001189A1 (en) | 1998-05-29 |
EP0661259A1 (en) | 1995-07-05 |
DE69500813D1 (de) | 1997-11-13 |
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