ATE157256T1 - Il-6 enthaltende pharmazeutische zusammensetzungen stabilisiert mit einem nicht- reduzierenden zucker - Google Patents

Il-6 enthaltende pharmazeutische zusammensetzungen stabilisiert mit einem nicht- reduzierenden zucker

Info

Publication number
ATE157256T1
ATE157256T1 AT93909917T AT93909917T ATE157256T1 AT E157256 T1 ATE157256 T1 AT E157256T1 AT 93909917 T AT93909917 T AT 93909917T AT 93909917 T AT93909917 T AT 93909917T AT E157256 T1 ATE157256 T1 AT E157256T1
Authority
AT
Austria
Prior art keywords
stabilized
pct
pharmaceutical compositions
compositions containing
reducing sugar
Prior art date
Application number
AT93909917T
Other languages
English (en)
Inventor
Fabrizio Samaritani
Filippo Rendina
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Application granted granted Critical
Publication of ATE157256T1 publication Critical patent/ATE157256T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/204—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT93909917T 1992-05-11 1993-05-07 Il-6 enthaltende pharmazeutische zusammensetzungen stabilisiert mit einem nicht- reduzierenden zucker ATE157256T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM920349A IT1254359B (it) 1992-05-11 1992-05-11 Composizioni farmaceutiche contenenti il-6

Publications (1)

Publication Number Publication Date
ATE157256T1 true ATE157256T1 (de) 1997-09-15

Family

ID=11400994

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93909917T ATE157256T1 (de) 1992-05-11 1993-05-07 Il-6 enthaltende pharmazeutische zusammensetzungen stabilisiert mit einem nicht- reduzierenden zucker

Country Status (12)

Country Link
US (1) US5635176A (de)
EP (1) EP0641216B1 (de)
JP (1) JP3714951B2 (de)
AT (1) ATE157256T1 (de)
AU (1) AU676833B2 (de)
CA (1) CA2117761C (de)
DE (1) DE69313444T2 (de)
DK (1) DK0641216T3 (de)
ES (1) ES2105257T3 (de)
GR (1) GR3024708T3 (de)
IT (1) IT1254359B (de)
WO (1) WO1993023065A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE220327T1 (de) 1992-09-29 2002-07-15 Inhale Therapeutic Syst Pulmonale abgabe von aktiven fragmenten des parathormons
ES2218543T3 (es) 1994-03-07 2004-11-16 Nektar Therapeutics Procedimiento y preparacion para la administracion de insulina por via pulmonar.
JP2000510813A (ja) * 1995-02-06 2000-08-22 ジェネテイックス・インスティテュート・インコーポレイテッド Ｉｌ−１２用処方
GB9508691D0 (en) * 1995-04-28 1995-06-14 Pafra Ltd Stable compositions
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
DE19539574A1 (de) 1995-10-25 1997-04-30 Boehringer Mannheim Gmbh Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren
US5770700A (en) * 1996-01-25 1998-06-23 Genetics Institute, Inc. Liquid factor IX formulations
US6632648B1 (en) * 1996-05-14 2003-10-14 Elan Drug Delivery Limited Methods of terminal sterilization of fibrinogen
US7141393B2 (en) * 1996-12-26 2006-11-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18-receptor proteins
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US6433760B1 (en) 1999-01-14 2002-08-13 University Of Central Florida Head mounted display with eyetracking capability
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US8637077B2 (en) 2000-12-28 2014-01-28 Takeda Pharmaceutical Company Limited Sustained-release preparation
US7368102B2 (en) 2001-12-19 2008-05-06 Nektar Therapeutics Pulmonary delivery of aminoglycosides
EP3192528A1 (de) * 2002-02-14 2017-07-19 Chugai Seiyaku Kabushiki Kaisha Formularierung anti-il-6r antikörper-enthaltender lösungen die einen zucker als stabilisator beinhalten

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4457916A (en) * 1982-08-31 1984-07-03 Asahi Kasei Kogyo Kabushiki Kaisha Method for stabilizing Tumor Necrosis Factor and a stable aqueous solution or powder containing the same
ATE68524T1 (de) * 1985-07-09 1991-11-15 Quadrant Bioresources Ltd Beschuetzung von proteinen und aehnlichem.
EP0536520B1 (de) * 1985-10-14 1999-03-03 Yeda Research And Development Co. Ltd. Verwendung von menschlichem Interferon-Beta 2A für die Herstellung von Medikamenten
US4762857A (en) * 1986-05-30 1988-08-09 E. I. Du Pont De Nemours And Company Trehalose as stabilizer and tableting excipient
DE3621828A1 (de) * 1986-06-28 1988-01-14 Biotest Pharma Gmbh Stabilisierung eines fuer therapeutische zwecke, insbesondere beim menschen, bestimmten interleukin-2-praeparates sowie dieses praeparat enthaltende stabilisierte waessrige loesung oder feststoff
US5078997A (en) * 1988-07-13 1992-01-07 Cetus Corporation Pharmaceutical composition for interleukin-2 containing physiologically compatible stabilizers
US5104651A (en) * 1988-12-16 1992-04-14 Amgen Inc. Stabilized hydrophobic protein formulations of g-csf
JP2805224B2 (ja) * 1989-01-13 1998-09-30 味の素株式会社 血小板減少症治療剤
JPH0327320A (ja) * 1989-06-26 1991-02-05 Ajinomoto Co Inc ヒトｂ細胞分化因子医薬組成物
JPH05963A (ja) * 1990-04-13 1993-01-08 Toray Ind Inc ポリペプチド類組成物
US5416071A (en) * 1991-03-12 1995-05-16 Takeda Chemical Industries, Ltd. Water-soluble composition for sustained-release containing epo and hyaluronic acid
EP0560998A4 (en) * 1991-10-09 1993-12-01 Toray Industries, Inc. Medicine for preventing and treating bleeding tendency
JP3027320U (ja) 1996-01-27 1996-08-09 三千男 高橋 野球グラブの装着補強具

Also Published As

Publication number Publication date
DK0641216T3 (da) 1998-01-26
AU4065393A (en) 1993-12-13
ITRM920349A0 (it) 1992-05-11
GR3024708T3 (en) 1997-12-31
DE69313444D1 (de) 1997-10-02
CA2117761A1 (en) 1993-11-25
JP3714951B2 (ja) 2005-11-09
ES2105257T3 (es) 1997-10-16
CA2117761C (en) 2005-10-04
WO1993023065A1 (en) 1993-11-25
EP0641216A1 (de) 1995-03-08
ITRM920349A1 (it) 1993-11-11
US5635176A (en) 1997-06-03
JPH08502722A (ja) 1996-03-26
AU676833B2 (en) 1997-03-27
EP0641216B1 (de) 1997-08-27
DE69313444T2 (de) 1998-01-02
IT1254359B (it) 1995-09-14

Similar Documents

Publication Publication Date Title
DE69313444D1 (de) IL-6 ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN stabilisiert mit einem nicht-reduzierenden Zucker
MY128629A (en) Stabilized interleukin 2
PL329386A1 (en) Growth hormone, amino acid and non-ionic detergent containing pharmaceutic
KR950703987A (ko) G-csf의 안정한 동결건조된 약제학적 제제(stable lyophilized pharma ceutical preparations g-csf)
FI910286A0 (fi) Analoger av humant insulin och preparat innehaollande dessa.
DE69228704D1 (de) Stabilisierte pharmazeutische formulierung, die wachstumshormon und asparagin enthält
DK395689D0 (da) Pharmaceutisk tilberedning til behandling af diabetes mellitus
DE69307977D1 (de) Stabilisierte Derivate von Vitamin D2 und D3 enthaltende pharmazeutische Zusammensetzungen
DE69230672D1 (de) Gonadotropin, das pharmazeutische zusammensetzungen mit sucrose stabilisator enthält
CA2123049A1 (en) Pharmaceutical containing the p40 subunit of interleukin 12
ATE184798T1 (de) Hgh enthaltende pharmazeutische zubereitungen
PH27257A (en) Therapeutically active chloro substituted benzimidazole
DK0759775T3 (da) Flydende IFN-beta-formuleringer
IL87778A0 (en) Pharmaceutical compositions containing stabilized therapeutically active proteins and their preparation
PH27446A (en) Compound with gastric acid inhibitory effect
ATE151636T1 (de) Diphosphonsäuren und deren salze enthaltende arzneimittel
EP0351876A3 (de) Zusammensetzung zur Steigerung der Impfungswirkung
YU44292A (sh) Superaktivni analozi faktora oslobadjanja hormona rasta

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee