ATE1502T1 - 7-methyl- und 7-methyl-8-niederalkyl b/c cis oder trans morphinan-6-one, verfahren zu ihrer herstellung und diese enthaltende arzneimittel. - Google Patents
7-methyl- und 7-methyl-8-niederalkyl b/c cis oder trans morphinan-6-one, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.Info
- Publication number
- ATE1502T1 ATE1502T1 AT80102616T AT80102616T ATE1502T1 AT E1502 T1 ATE1502 T1 AT E1502T1 AT 80102616 T AT80102616 T AT 80102616T AT 80102616 T AT80102616 T AT 80102616T AT E1502 T1 ATE1502 T1 AT E1502T1
- Authority
- AT
- Austria
- Prior art keywords
- methyl
- morphinan
- cis
- trans
- lower alkyl
- Prior art date
Links
- XUSCOHKHRDQKCI-ARFHVFGLSA-N (1S,9R,10R)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2,4,6-trien-13-one Chemical compound C1C(=O)CC[C@H]2[C@]3([H])NCC[C@@]21C1=CC=CC=C1C3 XUSCOHKHRDQKCI-ARFHVFGLSA-N 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004850 cyclobutylmethyl group Chemical group C1(CCC1)C* 0.000 abstract 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 239000003887 narcotic antagonist Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/040,664 US4230712A (en) | 1978-02-10 | 1979-05-21 | 7-Methyl-8β-lower alkyl or 7-methyl-8-lower alkyl B/C cis or trans morphinan-6-one compounds and therapeutic method of treating pain employing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE1502T1 true ATE1502T1 (de) | 1982-09-15 |
Family
ID=21912259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT80102616T ATE1502T1 (de) | 1979-05-21 | 1980-05-12 | 7-methyl- und 7-methyl-8-niederalkyl b/c cis oder trans morphinan-6-one, verfahren zu ihrer herstellung und diese enthaltende arzneimittel. |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0019254B1 (de) |
| JP (1) | JPS55154957A (de) |
| AT (1) | ATE1502T1 (de) |
| CA (1) | CA1135692A (de) |
| DE (1) | DE3060798D1 (de) |
| IL (1) | IL59992A0 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4370333A (en) * | 1981-06-29 | 1983-01-25 | Sisa, Incorporated | 17-Cyclopropylmethyl-3-hydroxy-14-methoxy 7α-methyl-morphinan-6-one and therapeutic method of treating pain with it |
| TW201441199A (zh) * | 2012-12-28 | 2014-11-01 | Purdue Pharma Lp | 經取代之嗎啡喃類及其用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2178010A (en) * | 1937-02-03 | 1939-10-31 | Small Lyndon Frederick | Nuclear substituted derivatives of the morphine series and methods for their preparation |
| US3654280A (en) * | 1968-03-21 | 1972-04-04 | Shionogi & Co | L-n allylic-3-hydroxy-6-oxomorphinans |
| CA1093070A (en) * | 1978-02-10 | 1981-01-06 | Michael P. Kotick | 8.beta.-ALKYL-SUBSTITUTED MORPHINAN-6-ONE COMPOUNDS |
-
1980
- 1980-04-30 CA CA000350957A patent/CA1135692A/en not_active Expired
- 1980-05-05 IL IL59992A patent/IL59992A0/xx unknown
- 1980-05-12 AT AT80102616T patent/ATE1502T1/de not_active IP Right Cessation
- 1980-05-12 EP EP80102616A patent/EP0019254B1/de not_active Expired
- 1980-05-12 DE DE8080102616T patent/DE3060798D1/de not_active Expired
- 1980-05-20 JP JP6603880A patent/JPS55154957A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPS55154957A (en) | 1980-12-02 |
| EP0019254B1 (de) | 1982-09-01 |
| EP0019254A1 (de) | 1980-11-26 |
| CA1135692A (en) | 1982-11-16 |
| IL59992A0 (en) | 1980-07-31 |
| DE3060798D1 (en) | 1982-10-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |