ATE14883T1 - Derivate von c-076-verbindungen. - Google Patents

Derivate von c-076-verbindungen.

Info

Publication number
ATE14883T1
ATE14883T1 AT82302375T AT82302375T ATE14883T1 AT E14883 T1 ATE14883 T1 AT E14883T1 AT 82302375 T AT82302375 T AT 82302375T AT 82302375 T AT82302375 T AT 82302375T AT E14883 T1 ATE14883 T1 AT E14883T1
Authority
AT
Austria
Prior art keywords
compounds
ethyl
chem
saturated
bond
Prior art date
Application number
AT82302375T
Other languages
English (en)
Inventor
Rudolf P Buhs
Theodore A Jacob
Gerald Miwa
Elena Sestokas
Rae Taub
John S Walsh
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE14883T1 publication Critical patent/ATE14883T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT82302375T 1981-05-11 1982-05-10 Derivate von c-076-verbindungen. ATE14883T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/262,082 US4333925A (en) 1981-05-11 1981-05-11 Derivatives of C-076 compounds
EP82302375A EP0065403B1 (de) 1981-05-11 1982-05-10 Derivate von C-076-Verbindungen

Publications (1)

Publication Number Publication Date
ATE14883T1 true ATE14883T1 (de) 1985-08-15

Family

ID=22996082

Family Applications (1)

Application Number Title Priority Date Filing Date
AT82302375T ATE14883T1 (de) 1981-05-11 1982-05-10 Derivate von c-076-verbindungen.

Country Status (12)

Country Link
US (1) US4333925A (de)
EP (1) EP0065403B1 (de)
JP (1) JPS57206695A (de)
AT (1) ATE14883T1 (de)
AU (1) AU550391B2 (de)
DE (1) DE3265386D1 (de)
DK (1) DK208382A (de)
ES (1) ES511953A0 (de)
GR (1) GR75502B (de)
NZ (1) NZ200497A (de)
PT (1) PT74846B (de)
ZA (1) ZA823196B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4510133A (en) * 1982-04-22 1985-04-09 Imperial Chemical Industries Plc Method for combating pests
US4560677A (en) * 1984-01-31 1985-12-24 Merck & Co., Inc. Synergistic avermectin combination for treating plant pests
GB2168345B (en) * 1984-12-14 1988-05-25 Ciba Geigy Ag Pesticidal 13b-substituted milbemycin derivatives
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
NZ216908A (en) * 1985-07-29 1989-06-28 Merck & Co Inc Avermectin derivatives
US4668696A (en) * 1985-07-29 1987-05-26 Merck & Co., Inc. Novel averonectin fermentation product of a microorganism with anthelmintic activity
US5840704A (en) * 1986-07-16 1998-11-24 Pfizer Inc. Antiparasitic agents and process for their preparation
US5525506A (en) * 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
US5234831A (en) * 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
US5238848A (en) * 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
DE3727648A1 (de) * 1987-08-19 1989-03-02 Bayer Ag Neue avermectin derivate, verfahren zu ihrer herstellung und ihre verwendung
US5240850A (en) * 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
PT88952B (pt) * 1987-11-09 1993-02-26 Pfizer Processo para a preparacao de avermectinas etiladas
US4963667A (en) * 1987-11-10 1990-10-16 Merck & Co., Inc. Ivermectin derivative compounds and process for preparing the same
GB8726730D0 (en) * 1987-11-14 1987-12-16 Pfizer Ltd Antiparasitic agents
US5008250A (en) * 1988-05-25 1991-04-16 Merck & Co., Inc. Avermectins with a cleaved furan ring and an 8a hydroxy group
US5188944A (en) * 1990-06-22 1993-02-23 Merck & Co., Inc. Process for the glycosylation of avermectin agylcones
US5189026A (en) * 1991-06-07 1993-02-23 Fractal Laboratories, Inc. Treatment of human diseases involving dysregulation or dysfunction of the nervous system
US6103504A (en) * 1992-03-25 2000-08-15 Pfizer Inc. Process for production of avermectins and cultures therefor
US5248678A (en) * 1992-06-30 1993-09-28 Fractal Laboratories, Inc. Methods for increasing arousal and alertness and for the amelioration of comatose states
US6265571B1 (en) 1999-07-12 2001-07-24 Magellan Laboratories, Inc. Purification process for anti-parasitic fermentation product
WO2007053902A1 (en) * 2005-11-10 2007-05-18 Bomac Animal Health Pty Limited Method of treating parasites
US8901163B2 (en) 2007-01-03 2014-12-02 Galderma S.A. Method of treating hyperesthesia, paresthesia, dolor, and pruritus caused by insect stings or noxious weeds or plants using avermectin compound
WO2012054328A1 (en) 2010-10-20 2012-04-26 Galderma S.A. Method of treating hemorrhoids using macrocyclic lactone compound
US8901090B2 (en) 2010-10-20 2014-12-02 Galderma S.A. Method of treating otitis externa using macrocyclic lactone compound
WO2012100835A1 (en) 2011-01-28 2012-08-02 Laboratorios Del Dr. Esteve, S.A. Methods and compositions for the treatment of aids
CN104402953B (zh) * 2014-11-28 2017-07-28 大庆志飞生物化工有限公司 阿维菌素单糖化合物及其制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (sv) 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
PH15982A (en) * 1977-10-03 1983-05-18 Merck & Co Inc Selective hydrogenation producta of c-076 compounds and derivatives thereof
US4199569A (en) * 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
US4200581A (en) * 1978-08-04 1980-04-29 Merck & Co., Inc. Alkyl derivatives of C-076 compounds
US4289760A (en) * 1980-05-02 1981-09-15 Merck & Co., Inc. 23-Keto derivatives of C-076 compounds
US4285963A (en) * 1980-08-07 1981-08-25 Merck & Co., Inc. Novel derivatives of C-076 compounds

Also Published As

Publication number Publication date
AU8329982A (en) 1982-11-18
JPS57206695A (en) 1982-12-18
EP0065403A1 (de) 1982-11-24
US4333925A (en) 1982-06-08
AU550391B2 (en) 1986-03-20
ZA823196B (en) 1983-03-30
ES8303528A1 (es) 1983-02-01
GR75502B (de) 1984-07-24
EP0065403B1 (de) 1985-08-14
NZ200497A (en) 1985-11-08
PT74846B (en) 1985-06-28
PT74846A (en) 1982-06-01
DE3265386D1 (en) 1985-09-19
ES511953A0 (es) 1983-02-01
DK208382A (da) 1982-11-12

Similar Documents

Publication Publication Date Title
ATE14883T1 (de) Derivate von c-076-verbindungen.
ES2044836T3 (es) Derivado de la piperidina, su utilizacion y compuesto farmaceutico que lo contiene.
CL2004001072A1 (es) Compuestos derivados de trifluorofenil-triazolopirimidina; procedimiento de preparacion de los compuestos; compuestos intermediarios utiles como fungicidas.
ES8701707A1 (es) Procedimiento para preparar derivados del acido acrilico conactividad fungicida
FI842419A (fi) 2-pyrimidinyl-1-piperazin-derivat, foerfarande foer deras framstaellning och dessa innehaollande laekemedel.
IL81002A (en) 3,4-diphenyl-pyrazoline-1-carboxamide derivatives,processes for the preparation thereof and insecticidal and acaricidal compositions containing the same
ES485621A1 (es) Un procedimiento para la preparacion de derivados de diben- zopirano
ES8801217A1 (es) Un procedimiento para la preparacion de un derivado de acido 5-imidazolcarboxilico
ES464354A1 (es) Procedimiento de preparacion de un complejo insectifugo e insecticida estable.
FI810559L (fi) Nya 3,4,5-trihydroxipiperidinderivat foerfaranden foer deras framstaellning och deras anvaendning som laekemedel samt i djurnaering
PL257730A1 (en) Insecticide
ATE37869T1 (de) Benzoylharnstoffderivate und diese verbindungen enthaltende pestizide kompositionen.
KR880004809A (ko) 안정화 제약 조성물
NZ234410A (en) 3-methoximinopropionic ester derivatives and fungicidal compositions
ES8102096A1 (es) Procedimiento para la obtencion de derivados de 3,4,5-trihi-droxipiperidina
FI833101A0 (fi) Substituerade tert. -butanol-derivat, foerfarande foer deras framstaellning och dessa innehaollandeantimykotiska medel
ATE18761T1 (de) Carbamoyloxybenzhydrol-derivate, ihre herstellung und ihre pharmazeutische zusammensetzungen.
KR910016252A (ko) 살충 및 살질균제
ES8708215A1 (es) Procedimiento para la obtencion de 1,2,4-triazoles
SE8702422D0 (sv) Improvements in or relating to fungicides
FR2382901A1 (de)
ES8400443A1 (es) Mejoras introducidas en un procedimiento para la preparacion de hidroximidatos y tiolhidroximidatos heterobiciclicos y derivados ester carbamato de lso mismos.
BE900063A (fr) Nouveaux derives de l'ethanol, leur preparation et leur utilisation comme fongicides.
RU94035664A (ru) Гидразоновое соединение, способы его получения, инсектицид, содержащий его в качестве активного ингредиента, способ подавления вредных насекомых
IT1224404B (it) Composti attivi sul sistema cardiovascolare

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee