ATE146082T1 - Feststellung kardiovaskulärer läsionen - Google Patents

Feststellung kardiovaskulärer läsionen

Info

Publication number
ATE146082T1
ATE146082T1 AT92912557T AT92912557T ATE146082T1 AT E146082 T1 ATE146082 T1 AT E146082T1 AT 92912557 T AT92912557 T AT 92912557T AT 92912557 T AT92912557 T AT 92912557T AT E146082 T1 ATE146082 T1 AT E146082T1
Authority
AT
Austria
Prior art keywords
imaging agent
agent conjugates
myosin
fibrin
leukocyte
Prior art date
Application number
AT92912557T
Other languages
English (en)
Inventor
David M Goldenberg
Original Assignee
Immunomedics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunomedics Inc filed Critical Immunomedics Inc
Application granted granted Critical
Publication of ATE146082T1 publication Critical patent/ATE146082T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1018—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Saccharide Compounds (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Steering Control In Accordance With Driving Conditions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT92912557T 1991-05-06 1992-04-24 Feststellung kardiovaskulärer läsionen ATE146082T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/694,977 US5364612A (en) 1991-05-06 1991-05-06 Detection of cardiovascular lesions

Publications (1)

Publication Number Publication Date
ATE146082T1 true ATE146082T1 (de) 1996-12-15

Family

ID=24791066

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92912557T ATE146082T1 (de) 1991-05-06 1992-04-24 Feststellung kardiovaskulärer läsionen

Country Status (11)

Country Link
US (2) US5364612A (de)
EP (1) EP0583390B1 (de)
JP (1) JP2823357B2 (de)
KR (1) KR100211394B1 (de)
AT (1) ATE146082T1 (de)
AU (1) AU657553B2 (de)
CA (1) CA2107567C (de)
DE (1) DE69215870T2 (de)
IL (1) IL101737A (de)
SG (1) SG46446A1 (de)
WO (1) WO1992019273A1 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US20010024638A1 (en) * 1992-11-02 2001-09-27 Michel Schneider Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US20040208826A1 (en) * 1990-04-02 2004-10-21 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
IN172208B (de) 1990-04-02 1993-05-01 Sint Sa
US6989141B2 (en) * 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US7083778B2 (en) * 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US20030194376A1 (en) * 1990-05-18 2003-10-16 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5364612A (en) * 1991-05-06 1994-11-15 Immunomedics, Inc. Detection of cardiovascular lesions
US5811447A (en) * 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
US6228362B1 (en) 1992-08-21 2001-05-08 Immunomedics, Inc. Boron neutron capture therapy using pre-targeting methods
GB9300686D0 (en) * 1993-01-15 1993-03-03 Imp Cancer Res Tech Compounds for targeting
ATE406909T1 (de) * 1993-05-13 2008-09-15 Poniard Pharmaceuticals Inc Prävention und behandlung von pathologien, die mit einer abnormalen proliferationglatter muskelzellen verbunden sind
PL182223B1 (pl) * 1993-12-15 2001-11-30 Bracco Research Sa Biokompatybilna faza rozproszona do otrzymywania srodka kontrastowego do badan ultradzwiekowych, srodek kontrastowy do badan ultradzwiekowych, suchy preparat srodka kontrastowego oraz dwuskladnikowy zestaw do otrzymywania srodka kontrastowego do badan ultradzwiekowych PL PL PL
GB9606452D0 (en) * 1996-03-27 1996-06-05 Sandoz Ltd Organic compounds
US6736769B2 (en) 1996-04-17 2004-05-18 Olivier Bertrand Radioactivity local delivery system
US6083484A (en) * 1996-10-17 2000-07-04 Molecular Biosystems, Inc. Microparticles stabilized by polynuclear chromium complexes and their use as ultrasound contrast agents
US6375925B1 (en) * 1996-11-08 2002-04-23 The Regents Of The University Of California Methods and reagents for non-invasive imaging of atherosclerotic plaque
AU1159497A (en) * 1996-11-08 1998-06-03 Regents Of The University Of California, The Methods and reagents for non-invasive imaging of atherosclerotic plaque
GB9705521D0 (en) * 1997-03-18 1997-05-07 Univ Sheffield The use of mononuclear phagocytes in the vivo imaging of hypoxic/ischaemic tissue
EP0998308B1 (de) * 1997-07-01 2007-12-19 GE Healthcare AS Diagnostisches verfahren zum nachweis von myokard-ischämie
US7060251B1 (en) * 1997-09-08 2006-06-13 The General Hospital Corporation Imaging agents for early detection and monitoring of cardiovascular plaque
WO1999059633A1 (en) 1998-05-20 1999-11-25 Immunomedics, Inc. Therapeutics using a bispecific anti-hla class ii invariant chain x anti-pathogen antibody
AU768859B2 (en) * 1999-07-29 2004-01-08 Dyax Corp. Binding moieties for fibrin
US6442228B1 (en) 2000-04-20 2002-08-27 Ge Medical Systems Global Technology Company, Llc Data acquisition modifications for improved reconstruction with conventional CT
US6506365B1 (en) * 2000-09-25 2003-01-14 Baxter Aktiengesellschaft Fibrin/fibrinogen binding conjugate
EP1348026A2 (de) * 2000-12-23 2003-10-01 Dyax Corp. Fibrin-bindende polypeptide verwendbar inter alia in medizinischen bilderzeugungsverfahren
US6984373B2 (en) * 2000-12-23 2006-01-10 Dyax Corp. Fibrin binding moieties useful as imaging agents
EP1401479B1 (de) * 2001-06-04 2007-04-18 The General Hospital Corporation Nachweis und therapie von empfindlichem plaque mit photodynamischen verbindungen
US20040062748A1 (en) * 2002-09-30 2004-04-01 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
US8129330B2 (en) 2002-09-30 2012-03-06 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
US8129123B2 (en) * 2004-10-05 2012-03-06 The Regents Of The University Of California Methods for assessing atherogenesis by determining oxidized phospholipid to apolipoprotein B ratios
WO2007030531A2 (en) * 2005-09-06 2007-03-15 Molecular Image Inc. Reagents for testing and molecular imaging of liver cancer
US20070088379A1 (en) * 2005-10-17 2007-04-19 Jacob Schneiderman Minimally invasive a AAPT extirpation
EP2674440B1 (de) 2005-12-16 2019-07-03 IBC Pharmaceuticals, Inc. Polyvalente bioaktive anordnungen auf immunglobulinbasis
EP2004268A4 (de) * 2006-03-27 2009-12-23 Tel Hashomer Medical Res Infrastructure & Services Ltd Intraluminaler massenkollektor
US8864821B2 (en) 2008-11-26 2014-10-21 Visen Medical, Inc. Methods and compositions for identifying subjects at risk of developing stent thrombosis
WO2012151199A1 (en) 2011-05-02 2012-11-08 Immunomedics, Inc. Ultrafiltration concentration of allotype selected antibodies for small-volume administration
CN104363919A (zh) 2012-06-01 2015-02-18 Ibc药品公司 具有改进的体内稳定性、药物代谢动力学和功效的多聚体复合物
WO2014028560A2 (en) 2012-08-14 2014-02-20 Ibc Pharmaceuticals, Inc. T-cell redirecting bispecific antibodies for treatment of disease
HRP20220399T1 (hr) 2012-12-13 2022-05-13 Immunomedics, Inc. Režim doziranja imunokonjugata protutijela i sn-38 za poboljšanu učinkovitost i smanjenu toksičnost
US10328149B2 (en) 2014-06-13 2019-06-25 Tenboron Oy Conjugates comprising an anti-EGFR1 antibody
WO2015200260A1 (en) 2014-06-24 2015-12-30 Immunomedics, Inc. Anti-histone therapy for vascular necrosis in severe glomerulonephritis
AU2021207586A1 (en) 2020-01-13 2022-07-21 Neoimmunetech, Inc. Method of treating a tumor with a combination of IL-7 protein and a bispecific antibody
EP4423664A1 (de) * 2021-10-25 2024-09-04 Singular Genomics Systems, Inc. Manipulation und detektion biologischer proben
WO2024076993A2 (en) * 2022-10-03 2024-04-11 Therini Bio, Inc. Multi-specific antigen binding proteins which bind human fibrin or fibrinogen ?c domain and vascular endothelial growth factor and methods of use

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4364936A (en) * 1980-01-08 1982-12-21 Ortho Pharmaceutical Corporation Monoclonal antibody to a human monocyte antigen and methods of preparing same
JPS6028998A (ja) * 1983-07-06 1985-02-14 Yamasa Shoyu Co Ltd 心筋ミオシン重鎖に対する単一クロ−ン抗体
US4624846A (en) * 1983-07-29 1986-11-25 Immunomedics, Inc. Method for enhancing target specificity of antibody localization and clearance of non-target diagnostic and therapeutic principles
JPS60201260A (ja) * 1984-03-27 1985-10-11 Yamasa Shoyu Co Ltd 心疾患診断薬
US4634586A (en) * 1984-05-21 1987-01-06 The Board Of Trustees Of The Leland Stanford Junior University Reagent and method for radioimaging leukocytes
US4863729A (en) * 1984-06-20 1989-09-05 Linus Pauling Institute Of Science And Medicine Method for preparing a macromolecular monoclonal antibody composition
US4859450A (en) * 1984-08-13 1989-08-22 The General Hospital Corporation Method of NMR imaging using antibody to cardiac myosin
US4783330A (en) * 1984-11-15 1988-11-08 New England Medical Center Hospitals, Inc. Monoclonal antibodies to activated platelets
US4698420A (en) * 1985-02-25 1987-10-06 Xoma Corporation Antibody hybrid molecules and process for their preparation
US4820505A (en) * 1985-04-04 1989-04-11 Scripps Clinic And Research Foundation Detection of activated platelets with antibodies to thrombospondin
NL8501219A (nl) * 1985-04-29 1986-11-17 Stichting Vrienden Van De Stic Immunologisch complex, de bereiding en toepassing daarvan.
US4990326A (en) * 1985-05-31 1991-02-05 Summa Medical Corporation Method for detecting blood platelets
US5225181A (en) * 1985-06-07 1993-07-06 The Research Foundation Of State University Of New York Radiolabeled antiplatelet monoclonal antibody for imaging in-vivo thrombi
US4926869A (en) * 1986-01-16 1990-05-22 The General Hospital Corporation Method for the diagnosis and treatment of inflammation
US4916070A (en) * 1986-04-14 1990-04-10 The General Hospital Corporation Fibrin-specific antibodies and method of screening for the antibodies
JP2635343B2 (ja) * 1986-04-14 1997-07-30 ザ・ジェネラル・ホスピタル・コーポレーション ヘテロ二官能性抗体および利用方法
FR2604092B1 (fr) * 1986-09-19 1990-04-13 Immunotech Sa Immunoreactifs destines a cibler les cellules animales pour leur visualisation ou leur destruction in vivo
US4844893A (en) * 1986-10-07 1989-07-04 Scripps Clinic And Research Foundation EX vivo effector cell activation for target cell killing
US5277894A (en) * 1988-02-26 1994-01-11 The General Hospital Corporation Method for tumor detection and treatment
US4925648A (en) * 1988-07-29 1990-05-15 Immunomedics, Inc. Detection and treatment of infectious and inflammatory lesions
US5439665A (en) * 1988-07-29 1995-08-08 Immunomedics Detection and treatment of infectious and inflammatory lesions
US5024829A (en) * 1988-11-21 1991-06-18 Centocor, Inc. Method of imaging coronary thrombi
WO1990006133A1 (en) * 1988-11-25 1990-06-14 Centocor, Inc. Heterobifunctional antibodies having specificity for platelets and thrombolytic agents
US5134071A (en) * 1989-02-06 1992-07-28 State University Of New York Polymerization and copolymerization of proteins
US5376356A (en) * 1989-03-14 1994-12-27 Neorx Corporation Imaging tissue sites of inflammation
US4986979A (en) * 1989-03-14 1991-01-22 Neorx Corporation Imaging tissue sites of inflammation
US5026537A (en) * 1989-04-06 1991-06-25 Centocor, Inc. Methods for imaging atherosclerotic plaque
US5185433A (en) * 1990-04-09 1993-02-09 Centocor, Inc. Cross-linking protein compositions having two or more identical binding sites
US5216130A (en) * 1990-05-17 1993-06-01 Albany Medical College Complex for in-vivo target localization
US5364612A (en) * 1991-05-06 1994-11-15 Immunomedics, Inc. Detection of cardiovascular lesions
US5541296A (en) * 1991-08-30 1996-07-30 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Monocyte adhesion protein and monoclonal antibody thereto
US5503982A (en) * 1993-09-30 1996-04-02 Research Corporation Technologies, Inc. Detection of an acute myocardial infarction in a patient
US5443953A (en) * 1993-12-08 1995-08-22 Immunomedics, Inc. Preparation and use of immunoconjugates

Also Published As

Publication number Publication date
KR100211394B1 (ko) 1999-08-02
IL101737A (en) 1996-05-14
EP0583390A1 (de) 1994-02-23
US5364612A (en) 1994-11-15
WO1992019273A1 (en) 1992-11-12
DE69215870D1 (de) 1997-01-23
AU2024292A (en) 1992-12-21
CA2107567A1 (en) 1992-11-07
JPH06507410A (ja) 1994-08-25
CA2107567C (en) 1999-04-06
DE69215870T2 (de) 1997-05-22
US5632968A (en) 1997-05-27
EP0583390A4 (de) 1994-04-27
JP2823357B2 (ja) 1998-11-11
AU657553B2 (en) 1995-03-16
EP0583390B1 (de) 1996-12-11
IL101737A0 (en) 1992-12-30
SG46446A1 (en) 1998-02-20

Similar Documents

Publication Publication Date Title
ATE146082T1 (de) Feststellung kardiovaskulärer läsionen
Bochenek et al. Role of endothelial cells in acute and chronic thrombosis
Oster et al. Thrombus radioimmunoscintigraphy: an approach using monoclonal antiplatelet antibody.
Houshmand et al. The role of molecular imaging in diagnosis of deep vein thrombosis
DE69026685D1 (de) Synthetische peptide zum in vivo nachweis von thrombosen
NO953886D0 (no) Radiomerkede blodplate-GPIIb/IIIa-reseptorantagonister som avbildingsmidler ved diagnose av tromboemboliske sykdommer
EP0683234A4 (de) ANTIKÖRPER GEGEN -g(b)-AMYLOID ODER DERIVATE DAVON UND SEINE VERWENDUNG.
AR240366A1 (es) Pano para la recoleccion de especimenes para la deteccion de sangre oculta.
BRPI9910394A (pt) moléculas de ligação específica para cintigrafia e conjugados contendo as mesmas
Alegre et al. Histopathologic and immunofluorescence study of skin lesions associated with circulating lupus anticoagulant
Héloire et al. Aggregates of endothelial microparticles and platelets circulate in peripheral blood. Variations during stable coronary disease and acute myocardial infarction
IT8320550A0 (it) Procedimento di purificazione peraffinita' in cui si impiegano anticorpi monoclonali.
DE69128543D1 (de) Monoklonale antikörper der maus
NO920852D0 (no) Midler for diagnostisering av demyelinisante neuropatier,saerlig multippel sklerose
Ebstein et al. A radioimmunoassay of human circulatory dopamine-β-hydroxylase
Nakamura et al. Effects of sarpogrelate hydrochloride on platelet aggregation, and its relation to the release of serotonin and P-selectin
ITFI980185A0 (it) Cassonetto.specialmente per la raccolta di indumenti usati
Nawroth et al. Mechanism of endothelial cell activation
IT1230329B (it) Dispositivo di tenuta tra due parti meccaniche imperniate tra loro, in particolare maglie di cingoli di veicoli cingolati.
FRIEDRICH et al. DAMPING AND MODULUS DEFECT DURING PLASTIC DEFORMATION--PART IV. MEASUREMENT OF AMPLITUDE DEPENDENCE ON ALUMINIUM[AND COPPER] SINGLE CRYSTALS
Scharf et al. Thrombin generation in acute myeloblastic leukemia
Weldeck et al. Fluorescence Reflectance Imaging of Macrophage-Rich Atherosclerotic Plaques Using an [alpha]^ sub v^[beta]^ sub 3^ Integrin-Targeted Fluorochrome
ITMI912188A0 (it) Composizioni farmaceutiche atte ad accelerare la ricostituzione di granulociti. monociti e piastrine
Srivastava The antibody approach of labeling blood cells
Hauutmann et al. Plasma clot lysis by staphylokinase in vitro. Effects on coagulation and platelets

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee