ATE128451T1 - Verfahren zur herstellung von ibuprofen. - Google Patents
Verfahren zur herstellung von ibuprofen.Info
- Publication number
- ATE128451T1 ATE128451T1 AT91305019T AT91305019T ATE128451T1 AT E128451 T1 ATE128451 T1 AT E128451T1 AT 91305019 T AT91305019 T AT 91305019T AT 91305019 T AT91305019 T AT 91305019T AT E128451 T1 ATE128451 T1 AT E128451T1
- Authority
- AT
- Austria
- Prior art keywords
- ibuprofen
- ibpe
- carbon monoxide
- reaction
- initially
- Prior art date
Links
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 title abstract 7
- 229960001680 ibuprofen Drugs 0.000 title abstract 7
- 238000004519 manufacturing process Methods 0.000 title 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 3
- 229910002091 carbon monoxide Inorganic materials 0.000 abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000006315 carbonylation Effects 0.000 abstract 1
- 238000005810 carbonylation reaction Methods 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052763 palladium Inorganic materials 0.000 abstract 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 230000035484 reaction time Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/10—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction with carbon monoxide
- C07C51/12—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction with carbon monoxide on an oxygen-containing group in organic compounds, e.g. alcohols
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Optical Radar Systems And Details Thereof (AREA)
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53363090A | 1990-06-04 | 1990-06-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE128451T1 true ATE128451T1 (de) | 1995-10-15 |
Family
ID=24126797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91305019T ATE128451T1 (de) | 1990-06-04 | 1991-06-03 | Verfahren zur herstellung von ibuprofen. |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0460905B1 (de) |
| JP (1) | JP2885542B2 (de) |
| KR (1) | KR100221484B1 (de) |
| AT (1) | ATE128451T1 (de) |
| BR (1) | BR9102236A (de) |
| CA (1) | CA2043108C (de) |
| DE (1) | DE69113321T2 (de) |
| ES (1) | ES2079032T3 (de) |
| FI (1) | FI102272B1 (de) |
| HU (1) | HU209123B (de) |
| IL (1) | IL98306A0 (de) |
| SG (1) | SG49020A1 (de) |
| YU (1) | YU97191A (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5360938A (en) * | 1991-08-21 | 1994-11-01 | Union Carbide Chemicals & Plastics Technology Corporation | Asymmetric syntheses |
| US5223640A (en) * | 1992-12-23 | 1993-06-29 | Hoechst Celanese Corporation | Preparation of optically active α-aryl propionic acids |
| US5315030A (en) * | 1993-09-29 | 1994-05-24 | Ethyl Corporation | Catalytic carbonylation of ethers and thioethers |
| CN113004139B (zh) * | 2019-12-18 | 2022-09-02 | 华东理工大学 | 一种低水含量下乙醇羰基合成丙酸的方法 |
| CN111689847B (zh) * | 2020-06-12 | 2022-05-17 | 浙江新和成股份有限公司 | 芳基丙酸类化合物的制备方法 |
| CN115353448B (zh) * | 2022-08-18 | 2023-07-21 | 浙江新和成股份有限公司 | 一种布洛芬的合成方法、催化体系及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1329396C (en) * | 1987-03-20 | 1994-05-10 | Varadaraj Elango | Method for producing ibuprofen |
| JPH01311043A (ja) * | 1988-04-15 | 1989-12-15 | Hoechst Celanese Corp | イソブチルフェニルエタノールのイブプロフェンヘのカルボニル化における触媒のリサイクル法 |
-
1991
- 1991-05-22 HU HU911730A patent/HU209123B/hu not_active IP Right Cessation
- 1991-05-23 CA CA002043108A patent/CA2043108C/en not_active Expired - Fee Related
- 1991-05-30 IL IL98306A patent/IL98306A0/xx unknown
- 1991-05-31 BR BR919102236A patent/BR9102236A/pt not_active Application Discontinuation
- 1991-05-31 YU YU97191A patent/YU97191A/sh unknown
- 1991-06-03 EP EP91305019A patent/EP0460905B1/de not_active Expired - Lifetime
- 1991-06-03 FI FI912658A patent/FI102272B1/fi active
- 1991-06-03 KR KR1019910009178A patent/KR100221484B1/ko not_active Expired - Fee Related
- 1991-06-03 SG SG1996005263A patent/SG49020A1/en unknown
- 1991-06-03 AT AT91305019T patent/ATE128451T1/de not_active IP Right Cessation
- 1991-06-03 DE DE69113321T patent/DE69113321T2/de not_active Expired - Fee Related
- 1991-06-03 ES ES91305019T patent/ES2079032T3/es not_active Expired - Lifetime
- 1991-06-04 JP JP3132715A patent/JP2885542B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR100221484B1 (ko) | 1999-09-15 |
| FI102272B (fi) | 1998-11-13 |
| SG49020A1 (en) | 1998-05-18 |
| FI912658A0 (fi) | 1991-06-03 |
| FI102272B1 (fi) | 1998-11-13 |
| ES2079032T3 (es) | 1996-01-01 |
| BR9102236A (pt) | 1992-04-28 |
| EP0460905A2 (de) | 1991-12-11 |
| HU209123B (en) | 1994-03-28 |
| CA2043108A1 (en) | 1991-12-05 |
| JPH04235943A (ja) | 1992-08-25 |
| IL98306A0 (en) | 1992-06-21 |
| DE69113321T2 (de) | 1996-03-07 |
| EP0460905A3 (en) | 1992-10-07 |
| FI912658L (fi) | 1991-12-05 |
| KR920000692A (ko) | 1992-01-29 |
| DE69113321D1 (de) | 1995-11-02 |
| CA2043108C (en) | 2001-07-17 |
| HUT57697A (en) | 1991-12-30 |
| JP2885542B2 (ja) | 1999-04-26 |
| YU97191A (sh) | 1993-11-16 |
| EP0460905B1 (de) | 1995-09-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |