YU97191A - Poboljšan postupak za dobijanje ibuprofena - Google Patents

Poboljšan postupak za dobijanje ibuprofena

Info

Publication number
YU97191A
YU97191A YU97191A YU97191A YU97191A YU 97191 A YU97191 A YU 97191A YU 97191 A YU97191 A YU 97191A YU 97191 A YU97191 A YU 97191A YU 97191 A YU97191 A YU 97191A
Authority
YU
Yugoslavia
Prior art keywords
ibuprofen
ibpe
carbon monoxide
reaction
improved procedure
Prior art date
Application number
YU97191A
Other languages
English (en)
Inventor
J.D. Hendricks
G.N. Mott
Original Assignee
Hoechst Celanese Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Celanese Co. filed Critical Hoechst Celanese Co.
Publication of YU97191A publication Critical patent/YU97191A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/10—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction with carbon monoxide
    • C07C51/12—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction with carbon monoxide on an oxygen-containing group in organic compounds, e.g. alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Optical Radar Systems And Details Thereof (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

POBOLJŠAN POSTUPAK ZA DOBIJANJE IBUPROFENA, dat je postupak za dobivanje ibuprofena karbonilacijom 1-(4'-izobutilfenil) etanola (IBPE) sa ugljem monoksidom koji obuhvata početno reakcionu smeu koja obuhvata IBPE, ibuprofen i katalizator za karbonilaciju sa ugljen monoksidom pod uslovima odpočinjanja reakcije i neprekidno šaržiranje ugljen monoksida u smešu radi dobivanja željenog prinosa ibuprofena. Poželjno, katalizator obuhvata paladijum i monodentatni fosfinski ligand. Prisustvo ibuprofena u šaržnoj smeši kada se reakcija odpočinje sa CO omogućava dobivanje visokih selektivnosti ibuprofena sa uglavnom potpunom konverzijom IBPE sa mnogo kraćim reakcionim vremenima nego kada ibuprofen nije početno prisutan.
YU97191A 1990-06-04 1991-05-31 Poboljšan postupak za dobijanje ibuprofena YU97191A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53363090A 1990-06-04 1990-06-04

Publications (1)

Publication Number Publication Date
YU97191A true YU97191A (sh) 1993-11-16

Family

ID=24126797

Family Applications (1)

Application Number Title Priority Date Filing Date
YU97191A YU97191A (sh) 1990-06-04 1991-05-31 Poboljšan postupak za dobijanje ibuprofena

Country Status (13)

Country Link
EP (1) EP0460905B1 (sh)
JP (1) JP2885542B2 (sh)
KR (1) KR100221484B1 (sh)
AT (1) ATE128451T1 (sh)
BR (1) BR9102236A (sh)
CA (1) CA2043108C (sh)
DE (1) DE69113321T2 (sh)
ES (1) ES2079032T3 (sh)
FI (1) FI102272B (sh)
HU (1) HU209123B (sh)
IL (1) IL98306A0 (sh)
SG (1) SG49020A1 (sh)
YU (1) YU97191A (sh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5360938A (en) * 1991-08-21 1994-11-01 Union Carbide Chemicals & Plastics Technology Corporation Asymmetric syntheses
US5223640A (en) * 1992-12-23 1993-06-29 Hoechst Celanese Corporation Preparation of optically active α-aryl propionic acids
US5315030A (en) * 1993-09-29 1994-05-24 Ethyl Corporation Catalytic carbonylation of ethers and thioethers
CN113004139B (zh) * 2019-12-18 2022-09-02 华东理工大学 一种低水含量下乙醇羰基合成丙酸的方法
CN111689847B (zh) * 2020-06-12 2022-05-17 浙江新和成股份有限公司 芳基丙酸类化合物的制备方法
CN115353448B (zh) * 2022-08-18 2023-07-21 浙江新和成股份有限公司 一种布洛芬的合成方法、催化体系及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1329396C (en) * 1987-03-20 1994-05-10 Varadaraj Elango Method for producing ibuprofen
CA1338673C (en) * 1988-04-15 1996-10-22 Graham N. Mott Catalyst recycle in the carbonylation of isobutylphenylethanol to ibuprofen

Also Published As

Publication number Publication date
SG49020A1 (en) 1998-05-18
IL98306A0 (en) 1992-06-21
FI912658A (fi) 1991-12-05
DE69113321T2 (de) 1996-03-07
DE69113321D1 (de) 1995-11-02
FI102272B1 (fi) 1998-11-13
FI912658A0 (fi) 1991-06-03
JPH04235943A (ja) 1992-08-25
CA2043108C (en) 2001-07-17
EP0460905A2 (en) 1991-12-11
CA2043108A1 (en) 1991-12-05
KR100221484B1 (ko) 1999-09-15
HUT57697A (en) 1991-12-30
ATE128451T1 (de) 1995-10-15
EP0460905A3 (en) 1992-10-07
FI102272B (fi) 1998-11-13
EP0460905B1 (en) 1995-09-27
KR920000692A (ko) 1992-01-29
JP2885542B2 (ja) 1999-04-26
ES2079032T3 (es) 1996-01-01
BR9102236A (pt) 1992-04-28
HU209123B (en) 1994-03-28

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