IL98306A0 - Improved method for producing ibuprofen - Google Patents
Improved method for producing ibuprofenInfo
- Publication number
- IL98306A0 IL98306A0 IL98306A IL9830691A IL98306A0 IL 98306 A0 IL98306 A0 IL 98306A0 IL 98306 A IL98306 A IL 98306A IL 9830691 A IL9830691 A IL 9830691A IL 98306 A0 IL98306 A0 IL 98306A0
- Authority
- IL
- Israel
- Prior art keywords
- ibuprofen
- ibpe
- carbon monoxide
- reaction
- improved method
- Prior art date
Links
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 title abstract 7
- 229960001680 ibuprofen Drugs 0.000 title abstract 7
- 238000004519 manufacturing process Methods 0.000 title 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 3
- 229910002091 carbon monoxide Inorganic materials 0.000 abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000006315 carbonylation Effects 0.000 abstract 1
- 238000005810 carbonylation reaction Methods 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052763 palladium Inorganic materials 0.000 abstract 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 230000035484 reaction time Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/10—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction with carbon monoxide
- C07C51/12—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction with carbon monoxide on an oxygen-containing group in organic compounds, e.g. alcohols
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Optical Radar Systems And Details Thereof (AREA)
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53363090A | 1990-06-04 | 1990-06-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL98306A0 true IL98306A0 (en) | 1992-06-21 |
Family
ID=24126797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL98306A IL98306A0 (en) | 1990-06-04 | 1991-05-30 | Improved method for producing ibuprofen |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0460905B1 (de) |
| JP (1) | JP2885542B2 (de) |
| KR (1) | KR100221484B1 (de) |
| AT (1) | ATE128451T1 (de) |
| BR (1) | BR9102236A (de) |
| CA (1) | CA2043108C (de) |
| DE (1) | DE69113321T2 (de) |
| ES (1) | ES2079032T3 (de) |
| FI (1) | FI102272B (de) |
| HU (1) | HU209123B (de) |
| IL (1) | IL98306A0 (de) |
| SG (1) | SG49020A1 (de) |
| YU (1) | YU97191A (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5360938A (en) * | 1991-08-21 | 1994-11-01 | Union Carbide Chemicals & Plastics Technology Corporation | Asymmetric syntheses |
| US5223640A (en) * | 1992-12-23 | 1993-06-29 | Hoechst Celanese Corporation | Preparation of optically active α-aryl propionic acids |
| US5315030A (en) * | 1993-09-29 | 1994-05-24 | Ethyl Corporation | Catalytic carbonylation of ethers and thioethers |
| CN113004139B (zh) * | 2019-12-18 | 2022-09-02 | 华东理工大学 | 一种低水含量下乙醇羰基合成丙酸的方法 |
| CN111689847B (zh) * | 2020-06-12 | 2022-05-17 | 浙江新和成股份有限公司 | 芳基丙酸类化合物的制备方法 |
| CN115353448B (zh) * | 2022-08-18 | 2023-07-21 | 浙江新和成股份有限公司 | 一种布洛芬的合成方法、催化体系及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL85736A (en) * | 1987-03-20 | 1992-07-15 | Hoechst Celanese Corp | Method for producing ibuprofen by high pressure carbonylation of 1-(4'-isobutylphenyl)ethanol |
| EP0337803A1 (de) * | 1988-04-15 | 1989-10-18 | Hoechst Celanese Corporation | Zurückführen eines Katalysators für die Karbonylierung von Isobutylphenylethanol zu Ibuprofen |
-
1991
- 1991-05-22 HU HU911730A patent/HU209123B/hu not_active IP Right Cessation
- 1991-05-23 CA CA002043108A patent/CA2043108C/en not_active Expired - Fee Related
- 1991-05-30 IL IL98306A patent/IL98306A0/xx unknown
- 1991-05-31 BR BR919102236A patent/BR9102236A/pt not_active Application Discontinuation
- 1991-05-31 YU YU97191A patent/YU97191A/sh unknown
- 1991-06-03 KR KR1019910009178A patent/KR100221484B1/ko not_active Expired - Fee Related
- 1991-06-03 ES ES91305019T patent/ES2079032T3/es not_active Expired - Lifetime
- 1991-06-03 EP EP91305019A patent/EP0460905B1/de not_active Expired - Lifetime
- 1991-06-03 DE DE69113321T patent/DE69113321T2/de not_active Expired - Fee Related
- 1991-06-03 FI FI912658A patent/FI102272B/fi active
- 1991-06-03 AT AT91305019T patent/ATE128451T1/de not_active IP Right Cessation
- 1991-06-03 SG SG1996005263A patent/SG49020A1/en unknown
- 1991-06-04 JP JP3132715A patent/JP2885542B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FI912658A0 (fi) | 1991-06-03 |
| JP2885542B2 (ja) | 1999-04-26 |
| BR9102236A (pt) | 1992-04-28 |
| HU209123B (en) | 1994-03-28 |
| FI102272B1 (fi) | 1998-11-13 |
| EP0460905B1 (de) | 1995-09-27 |
| FI102272B (fi) | 1998-11-13 |
| KR920000692A (ko) | 1992-01-29 |
| CA2043108A1 (en) | 1991-12-05 |
| DE69113321D1 (de) | 1995-11-02 |
| EP0460905A2 (de) | 1991-12-11 |
| DE69113321T2 (de) | 1996-03-07 |
| YU97191A (sh) | 1993-11-16 |
| SG49020A1 (en) | 1998-05-18 |
| HUT57697A (en) | 1991-12-30 |
| KR100221484B1 (ko) | 1999-09-15 |
| ATE128451T1 (de) | 1995-10-15 |
| CA2043108C (en) | 2001-07-17 |
| ES2079032T3 (es) | 1996-01-01 |
| JPH04235943A (ja) | 1992-08-25 |
| EP0460905A3 (en) | 1992-10-07 |
| FI912658L (fi) | 1991-12-05 |
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