ATE127696T1 - Wellenlängenspeziphisches, cytotoxisches mittel. - Google Patents
Wellenlängenspeziphisches, cytotoxisches mittel.Info
- Publication number
- ATE127696T1 ATE127696T1 AT89307281T AT89307281T ATE127696T1 AT E127696 T1 ATE127696 T1 AT E127696T1 AT 89307281 T AT89307281 T AT 89307281T AT 89307281 T AT89307281 T AT 89307281T AT E127696 T1 ATE127696 T1 AT E127696T1
- Authority
- AT
- Austria
- Prior art keywords
- tissues
- cells
- specific
- wavelength
- cytotoxic agent
- Prior art date
Links
- 229940127089 cytotoxic agent Drugs 0.000 title 1
- 239000002254 cytotoxic agent Substances 0.000 title 1
- 231100000599 cytotoxic agent Toxicity 0.000 title 1
- UJKPHYRXOLRVJJ-MLSVHJFASA-N CC(O)C1=C(C)/C2=C/C3=N/C(=C\C4=C(CCC(O)=O)C(C)=C(N4)/C=C4\N=C(\C=C\1/N\2)C(C)=C4C(C)O)/C(CCC(O)=O)=C3C Chemical class CC(O)C1=C(C)/C2=C/C3=N/C(=C\C4=C(CCC(O)=O)C(C)=C(N4)/C=C4\N=C(\C=C\1/N\2)C(C)=C4C(C)O)/C(CCC(O)=O)=C3C UJKPHYRXOLRVJJ-MLSVHJFASA-N 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 150000004032 porphyrins Chemical class 0.000 abstract 1
- 230000005855 radiation Effects 0.000 abstract 1
- 238000007086 side reaction Methods 0.000 abstract 1
- 229940043517 specific immunoglobulins Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0485—Porphyrins, texaphyrins wherein the nitrogen atoms forming the central ring system complex the radioactive metal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0036—Porphyrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0058—Antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Optics & Photonics (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/221,161 US4920143A (en) | 1987-04-23 | 1988-07-19 | Hydro-monobenzoporphyrin wavelength-specific cytotoxic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE127696T1 true ATE127696T1 (de) | 1995-09-15 |
Family
ID=22826617
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT94115192T ATE209650T1 (de) | 1988-07-19 | 1989-07-19 | Wellenlängenspezifisches, cytotoxisches mittel |
AT89307281T ATE127696T1 (de) | 1988-07-19 | 1989-07-19 | Wellenlängenspeziphisches, cytotoxisches mittel. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT94115192T ATE209650T1 (de) | 1988-07-19 | 1989-07-19 | Wellenlängenspezifisches, cytotoxisches mittel |
Country Status (10)
Country | Link |
---|---|
US (1) | US4920143A (de) |
EP (2) | EP0352076B1 (de) |
AT (2) | ATE209650T1 (de) |
AU (1) | AU638675B2 (de) |
CA (1) | CA1339927C (de) |
DE (3) | DE68929351T2 (de) |
ES (2) | ES2169060T3 (de) |
GR (1) | GR3017426T3 (de) |
LU (1) | LU90718I2 (de) |
NL (1) | NL300037I2 (de) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5095030A (en) * | 1987-01-20 | 1992-03-10 | University Of British Columbia | Wavelength-specific cytotoxic agents |
US5198460A (en) * | 1988-07-20 | 1993-03-30 | Health Research Inc. | Pyropheophorbides and their use in photodynamic therapy |
US5002962A (en) * | 1988-07-20 | 1991-03-26 | Health Research, Inc. | Photosensitizing agents |
USRE38994E1 (en) | 1988-07-20 | 2006-02-28 | Health Research, Inc. | Pyropheophorbides conjugates and their use in photodynamic therapy |
USRE39094E1 (en) * | 1988-07-20 | 2006-05-09 | Health Research, Inc. | Pyropheophorbides and their use in photodynamic therapy |
AU641658B2 (en) * | 1989-06-07 | 1993-09-30 | University Of British Columbia, The | Photosensitizing diels-alder porphyrin derivatives |
US5087636A (en) * | 1990-02-20 | 1992-02-11 | University Of British Columbia | Method to destroy malignant cells in mononuclear cell populations |
US5214036A (en) * | 1990-03-08 | 1993-05-25 | University Of British Columbia | Benzoporphyrin derivatives for photodynamic therapy |
US5053423A (en) * | 1990-03-22 | 1991-10-01 | Quadra Logic Technologies Inc. | Compositions for photodynamic therapy |
US5120649A (en) * | 1990-05-15 | 1992-06-09 | New York Blood Center, Inc. | Photodynamic inactivation of viruses in blood cell-containing compositions |
GB9014307D0 (en) * | 1990-06-27 | 1990-08-15 | Scient Generics Ltd | Method of treatment and compositions therefor |
US5219878A (en) * | 1990-10-05 | 1993-06-15 | Queen's University | Tetrapyrrole hydroxyalkylamide photochemotherapeutic agents |
US5435307A (en) * | 1991-03-29 | 1995-07-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Surface fluorescent monitor |
US6890555B1 (en) | 1992-02-05 | 2005-05-10 | Qlt, Inc. | Liposome compositions of porphyrin photosensitizers |
CA2087902C (en) * | 1992-02-05 | 2006-10-17 | Narendra Raghunathji Desai | Liposome compositions of porphyrin photosensitizers |
US5330741A (en) * | 1992-02-24 | 1994-07-19 | The Regents Of The University Of California | Long-wavelength water soluble chlorin photosensitizers useful for photodynamic therapy and diagnosis of tumors |
CA2097280A1 (en) * | 1992-06-01 | 1993-12-02 | Sandor G. Vari | Apparatus and method of use for a photosensitizer enhanced fluorescence based bipsy needle |
JPH08505361A (ja) * | 1992-08-17 | 1996-06-11 | クアドラ・ロジック・テクノロジーズ・インコーポレーテッド | 不所望細胞または組織を破壊しもしくはその成長を阻害する方法 |
US5798349A (en) | 1994-03-14 | 1998-08-25 | The General Hospital Corporation | Use of green porphyrins to treat neovasculature in the eye |
US6551618B2 (en) * | 1994-03-15 | 2003-04-22 | University Of Birmingham | Compositions and methods for delivery of agents for neuronal regeneration and survival |
ITFI940095A1 (it) * | 1994-05-23 | 1995-11-23 | Molteni & C | Coniugati fotodinamici aventi proprieta' biocide |
US5882328A (en) * | 1995-01-13 | 1999-03-16 | Qlt Phototherapeutics, Inc. | Method to prevent transplant rejection |
US5789433A (en) * | 1995-01-17 | 1998-08-04 | Quadra Logic Technologies, Inc. | Green porphyrins as immunomodulators |
US6107325A (en) * | 1995-01-17 | 2000-08-22 | Qlt Phototherapeutics, Inc. | Green porphyrins as immunomodulators |
US6096776A (en) * | 1995-01-17 | 2000-08-01 | Qlt Phototherapeutics, Inc. | Green porphyrins as immunomodulators |
DE19514088A1 (de) | 1995-04-13 | 1996-10-17 | Deutsches Krebsforsch | Konjugat zur Behandlung von Entzünduns-, Infektions- und/oder Hauterkrankungen |
US5707608A (en) * | 1995-08-02 | 1998-01-13 | Qlt Phototherapeutics, Inc. | Methods of making liposomes containing hydro-monobenzoporphyrin photosensitizer |
WO1997026885A1 (en) * | 1996-01-23 | 1997-07-31 | The General Hospital Corporation Doing Business As Massachusetts General Hospital | Benzophenothiazine and benzoporphyrin dye combination photodynamic therapy of tumors |
WO1999013943A1 (en) | 1996-03-05 | 1999-03-25 | Ekos Corporation | Ultrasound assembly for use with light activated drugs |
US5693789A (en) * | 1996-04-10 | 1997-12-02 | Abbott Laboratories | Process for the preparation of a protoporphyrin |
US5834503A (en) | 1996-06-14 | 1998-11-10 | Qlt Phototherapeutics, Inc. | Methods to treat arterial plaque |
US6043237A (en) * | 1996-12-10 | 2000-03-28 | Qlt Phototherapeutics, Inc. | Use of photodynamic therapy for prevention of secondary cataracts |
US6756396B1 (en) | 1997-05-07 | 2004-06-29 | Qlt Inc. | Ethylene glycol esters as photoactive agents |
IL132494A0 (en) * | 1997-05-07 | 2001-03-19 | Univ British Columbia | A new class of benzoporphyrin derivative photoactive compounds |
KR100397131B1 (ko) * | 1997-05-07 | 2003-09-13 | 유니버시티 오브 브리티시 콜롬비아 | 광활성제로서 모노하이드로벤조포르피린 유도체의 에틸렌글리콜 에스테르 |
US5880145A (en) * | 1997-05-07 | 1999-03-09 | The University Of British Columbia | Class of benzoporphyrin derivative photoactive compounds |
AU8732598A (en) | 1997-07-28 | 1999-02-16 | Novartis Ag | Device and method for irradiating a patient's eye for photodynamic therapy |
CA2221912A1 (en) * | 1997-11-21 | 1999-05-21 | David Dolphin | Photosensitizers with improved biodistribution and light-absorbing properties |
US6316215B1 (en) | 1999-12-27 | 2001-11-13 | Edwin L. Adair | Methods of cancer screening utilizing fluorescence detection techniques and selectable imager charge integration periods |
DE69826521T2 (de) | 1998-01-06 | 2005-09-29 | Cerus Corp., Concord | Verfahren zum quenchen von pathogen-inaktivatoren in biologischen materialien |
US7157418B1 (en) | 1998-07-22 | 2007-01-02 | Osprey Pharmaceuticals, Ltd. | Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders |
US20030215421A1 (en) * | 1999-07-21 | 2003-11-20 | Mcdonald John R. | Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders |
AU4139600A (en) | 1999-04-14 | 2000-11-14 | University Of British Columbia, The | 1,3-dipolar cycloadditions to polypyrrolic macrocycles |
US20020022032A1 (en) * | 1999-04-23 | 2002-02-21 | Curry Patrick Mark | Immuno-adjuvant PDT treatment of metastatic tumors |
US7122568B1 (en) | 1999-11-17 | 2006-10-17 | Qlt, Inc. | Use of low-dose PDT to inhibit restenosis |
US6190877B1 (en) | 1999-12-27 | 2001-02-20 | Edwin L. Adair | Method of cancer screening primarily utilizing non-invasive cell collection and fluorescence detection techniques |
US6984498B2 (en) * | 1999-12-27 | 2006-01-10 | Adair Edwin L | Method of cancer screening primarily utilizing non-invasive cell collection, fluorescence detection techniques, and radio tracing detection techniques |
US6750037B2 (en) * | 1999-12-27 | 2004-06-15 | Edwin L. Adair | Method of cancer screening primarily utilizing non-invasive cell collection, fluorescence detection techniques, and radio tracing detection techniques |
WO2001074389A2 (en) * | 2000-03-24 | 2001-10-11 | Novartis Ag | Improved treatment of neovascularization |
CA2408332C (en) | 2000-05-08 | 2011-02-15 | The University Of British Columbia | Supports for photosensitizer formulations |
US6984395B2 (en) * | 2001-04-11 | 2006-01-10 | Qlt, Inc. | Drug delivery system for hydrophobic drugs |
CA2449828A1 (en) | 2001-06-04 | 2003-01-16 | The General Hospital Corporation | Detection and therapy of vulnerable plaque with photodynamic compounds |
WO2003037295A2 (en) * | 2001-11-02 | 2003-05-08 | The Governors Of The University Of Alberta | Micelle compositions containing pegylated phospholipids and a photosensitizer |
JP2005514346A (ja) * | 2001-11-09 | 2005-05-19 | キュー エル ティー インク. | 光感作剤及び皮膚浸透エンハンサーを含有する組成物並びに光力学療法におけるそれらの使用 |
DE60307545T2 (de) * | 2002-06-21 | 2007-10-04 | Adair, Edwin L., Castle Pines Village | Anwendung von Metalloporphyrinen zur Behandlung von Arteriosklerose |
US20060258629A1 (en) * | 2002-10-18 | 2006-11-16 | Freeman William R | Photodynamic therapy for ocular neovascularization |
US20040220167A1 (en) * | 2003-05-02 | 2004-11-04 | Nasrollah Samiy | Methods of treating neuralgic pain |
CA2437638A1 (en) * | 2003-08-20 | 2005-02-20 | John Robert North | Photodynamic therapy |
CA2457214A1 (en) * | 2004-02-06 | 2005-08-06 | Qlt Inc. | Photodynamic therapy for the treatment of acne |
WO2006020979A2 (en) * | 2004-08-13 | 2006-02-23 | Yale University | Factor vii conjugates for selectively treating neovascularization disorders |
DK1838355T3 (da) | 2004-10-29 | 2013-10-28 | Cerus Corp | Forbedrede quenching-fremgangsmåder til erytrocyt-inaktiveringsfremgangsmåde |
AU2009233807B2 (en) | 2008-04-09 | 2014-11-27 | Cerus Corporation | Improved quenching methods for red blood cell pathogen inactivation |
US8829020B2 (en) | 2009-07-16 | 2014-09-09 | Mallinckrodt Llc | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
JP5964322B2 (ja) | 2011-01-13 | 2016-08-03 | キュー エル ティー インク.QLT Inc. | 光増感剤の局所送達用医薬組成物及びその使用 |
CN104379602B (zh) | 2012-03-08 | 2017-05-03 | 哈洛齐梅公司 | 具有条件活性的抗表皮生长因子受体抗体及其使用方法 |
MX2015000429A (es) | 2012-07-11 | 2015-07-14 | Dermira Inc | Composiciones farmaceuticas para el suministro topico de fotosesibilizadores y usos de los mismos. |
EP3044236A2 (de) | 2013-09-12 | 2016-07-20 | Halozyme, Inc. | Modifizierte anti-egfr-antikörper und verfahren zur verwendung davon |
WO2017161206A1 (en) | 2016-03-16 | 2017-09-21 | Halozyme, Inc. | Conjugates containing conditionally active antibodies or antigen-binding fragments thereof, and methods of use |
AU2018235945A1 (en) | 2017-03-14 | 2019-10-17 | Ohio State Innovation Foundation | Methods and compositions related to a tissue factor-targeting IgG3 immunoconjugates |
US12006356B2 (en) | 2017-12-15 | 2024-06-11 | Juno Therapeutics, Inc. | Anti-CCT5 binding molecules and chimeric antigen receptors comprising the same |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2951800A (en) * | 1957-11-13 | 1960-09-06 | Monsanto Chemicals | Photoxidation processes utilizing improved catalysts |
ATE53204T1 (de) * | 1982-09-27 | 1990-06-15 | Photofrin Medical Inc | Gereinigte hematoporphyrinabkoemmlinge fuer diagnose und tumorbehandlung sowie verfahren. |
US4649151A (en) * | 1982-09-27 | 1987-03-10 | Health Research, Inc. | Drugs comprising porphyrins |
US4675338A (en) * | 1984-07-18 | 1987-06-23 | Nippon Petrochemicals Co., Ltd. | Tetrapyrrole therapeutic agents |
AU583854B2 (en) * | 1984-09-13 | 1989-05-11 | Cytogen Corporation | Antibody therapeutic agent conjugates |
US4883790A (en) * | 1987-01-20 | 1989-11-28 | University Of British Columbia | Wavelength-specific cytotoxic agents |
-
1988
- 1988-07-19 US US07/221,161 patent/US4920143A/en not_active Expired - Lifetime
-
1989
- 1989-07-17 CA CA000605858A patent/CA1339927C/en not_active Expired - Lifetime
- 1989-07-19 EP EP89307281A patent/EP0352076B1/de not_active Expired - Lifetime
- 1989-07-19 AT AT94115192T patent/ATE209650T1/de not_active IP Right Cessation
- 1989-07-19 DE DE68929351T patent/DE68929351T2/de not_active Expired - Lifetime
- 1989-07-19 DE DE2001199008 patent/DE10199008I2/de active Active
- 1989-07-19 EP EP94115192A patent/EP0641796B1/de not_active Expired - Lifetime
- 1989-07-19 ES ES94115192T patent/ES2169060T3/es not_active Expired - Lifetime
- 1989-07-19 DE DE68924215T patent/DE68924215T2/de not_active Expired - Lifetime
- 1989-07-19 AU AU38258/89A patent/AU638675B2/en not_active Expired
- 1989-07-19 ES ES89307281T patent/ES2080745T3/es not_active Expired - Lifetime
- 1989-07-19 AT AT89307281T patent/ATE127696T1/de active
-
1995
- 1995-09-18 GR GR950402549T patent/GR3017426T3/el unknown
-
2000
- 2000-01-17 LU LU90718C patent/LU90718I2/fr unknown
-
2001
- 2001-01-15 NL NL300037C patent/NL300037I2/nl unknown
Also Published As
Publication number | Publication date |
---|---|
DE68924215D1 (de) | 1995-10-19 |
EP0352076A2 (de) | 1990-01-24 |
GR3017426T3 (en) | 1995-12-31 |
NL300037I2 (nl) | 2001-08-01 |
DE68924215T2 (de) | 1996-02-15 |
ATE209650T1 (de) | 2001-12-15 |
EP0641796B1 (de) | 2001-11-28 |
AU638675B2 (en) | 1993-07-08 |
ES2169060T3 (es) | 2002-07-01 |
NL300037I1 (nl) | 2001-03-01 |
DE68929351D1 (de) | 2002-01-10 |
CA1339927C (en) | 1998-06-23 |
ES2080745T3 (es) | 1996-02-16 |
DE10199008I1 (de) | 2003-06-12 |
EP0352076A3 (de) | 1991-07-17 |
DE10199008I2 (de) | 2004-10-14 |
EP0641796A1 (de) | 1995-03-08 |
US4920143A (en) | 1990-04-24 |
LU90718I2 (fr) | 2001-03-01 |
EP0352076B1 (de) | 1995-09-13 |
DE68929351T2 (de) | 2002-05-08 |
AU3825889A (en) | 1990-02-08 |
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