ATE122035T1 - Naphthylethylharnstoff und naphthylethylthioharnstoff verbindungen, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten. - Google Patents

Naphthylethylharnstoff und naphthylethylthioharnstoff verbindungen, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten.

Info

Publication number
ATE122035T1
ATE122035T1 AT92402321T AT92402321T ATE122035T1 AT E122035 T1 ATE122035 T1 AT E122035T1 AT 92402321 T AT92402321 T AT 92402321T AT 92402321 T AT92402321 T AT 92402321T AT E122035 T1 ATE122035 T1 AT E122035T1
Authority
AT
Austria
Prior art keywords
compounds
naphthylethylthiourea
naphthylethyl
urea
production
Prior art date
Application number
AT92402321T
Other languages
English (en)
Inventor
Daniel Lesieur
Said Yous
Patrick Depruex
Gerard Adam
Pierre Renard
Bruno Pfeiffer
Beatrice Guardiola-Lemaitre
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Application granted granted Critical
Publication of ATE122035T1 publication Critical patent/ATE122035T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
    • C07C335/10—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C335/12—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
AT92402321T 1991-08-23 1992-08-21 Naphthylethylharnstoff und naphthylethylthioharnstoff verbindungen, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten. ATE122035T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9110547A FR2680507B1 (fr) 1991-08-23 1991-08-23 Nouvelles naphtylethylurees et naphtylethylthiourees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
ATE122035T1 true ATE122035T1 (de) 1995-05-15

Family

ID=9416355

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92402321T ATE122035T1 (de) 1991-08-23 1992-08-21 Naphthylethylharnstoff und naphthylethylthioharnstoff verbindungen, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten.

Country Status (12)

Country Link
US (4) US5389683A (de)
EP (1) EP0530087B1 (de)
JP (1) JPH0780831B2 (de)
AT (1) ATE122035T1 (de)
AU (1) AU646968B2 (de)
CA (1) CA2076589C (de)
DE (1) DE69202313T2 (de)
DK (1) DK0530087T3 (de)
ES (1) ES2074846T3 (de)
FR (1) FR2680507B1 (de)
NZ (1) NZ244051A (de)
ZA (1) ZA926328B (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2680507B1 (fr) * 1991-08-23 1993-10-08 Adir Cie Nouvelles naphtylethylurees et naphtylethylthiourees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
NZ273741A (en) * 1993-08-24 2000-06-23 Medivir Ab Heterocyclically-substituted guanidine, urea and thiourea derivatives
FR2713636B1 (fr) * 1993-12-07 1996-01-05 Adir Nouveaux dérivés naphtaléniques, leur procédé de préparation, et les compositions pharmaceutiques qui les contiennent.
AU2109695A (en) 1994-03-30 1995-10-23 Novartis Ag Screening method using the rzr receptor family
US5849769A (en) * 1994-08-24 1998-12-15 Medivir Ab N-arylalkyl-N-heteroarylurea and guandine compounds and methods of treating HIV infection
US6235789B1 (en) 1994-09-12 2001-05-22 Takeda Chemical Industries, Ltd. Benzocycloalkene compounds, their production and use
US5541228A (en) * 1994-10-14 1996-07-30 Bristol-Myers Squibb Co. Melatonergic agents
US6071946A (en) * 1994-10-21 2000-06-06 Adir Et Compagnie Tricyclic urea compounds
FR2725985B1 (fr) * 1994-10-21 1996-11-15 Adir Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5998461A (en) * 1994-10-21 1999-12-07 Adir Et Compagnie Tricyclic amide compounds
US5530012A (en) 1994-12-22 1996-06-25 Bristol-Myers Squibb Co. 3-alkoxybenzylpiperidine derivatives as melatonergic agents
FR2729147A1 (fr) * 1995-01-11 1996-07-12 Adir Nouveaux composes (hetero) cycliques alkyles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5661186A (en) * 1995-02-24 1997-08-26 Bristol-Myers Squibb Co. Tetralinyl-and indanyl-ethylamides
FR2734815B1 (fr) * 1995-05-31 1997-07-04 Adir Nouveaux composes arylalkyl (thio) carboxamides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2734814B1 (fr) * 1995-05-31 1997-07-04 Adir Nouveaux composes alkoxy-aryles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2741799B1 (fr) * 1995-12-04 1998-01-02 Oreal Utilisation de melatonine dans une composition pour traiter les signes cutanes des etats de fatigue
FR2741802B1 (fr) * 1995-12-04 1998-01-02 Oreal Utilisation de melatonine pour traiter les peaux sensibles
US5808151A (en) * 1996-04-17 1998-09-15 Bristol-Myers Squibb Company Biphenylamido derivatives as melatonergic agents
AUPO274596A0 (en) * 1996-10-04 1996-10-31 Armstrong, Stuart Maxwell Method for the treatment of neurological or neuropsychiatric disorders
CZ297673B6 (cs) * 1996-12-10 2007-02-28 Bristol-Myers Squibb Company Benzodioxolová, benzofuranová, dihydrobenzofuranová a benzodioxanová melatonergická cinidla
US5958964A (en) * 1997-02-18 1999-09-28 South Alabama Medical Science Foundation Use of melatonin to prevent cytotoxic effects of amyloid beta protein
US6028112A (en) * 1997-05-23 2000-02-22 Bristol-Myers Squibb Company Spirocyclopropyl fluorenes as melatonergic agents
FR2778662B1 (fr) * 1998-05-12 2000-06-16 Adir Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP4989830B2 (ja) * 1999-07-21 2012-08-01 サーントゥル ナシオナル ドゥ ラ ルシェルシュ シャーンティフィク 脳によるグルタミン酸塩の放出に対して抑制効果を示す薬剤を製造するためのベータ−ナフトキノン誘導体の使用
IL144900A (en) 2001-08-14 2013-12-31 Neurim Pharma 1991 Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs
WO2004012695A1 (en) * 2002-08-02 2004-02-12 Arye Rubinstein The use of alkylureas for treating acne
FR2848850B1 (fr) * 2002-12-20 2005-06-24 Guerbet Sa Nouvelles compositions de particules magnetiques recouvertes de derives gem-bisphosphonates.
US20050272819A1 (en) * 2003-07-31 2005-12-08 Arye Rubinstein Use of alkylureas for treating acne
EP2909166A4 (de) * 2012-10-22 2016-10-26 Symed Labs Ltd Prozesse zur herstellung von agomelatin mithilfe neuartiger zwischenstoffe
CN104276979B (zh) * 2013-07-10 2018-09-07 江苏豪森药业集团有限公司 阿戈美拉汀中间体的制备方法
WO2022022542A1 (zh) * 2020-07-28 2022-02-03 上海翰森生物医药科技有限公司 双环类衍生物调节剂、其制备方法和应用
CN117377777A (zh) 2021-05-11 2024-01-09 纽瑞姆制药（1991）有限公司 诊断和治疗具有2号染色体2:107,510,000-107,540,000基因座单核苷酸多态性受试者的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH490003A (de) * 1966-03-08 1970-05-15 Ciba Geigy Molluskizides Mittel
DE68911203T2 (de) * 1988-03-30 1994-04-14 Warner Lambert Co N-[[(2,6-disubstituierte)phenyl]N'- arylalkyl] Harnstoffe als antihypercholesterolemische und antiatherosclerotische Mittel.
FR2680507B1 (fr) * 1991-08-23 1993-10-08 Adir Cie Nouvelles naphtylethylurees et naphtylethylthiourees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
AU646968B2 (en) 1994-03-10
US5389683A (en) 1995-02-14
DK0530087T3 (da) 1995-10-02
DE69202313T2 (de) 1996-01-25
NZ244051A (en) 1995-02-24
US5449690A (en) 1995-09-12
AU2125192A (en) 1993-02-25
FR2680507B1 (fr) 1993-10-08
FR2680507A1 (fr) 1993-02-26
JPH0780831B2 (ja) 1995-08-30
US5449689A (en) 1995-09-12
DE69202313D1 (de) 1995-06-08
EP0530087B1 (de) 1995-05-03
JPH0692926A (ja) 1994-04-05
US5385944A (en) 1995-01-31
CA2076589A1 (en) 1993-02-24
EP0530087A1 (de) 1993-03-03
ES2074846T3 (es) 1995-09-16
CA2076589C (fr) 1998-08-11
ZA926328B (en) 1993-03-11

Similar Documents

Publication Publication Date Title
ATE122035T1 (de) Naphthylethylharnstoff und naphthylethylthioharnstoff verbindungen, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten.
ATE145904T1 (de) Isochinolin-5-yl-sulfonsäureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten
ATE174920T1 (de) Pyridothiadiazine, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen
ATE144503T1 (de) Thiazolidin-2,4-dionderivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen
ATE113585T1 (de) Aminsäure-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen.
ATE160344T1 (de) Heterozyklische alkylamine, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die sie enthalten
DE59010312D1 (de) 11-Beta-aryl-4-estrene, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel
AU656466B2 (en) New benzimidazole compounds, a process for their preparation and pharmaceutical compositions containing them
ATE164578T1 (de) Verzweigte aminothiazole-derivate, verfahren zu ihrer herstellung und pharmazeutische zusammenstellungen die sie enthalten
ATE160338T1 (de) Alpha aminosäurederivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen
ATE152707T1 (de) Neue naphthalin-amide und sulfonamide, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen
ATE193531T1 (de) Phenyl-carboxamide-isoxazole-derivate und salze, verfahren zu ihrer herstellung ihre anwendung als arzneimittel und pharmazeutische zusammensetzungen die sie enthalten
ATE172976T1 (de) 3-aminochroman-spiroderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen
ATE66209T1 (de) Dihydropyridinamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln.
ATE118212T1 (de) 1-(alkoxybenzyl)piperazineamide, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
ATE25679T1 (de) Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung.
ATE144510T1 (de) N-(isochinolein-5-yl)-sulfonyl azazykloalkane, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen
ATE170520T1 (de) Eburnan-derivate, verfahren zur ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen
ATE26577T1 (de) 1-0-alkyl-3-amino-propan-1.2-diol-2-0phospholipide, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die sie enthalten.
ATE113598T1 (de) Substituierte vinylcephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
ATE193703T1 (de) N-benzylpiperazinverbindungen, verfahren zu ihrer herstellung und sie enthaltende zusammensetzungen
ATE123776T1 (de) Aminoalkylchromone, verfahren zu ihrer herstellung und diese enthaltende zusammensetzungen.
ATE32063T1 (de) Iminosulfonamide und verfahren zu ihrer herstellung, die pharmazeutische praeparate solche verbindungen enthalten, sowie die verbindungen zur verwendung.
ATE153995T1 (de) Cyclizierte analoge der fettsäurenmetaboliten, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen
ATA52288A (de) Malonsaeurederivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzung, enthaltend diese verbindungen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee