ATE120486T1 - Vektor zur integrationsstellenunabhängigen genexpression in säugetier-wirtszellen. - Google Patents

Vektor zur integrationsstellenunabhängigen genexpression in säugetier-wirtszellen.

Info

Publication number
ATE120486T1
ATE120486T1 AT88906964T AT88906964T ATE120486T1 AT E120486 T1 ATE120486 T1 AT E120486T1 AT 88906964 T AT88906964 T AT 88906964T AT 88906964 T AT88906964 T AT 88906964T AT E120486 T1 ATE120486 T1 AT E120486T1
Authority
AT
Austria
Prior art keywords
vector
integration site
gene expression
host cells
gene
Prior art date
Application number
AT88906964T
Other languages
English (en)
Inventor
Franklin Gerardus Grosveld
Dimitris Kioussis
Original Assignee
Medical Res Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10621987&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE120486(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Medical Res Council filed Critical Medical Res Council
Application granted granted Critical
Publication of ATE120486T1 publication Critical patent/ATE120486T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70507—CD2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Environmental Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Husbandry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT88906964T 1987-08-07 1988-08-08 Vektor zur integrationsstellenunabhängigen genexpression in säugetier-wirtszellen. ATE120486T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878718779A GB8718779D0 (en) 1987-08-07 1987-08-07 Dna sequence & expression vector

Publications (1)

Publication Number Publication Date
ATE120486T1 true ATE120486T1 (de) 1995-04-15

Family

ID=10621987

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88906964T ATE120486T1 (de) 1987-08-07 1988-08-08 Vektor zur integrationsstellenunabhängigen genexpression in säugetier-wirtszellen.

Country Status (8)

Country Link
EP (2) EP0668357A1 (de)
JP (3) JP3181049B2 (de)
AT (1) ATE120486T1 (de)
CA (1) CA1336269C (de)
DE (1) DE3853474T3 (de)
GB (1) GB8718779D0 (de)
HK (1) HK161295A (de)
WO (1) WO1989001517A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048729A (en) * 1987-05-01 2000-04-11 Transkaryotic Therapies, Inc. In vivo protein production and delivery system for gene therapy
WO1991005041A1 (en) * 1989-09-26 1991-04-18 Townes Tim M Erythroid-specific gene expression system
JPH04505710A (ja) * 1990-02-22 1992-10-08 ファーミング　ビーブイ ポリペプチドの改良された発現
GB9027917D0 (en) * 1990-12-21 1991-02-13 Ici Plc Expression systems
US5922854A (en) * 1991-06-14 1999-07-13 Kumar; Ramesh Purifying Human Hemogloblin from transgenic pig red cells and plasmids containing pig globin nucleic acids
US5733761A (en) * 1991-11-05 1998-03-31 Transkaryotic Therapies, Inc. Protein production and protein delivery
US6063630A (en) * 1991-11-05 2000-05-16 Transkaryotic Therapies, Inc. Targeted introduction of DNA into primary or secondary cells and their use for gene therapy
PT101031B (pt) 1991-11-05 2002-07-31 Transkaryotic Therapies Inc Processo para o fornecimento de proteinas por terapia genetica
US5641670A (en) * 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
US6692737B1 (en) 1991-11-05 2004-02-17 Transkaryotic Therapies, Inc. In vivo protein production and delivery system for gene therapy
US6054288A (en) * 1991-11-05 2000-04-25 Transkaryotic Therapies, Inc. In vivo protein production and delivery system for gene therapy
US6270989B1 (en) 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
US6670178B1 (en) 1992-07-10 2003-12-30 Transkaryotic Therapies, Inc. In Vivo production and delivery of insulinotropin for gene therapy
US6531124B1 (en) 1992-07-10 2003-03-11 Transkaryotic Therapies, Inc. In vivo production and delivery of insulinotropin for gene therapy
US5631162A (en) * 1993-06-11 1997-05-20 Massachusetts Institute Of Technology Retroviral vectors for transducing β-globin gene and β-locus control region derivatives
GB9319772D0 (en) * 1993-09-24 1993-11-10 Therexsys Ltd Therapeutic agent
US5627268A (en) * 1994-06-07 1997-05-06 Dnx Biotherapeutics Hemoglobin comprising globin fusion proteins
US5821351A (en) * 1994-06-10 1998-10-13 Dnx Biotherapeutics Production of hemoglobin having a delta-like globin
AU7071598A (en) * 1997-04-10 1998-10-30 Erasmus University Rotterdam Diagnosis method and reagents
JP4220673B2 (ja) 1998-07-21 2009-02-04 ミリポア・コーポレイション 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド
CN108012545B (zh) * 2015-03-31 2022-08-30 葛莱高托普有限公司 包含珠蛋白基因簇的调控元件的真核表达载体
USD937539S1 (en) * 2020-02-18 2021-12-07 Traci Sawtelle Wearable towel

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989002469A2 (en) * 1987-09-17 1989-03-23 Massachusetts Institute Of Technology Human erythroid-specific transcriptional enhancer

Also Published As

Publication number Publication date
HK161295A (en) 1995-10-20
EP0668357A1 (de) 1995-08-23
JPH10113177A (ja) 1998-05-06
JP2000245462A (ja) 2000-09-12
EP0332667A1 (de) 1989-09-20
GB8718779D0 (en) 1987-09-16
DE3853474T2 (de) 1995-09-21
DE3853474D1 (de) 1995-05-04
EP0332667B2 (de) 1998-12-09
DE3853474T3 (de) 1999-07-08
JP3181049B2 (ja) 2001-07-03
CA1336269C (en) 1995-07-11
JPH02500802A (ja) 1990-03-22
EP0332667B1 (de) 1995-03-29
WO1989001517A1 (en) 1989-02-23

Similar Documents

Publication Publication Date Title
ATE120486T1 (de) Vektor zur integrationsstellenunabhängigen genexpression in säugetier-wirtszellen.
NO964445L (no) DNA-sekvens, vektor, vertscelle og fremgangsmåte for transfeksjon av hematopoeseceller med eksogen DNA
FI883722A0 (fi) Alfa-amiderande enzymkompositioner och foerfaranden foer deras framstaellning och anvaendning.
ATE27000T1 (de) Expression von polypeptiden in hefen.
SG122763A1 (en) Production of proteins using homologous recombination
IL68366A (en) Process for expressing a gene encoding a protein comprising the enzymatic portion of human urokinase in a microorganism or cell culture
DK224185D0 (da) Vektor til inkorporering i gaercellers chromosomer
ATE192499T1 (de) Herstellung rekombinanter proteine unter verwendung von herpes-virus-promotoren und vp16- transaktivatoren
DK488289D0 (da) Fremgangsmaade til transformation af enkaryote vaertsceller og plasmider til brug ved fremgangsmaaden
EP0319206A3 (de) Gen-Vermehrung
ATE102994T1 (de) Verfahren zur herstellung von proteinen.
AU2253288A (en) Expression vectors for the synthesis of proteins and plasmid replicons and sequence cassettes for use in constructing such vectors
CA1312566C (en) Method for increasing the expression of polypeptides in recombinant cell culture
EP0350052A3 (de) Transgene Tiere, die mit einem Plasmid mit autonomer Replikationssequenz transformiert sind
ATE129287T1 (de) Bakterielles kollagenase-gen.
IL97048A0 (en) Bioluminescence assay for gene expression in growing mammalian cells
DK561889D0 (da) Ekspressionsforstaerker samt anvendelse heraf til forhoejelse af udbyttet ved ekspression af rekombinante gener

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee