ATE112309T1 - Schutz zytolytischer aktivität von nk-zellen in peripheren blut-mononuklearzellen. - Google Patents
Schutz zytolytischer aktivität von nk-zellen in peripheren blut-mononuklearzellen.Info
- Publication number
- ATE112309T1 ATE112309T1 AT90911369T AT90911369T ATE112309T1 AT E112309 T1 ATE112309 T1 AT E112309T1 AT 90911369 T AT90911369 T AT 90911369T AT 90911369 T AT90911369 T AT 90911369T AT E112309 T1 ATE112309 T1 AT E112309T1
- Authority
- AT
- Austria
- Prior art keywords
- cells
- peripheral blood
- blood mononuclear
- protection
- cytolytic activity
- Prior art date
Links
- 210000004027 cell Anatomy 0.000 title 1
- 230000001461 cytolytic effect Effects 0.000 title 1
- 210000005087 mononuclear cell Anatomy 0.000 title 1
- 210000005259 peripheral blood Anatomy 0.000 title 1
- 239000011886 peripheral blood Substances 0.000 title 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 230000031942 natural killer cell mediated cytotoxicity Effects 0.000 abstract 2
- VPSSPAXIFBTOHY-LURJTMIESA-N (2s)-2-amino-4-methylpentan-1-ol Chemical compound CC(C)C[C@H](N)CO VPSSPAXIFBTOHY-LURJTMIESA-N 0.000 abstract 1
- 108010016626 Dipeptides Proteins 0.000 abstract 1
- 108010002350 Interleukin-2 Proteins 0.000 abstract 1
- STVVMTBJNDTZBF-VIFPVBQESA-N L-phenylalaninol Chemical compound OC[C@@H](N)CC1=CC=CC=C1 STVVMTBJNDTZBF-VIFPVBQESA-N 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000011534 incubation Methods 0.000 abstract 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0081—Purging biological preparations of unwanted cells
- C12N5/0087—Purging against subsets of blood cells, e.g. purging alloreactive T cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Electrophonic Musical Instruments (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/383,222 US5198334A (en) | 1989-07-21 | 1989-07-21 | Protection of natural killer cell cytolytic activity in peripheral blood mononuclear cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE112309T1 true ATE112309T1 (de) | 1994-10-15 |
Family
ID=23512227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90911369T ATE112309T1 (de) | 1989-07-21 | 1990-07-17 | Schutz zytolytischer aktivität von nk-zellen in peripheren blut-mononuklearzellen. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5198334A (de) |
| EP (1) | EP0483237B1 (de) |
| JP (1) | JPH05504884A (de) |
| AT (1) | ATE112309T1 (de) |
| AU (1) | AU6049390A (de) |
| CA (1) | CA2063788A1 (de) |
| DE (1) | DE69012999T2 (de) |
| DK (1) | DK0483237T3 (de) |
| ES (1) | ES2061057T3 (de) |
| WO (1) | WO1991001370A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4308350B2 (ja) * | 1998-11-27 | 2009-08-05 | 小林製薬株式会社 | シイタケ菌糸体抽出物を含有するｌａｋ活性スクリーニング物質およびそれを用いたｌａｋ活性スクリーニング法 |
| US6153113A (en) * | 1999-02-22 | 2000-11-28 | Cobe Laboratories, Inc. | Method for using ligands in particle separation |
| US6354986B1 (en) | 2000-02-16 | 2002-03-12 | Gambro, Inc. | Reverse-flow chamber purging during centrifugal separation |
| AU2001262697A1 (en) * | 2000-06-06 | 2001-12-17 | Kirin Beer Kabushiki Kaisha | Method of amplifying natural killer t cells |
| CN102781958B (zh) * | 2009-12-05 | 2017-07-11 | 马尔瓦有限责任公司 | 基于顶复虫Ferlin、Ferlin样蛋白和其它含有C2结构域的蛋白的疟疾疫苗 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4752602A (en) * | 1985-09-09 | 1988-06-21 | Board Of Regents, The University Of Texas System | Dipeptide alkyl esters and their uses |
| US4849329A (en) * | 1986-05-30 | 1989-07-18 | E. I. Du Pont De Nemours And Company | Process for preparing lymphokine activated killer cells |
-
1989
- 1989-07-21 US US07/383,222 patent/US5198334A/en not_active Expired - Lifetime
-
1990
- 1990-07-17 EP EP90911369A patent/EP0483237B1/de not_active Expired - Lifetime
- 1990-07-17 AT AT90911369T patent/ATE112309T1/de not_active IP Right Cessation
- 1990-07-17 WO PCT/US1990/003902 patent/WO1991001370A1/en not_active Ceased
- 1990-07-17 CA CA002063788A patent/CA2063788A1/en not_active Abandoned
- 1990-07-17 AU AU60493/90A patent/AU6049390A/en not_active Abandoned
- 1990-07-17 JP JP2510589A patent/JPH05504884A/ja active Pending
- 1990-07-17 DE DE69012999T patent/DE69012999T2/de not_active Expired - Fee Related
- 1990-07-17 ES ES90911369T patent/ES2061057T3/es not_active Expired - Lifetime
- 1990-07-17 DK DK90911369.8T patent/DK0483237T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| DK0483237T3 (da) | 1995-04-10 |
| EP0483237B1 (de) | 1994-09-28 |
| JPH05504884A (ja) | 1993-07-29 |
| CA2063788A1 (en) | 1991-01-22 |
| US5198334A (en) | 1993-03-30 |
| EP0483237A1 (de) | 1992-05-06 |
| WO1991001370A1 (en) | 1991-02-07 |
| ES2061057T3 (es) | 1994-12-01 |
| DE69012999T2 (de) | 1995-01-26 |
| AU6049390A (en) | 1991-02-22 |
| DE69012999D1 (de) | 1994-11-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |