ATE110717T1 - Pharmakologisch wirksame 2- und 3-substituierte (1',5'-diaryl-3-pyrazolyl)-n-hydroxypropanamide und verfahren zu ihrer herstellung. - Google Patents

Pharmakologisch wirksame 2- und 3-substituierte (1',5'-diaryl-3-pyrazolyl)-n-hydroxypropanamide und verfahren zu ihrer herstellung.

Info

Publication number
ATE110717T1
ATE110717T1 AT88304821T AT88304821T ATE110717T1 AT E110717 T1 ATE110717 T1 AT E110717T1 AT 88304821 T AT88304821 T AT 88304821T AT 88304821 T AT88304821 T AT 88304821T AT E110717 T1 ATE110717 T1 AT E110717T1
Authority
AT
Austria
Prior art keywords
hydroxypropanamides
diaryl
pyrazolyl
substituted
production
Prior art date
Application number
AT88304821T
Other languages
English (en)
Inventor
William V Murray
Michael P Wachter
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Application granted granted Critical
Publication of ATE110717T1 publication Critical patent/ATE110717T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/88—Unsaturated compounds containing keto groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/18—Saturated compounds containing keto groups
    • C07C62/22—Saturated compounds containing keto groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/38—Unsaturated compounds containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/34—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT88304821T 1987-05-29 1988-05-27 Pharmakologisch wirksame 2- und 3-substituierte (1',5'-diaryl-3-pyrazolyl)-n-hydroxypropanamide und verfahren zu ihrer herstellung. ATE110717T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5580687A 1987-05-29 1987-05-29
US18103588A 1988-04-27 1988-04-27

Publications (1)

Publication Number Publication Date
ATE110717T1 true ATE110717T1 (de) 1994-09-15

Family

ID=26734641

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88304821T ATE110717T1 (de) 1987-05-29 1988-05-27 Pharmakologisch wirksame 2- und 3-substituierte (1',5'-diaryl-3-pyrazolyl)-n-hydroxypropanamide und verfahren zu ihrer herstellung.

Country Status (9)

Country Link
EP (1) EP0293220B1 (de)
JP (2) JP2668796B2 (de)
AT (1) ATE110717T1 (de)
AU (1) AU611437B2 (de)
CA (2) CA1319149C (de)
DE (1) DE3851258T2 (de)
DK (1) DK289988A (de)
ES (1) ES2058280T3 (de)
IE (1) IE65095B1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE59813B1 (en) * 1986-05-09 1994-04-06 Warner Lambert Co Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them
DE3907180A1 (de) * 1989-03-06 1990-09-13 Windmoeller & Hoelscher Verfahren zum ueberpruefen der funktionsfaehigkeit von mit kuehlabschnitten versehenen extrusionsduesen von kunststoffextrudern zur herstellung von flach- oder schlauchfolien
PH27357A (en) * 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
GB9005028D0 (en) * 1990-03-06 1990-05-02 Sandoz Ltd Improvements in or relating to organic compounds
US5117054A (en) * 1991-09-26 1992-05-26 Ortho Pharmaceutical Corporation N-hydroxy, N-methyl propanamides
IL104311A (en) * 1992-02-05 1997-07-13 Fujisawa Pharmaceutical Co Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
FR2692575B1 (fr) * 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
AU3815495A (en) * 1994-11-08 1996-05-31 Eisai Co. Ltd. Pyrazole derivatives exhibiting anti-inflammatory and analgesic effects
EP0833622B8 (de) * 1995-06-12 2005-10-12 G.D. Searle & Co. Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor
CA2460149A1 (en) * 2001-09-12 2003-03-27 Kaken Pharmaceutical Co., Ltd. 2-phenyl-3-heteroarylpropionic acid derivative or salt thereof and medicine containing the same
UA79804C2 (en) 2002-07-03 2007-07-25 Janssen Pharmaceutica Nv Cck-1 receptor modulators
US7640164B2 (en) 2002-07-04 2009-12-29 Denso Corporation System for performing interactive dialog
WO2004037793A1 (ja) * 2002-10-24 2004-05-06 Wakamoto Pharmaceutical Co., Ltd. シクロオキシゲナーゼ及び５−リポキシゲナーゼを阻害するピラゾール−４−アルカン酸誘導体
US7129239B2 (en) 2002-10-28 2006-10-31 Pfizer Inc. Purine compounds and uses thereof
US7247628B2 (en) 2002-12-12 2007-07-24 Pfizer, Inc. Cannabinoid receptor ligands and uses thereof
US7329658B2 (en) 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
US7176210B2 (en) 2003-02-10 2007-02-13 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
US7268133B2 (en) 2003-04-23 2007-09-11 Pfizer, Inc. Patent Department Cannabinoid receptor ligands and uses thereof
US7145012B2 (en) 2003-04-23 2006-12-05 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
WO2005063716A1 (en) 2003-12-22 2005-07-14 Janssen Pharmaceutica, N.V. Imidazoles and their use cck-1 receptor modulators
US20130164226A1 (en) * 2010-09-10 2013-06-27 Daizo Corporation Foamable aerosol composition

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE755924A (fr) * 1969-09-12 1971-02-15 Byk Gulden Lomberg Chem Fab Derives d'acide pyrazole-4-acetique, leur procede de preparation et medicaments en contenant
DE2633992A1 (de) * 1975-08-08 1978-02-09 Schering Ag Neue pyrazol-derivate, ihre herstellung und verwendung
EP0014508B1 (de) * 1979-02-09 1983-06-08 Shell Internationale Researchmaatschappij B.V. Verfahren zur Herstellung farbenstabiler Vinylchlorid-Polymere
DE2906252A1 (de) * 1979-02-19 1980-08-28 Merck Patent Gmbh Pyrazolderivate, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung
JPS5699254A (en) * 1980-01-14 1981-08-10 Adeka Argus Chem Co Ltd Stabilized halogen-containing resin composition
JPS60190708A (ja) * 1984-03-12 1985-09-28 Kao Corp 長波長紫外線吸収剤
JPS61140543A (ja) * 1984-12-11 1986-06-27 Kao Corp ４−メトキシ−２′−カルボキシジベンゾイルメタンおよびその塩
JPS6259243A (ja) * 1985-09-10 1987-03-14 Kao Corp ２−カルボキシジベンゾイルメタン類の製造法
US4694018A (en) * 1985-11-29 1987-09-15 G. D. Serale & Co. Substituted 1,5-diphenyl-2-pyrrolepropionic acids and derivatives
US4826868A (en) * 1986-05-29 1989-05-02 Ortho Pharmaceutical Corporation 1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use

Also Published As

Publication number Publication date
IE881612L (en) 1988-11-29
JPH09328475A (ja) 1997-12-22
CA1341424C (en) 2003-03-04
EP0293220A2 (de) 1988-11-30
DE3851258D1 (de) 1994-10-06
DE3851258T2 (de) 1994-12-15
CA1319149C (en) 1993-06-15
ES2058280T3 (es) 1994-11-01
JP2668796B2 (ja) 1997-10-27
DK289988D0 (da) 1988-05-27
AU1657488A (en) 1988-12-01
IE65095B1 (en) 1995-10-04
EP0293220A3 (en) 1990-07-11
JP2848375B2 (ja) 1999-01-20
EP0293220B1 (de) 1994-08-31
AU611437B2 (en) 1991-06-13
JPS6452758A (en) 1989-02-28
DK289988A (da) 1988-11-30

Similar Documents

Publication Publication Date Title
ATE110717T1 (de) Pharmakologisch wirksame 2- und 3-substituierte (1',5'-diaryl-3-pyrazolyl)-n-hydroxypropanamide und verfahren zu ihrer herstellung.
DE10199049I1 (de) Pharmakologisch wirksame 3-substituierte 1,5-Diaryl-pyrazole und Verfahren zu ihrer Herstellung
EP0161877A3 (en) 1,4-dihydropyridine derivatives, methods for their production and pharmaceutical compositions comprising the same
PT77058B (de) Neue derivate der 2-aza-bicyclo <2.2.2> octan-3-carbonsaeure verfahren zu ihrer herstellung diese enthaltende mittel und deren verwendung sowie 2-aza-bicyclo <2.2.2> octan-3-carbonsaeure als zwischenstufe und verfahren zu deren herstellung
HUT47113A (en) Process for producing 3-(benzopyrano- and -thiopyrano-pyrazolyl)-3-oxo-propionitriles and pharmaceutical compositions comprising the same
DE3872620D1 (de) (arylsulphonyl)-nitromethane, verfahren zu deren herstellung und deren verwendung in pharmazeutischen zusammensetzungen.
EE9700078A (et) Pürimido(1,2-a)indoolid, nende valmistamismeetod, kasutamine ravimite valmistamiseks,nimetatud indoole sisaldavad ravimid ning indoolide valmistamiseks kasutatavad karboksüülhapped ja nende valmistamismeetod
CS235488A2 (en) Method of new dihydropyridinamides production
ATA328587A (de) Neue furanuronsaeure-derivate, verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen
DE3574706D1 (de) Chartreusin-derivate, ihre salze, antitumorale zusammensetzungen und verfahren zu ihrer herstellung.
DE3587260D1 (de) 4-substituiertes-1,2,3,6-tetrahydrophthalsaeure-anhydrid und verfahren zu dessen produktion.
DE3675271D1 (de) 1,4-dihydropyridinderivate verwendbar in der behandlung von kardiovaskulaeren stoerungen und verfahren zu ihrer herstellung.
ATA392484A (de) Verfahren zur herstellung von neuen 4,5,6,7tetrahydrothiazolo(5,4-c)pyridinderivaten und deren pharmazeutisch annehmbaren saeureadditionssalzen
DE3586817D1 (de) 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
ATE19855T1 (de) Pharmazeutische und diaetetische zusammensetzung.
DE3483628D1 (de) 1,n-diaryl-4,5-dihydro-1h-pyrazol-3-amine, diese enthaltende zusammensetzungen und verfahren zu ihrer herstellung.
ZA843712B (en) 2,6-disubstituted-1,4-dihydropyridine derivative,process for the preparation of the same and pharmaceutical composition comprising the same
ATE103899T1 (de) Zwischenprodukte und verfahren zu ihrer herstellung.
DE3863535D1 (de) Prepolymer-zusammensetzungen vom imidtyp und verfahren zu deren herstellung.
DE3869660D1 (de) Ionomerzusammensetzung und verfahren zu ihrer herstellung.
DE3867861D1 (de) Mehlzusammensetzung und verfahren zu deren herstellung.
HUT47109A (en) Process for producing 3-(acylaminomethyl)-5,6,7,8-tetrahydro-imidazo-(1,2-a)pyridine derivatives and pharmaceutical compositions comprising these compounds
ATA247380A (de) Verfahren zur herstellung von neuen, 3-substituierten 2-oxo-hexahydro-pyrimido (1,2-a)azepinen sowie von deren pharmazeutisch geeigneten salzen
DE3586910D1 (de) 1,4-benzochinon-derivate und benzol-derivate und verfahren zu ihrer herstellung.
DE3863665D1 (de) 2-(benzhydrylsulfonyl) acetamid, verfahren zu dessen herstellung und dessen verwendung in der therapie.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee