ATA675979A - Verfahren zur herstellung von digoxin enthaltenden tabletten zur peroralen applikation - Google Patents
Verfahren zur herstellung von digoxin enthaltenden tabletten zur peroralen applikationInfo
- Publication number
- ATA675979A ATA675979A AT0675979A AT675979A ATA675979A AT A675979 A ATA675979 A AT A675979A AT 0675979 A AT0675979 A AT 0675979A AT 675979 A AT675979 A AT 675979A AT A675979 A ATA675979 A AT A675979A
- Authority
- AT
- Austria
- Prior art keywords
- producing
- containing tablets
- peroral application
- digoxin
- digoxin containing
- Prior art date
Links
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 title 1
- LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 title 1
- 229960005156 digoxin Drugs 0.000 title 1
- LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2845326A DE2845326C2 (de) | 1978-10-18 | 1978-10-18 | Verwendung einer spezifischen mikrodispersen, amorphen, porösen Kieselsäure zur Herstellung von Digoxin enthaltenden Tabletten mit stark beschleunigter Wirkstoff-Freisetzung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA675979A true ATA675979A (de) | 1982-12-15 |
| AT371712B AT371712B (de) | 1983-07-25 |
Family
ID=6052475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0675979A AT371712B (de) | 1978-10-18 | 1979-10-17 | Verfahren zur herstellung von digoxin enthaltenden tabletten zur peroralen applikation |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4254099A (de) |
| JP (1) | JPS5555113A (de) |
| AT (1) | AT371712B (de) |
| AU (1) | AU523794B2 (de) |
| BE (1) | BE879487A (de) |
| CA (1) | CA1125656A (de) |
| CH (1) | CH640738A5 (de) |
| DE (1) | DE2845326C2 (de) |
| ES (1) | ES485399A0 (de) |
| FR (1) | FR2439018A1 (de) |
| GB (1) | GB2033225B (de) |
| NL (1) | NL7907244A (de) |
| SE (1) | SE445295B (de) |
| ZA (1) | ZA795530B (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1146866A (en) * | 1979-07-05 | 1983-05-24 | Yamanouchi Pharmaceutical Co. Ltd. | Process for the production of sustained release pharmaceutical composition of solid medical material |
| JPS56152416A (en) * | 1980-04-25 | 1981-11-26 | Tsumura Juntendo Inc | Preparation of chinese herbal remedy tablet |
| EP0080673B1 (de) * | 1981-11-28 | 1985-05-29 | Roche Diagnostics GmbH | Oral applizierte Zubereitungsformen von Guar-Mehl |
| US4581232A (en) * | 1983-07-20 | 1986-04-08 | Warner-Lambert Company | Magnesium trisilicate suitable for preparation of medicament adsorbates |
| GB8413191D0 (en) * | 1984-05-23 | 1984-06-27 | Beecham Group Plc | Pharmaceutical composition |
| US4617294A (en) * | 1985-04-22 | 1986-10-14 | Ppg Industries, Inc. | Animal feed supplement |
| US5310572A (en) * | 1987-02-03 | 1994-05-10 | Dow Corning Corporation | Process for forming a coated active agent-containing article |
| IT1216570B (it) * | 1988-04-08 | 1990-03-08 | Vectorpharma Int | Composizione farmaceutiche a rilascio controllato e procedimento per la loro preparazione. |
| US5039699A (en) * | 1989-03-27 | 1991-08-13 | Lederle (Japan), Ltd. | Anti-peptic ulcer agent |
| JPH03109332A (ja) * | 1989-09-21 | 1991-05-09 | Shiseido Co Ltd | 薬剤組成物 |
| GB9025251D0 (en) * | 1990-11-20 | 1991-01-02 | Solomon Montague C | Nifedipine dosage forms |
| US5629016A (en) * | 1991-01-30 | 1997-05-13 | Glaxo Wellcome Inc. | Water-dispersible tablets |
| AU653203B2 (en) * | 1991-01-30 | 1994-09-22 | Wellcome Foundation Limited, The | Water-dispersible tablets |
| US5698226A (en) * | 1993-07-13 | 1997-12-16 | Glaxo Wellcome Inc. | Water-dispersible tablets |
| JP4064476B2 (ja) * | 1996-03-29 | 2008-03-19 | エラワン ファーマスーティカル リサーチ アンドラボラトリー カンパニー リミテッド | 二酸化珪素を有する球状凝集した澱粉 |
| GB9720061D0 (en) * | 1997-09-19 | 1997-11-19 | Crosfield Joseph & Sons | Metal compounds as phosphate binders |
| CA2311734C (en) * | 2000-04-12 | 2011-03-08 | Bristol-Myers Squibb Company | Flash-melt oral dosage formulation |
| UA75135C2 (en) * | 2001-05-01 | 2006-03-15 | Pfizer Prod Inc | Dry granulation method for manufacturing pharmaceutical composition containing tetrahydronaphthalene-2-ol derivative and low dosage tablet compositions |
| TWI324074B (en) * | 2001-10-09 | 2010-05-01 | Bristol Myers Squibb Co | Flashmelt oral dosage formulation |
| MY142989A (en) * | 2004-03-10 | 2011-02-14 | Bayer Schering Pharma Ag | Stabilised supersaturated solids of lipophilic drugs |
| JP2009502807A (ja) * | 2005-07-22 | 2009-01-29 | ミリアド ジェネティクス， インコーポレイテッド | 薬剤含有率の高い製剤および投与量形態 |
| MY157620A (en) | 2006-01-31 | 2016-06-30 | Cytochroma Dev Inc | A granular material of a solid water-soluble mixed metal compound capable of binding phosphate |
| BRPI0807581A2 (pt) | 2007-02-23 | 2014-07-01 | Gilead Science, Inc. | Moduladores de propriedades farmacocinéticas de produtos terapêuticos |
| GB0714670D0 (en) * | 2007-07-27 | 2007-09-05 | Ineos Healthcare Ltd | Use |
| GB0720220D0 (en) * | 2007-10-16 | 2007-11-28 | Ineos Healthcare Ltd | Compound |
| SI2296633T1 (sl) | 2008-05-02 | 2015-11-30 | Gilead Sciences, Inc. | Uporaba trdnih nosilnih delcev za izboljšanje predelovalnih sposobnosti farmacevtskega sredstva |
| GB0913525D0 (en) | 2009-08-03 | 2009-09-16 | Ineos Healthcare Ltd | Method |
| GB201001779D0 (en) | 2010-02-04 | 2010-03-24 | Ineos Healthcare Ltd | Composition |
| HUE051406T2 (hu) * | 2012-11-14 | 2021-03-01 | Grace W R & Co | Biológiailag aktív anyagot és rendezetlen szervetlen oxidot tartalmazó kompozíciók |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR541197A (fr) * | 1920-01-08 | 1922-07-24 | Lilly Co Eli | Procédé d'enrobage de remèdes et en particulier d'alcaloîdes d'ipéca de manière à ce qu'ils puissent être administrés par la bouche et absorbés par l'intestin |
| US2038694A (en) * | 1930-10-15 | 1936-04-28 | Davision Chemical Corp | Medicament |
| US2698822A (en) * | 1951-04-28 | 1955-01-04 | Fougera & Co Inc E | Cardiac glycoside buccal composition |
| US2820741A (en) * | 1954-04-29 | 1958-01-21 | Abbott Lab | Aluminum aspirin granulation and method for making |
| US2857313A (en) * | 1956-03-27 | 1958-10-21 | Ciba Pharm Prod Inc | Self-lubricating granulation |
| US3034911A (en) * | 1959-03-25 | 1962-05-15 | Nat Starch Chem Corp | Tablet disintegrants |
| NL271458A (de) * | 1960-11-17 | |||
| US3148124A (en) * | 1962-06-12 | 1964-09-08 | William E Gaunt | Method of preparing sustained release pharmaceutical tablets |
| DE1228029C2 (de) * | 1964-05-09 | 1973-05-17 | Merck Ag E | Verfahren zur Herstellung von Tabletten durch Pressen von Pulvergemischen ohne vorhergehende Granulation |
| US3400197A (en) * | 1965-01-26 | 1968-09-03 | Robins Co Inc A H | Compressible sustained release pharmaceutical tablet lipid-colloidal silica gel matrix fragment granules |
| DE1492034A1 (de) * | 1965-05-18 | 1969-02-20 | Merck Ag E | Verfahren zur Herstellung fester haltbarer Zubereitungen von empfindlichen,in Wasser schwer loeslichen Wirkstoffen,vorzugsweise Arzneimitteln |
| NL6906980A (de) * | 1968-05-22 | 1969-11-25 | ||
| US3696091A (en) * | 1970-06-03 | 1972-10-03 | Boehringer Sohn Ingelheim | Novel cardiac-active principles of the cardenolide glycoside class |
| US3632778A (en) * | 1970-06-10 | 1972-01-04 | Hoffmann La Roche | Tablets containing l-dopa |
| US3725556A (en) * | 1970-11-12 | 1973-04-03 | D Hanssen | Method of manufacturing rapidly disintegrating pharmaceutical tablets |
| US3908003A (en) * | 1971-07-02 | 1975-09-23 | American Home Prod | Enrobed solid hydrophobic tableting lubricants and compositions |
| US3923969A (en) * | 1973-06-12 | 1975-12-02 | Battelle Institut E V | Carrier system for a drug with sustained release |
| US3929996A (en) * | 1973-06-29 | 1975-12-30 | Interx Research Corp | Pharmaceutical compositions containing a digoxin complex |
| US3884905A (en) * | 1974-05-02 | 1975-05-20 | Interx Research Corp | Pro-drug forms of digoxin |
| US3946110A (en) * | 1974-05-30 | 1976-03-23 | Peter, Strong Research And Development Company, Inc. | Medicinal compositions and methods of preparing the same |
| US4151273A (en) * | 1974-10-31 | 1979-04-24 | The Regents Of The University Of California | Increasing the absorption rate of insoluble drugs |
| US4013785A (en) * | 1975-03-21 | 1977-03-22 | Bristol-Myers Company | Apap tablet containing fumed silica and process for manufacturing same |
| US4143129A (en) * | 1975-10-11 | 1979-03-06 | Lilly Industries Limited | Cephalexin tablets |
| US4021546A (en) * | 1976-03-08 | 1977-05-03 | Interx Research Corporation | Pro-drug forms of digoxin and method of preparing and using same |
| US4202888A (en) * | 1976-07-12 | 1980-05-13 | Kali-Chemie Pharma Gmbh. | Readily enterally absorbable pharmaceutical compositions of cardiac glycosides and preparation thereof |
| US4147768A (en) * | 1976-09-13 | 1979-04-03 | Interx Research Corporation | Enteric coated digoxin and therapeutic use thereof |
-
1978
- 1978-10-18 DE DE2845326A patent/DE2845326C2/de not_active Expired
-
1979
- 1979-08-31 CH CH791679A patent/CH640738A5/de not_active IP Right Cessation
- 1979-09-11 SE SE7907527A patent/SE445295B/sv unknown
- 1979-09-28 NL NL7907244A patent/NL7907244A/nl not_active Application Discontinuation
- 1979-10-01 US US06/080,900 patent/US4254099A/en not_active Expired - Lifetime
- 1979-10-15 AU AU51789/79A patent/AU523794B2/en not_active Ceased
- 1979-10-16 JP JP13250879A patent/JPS5555113A/ja active Pending
- 1979-10-17 FR FR7925763A patent/FR2439018A1/fr active Granted
- 1979-10-17 AT AT0675979A patent/AT371712B/de not_active IP Right Cessation
- 1979-10-17 ZA ZA00795530A patent/ZA795530B/xx unknown
- 1979-10-17 ES ES485399A patent/ES485399A0/es active Granted
- 1979-10-17 GB GB7936001A patent/GB2033225B/en not_active Expired
- 1979-10-17 CA CA337,779A patent/CA1125656A/en not_active Expired
- 1979-10-18 BE BE0/197703A patent/BE879487A/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SE7907527L (sv) | 1980-04-19 |
| CH640738A5 (de) | 1984-01-31 |
| DE2845326C2 (de) | 1985-05-23 |
| US4254099A (en) | 1981-03-03 |
| ES8100077A1 (es) | 1980-11-01 |
| FR2439018A1 (fr) | 1980-05-16 |
| AU523794B2 (en) | 1982-08-12 |
| AU5178979A (en) | 1980-04-24 |
| GB2033225A (en) | 1980-05-21 |
| ZA795530B (en) | 1980-09-24 |
| FR2439018B1 (de) | 1983-03-04 |
| CA1125656A (en) | 1982-06-15 |
| JPS5555113A (en) | 1980-04-22 |
| AT371712B (de) | 1983-07-25 |
| ES485399A0 (es) | 1980-11-01 |
| GB2033225B (en) | 1983-06-15 |
| NL7907244A (nl) | 1980-04-22 |
| SE445295B (sv) | 1986-06-16 |
| BE879487A (fr) | 1980-02-15 |
| DE2845326A1 (de) | 1980-04-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELJ | Ceased due to non-payment of the annual fee |