AT72137B - Process for the manufacture of anti-hypertensive agents. - Google Patents

Process for the manufacture of anti-hypertensive agents.

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Publication number
AT72137B
AT72137B AT72137DA AT72137B AT 72137 B AT72137 B AT 72137B AT 72137D A AT72137D A AT 72137DA AT 72137 B AT72137 B AT 72137B
Authority
AT
Austria
Prior art keywords
manufacture
hypertensive agents
bacterium
blood pressure
coli
Prior art date
Application number
Other languages
German (de)
Inventor
Georg Dr Med Zuelzer
Original Assignee
Georg Dr Med Zuelzer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georg Dr Med Zuelzer filed Critical Georg Dr Med Zuelzer
Application granted granted Critical
Publication of AT72137B publication Critical patent/AT72137B/en

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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Description

  

   <Desc/Clms Page number 1> 
 



  Verfahren zur Herstellung von den Blutdruck herabsetzenden   Mitteln.   



     Ks ist bekannt,   dass Albumosen den Blutdruck beträchtlich herabzusetzen vermögen. Da die Blutdrucksenkung aber schr rasch erfolgt, so bedeutet die Anwendung von   Albumosen   zu diesem Zwecke mitunter eine erhebliche Gefahr für die Gesundheit der Patienten. 



   Gegenstand der vorliegenden Erfindung bildet nun ein Verfahren zur Herstellung von Blutdruck herabsetzenden Mitteln, welche ihre Wirkung auf den Blutdruck weniger   sturmisch,   aber desto anhaltender entfalten. Bei der Darstellung eines solchen Präparates   vorfahrt   man beispielsweise wie folgt :
2 mg Bacterium coli, das eine bestimmte Anzahl Kaninchenpassagen (in der Regel drei 
 EMI1.1 
 die Behandlung eines Tieres mit dem gleichen Bacterium gewonnenen, auf dieses Bacterium nunmohr eingestellten Serum, 12 Stunden in den Eisschrank gestellt, dann durch scharfes Zentrifugieren von dem Serum befreit und wiederholt   ausgewaschen. Dieser ansgewaschene     Bodonsatz wird   nun in   100 (, W 101/, iger   Gelatine gebracht und nach Mischung abgekühlt. 



  Das Präparat ist dann verendungsfähig. 



   An Stelle von Bacterium coli können auch andere, leicht   endotoxinabgebende, sonst   saprophytische Bacterien, die man vorher noch mit spezifischem oder Normalamboceptoren belädt, verwendet werden. Ausser dem bacterium coli kommen also die Vertreter der ganzen Coli-Typhusgruppe, der hämorrhagischen Septikamie und die säurefesten in Betracht. 
 EMI1.2 
 

**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.



   <Desc / Clms Page number 1>
 



  Process for the manufacture of anti-hypertensive agents.



     It is known that albumoses can reduce blood pressure considerably. However, since the blood pressure lowering occurs rapidly, the use of albumoses for this purpose sometimes represents a considerable risk to the health of the patient.



   The subject matter of the present invention is a process for the production of blood pressure-lowering agents which develop their effect on blood pressure in a less violent but more persistent manner. When displaying such a preparation, proceed as follows, for example:
2 mg of Bacterium coli, which a certain number of rabbit passages (usually three
 EMI1.1
 the treatment of an animal with the same bacterium obtained serum adjusted to this bacterium, placed in the refrigerator for 12 hours, then freed from the serum by vigorous centrifugation and washed out repeatedly. This washed-on Bodon compound is then placed in 100% gelatin and, after mixing, cooled.



  The preparation is then ready for use.



   Instead of Bacterium coli, it is also possible to use other, easily endotoxin-releasing, otherwise saprophytic bacteria that are previously loaded with specific or normal anabolic receptors. In addition to the bacterium coli, the representatives of the entire coli typhus group, hemorrhagic septicemia and the acid-fast ones come into consideration.
 EMI1.2
 

** WARNING ** End of DESC field may overlap beginning of CLMS **.

Claims (1)

**WARNUNG** Ende CLMS Feld Kannt Anfang DESC uberlappen**. ** WARNING ** End of CLMS field may overlap beginning of DESC **.
AT72137D 1913-06-20 1914-06-13 Process for the manufacture of anti-hypertensive agents. AT72137B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE72137X 1913-06-20

Publications (1)

Publication Number Publication Date
AT72137B true AT72137B (en) 1916-07-10

Family

ID=5636022

Family Applications (1)

Application Number Title Priority Date Filing Date
AT72137D AT72137B (en) 1913-06-20 1914-06-13 Process for the manufacture of anti-hypertensive agents.

Country Status (1)

Country Link
AT (1) AT72137B (en)

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