AT399881B - Verfahren zur herstellung von threoninb30-estern von menschlichem insulin - Google Patents
Verfahren zur herstellung von threoninb30-estern von menschlichem insulinInfo
- Publication number
- AT399881B AT399881B AT0063681A AT63681A AT399881B AT 399881 B AT399881 B AT 399881B AT 0063681 A AT0063681 A AT 0063681A AT 63681 A AT63681 A AT 63681A AT 399881 B AT399881 B AT 399881B
- Authority
- AT
- Austria
- Prior art keywords
- esters
- producing
- human insulin
- insulin
- human
- Prior art date
Links
- 101000976075 Homo sapiens Insulin Proteins 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK57480A DK147109C (da) | 1980-02-11 | 1980-02-11 | Fremgangsmaade til fremstilling af humant insulin eller humane insulinestere eller et salt eller kompleks deraf |
| DK366280 | 1980-08-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA63681A ATA63681A (de) | 1994-12-15 |
| AT399881B true AT399881B (de) | 1995-08-25 |
Family
ID=26064239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0063681A AT399881B (de) | 1980-02-11 | 1981-02-11 | Verfahren zur herstellung von threoninb30-estern von menschlichem insulin |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US4343898A (cg-RX-API-DMAC7.html) |
| AT (1) | AT399881B (cg-RX-API-DMAC7.html) |
| FR (1) | FR2475542B1 (cg-RX-API-DMAC7.html) |
| IE (1) | IE50892B1 (cg-RX-API-DMAC7.html) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK319780A (da) * | 1980-07-24 | 1982-01-25 | Forenede Bryggerier As | Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner |
| DK353781A (da) * | 1981-08-10 | 1983-02-11 | Novo Industri As | Fremgangsmaade til fremstilling af insulinderivater |
| AU551174B2 (en) * | 1981-09-15 | 1986-04-17 | Nordisk Insulinlaboratorium | Enzymatic preparation of human insulin or b-30 esters thereof |
| NL8201650A (nl) * | 1982-04-21 | 1983-11-16 | Akzo Nv | Semisynthetische bereiding van humane insuline. |
| US4528134A (en) * | 1982-12-27 | 1985-07-09 | University Of Tn Research Corporation | Method of separating A14 -125 I-insulin from heterogeneously labeled insulin molecules for biological studies |
| DK58285D0 (da) * | 1984-05-30 | 1985-02-08 | Novo Industri As | Peptider samt fremstilling og anvendelse deraf |
| PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| DK257988D0 (da) * | 1988-05-11 | 1988-05-11 | Novo Industri As | Nye peptider |
| DE3844211A1 (de) * | 1988-12-29 | 1990-07-05 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| DK134189D0 (da) * | 1989-03-20 | 1989-03-20 | Nordisk Gentofte | Insulinforbindelser |
| US5512459A (en) * | 1993-07-20 | 1996-04-30 | Bionebraska, Inc. | Enzymatic method for modification or recombinant polypeptides |
| CA2306905A1 (en) | 1997-10-24 | 1999-05-06 | Eli Lilly And Company | Fatty acid-acylated insulin analogs |
| CO4970787A1 (es) | 1997-12-23 | 2000-11-07 | Lilly Co Eli | Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea |
| BR0016860A (pt) | 1999-12-29 | 2002-10-01 | Novo Nordisk As | Precursor da insulina ou análogo de precursor de insulina, sequência de polinucleotìdeo, vetor de expressão, célula hospedeira, e, processos para fabricar um precursor da insulina ou análogo de precursor de insulina, e, insulina ou um análogo de insulina |
| AR025646A1 (es) * | 2000-09-13 | 2002-12-04 | Beta Lab Sa | Cepa de levaduras metilotroficas recombinantes productoras de un precursor de insulina, construcciones de adn y metodo para obtener la cepa. |
| US7396903B2 (en) * | 2001-11-19 | 2008-07-08 | Novo Nordisk A/S | Process for preparing insulin compounds |
| IL161358A0 (en) | 2001-11-19 | 2004-09-27 | Novo Nordisk As | Process for preparing insulin compounds |
| UA46667C2 (en) * | 2001-12-29 | 2006-01-16 | Omakooe Ltd Liability Company | Method for preparing semisynthetic human insulin |
| US20080085298A1 (en) * | 2004-03-12 | 2008-04-10 | Biodel, Inc. | Rapid Mucosal Gel or Film Insulin Compositions |
| US20080248999A1 (en) * | 2007-04-04 | 2008-10-09 | Biodel Inc. | Amylin formulations |
| US20080096800A1 (en) * | 2004-03-12 | 2008-04-24 | Biodel, Inc. | Rapid mucosal gel or film insulin compositions |
| US20080090753A1 (en) * | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
| US7279457B2 (en) * | 2004-03-12 | 2007-10-09 | Biodel, Inc. | Rapid acting drug delivery compositions |
| ATE482724T1 (de) | 2005-05-13 | 2010-10-15 | Lilly Co Eli | Pegylierte glp-1-verbindungen |
| US7977454B2 (en) * | 2005-07-08 | 2011-07-12 | Biocon Limited | Preparation of insulin conjugates |
| US7713929B2 (en) * | 2006-04-12 | 2010-05-11 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
| US8084420B2 (en) * | 2005-09-29 | 2011-12-27 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
| JP2009533471A (ja) * | 2006-04-12 | 2009-09-17 | バイオデル， インコーポレイテッド | 即効型および長時間作用型組合せインスリン製剤 |
| EP2573111A1 (en) | 2006-04-20 | 2013-03-27 | Amgen Inc. | GLP-1 compounds |
| EP2234644B1 (en) * | 2008-01-04 | 2013-07-31 | Biodel, Inc. | Insulin formulations for insulin release as a function of tissue glucose levels |
| JP5698977B2 (ja) | 2008-07-30 | 2015-04-08 | 武田薬品工業株式会社 | メタスチン誘導体およびその用途 |
| US9060927B2 (en) | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
| WO2011031662A1 (en) | 2009-09-08 | 2011-03-17 | Kent Stephen B H | Ester insulin |
| JP5973427B2 (ja) | 2010-06-23 | 2016-08-23 | ノヴォ ノルディスク アー／エス | 追加のジスルフィド結合を含有するインスリン類似体 |
| JP5931857B2 (ja) | 2010-06-23 | 2016-06-08 | ノヴォ ノルディスク アー／エス | 追加のジスルフィド結合を含有するインスリン誘導体 |
| EP2585483A1 (en) | 2010-06-23 | 2013-05-01 | Novo Nordisk A/S | Human insulin containing additional disulfide bonds |
| WO2012123519A2 (en) | 2011-03-15 | 2012-09-20 | Novo Nordisk A/S | Human insulin analogues and derivatives comprising cysteine substitutions |
| JP6058646B2 (ja) | 2011-06-15 | 2017-01-11 | ノヴォ ノルディスク アー／エス | 多置換インスリン |
| JP6735561B2 (ja) | 2012-12-03 | 2020-08-05 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | Ｏ−グリコシル化カルボキシ末端部分（ｃｔｐ）ペプチド系のインスリンおよびインスリン類似体 |
| EP3004156A1 (en) | 2013-06-07 | 2016-04-13 | Novo Nordisk A/S | Method for making mature insulin polypeptides |
| UA119762C2 (uk) * | 2013-12-23 | 2019-08-12 | Біокон Ресерч Лімітед | Спосіб отримання метилового ефіру інсуліну людини |
| TW201917134A (zh) | 2017-08-17 | 2019-05-01 | 丹麥商諾佛 儂迪克股份有限公司 | 新穎的醯基化胰島素類似物及其用途 |
| WO2023144240A1 (en) | 2022-01-26 | 2023-08-03 | Novo Nordisk Research Centre Oxford Limited | Glucose sensitive insulin derivatives and uses thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3276961A (en) * | 1963-04-08 | 1966-10-04 | Squibb & Sons Inc | Process for preparing human insulin |
-
1981
- 1981-02-10 US US06/233,051 patent/US4343898A/en not_active Expired - Lifetime
- 1981-02-10 IE IE251/81A patent/IE50892B1/en not_active IP Right Cessation
- 1981-02-11 FR FR8102716A patent/FR2475542B1/fr not_active Expired
- 1981-02-11 AT AT0063681A patent/AT399881B/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IE50892B1 (en) | 1986-08-06 |
| IE810251L (en) | 1981-08-11 |
| FR2475542A1 (cg-RX-API-DMAC7.html) | 1981-08-14 |
| FR2475542B1 (cg-RX-API-DMAC7.html) | 1988-09-09 |
| US4343898A (en) | 1982-08-10 |
| ATA63681A (de) | 1994-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties | ||
| ELJ | Ceased due to non-payment of the annual fee |