AT366379B - METHOD FOR PRODUCING RIGHT-ROTATING D-BIS-2- (4-AETHYL-OXAZOLIDIN) - Google Patents

METHOD FOR PRODUCING RIGHT-ROTATING D-BIS-2- (4-AETHYL-OXAZOLIDIN)

Info

Publication number
AT366379B
AT366379B AT0466477A AT466477A AT366379B AT 366379 B AT366379 B AT 366379B AT 0466477 A AT0466477 A AT 0466477A AT 466477 A AT466477 A AT 466477A AT 366379 B AT366379 B AT 366379B
Authority
AT
Austria
Prior art keywords
bis
aethyl
oxazolidin
rotating
producing right
Prior art date
Application number
AT0466477A
Other languages
German (de)
Other versions
ATA466477A (en
Inventor
Ludwig H Dr Schlager
Original Assignee
Gerot Pharmazeutika
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gerot Pharmazeutika filed Critical Gerot Pharmazeutika
Priority to AT0466477A priority Critical patent/AT366379B/en
Publication of ATA466477A publication Critical patent/ATA466477A/en
Application granted granted Critical
Publication of AT366379B publication Critical patent/AT366379B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Description

  

   <Desc/Clms Page number 1> 
 



   Die Erfindung betrifft ein neues Verfahren zur Herstellung von rechtsdrehendem d-Bis-   - Z-H-äthyl-oxazolidin)   der Formel 
 EMI1.1 
 
 EMI1.2 
 

 <Desc/Clms Page number 2> 

 



   Dann dampft man die Benzollösung im Vakuum ein, nimmt den Rückstand in 200 ml Isopropyl- äther auf, behandelt diese Lösung mit Aktivkohle und dampft das Filtrat nochmals ein. 



   Der erhaltene Rückstand kristallisiert beim Stehen in der Kälte. Die Ausbeute an d-Bis-   - 2- (4-äthyl-oxazolidin)   ist fast quantitativ. 



   PATENTANSPRÜCHE : 
1. Verfahren zur Herstellung von d-Bis-2- (4-äthyl-oxazolidin) der Formel 
 EMI2.1 
 sowie dessen Salzen, dadurch gekennzeichnet, dass man   d-2-Amino-1-butanol   mit Polyglyoxal gegebenenfalls unter Zusatz von etwas Jod durch Erhitzen in einem inerten, aromatischen Lösungsmittel, welches die azeotrope Entfernung von Wasser bewirkt, kondensiert und das so erhaltene Produkt der Formel (1) gegebenenfalls in das gewünschte Salz überführt. 
 EMI2.2 




   <Desc / Clms Page number 1>
 



   The invention relates to a new process for the production of clockwise d-bis- (Z-H-ethyl-oxazolidine) of the formula
 EMI1.1
 
 EMI1.2
 

 <Desc / Clms Page number 2>

 



   Then the benzene solution is evaporated in vacuo, the residue is taken up in 200 ml of isopropyl ether, this solution is treated with activated carbon and the filtrate is evaporated again.



   The residue obtained crystallizes on standing in the cold. The yield of d-bis- - 2- (4-ethyl-oxazolidine) is almost quantitative.



   PATENT CLAIMS:
1. Process for the preparation of d-bis-2- (4-ethyl-oxazolidine) of the formula
 EMI2.1
 and its salts, characterized in that d-2-amino-1-butanol is condensed with polyglyoxal, optionally with the addition of a little iodine, by heating in an inert, aromatic solvent which brings about the azeotropic removal of water, and the product thus obtained is condensed Formula (1) optionally converted into the desired salt.
 EMI2.2

Claims (1)

3. Verfahren nach Anspruch 1 oder 2, dadurch gekennzeichnet, dass man die Benzollösung nach beendeter Wasserabscheidung eindampft und den Rückstand gegebenenfalls nach Reinigung mit Aktivkohle in Isopropyläther und neuerlichem Eindampfen in einem inerten Lösungsmittel aufnimmt.  3. The method according to claim 1 or 2, characterized in that the benzene solution is evaporated after the water separation has ended and the residue is optionally taken up after cleaning with activated carbon in isopropyl ether and renewed evaporation in an inert solvent.
AT0466477A 1977-06-30 1977-06-30 METHOD FOR PRODUCING RIGHT-ROTATING D-BIS-2- (4-AETHYL-OXAZOLIDIN) AT366379B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT0466477A AT366379B (en) 1977-06-30 1977-06-30 METHOD FOR PRODUCING RIGHT-ROTATING D-BIS-2- (4-AETHYL-OXAZOLIDIN)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0466477A AT366379B (en) 1977-06-30 1977-06-30 METHOD FOR PRODUCING RIGHT-ROTATING D-BIS-2- (4-AETHYL-OXAZOLIDIN)

Publications (2)

Publication Number Publication Date
ATA466477A ATA466477A (en) 1981-08-15
AT366379B true AT366379B (en) 1982-04-13

Family

ID=3566813

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0466477A AT366379B (en) 1977-06-30 1977-06-30 METHOD FOR PRODUCING RIGHT-ROTATING D-BIS-2- (4-AETHYL-OXAZOLIDIN)

Country Status (1)

Country Link
AT (1) AT366379B (en)

Also Published As

Publication number Publication date
ATA466477A (en) 1981-08-15

Similar Documents

Publication Publication Date Title
AT366379B (en) METHOD FOR PRODUCING RIGHT-ROTATING D-BIS-2- (4-AETHYL-OXAZOLIDIN)
DE2521040C3 (en) p-Iobutylhydratropaic acid (4-acetamidophenyl) ester and process for its preparation
AT346838B (en) PROCESS FOR MANUFACTURING NEW OPTICALLY ACTIVE ANTHRACYCLINONES
CH668423A5 (en) PROCESS FOR THE PREPARATION OF 4-ALKOXY-3-PYRROLIN-2-ONES.
DE2331665A1 (en) DIALKYLAMINO ALKYLESTERS OF ARYLALIPHATIC ACIDS AND THEIR ACID ADDITIONAL SALTS AND PROCESS FOR THEIR PRODUCTION
DE2138857A1 (en) Process for the preparation of 2,3-disubstituted 1,3-butadienes
DE2558399B2 (en) PROCESS FOR THE PREPARATION OF 3,6-DICHLOROPICOLIC ACID
CH345016A (en) Process for the preparation of p-oxy-phenylamides
AT214582B (en) Process for the preparation of 3β-hydroxy- or 3β-acyloxy-6-methyl-25D-spirost-5-ene
AT211821B (en) Process for the preparation of alkylaminoacetarylides
AT228945B (en) Process for the production of new modification products of the 17α-hydroxyprogesterone ester
AT375343B (en) METHOD FOR PRODUCING THE NEW 1-METHYL-5 (P-TOLUOYL) -3-CARBOXYPYRROL-2-ACETIC ACID
AT212982B (en) Process for the separation of the optical antipodes of 3,5-diiodothyronine
AT333981B (en) METHOD OF PREPARING THE NEW N- (D-6-METHYL-8-ISOERGOLIN-I-YL) -N &#39;, N&#39;-DIATHYL URINE
AT233745B (en) Process for the production of reserpic acid esters and their salts
CH370064A (en) Process for producing a double compound
AT233567B (en) Process for the preparation of new 1- (trialkoxybenzyl) piperazines or of their acid addition salts
DE702829C (en) Process for the manufacture of pyridine caps
DE1793674C2 (en)
AT221501B (en) Process for the preparation of the new 4-chloro-3-sulfamylbenzoic acid and its alkali metal salts
CH298333A (en) Process for the preparation of a 17-methylpregnene compound.
DE2412323A1 (en) 1,2-DIPHENYL ETHANE DERIVATIVES, METHOD FOR THEIR PRODUCTION AND USE
CH593227A5 (en)
CH407101A (en) Process for the preparation of 5,6,7,12-tetrahydrodibenzo (a, d) cycloocten 12-one
DE1156814B (en) Process for the preparation of ª-morpholino-fatty acid anilides

Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee