AT350569B - Verfahren zur herstellung von neuen 2- piperidinoalkyl-(1-benzofuranen, 1,4-benzo- dioxanen oder 1,4-benzoxathianen) und deren salzen - Google Patents

Verfahren zur herstellung von neuen 2- piperidinoalkyl-(1-benzofuranen, 1,4-benzo- dioxanen oder 1,4-benzoxathianen) und deren salzen

Info

Publication number
AT350569B
AT350569B AT453776A AT453776A AT350569B AT 350569 B AT350569 B AT 350569B AT 453776 A AT453776 A AT 453776A AT 453776 A AT453776 A AT 453776A AT 350569 B AT350569 B AT 350569B
Authority
AT
Austria
Prior art keywords
benzoxathianes
piperidinoalkyl
benzofurans
dioxanes
benzo
Prior art date
Application number
AT453776A
Other languages
English (en)
Other versions
ATA453776A (de
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Priority claimed from US05/760,493 external-priority patent/US4129655A/en
Publication of ATA453776A publication Critical patent/ATA453776A/de
Application granted granted Critical
Publication of AT350569B publication Critical patent/AT350569B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AT453776A 1975-06-23 1976-06-22 Verfahren zur herstellung von neuen 2- piperidinoalkyl-(1-benzofuranen, 1,4-benzo- dioxanen oder 1,4-benzoxathianen) und deren salzen AT350569B (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/589,118 US4039676A (en) 1975-06-23 1975-06-23 2-piperidinoalkyl-1,4-benzodioxans
US05/760,493 US4129655A (en) 1976-04-26 1977-01-19 Neuroleptic 2-piperidinoalkyl-1,4-benzodioxans

Publications (2)

Publication Number Publication Date
ATA453776A ATA453776A (de) 1978-11-15
AT350569B true AT350569B (de) 1979-06-11

Family

ID=27080452

Family Applications (1)

Application Number Title Priority Date Filing Date
AT453776A AT350569B (de) 1975-06-23 1976-06-22 Verfahren zur herstellung von neuen 2- piperidinoalkyl-(1-benzofuranen, 1,4-benzo- dioxanen oder 1,4-benzoxathianen) und deren salzen

Country Status (10)

Country Link
US (3) US4039676A (de)
JP (1) JPS523073A (de)
AT (1) AT350569B (de)
AU (1) AU502667B2 (de)
BE (1) BE843241A (de)
DE (1) DE2627616A1 (de)
FR (1) FR2315272A1 (de)
GB (1) GB1544647A (de)
NL (1) NL7606856A (de)
SE (1) SE7607152L (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2349331A1 (fr) * 1976-04-30 1977-11-25 Roussel Uclaf Nouveaux derives de 2,3 dihydro a/4-(3-indolyl) 1-piperidinyl/methyl 1,4-benzodioxin-2-methanol, un procede pour leur preparation et leur application comme medicaments
EP0014295B1 (de) * 1979-02-05 1983-01-19 Bouchara, Emile Dr. Benzodioxan-Derivate, Verfahren zu ihrer Herstellung und ihre therapeutischen Verwendungen
FR2480283A1 (fr) * 1980-04-10 1981-10-16 Science Union & Cie Nouveaux derives tricycliques, leurs procedes de preparation et leur utilisation comme medicament
US4302469A (en) * 1980-09-10 1981-11-24 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antidepressants
GB2094790B (en) * 1981-03-13 1985-10-09 Spofa Vereinigte Pharma Werke Tricycle compounds
FR2530632A1 (fr) * 1982-07-26 1984-01-27 Bouchara Emile Nouveaux derives substitues du 2,5-diamino 1,4-diazole, leurs procedes de preparation et les compositions pharmaceutiques en renfermant
JPS59191037U (ja) * 1984-03-30 1984-12-18 斉藤　太都司 流動性廃棄物の連続焼却装置
US4569933A (en) * 1984-04-13 1986-02-11 Cornu Pierre Jean Antihypertensive substituted derivatives of 2,5-diamino 1,4-diazole
JPS614140U (ja) * 1985-05-17 1986-01-11 太都司 斉藤 流動性廃棄物の連続焼却装置
GB8526209D0 (en) * 1985-10-23 1985-11-27 Glaxo Group Ltd Chemical process
US4957928A (en) * 1986-06-26 1990-09-18 Ciba-Geigy Corporation Hydrogenated 1-benzooxacycloalkylpyridinecarboxylic acid compounds
KR900701774A (ko) * 1988-08-16 1990-12-04 제임스 제이. 플린 살진균성 벤조디옥산 아민 유도체
EP0389425B1 (de) * 1989-03-22 1995-04-26 Ciba-Geigy Ag Neue Benzothiopyranylamine
FR2704857B1 (fr) * 1993-05-07 1995-06-23 Adir Nouvelles benzodioxines substituées, leur procédé de préparation et les compositions pharmaceutiques les contenant.
EP0846683B1 (de) * 1996-12-03 2001-09-19 F. Hoffmann-La Roche Ag 4-Hydroxypiperidinderivate
CA2220649C (en) 1996-12-03 2007-02-13 F. Hoffmann-La Roche Ag 4-hydroxy-piperidine derivatives
AU2001290743A1 (en) * 2000-09-14 2002-03-26 Ortho-Mcneil Pharmaceutical, Inc. Solid salt forms of n-(2-(4-(2-(1-methylethoxy)phenyl)-1-piperazinyl)ethyl)-2-oxo-1-piperidineacetamide
US6656951B2 (en) 2001-04-24 2003-12-02 Wyeth 8-aza-bicyclo[3.2.1]octan-3-ol derivatives of 2,3-dihydro-1,4-benzodioxan as 5-HT1A antagonists
TWI457122B (zh) * 2007-07-20 2014-10-21 Orion Corp 作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3－二氫苯並[1,4]戴奧辛－2－基甲基衍生物
EP3233799B1 (de) 2014-12-19 2021-05-19 The Broad Institute, Inc. Dopamin-d2-rezeptor-liganden
US10633336B2 (en) 2014-12-19 2020-04-28 The Broad Institute, Inc. Dopamine D2 receptor ligands
WO2022047031A1 (en) 2020-08-26 2022-03-03 Vertex Pharmaceuticals Incorporated Inhibitors of apol1 and methods of using same
WO2023154310A1 (en) * 2022-02-08 2023-08-17 Vertex Pharmaceuticals Incorporated 2-methyl-4-phenylpiperidin-4-ol derivatives as inhibitors of apol1 and methods of using same

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2056046A (en) * 1933-05-19 1936-09-29 Rhone Poulenc Sa Manufacture of bases derived from benz-dioxane
US2956058A (en) * 1957-08-19 1960-10-11 Lilly Co Eli Novel substituted piperidines and pyrrolidines
US3149108A (en) * 1961-10-30 1964-09-15 Geigy Chem Corp Preparation of derivatives of 1, 4-benzodioxan
BE632701A (de) * 1962-05-22
NL296841A (de) * 1962-08-20
JPS4311456Y1 (de) * 1965-06-25 1968-05-18
JPS422708Y1 (de) * 1965-07-25 1967-02-17
GB1148214A (en) * 1965-11-26 1969-04-10 Ward Blenkinsop & Co Ltd Heterocyclic guanidine derivatives
US3476760A (en) * 1967-03-06 1969-11-04 Smithkline Corp Substituted piperidinoalkylthianaphthenes and benzofurans
US3513239A (en) * 1967-03-15 1970-05-19 Smithkline Corp Pharmaceutical compositions containing 2-aminoalkyl coumaran derivatives and methods of treating depression therewith
BE755589A (fr) * 1969-09-03 1971-03-02 Janssen Pharmaceutica Nv Benzimidazoolcarbamaten

Also Published As

Publication number Publication date
US4104396A (en) 1978-08-01
US4039676A (en) 1977-08-02
SE7607152L (sv) 1976-12-24
NL7606856A (nl) 1976-12-27
DE2627616A1 (de) 1977-01-13
US4140781A (en) 1979-02-20
AU502667B2 (en) 1979-08-02
ATA453776A (de) 1978-11-15
JPS523073A (en) 1977-01-11
GB1544647A (en) 1979-04-25
BE843241A (fr) 1976-12-22
AU1513076A (en) 1978-01-05
FR2315272A1 (fr) 1977-01-21

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