AT319239B - Verfahren zur Herstellung von neuen heterocyclischen Verbindungen - Google Patents
Verfahren zur Herstellung von neuen heterocyclischen VerbindungenInfo
- Publication number
- AT319239B AT319239B AT760671A AT760671A AT319239B AT 319239 B AT319239 B AT 319239B AT 760671 A AT760671 A AT 760671A AT 760671 A AT760671 A AT 760671A AT 319239 B AT319239 B AT 319239B
- Authority
- AT
- Austria
- Prior art keywords
- preparation
- heterocyclic compounds
- new heterocyclic
- new
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4209070 | 1970-09-03 | ||
| GB3437671 | 1971-07-22 | ||
| US32368473A | 1973-01-15 | 1973-01-15 | |
| US524161A US3917614A (en) | 1970-09-03 | 1974-11-15 | 1-Pyrrolyl alkylene-piperidines |
| US524028A US3912741A (en) | 1970-09-03 | 1974-11-15 | 1-(Benzo{8 b{9 thienylalkyl)piperidines |
| US524027A US3907810A (en) | 1970-09-03 | 1974-11-15 | 1-Imidazolylalkylene-piperidines |
| US524030A US3910932A (en) | 1970-09-03 | 1974-11-15 | 1-Pyridylalkyl piperidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT319239B true AT319239B (de) | 1974-12-10 |
Family
ID=27562647
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT297873A AT316553B (de) | 1970-09-03 | 1971-09-01 | Verfahren zur Herstellung von 1-substituierten Tetrahydropyridin- und Piperidinderivaten |
| AT760671A AT319239B (de) | 1970-09-03 | 1971-09-01 | Verfahren zur Herstellung von neuen heterocyclischen Verbindungen |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT297873A AT316553B (de) | 1970-09-03 | 1971-09-01 | Verfahren zur Herstellung von 1-substituierten Tetrahydropyridin- und Piperidinderivaten |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US3917614A (de) |
| AT (2) | AT316553B (de) |
| AU (1) | AU461209B2 (de) |
| BE (1) | BE772190A (de) |
| CA (1) | CA955252A (de) |
| CH (3) | CH598218A5 (de) |
| DE (1) | DE2144080C2 (de) |
| FR (1) | FR2105223B1 (de) |
| GB (1) | GB1345872A (de) |
| NL (1) | NL173954C (de) |
| SE (1) | SE402284B (de) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4028365A (en) * | 1970-09-03 | 1977-06-07 | John Wyeth & Brother Limited | Benz[g]indolyl compounds |
| US4046767A (en) * | 1970-09-03 | 1977-09-06 | John Wyeth & Brother Limited | Piperidino compounds |
| JPS5760335B2 (de) * | 1972-06-14 | 1982-12-18 | Sumitomo Chemical Co | |
| US4024147A (en) * | 1972-06-30 | 1977-05-17 | John Wyeth & Brother Limited | Heterocyclic compounds |
| US4061758A (en) * | 1972-06-30 | 1977-12-06 | John Wyeth & Brother Limited | Treating hypertension and central nervous system abnormalities |
| GB1459506A (en) * | 1974-02-18 | 1976-12-22 | Wyeth John & Brother Ltd | Piperidine derivatives |
| GB1507462A (en) * | 1974-03-21 | 1978-04-12 | Gallardo Antonio Sa | N-heterocyclic substituted benzamides methods for their preparation and compositions containing them |
| GB1593851A (en) * | 1976-10-27 | 1981-07-22 | Gallardo Antonio Sa | N-(4-piperidyl)-benzamides and pharmaceutical compositions containing them |
| DE2513136C3 (de) * | 1974-03-21 | 1981-04-30 | Anphar S.A., Madrid | N-(1-Benzylpiperid-4-yl)-benzamide, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate |
| US4069331A (en) * | 1974-05-16 | 1978-01-17 | Boehringer Ingelheim Gmbh | N-(p-fluorobenzoyl-n-propyl)-4-piperidylamides and salts thereof |
| GB1498884A (en) * | 1975-04-15 | 1978-01-25 | Wyeth John & Brother Ltd | Aminoacetamide-pyridyl-tetrahydropyridyl and-piperidyl derivatives |
| US4191683A (en) * | 1975-05-28 | 1980-03-04 | Ciba-Geigy Corporation | Derivatives of 4-aminopiperidine as stabilizers for polymers |
| US4027028A (en) * | 1975-11-10 | 1977-05-31 | Science Union Et Cie | Arylethers and pharmaceutical compositions |
| US4163789A (en) * | 1976-02-17 | 1979-08-07 | Anphar, S.A. | Anti-psychotic (cycloalkenylalkylpiperidino) benzamides |
| GB1574418A (en) * | 1976-11-16 | 1980-09-03 | Anphar Sa | Piperidine derivatives |
| GB1582239A (en) * | 1976-12-11 | 1981-01-07 | Wyeth John & Brother Ltd | Piperidin-4-yl ureas and thioureas |
| US4962115A (en) * | 1981-10-01 | 1990-10-09 | Janssen Pharmaceutica N.V. | Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
| FR2530632A1 (fr) * | 1982-07-26 | 1984-01-27 | Bouchara Emile | Nouveaux derives substitues du 2,5-diamino 1,4-diazole, leurs procedes de preparation et les compositions pharmaceutiques en renfermant |
| JPS6084281A (ja) * | 1983-09-14 | 1985-05-13 | Yoshitomi Pharmaceut Ind Ltd | ３−インド−ルカルボキサミド類 |
| JPS60123485A (ja) * | 1983-12-08 | 1985-07-02 | Yoshitomi Pharmaceut Ind Ltd | インド−ル−３−カルボキサミド誘導体 |
| JPS60142981A (ja) * | 1983-12-28 | 1985-07-29 | Yoshitomi Pharmaceut Ind Ltd | ３−インド−ルカルボキサミド誘導体 |
| US4569933A (en) * | 1984-04-13 | 1986-02-11 | Cornu Pierre Jean | Antihypertensive substituted derivatives of 2,5-diamino 1,4-diazole |
| ZA86171B (en) * | 1985-01-16 | 1986-08-27 | Hoffmann La Roche | Polycyclic salts |
| JP2832979B2 (ja) * | 1988-02-15 | 1998-12-09 | 武田薬品工業株式会社 | 不飽和カルボン酸アミド誘導体 |
| US5280032A (en) * | 1989-02-14 | 1994-01-18 | Toyama Chemical Co., Ltd. | 1,2-ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same |
| US5210090A (en) * | 1989-09-05 | 1993-05-11 | G. D. Searle & Co. | Substituted N-benzylpiperidine amides and cardiac regulatory compositions thereof |
| US5070094A (en) * | 1989-09-05 | 1991-12-03 | G. D. Searle & Co. | N-benzyltropaneamides |
| US4992446A (en) * | 1989-09-05 | 1991-02-12 | G. D. Searle & Co. | Tricyclic quinolizine amides |
| US5028616A (en) * | 1989-09-05 | 1991-07-02 | G. D. Searle & Co. | N-benzylpiperidine amides |
| US5053413A (en) * | 1989-09-05 | 1991-10-01 | G. D. Searle & Co. | N-benzylpiperidineisoindolinones |
| US5098915A (en) * | 1989-09-05 | 1992-03-24 | G. D. Searle & Co. | Substituted N-benzylpiperidine amides |
| US5403847A (en) * | 1992-11-13 | 1995-04-04 | Synaptic Pharmaceutical Corporation | Use of α1C specific compounds to treat benign prostatic hyperlasia |
| US6015819A (en) | 1992-11-13 | 2000-01-18 | Synaptic Pharmaceutical Corporation | Use of alpha-1C specific compounds to treat benign prostatic hyperplasia |
| US5578611A (en) * | 1992-11-13 | 1996-11-26 | Synaptic Pharmaceutical Corporation | Use of α-1C specific compounds to treat benign prostatic hyperplasia |
| CZ130595A3 (en) * | 1992-11-20 | 1995-10-18 | Kaken Pharma Co Ltd | Acetamide derivatives, medicaments based thereon and aminoethanethiol derivatives |
| MXPA03000708A (es) | 2000-07-26 | 2003-06-04 | Smithkline Beecham Plc | Aminopiperidin quinolinas y sus analogos azaisostericos con actividad antibacteriana. |
| FR2813306B1 (fr) * | 2000-08-23 | 2005-10-21 | Sanofi Synthelabo | Aminoalkybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation et les compositions les contenant |
| GB0101577D0 (en) | 2001-01-22 | 2001-03-07 | Smithkline Beecham Plc | Compounds |
| US7312212B2 (en) | 2002-01-29 | 2007-12-25 | Glaxo Group Limited | Aminopiperidine derivatives |
| EP1470131A2 (de) | 2002-01-29 | 2004-10-27 | Glaxo Group Limited | "aminopiperidinverbindugen, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen " |
| EP1485364B1 (de) | 2002-03-13 | 2009-03-11 | Janssen Pharmaceutica N.V. | Aminocarbonylderivate als histone-deacetylase-inhibitoren |
| BR0307607A (pt) * | 2002-03-13 | 2004-12-21 | Janssen Pharmaceutica Nv | Derivados de carbonilamino como inibidores de histona desacetilase |
| JP4725945B2 (ja) | 2002-03-13 | 2011-07-13 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼの新規な阻害剤としてのスルホニルアミノ誘導体 |
| KR20040093692A (ko) | 2002-03-13 | 2004-11-08 | 얀센 파마슈티카 엔.브이. | 히스톤 디아세틸라제의 신규한 저해제로서의 피페라지닐-,피페리디닐- 및 모르폴리닐-유도체 |
| KR101261305B1 (ko) | 2004-07-28 | 2013-05-08 | 얀센 파마슈티카 엔.브이. | 히스톤 디아세틸라제의 신규한 저해제로의 치환된 인돌릴알킬 아미노 유도체 |
| JP5055268B2 (ja) | 2005-05-18 | 2012-10-24 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼの新規な阻害剤としての置換されたアミノプロペニルピペリジンまたはモルホリン誘導体 |
| CN101370803B (zh) | 2006-01-19 | 2012-12-12 | 詹森药业有限公司 | 作为组蛋白脱乙酰酶抑制剂的取代的吲哚基-烷基-氨基衍生物 |
| CA2630717C (en) | 2006-01-19 | 2015-02-24 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
| DE602007001190D1 (de) | 2006-01-19 | 2009-07-09 | Janssen Pharmaceutica Nv | Aminophenylderivate als neue inhibitoren von histondeacetylase |
| AU2007206944B2 (en) | 2006-01-19 | 2012-08-23 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL267843A (de) * | 1960-08-03 | |||
| US3270026A (en) * | 1963-07-03 | 1966-08-30 | Hoffmann La Roche | Substituted benzamidotetrahydro-pyridines and processes |
| GB1154744A (en) * | 1966-05-17 | 1969-06-11 | Whitefin Holding Sa | Disubstituted Aminoethanols |
| GB1221061A (en) * | 1967-01-18 | 1971-02-03 | May & Baker Ltd | Quaternary ammonium derivatives, their use as anthelmintics and methods for their preparation |
| US3855242A (en) * | 1967-12-15 | 1974-12-17 | Aspro Nicholas Ltd | Benzo{8 b{9 thienyl-alkyl-guanidines |
| DE2060816C3 (de) * | 1970-12-10 | 1980-09-04 | Merck Patent Gmbh, 6100 Darmstadt | 4-Phenylpiperidinderivate Verfahren zu ihrer Herstellung und pharmazeutische Zubereitungen enthaltend diese Verbindungen |
-
1970
- 1970-09-03 GB GB4209070A patent/GB1345872A/en not_active Expired
-
1971
- 1971-08-31 CH CH1670775A patent/CH598218A5/xx not_active IP Right Cessation
- 1971-08-31 CH CH1280971A patent/CH593258A5/xx not_active IP Right Cessation
- 1971-08-31 CA CA121,748A patent/CA955252A/en not_active Expired
- 1971-09-01 AT AT297873A patent/AT316553B/de not_active IP Right Cessation
- 1971-09-01 AT AT760671A patent/AT319239B/de not_active IP Right Cessation
- 1971-09-02 FR FR7131823A patent/FR2105223B1/fr not_active Expired
- 1971-09-02 DE DE2144080A patent/DE2144080C2/de not_active Expired
- 1971-09-02 AU AU33005/71A patent/AU461209B2/en not_active Expired
- 1971-09-03 BE BE772190A patent/BE772190A/xx not_active IP Right Cessation
- 1971-09-03 NL NLAANVRAGE7112176,A patent/NL173954C/xx not_active IP Right Cessation
- 1971-09-03 SE SE7111236A patent/SE402284B/xx unknown
-
1974
- 1974-11-15 US US524161A patent/US3917614A/en not_active Expired - Lifetime
- 1974-11-15 US US524030A patent/US3910932A/en not_active Expired - Lifetime
- 1974-11-15 US US524028A patent/US3912741A/en not_active Expired - Lifetime
- 1974-11-15 US US524027A patent/US3907810A/en not_active Expired - Lifetime
-
1975
- 1975-08-31 CH CH1670875A patent/CH598219A5/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US3907810A (en) | 1975-09-23 |
| NL173954B (nl) | 1983-11-01 |
| AU3300571A (en) | 1973-03-08 |
| CH593258A5 (de) | 1977-11-30 |
| US3910932A (en) | 1975-10-07 |
| CH598218A5 (de) | 1978-04-28 |
| SE402284B (sv) | 1978-06-26 |
| US3917614A (en) | 1975-11-04 |
| CA955252A (en) | 1974-09-24 |
| US3912741A (en) | 1975-10-14 |
| FR2105223A1 (de) | 1972-04-28 |
| DE2144080C2 (de) | 1983-12-08 |
| FR2105223B1 (de) | 1975-10-10 |
| BE772190A (fr) | 1972-01-17 |
| AU461209B2 (en) | 1975-05-22 |
| CH598219A5 (de) | 1978-04-28 |
| NL7112176A (de) | 1972-03-07 |
| NL173954C (nl) | 1984-04-02 |
| DE2144080A1 (de) | 1972-03-09 |
| AT316553B (de) | 1974-07-25 |
| GB1345872A (en) | 1974-02-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELJ | Ceased due to non-payment of the annual fee |