AT299449B - Verfahren zur herstellung von neuen, antibiotisch wirksamen benzdiazepin-verbindungen - Google Patents

Verfahren zur herstellung von neuen, antibiotisch wirksamen benzdiazepin-verbindungen

Info

Publication number
AT299449B
AT299449B AT1212169A AT1212169A AT299449B AT 299449 B AT299449 B AT 299449B AT 1212169 A AT1212169 A AT 1212169A AT 1212169 A AT1212169 A AT 1212169A AT 299449 B AT299449 B AT 299449B
Authority
AT
Austria
Prior art keywords
benzdiazepine
compounds
new
production
antibiotically effective
Prior art date
Application number
AT1212169A
Other languages
German (de)
English (en)
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP44050780A external-priority patent/JPS4843755B1/ja
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Application granted granted Critical
Publication of AT299449B publication Critical patent/AT299449B/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT1212169A 1968-12-30 1969-12-30 Verfahren zur herstellung von neuen, antibiotisch wirksamen benzdiazepin-verbindungen AT299449B (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8369 1968-12-30
JP44050780A JPS4843755B1 (enExample) 1969-06-26 1969-06-26

Publications (1)

Publication Number Publication Date
AT299449B true AT299449B (de) 1972-05-15

Family

ID=26332993

Family Applications (1)

Application Number Title Priority Date Filing Date
AT1212169A AT299449B (de) 1968-12-30 1969-12-30 Verfahren zur herstellung von neuen, antibiotisch wirksamen benzdiazepin-verbindungen

Country Status (5)

Country Link
AT (1) AT299449B (enExample)
BE (1) BE743875A (enExample)
DE (1) DE1965304A1 (enExample)
FR (1) FR2027356A1 (enExample)
NL (1) NL6919607A (enExample)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9818731D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Compounds
GB9818730D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
ES2260570T3 (es) 1998-08-27 2006-11-01 Spirogen Limited Pirrolobenziodiazepinas dimericas.
GB9818732D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collection of compounds
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
GB0404577D0 (en) 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
ATE542821T1 (de) 2004-03-01 2012-02-15 Spirogen Ltd 11-hydroxy-5h-pyrroloä2,1-cüä1,4übenzodiazepin- - on derivate als zwischenverbindungen für die herstellung von c2 substituierten pyrrolobenzodiazepinen
JP5166861B2 (ja) 2004-03-09 2013-03-21 スピロゲン リミティッド ピロロベンゾジアゼピン
GB0819095D0 (en) 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
BR112012026801B8 (pt) 2010-04-15 2021-05-25 Medimmune Ltd conjugados de pirrolobenzodiazepina direcionados, composição farmacêutica, uso dos mesmos para tratamento de uma doença proliferativa ou autoimune e ligante de medicamento
GB201006340D0 (en) 2010-04-15 2010-06-02 Spirogen Ltd Synthesis method and intermediates
MX368648B (es) 2010-04-15 2019-10-09 Seattle Genetics Inc Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas.
EA027971B1 (ru) 2011-09-20 2017-09-29 Медимьюн Лимитед Пирролбензодиазепины
CA2850264C (en) 2011-10-14 2019-11-05 Spirogen Sarl Pyrrolobenzodiazepines
EP2751111B1 (en) 2011-10-14 2017-04-26 MedImmune Limited Asymmetrical bis-(5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one) derivatives for the treatment of proliferative or autoimmune diseases
MX375987B (es) 2011-10-14 2025-03-07 Seagen Inc Pirrolobenzodiazepinas y conjugados dirigidos
WO2013053872A1 (en) 2011-10-14 2013-04-18 Spirogen Sàrl Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines
JP6393617B2 (ja) 2011-10-14 2018-09-19 シアトル ジェネティクス,インコーポレーテッド ピロロベンゾジアゼピンおよび標的コンジュゲート
AU2013328673B2 (en) 2012-10-12 2017-07-13 Medimmune Limited Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
AU2013328628B2 (en) 2012-10-12 2016-12-15 Adc Therapeutics Sa Pyrrolobenzodiazepine-anti-CD22 antibody conjugates
WO2014057114A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-anti-psma antibody conjugates
AU2013328580B2 (en) 2012-10-12 2016-01-21 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
HRP20180945T1 (hr) 2012-10-12 2018-08-10 Adc Therapeutics Sa Konjugati protutijelo-pirolobenzodiazepin
JP6270859B2 (ja) 2012-10-12 2018-01-31 エイディーシー・セラピューティクス・エス・アー・エール・エルAdc Therapeutics Sarl ピロロベンゾジアゼピン−抗体結合体
EP3470086B1 (en) 2012-10-12 2020-11-25 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
HUE042731T2 (hu) 2012-10-12 2019-07-29 Adc Therapeutics Sa Pirrolobenzodiazepin-antitest konjugátumok
WO2014057120A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-antibody conjugates
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
US10010624B2 (en) 2013-10-11 2018-07-03 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
WO2015052535A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
EP3054985B1 (en) 2013-10-11 2018-12-26 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
US10780096B2 (en) 2014-11-25 2020-09-22 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
EP3544636B1 (en) 2017-02-08 2021-03-31 ADC Therapeutics SA Pyrrolobenzodiazepine-antibody conjugates
CA3059519C (en) 2017-04-18 2021-03-23 Medimmune Limited Pyrrolobenzodiazepine conjugates
CN110536703B (zh) 2017-04-20 2024-07-12 Adc治疗有限公司 使用抗axl抗体-药物缀合物的组合疗法
UA127900C2 (uk) 2017-06-14 2024-02-07 Ейдісі Терапьютікс Са Схема дозування для введення adc до cd19
MX384245B (es) 2017-08-18 2025-03-14 Medimmune Ltd Conjugados de pirrolobenzodiazepina
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
AU2020242747B2 (en) 2019-03-15 2025-09-18 Medimmune Limited Azetidobenzodiazepine dimers and conjugates comprising them for use in the treatment of cancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3361742A (en) * 1964-12-07 1968-01-02 Hoffmann La Roche 5-oxo-1h-pyrrolo-[2, 1-c][1, 4]-benzodiazepin-2-crylamides

Also Published As

Publication number Publication date
FR2027356B1 (enExample) 1974-01-11
NL6919607A (enExample) 1970-07-02
FR2027356A1 (en) 1970-09-25
DE1965304A1 (de) 1970-07-23
BE743875A (enExample) 1970-05-28

Similar Documents

Publication Publication Date Title
AT299449B (de) Verfahren zur herstellung von neuen, antibiotisch wirksamen benzdiazepin-verbindungen
AT301020B (de) Verfahren zur Herstellung von neuen α-Amino-cyclohexadienylalkylen-penicillinen und -cephalosporinen
AT301544B (de) Verfahren zur Herstellung von neuen Chromonen
CH513152A (de) Verfahren zur Herstellung von neuen Dibenz-oxepinen, -thiepinen und -azepinen
AT298451B (de) Verfahren zur Herstellung von neuen, basisch substituierten Phenolen
AT308981B (de) Verfahren zur Herstellung von neuen Perhydrobenzindenen
AT287198B (de) Verfahren zur Herstellung von neuen Penicillinen
CH558342A (de) Verfahren zur herstellung von neuen phenolderivaten.
AT295486B (de) Verfahren zur Herstellung von neuen Disulfiden
CH510668A (de) Verfahren zur Herstellung von neuen 1,6-Dimethyl-10a-ergolinderivaten
AT291233B (de) Verfahren zur Herstellung von neuen Indanderivaten
AT293425B (de) Verfahren zur Herstellung von neuen Bisammoniumverbindungen
AT293640B (de) Verfahren zur Herstellung von neuen Oxydo-cardadienoliden und -bufatrienoliden
AT284834B (de) Verfahren zur Herstellung von neuen Triazolyl-cumarinen
CH524630A (de) Verfahren zur Herstellung von neuen 2-Desoxyuridinen
CH525893A (de) Verfahren zur Herstellung von neuen Benzomorphanderivaten
CH514572A (de) Verfahren zur Herstellung von neuen Benzofuranderivaten
AT289296B (de) Verfahren zur Herstellung von neuen Penicillinen
CH505121A (de) Verfahren zur Herstellung von neuen Ammoniumverbindungen
AT309703B (de) Verfahren zur Herstellung von neuen 9α-unsubstituierten 11β-Chlor-19-norsteroiden
CH523256A (de) Verfahren zur Herstellung von neuen Bisimidazolyl-bisphenylmethanen
CH550202A (de) Verfahren zur herstellung von neuen cephalosporinverbindungen.
AT295144B (de) Verfahren zur Herstellung von neuen, überwiegend linearen Polybiureten
AT294311B (de) Verfahren zur Herstellung von neuen 2-Hydroxy-penamverbindungen
AT289814B (de) Verfahren zur Herstellung von neuen Chinoxalin-di-N-oxyd-lactonen

Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee