AR247218A1 - Procedimiento para preparacion 6-sulfanamida,6-sulfinamida y 6-sulfonamida-purinas y de nucleosidos y nucleotidos de purina, utiles para el tratamiento de tumores. - Google Patents

Procedimiento para preparacion 6-sulfanamida,6-sulfinamida y 6-sulfonamida-purinas y de nucleosidos y nucleotidos de purina, utiles para el tratamiento de tumores.

Info

Publication number
AR247218A1
AR247218A1 AR88312708A AR31270888A AR247218A1 AR 247218 A1 AR247218 A1 AR 247218A1 AR 88312708 A AR88312708 A AR 88312708A AR 31270888 A AR31270888 A AR 31270888A AR 247218 A1 AR247218 A1 AR 247218A1
Authority
AR
Argentina
Prior art keywords
purine
sulfinamide
sulfenamide
purines
sulfonamide
Prior art date
Application number
AR88312708A
Other languages
English (en)
Original Assignee
Nucleic Acid Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nucleic Acid Res Inst filed Critical Nucleic Acid Res Inst
Application granted granted Critical
Publication of AR247218A1 publication Critical patent/AR247218A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

PREPARACION DE COMPUESTOS DE 6-SULFENAMIDA, 6-SULFINAMIDA DE PURINAS Y DE NUCLEOTIDOS Y NUCLEOSIDOS DE PURINA DE FORMULA (I), DONDE Z ES H O -NH2; X ES FORMULA (II); G, T Y Q SON C-H O N, E Y ESH O UNA ALFA-PENTOFURANOSA DE FORMULA (III), DONDE R1 Y R2 SON H, OH, -O-ACILO O UN GRUPO A O EN CONJUNTO R1 Y R2 SON B, Y R3 Y R4 SON H O UNO DE R3 O R4 ES OH Y EL OTRO ES H, Y CUANDO Y ES H, ZES -NH2, QUE COMPRENDE HACER REACCIONAR COMPUESTOS DE FORMULA (IV), CON CLORAMINA, PARA FORMAR LOS CORRESPONDIENTES COMPUESTOS DONDE X ES UN GRUPO -SNH2, QUE LUEGO SE OXIDAN CON UN AGENTE OXIDANTE.
AR88312708A 1987-12-14 1988-12-13 Procedimiento para preparacion 6-sulfanamida,6-sulfinamida y 6-sulfonamida-purinas y de nucleosidos y nucleotidos de purina, utiles para el tratamiento de tumores. AR247218A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13314387A 1987-12-14 1987-12-14
US07/275,113 US5026836A (en) 1987-12-14 1988-11-22 6-sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides, pharmaceutical compositions, and processes of making

Publications (1)

Publication Number Publication Date
AR247218A1 true AR247218A1 (es) 1994-11-30

Family

ID=26831092

Family Applications (1)

Application Number Title Priority Date Filing Date
AR88312708A AR247218A1 (es) 1987-12-14 1988-12-13 Procedimiento para preparacion 6-sulfanamida,6-sulfinamida y 6-sulfonamida-purinas y de nucleosidos y nucleotidos de purina, utiles para el tratamiento de tumores.

Country Status (9)

Country Link
US (1) US5026836A (es)
EP (1) EP0353268B1 (es)
JP (1) JP2698460B2 (es)
KR (1) KR0137763B1 (es)
AR (1) AR247218A1 (es)
AT (1) ATE109791T1 (es)
AU (1) AU2816789A (es)
DE (1) DE3851054T2 (es)
GR (1) GR1000386B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3760489A (en) * 1988-05-23 1989-12-12 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Derivatives of cyclic amp as treatment for cancer
US6069132A (en) * 1996-08-14 2000-05-30 Revanker; Ganapathi R. Phosphazole compounds
US6531477B1 (en) * 1998-10-13 2003-03-11 Dupont Pharmaceuticals Company 6-substituted pyrazolo [3,4-d] pyrimidin-4-ones useful as cyclin dependent kinase inhibitors

Also Published As

Publication number Publication date
ATE109791T1 (de) 1994-08-15
DE3851054T2 (de) 1995-03-09
GR1000386B (el) 1992-06-30
KR900700498A (ko) 1990-08-13
EP0353268A1 (en) 1990-02-07
DE3851054D1 (de) 1994-09-15
EP0353268A4 (en) 1990-05-14
JP2698460B2 (ja) 1998-01-19
US5026836A (en) 1991-06-25
EP0353268B1 (en) 1994-08-10
JPH02502912A (ja) 1990-09-13
KR0137763B1 (ko) 1998-04-30
AU2816789A (en) 1989-07-19

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