AR245444A1 - Procedimiento para la preparacion de maleato acido de levomepromazina - Google Patents

Procedimiento para la preparacion de maleato acido de levomepromazina

Info

Publication number
AR245444A1
AR245444A1 AR87307968A AR30796887A AR245444A1 AR 245444 A1 AR245444 A1 AR 245444A1 AR 87307968 A AR87307968 A AR 87307968A AR 30796887 A AR30796887 A AR 30796887A AR 245444 A1 AR245444 A1 AR 245444A1
Authority
AR
Argentina
Prior art keywords
acid
toluil
preparation
levomepromazine
tartarico
Prior art date
Application number
AR87307968A
Other languages
English (en)
Original Assignee
Rhone Poulenc Sante
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Sante filed Critical Rhone Poulenc Sante
Application granted granted Critical
Publication of AR245444A1 publication Critical patent/AR245444A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
    • C07D279/28—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom with other substituents attached to the ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DEL MALEATO ACIDO DE LEVOMEPROMAZINA A PARTIR DE LA (+/-) (DIMETILAMINO-3 METIL-2 PROPIL)-10 METOXI-2 FENOTIAZINA, DONDE (+/-)(DIMETILAMINO-3 METIL-2 PROPIL)-10 METOXI-2 FENOTIAZINA ES DESDOBLADA POR MEDIO DEL ACIDO (-) L-DI.P.TOLUIL-TARTARICO PARA OBTENER LA SAL NEUTRA DEL ACIDO DI.P.TOLUIL-TARTARICO PARA OBTENER LA SAL NEUTRA DEL ACIDO DI.P.TOLUIL-TARTARICO Y DE LA (DIMETIL-AMINO-3 METIL-2 PROPIL)-10 METOXI-2 FENOTIAZINA, DESPUES DE LO CUAL ES HECHO PRECIPITAR EL MALEATO ACIDO DE LEVOMEPROMAZINA POR ACCION DEL ACIDO MALEICO SOBRE LAS AGUASMADRES DE CRISTALIZACION DE LA SAL NEUTRA DE LA BASE DEXTROGIRA Y, EVENTUALMENTE, SE AISLA LA BASE RACEMICA NO DESDOBLADA Y SE REGENERA EL ACIDO (-) L- DI.P.TOLUIL-TARTARICO.
AR87307968A 1986-06-26 1987-06-25 Procedimiento para la preparacion de maleato acido de levomepromazina AR245444A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8609261A FR2600649B1 (fr) 1986-06-26 1986-06-26 Procede de preparation du maleate acide de levomepromazine

Publications (1)

Publication Number Publication Date
AR245444A1 true AR245444A1 (es) 1994-01-31

Family

ID=9336740

Family Applications (1)

Application Number Title Priority Date Filing Date
AR87307968A AR245444A1 (es) 1986-06-26 1987-06-25 Procedimiento para la preparacion de maleato acido de levomepromazina

Country Status (11)

Country Link
US (1) US4798895A (es)
EP (1) EP0251904B1 (es)
JP (1) JPS6339870A (es)
AR (1) AR245444A1 (es)
AT (1) ATE49406T1 (es)
CA (1) CA1276932C (es)
DE (1) DE3761378D1 (es)
DK (1) DK165742C (es)
ES (1) ES2012404B3 (es)
FR (1) FR2600649B1 (es)
GR (1) GR3000299T3 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5227526A (en) * 1992-06-16 1993-07-13 Mallinckrodt Specialty Chemicals Company Resolution of 3-dimethylamino-2-methylpropiophenone (3-DAMP)
GB0217447D0 (en) * 2002-07-29 2002-09-04 Betts John A Personal deodorant
EP2743263B1 (en) 2012-11-29 2018-01-03 ZCL Chemicals Ltd. An improved process for the preparation of levomepromazine maleate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2907461A1 (de) * 1978-03-10 1979-09-20 Sandoz Ag Isochinolinderivate, ihre herstellung und diese enthaltende pharmazeutische zubereitungen
US4471121A (en) * 1982-11-03 1984-09-11 Eli Lilly And Company Method of resolving trans-d alpha-1-n-propyl-6-oxodecahydroquinoline and di-p-toluoyltartaric acid salts thereof
DE3243518A1 (de) * 1982-11-25 1984-05-30 Basf Ag, 6700 Ludwigshafen Substituierte 1-oxo-2-phenyl-2-(2-alkylaminoethyl)-1,2,3,4- tetrahydronaphthaline, ihre herstellung und verwendung

Also Published As

Publication number Publication date
EP0251904A1 (fr) 1988-01-07
ES2012404B3 (es) 1990-03-16
DK165742B (da) 1993-01-11
US4798895A (en) 1989-01-17
DE3761378D1 (de) 1990-02-15
ATE49406T1 (de) 1990-01-15
DK165742C (da) 1993-06-14
GR3000299T3 (en) 1991-06-07
DK324887A (da) 1987-12-27
EP0251904B1 (fr) 1990-01-10
CA1276932C (fr) 1990-11-27
FR2600649A1 (fr) 1987-12-31
JPS6339870A (ja) 1988-02-20
DK324887D0 (da) 1987-06-25
FR2600649B1 (fr) 1989-02-24

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