AR126889A1 - Compuestos de aminopiridina que contienen heteroarilo de 5 miembros como inhibidores de egfr - Google Patents
Compuestos de aminopiridina que contienen heteroarilo de 5 miembros como inhibidores de egfrInfo
- Publication number
- AR126889A1 AR126889A1 ARP220102309A ARP220102309A AR126889A1 AR 126889 A1 AR126889 A1 AR 126889A1 AR P220102309 A ARP220102309 A AR P220102309A AR P220102309 A ARP220102309 A AR P220102309A AR 126889 A1 AR126889 A1 AR 126889A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds containing
- aminopyridine compounds
- egfr inhibitors
- member heteroaryl
- egfr
- Prior art date
Links
- -1 AMINOPYRIDINE COMPOUNDS Chemical class 0.000 title abstract 2
- 229940121647 egfr inhibitor Drugs 0.000 title 1
- 125000006163 5-membered heteroaryl group Chemical group 0.000 abstract 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 abstract 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención proporciona nuevos compuestos de aminopiridina que contienen heteroarilo de 5 miembros y composiciones farmacéuticamente aceptables de los mismos que exhiben actividad de inhibición contra ciertas formas mutadas de EGFR.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163237653P | 2021-08-27 | 2021-08-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR126889A1 true AR126889A1 (es) | 2023-11-22 |
Family
ID=85321858
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP220102311A AR126893A1 (es) | 2021-08-27 | 2022-08-26 | Compuestos de aminopiridina que contienen heteroarilo de 6 miembros como inhibidores de egfr |
ARP220102309A AR126889A1 (es) | 2021-08-27 | 2022-08-26 | Compuestos de aminopiridina que contienen heteroarilo de 5 miembros como inhibidores de egfr |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP220102311A AR126893A1 (es) | 2021-08-27 | 2022-08-26 | Compuestos de aminopiridina que contienen heteroarilo de 6 miembros como inhibidores de egfr |
Country Status (5)
Country | Link |
---|---|
US (3) | US11945798B2 (es) |
KR (1) | KR20240052796A (es) |
AR (2) | AR126893A1 (es) |
TW (2) | TW202328096A (es) |
WO (3) | WO2023027516A1 (es) |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2446864C (en) * | 2001-05-16 | 2011-02-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of src and other protein kinases |
DE602004021558D1 (de) | 2003-01-17 | 2009-07-30 | Warner Lambert Co | 2-aminopyridin-substituierteheterocyclen als inhibitoren der zellulären proliferation |
US7642354B2 (en) * | 2004-04-13 | 2010-01-05 | Icagen, Inc. | Polycyclic pyrazines as potassium ion channel modulators |
AU2005233642A1 (en) | 2004-04-13 | 2005-10-27 | Astellas Pharma Inc. | Polycyclic pyridines as potassium ion channel modulators |
ATE485824T1 (de) * | 2004-04-13 | 2010-11-15 | Icagen Inc | Polycyclische pyrimidine als kaliumionenkanal- modulatoren |
GB0719644D0 (en) | 2007-10-05 | 2007-11-14 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
US9242984B2 (en) * | 2012-06-20 | 2016-01-26 | Merck Sharp & Dohme Corp. | Pyrazolyl derivatives as Syk inhibitors |
EP2991977B1 (en) * | 2013-05-01 | 2020-07-22 | F.Hoffmann-La Roche Ag | C-linked heterocycloalkyl substituted pyrimidines and their uses |
CN104761544B (zh) | 2014-01-03 | 2019-03-15 | 北京轩义医药科技有限公司 | Egfr酪氨酸激酶的临床重要突变体的选择性抑制剂 |
CN106588885B (zh) * | 2016-11-10 | 2019-03-19 | 浙江大学 | 2-取代芳环-嘧啶类衍生物及制备和应用 |
JP2021506978A (ja) | 2017-12-22 | 2021-02-22 | ラヴェンナ ファーマシューティカルズ,インコーポレイテッド | ホスファチジルイノシトールリン酸キナーゼ阻害剤としてのアミノピリジン誘導体 |
WO2019222538A1 (en) * | 2018-05-16 | 2019-11-21 | The University Of North Carolina At Chapel Hill | Aminopyrimidines and aminopyridines as mertk inhibitors and their application in cancer treatment |
KR102297587B1 (ko) * | 2018-08-07 | 2021-09-06 | 재단법인 대구경북첨단의료산업진흥재단 | 치환된 n-헤테로아릴 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물 |
US20220177459A1 (en) | 2019-04-02 | 2022-06-09 | Hinova Pharmaceuticals Inc. | Aromatic amine compound and use thereof in preparation of ar and brd4 dual inhibitors and regulators |
TW202112767A (zh) * | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物 |
US20220298140A1 (en) | 2019-06-28 | 2022-09-22 | Chengdu Zenitar Biomedical Technology Co., Ltd. | 2,4-disubstituted pyrimidine derivative, preparation method therefor and use thereof |
WO2021097326A1 (en) * | 2019-11-15 | 2021-05-20 | The University Of North Carolina At Chapel Hill | Aryl aminopyrimidines as dual mertk and tyro3 inhibitors and methods thereof |
CN115151534B (zh) * | 2020-02-14 | 2024-02-06 | 南京药石科技股份有限公司 | 白细胞介素-1受体相关激酶(irak)/fms样受体酪氨酸激酶(flt3)的抑制剂、其药物产品及其方法 |
-
2022
- 2022-08-24 TW TW111131847A patent/TW202328096A/zh unknown
- 2022-08-24 TW TW111131848A patent/TW202317105A/zh unknown
- 2022-08-25 WO PCT/KR2022/012694 patent/WO2023027516A1/en unknown
- 2022-08-25 WO PCT/KR2022/012695 patent/WO2023027517A1/en unknown
- 2022-08-25 KR KR1020247009716A patent/KR20240052796A/ko unknown
- 2022-08-25 WO PCT/KR2022/012693 patent/WO2023027515A1/en unknown
- 2022-08-26 US US17/822,438 patent/US11945798B2/en active Active
- 2022-08-26 AR ARP220102311A patent/AR126893A1/es unknown
- 2022-08-26 US US17/822,445 patent/US20230090406A1/en active Pending
- 2022-08-26 US US17/822,443 patent/US20230085912A1/en active Pending
- 2022-08-26 AR ARP220102309A patent/AR126889A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
WO2023027517A1 (en) | 2023-03-02 |
AR126893A1 (es) | 2023-11-29 |
US20230086795A1 (en) | 2023-03-23 |
KR20240052796A (ko) | 2024-04-23 |
TW202317105A (zh) | 2023-05-01 |
US11945798B2 (en) | 2024-04-02 |
US20230085912A1 (en) | 2023-03-23 |
US20230090406A1 (en) | 2023-03-23 |
TW202328096A (zh) | 2023-07-16 |
WO2023027515A1 (en) | 2023-03-02 |
WO2023027516A1 (en) | 2023-03-02 |
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Legal Events
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