AR123306A1 - Anticuerpos fgfr3 y métodos de uso - Google Patents
Anticuerpos fgfr3 y métodos de usoInfo
- Publication number
- AR123306A1 AR123306A1 ARP210102356A ARP210102356A AR123306A1 AR 123306 A1 AR123306 A1 AR 123306A1 AR P210102356 A ARP210102356 A AR P210102356A AR P210102356 A ARP210102356 A AR P210102356A AR 123306 A1 AR123306 A1 AR 123306A1
- Authority
- AR
- Argentina
- Prior art keywords
- sequence
- seq
- cdr
- amino acid
- acid sequence
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063068575P | 2020-08-21 | 2020-08-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR123306A1 true AR123306A1 (es) | 2022-11-16 |
Family
ID=77774991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP210102356A AR123306A1 (es) | 2020-08-21 | 2021-08-20 | Anticuerpos fgfr3 y métodos de uso |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11505611B2 (https=) |
| EP (1) | EP4200019A1 (https=) |
| JP (1) | JP2023538098A (https=) |
| KR (1) | KR20230052963A (https=) |
| CN (1) | CN116323666A (https=) |
| AR (1) | AR123306A1 (https=) |
| AU (1) | AU2021327387A1 (https=) |
| BR (1) | BR112023002455A2 (https=) |
| CA (1) | CA3189470A1 (https=) |
| CO (1) | CO2023001559A2 (https=) |
| IL (1) | IL300623A (https=) |
| MX (1) | MX2023002106A (https=) |
| TW (1) | TW202229343A (https=) |
| WO (1) | WO2022040560A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024104922A1 (en) | 2022-11-14 | 2024-05-23 | Ascendis Pharma Growth Disorders A/S | Method of improving skeletal muscle function |
| AU2023379451A1 (en) * | 2022-11-14 | 2025-05-01 | Regeneron Pharmaceuticals, Inc. | Anti-fgfr3 antibodies and antigen-binding fragments and methods of use thereof |
| KR20250148746A (ko) | 2023-01-13 | 2025-10-14 | 리제너론 파아마슈티컬스, 인크. | Fgfr3 결합 분자 및 그의 사용 방법 |
| AU2024240722A1 (en) | 2023-03-20 | 2025-09-18 | Ascendis Pharma Growth Disorders A/S | Method of treatment of a thoracolumbar deformity in a human subject with achondroplasia |
| WO2025207944A1 (en) * | 2024-03-29 | 2025-10-02 | Sidewinder Therapeutics, Inc. | Fgfr3-iiib-binding antibodies |
| WO2025240335A1 (en) | 2024-05-13 | 2025-11-20 | Regeneron Pharmaceuticals, Inc. | Fgfr3 binding molecules and methods of use thereof |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU215581B (hu) | 1989-07-06 | 1999-01-28 | Regents Of The University Of California | Eljárás fibroblaszt növekedési faktor receptorok előállítására és terápiás alkalmazására |
| WO1994000599A2 (en) | 1992-06-18 | 1994-01-06 | Whittier Institute For Diabetes And Endocrinology | Process for detection of neoplastic disease |
| AU6446194A (en) | 1993-03-17 | 1994-10-11 | Whittier Institute For Diabetes And Endocrinology, The | Monoclonal antibodies specific for fibroblast growth factor receptors, immunotoxins, and use thereof |
| US6517872B1 (en) | 1995-06-12 | 2003-02-11 | Yeda Research And Development Co., Ltd. | FGFR3 as a marker for mesenchymal skeletal progenitor cells |
| GB9524973D0 (en) | 1995-12-06 | 1996-02-07 | Lynxvale Ltd | Viral vectors |
| ZA200007412B (en) | 1998-05-15 | 2002-03-12 | Imclone Systems Inc | Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases. |
| US20030143676A1 (en) | 1999-03-25 | 2003-07-31 | Genesis Research And Development Corporation Limited | Fibroblast growth factor receptors and methods for their use |
| US7135311B1 (en) | 1999-05-05 | 2006-11-14 | Institut Curie | Means for detecting and treating pathologies linked to FGFR3 |
| AU5214500A (en) | 1999-05-05 | 2000-11-21 | Centre National De La Recherche Scientifique (C.N.R.S.) | Means for detecting and treating pathologies linked to fgfr3 |
| DE20023659U1 (de) | 1999-10-06 | 2005-07-07 | Tigenix N.V. | Molekulare Marker zum Testen der phänotypischen Stabilität von Zellpopulationen und Zellpopulationen für die autologe Transplantation |
| CA2450793A1 (en) | 2001-06-20 | 2002-12-27 | Prochon Biotech Ltd. | Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof |
| EP1469878B1 (en) | 2002-01-31 | 2011-03-23 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Fgfr agonists |
| WO2004003179A1 (en) | 2002-06-27 | 2004-01-08 | The University Of Queensland | Differentiation modulating agents and uses therefor |
| WO2004022095A1 (en) | 2002-09-04 | 2004-03-18 | Abtech | Anti-idiotypic antibodies as vegf or fgf agonists for bone therapy |
| JP2007524566A (ja) | 2002-12-20 | 2007-08-30 | エンカム ファーマシューティカルズ アクティーゼルスカブ | レセプターとリガンドの間の相互作用の調節の方法 |
| WO2004074506A2 (en) | 2003-02-13 | 2004-09-02 | Mergen Ltd | Polynucleotide sequences and corresponding encoded polypeptides of particular secreted and membrane-bound proteins overexpressed in certain cancers |
| EP1611252B1 (en) | 2003-03-26 | 2009-07-29 | Progenika Biopharma, S.A. | In vitro method to detect bladder transitional cell carcinoma |
| IL156495A0 (en) | 2003-06-17 | 2004-01-04 | Prochon Biotech Ltd | Use of fgfr3 antagonists for treating t cell mediated diseases |
| EP1544213B1 (en) | 2003-12-19 | 2008-02-20 | Charité - Universitätsmedizin Berlin | Use of ligands of the antigen cd52 for the treatment of solid tumours and bone-related cancerous diseases |
| EP1697420A2 (en) | 2003-12-19 | 2006-09-06 | Five Prime Therapeutics, Inc. | Fibroblast growth factor receptors 1, 2, 3, and 4 as targets for therapeutic intervention |
| ES2374822T3 (es) | 2004-02-24 | 2012-02-22 | Allergan, Inc. | Ensayo de selección de toxinas botul�?nicas. |
| WO2005115363A2 (en) | 2004-05-25 | 2005-12-08 | Yale University | Method for treating skeletal disorders resulting from fgfr malfunction |
| AU2005302083A1 (en) | 2004-11-04 | 2006-05-11 | Fibron Limited | Treatment of B-cell malignancies |
| EP1659175A1 (en) | 2004-11-18 | 2006-05-24 | Institut Curie | Alterations in seborrheic keratoses and their applications |
| EP1699826B1 (en) | 2005-01-05 | 2009-03-11 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions |
| AU2006227816B2 (en) | 2005-03-15 | 2012-04-05 | Allergan, Inc. | Modified clostridial toxins with enhanced targeting capabilities for endogenous clostridial toxin receptor systems |
| EP2083081A1 (en) | 2005-07-22 | 2009-07-29 | Five Prime Therapeutics, Inc. | Compositions and methods of treating disease with FGFR fusion proteins |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| JP2009511613A (ja) | 2005-10-17 | 2009-03-19 | エンカム ファーマシューティカルズ アクティーゼルスカブ | 神経細胞接着分子ｌ１のペプチド断片を含む新規ｆｇｆ受容体結合化合物 |
| KR20080080525A (ko) | 2005-12-08 | 2008-09-04 | 노파르티스 아게 | 유전자 전사에 대한 ｆｇｆｒ３의 억제제의 효과 |
| US8101721B2 (en) | 2006-06-15 | 2012-01-24 | Fibron Ltd. | Antibodies blocking fibroblast growth factor receptor activation and methods of use thereof |
| WO2008127707A1 (en) | 2007-04-13 | 2008-10-23 | Dana Farber Cancer Institute, Inc. | Receptor tyrosine kinase profiling |
| US20090304719A1 (en) | 2007-08-22 | 2009-12-10 | Patrick Daugherty | Activatable binding polypeptides and methods of identification and use thereof |
| AU2009219437B2 (en) | 2008-02-25 | 2014-10-16 | Nestec S.A. | Drug selection for breast cancer therapy using antibody-based arrays |
| WO2009146033A2 (en) | 2008-03-31 | 2009-12-03 | Sma Foundation | Compositions and methods for modulating smn activity |
| KR101590495B1 (ko) | 2008-05-29 | 2016-02-01 | 갤럭시 바이오테크, 엘엘씨 | 염기성 섬유모세포 성장 인자에 대한 모노클로날 항체 |
| EP2313435A4 (en) * | 2008-07-01 | 2012-08-08 | Aveo Pharmaceuticals Inc | FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) BINDING PROTEINS |
| AR073770A1 (es) | 2008-10-20 | 2010-12-01 | Imclone Llc | Anticuerpo aislado que se enlaza especificamente con, e induce la degradacion del receptor-3 del factor de crecimiento del fibroblasto humano (fgfr-3), fragmento de enlace fgfr-3 humano del mismo, composicion farmaceutica y producto que lo comprenden |
| MA33208B1 (fr) | 2009-03-25 | 2012-04-02 | Genentech Inc | Anticorps anti-fgfr3 et procédés d'utilisation de ceux-ci |
| RU2012134637A (ru) | 2010-01-14 | 2014-02-20 | Йейл Юниверсити | Ингибиторы рецепторных тирозинкиназ (rtk) и способы их применения |
| TWI452136B (zh) * | 2010-11-17 | 2014-09-11 | 中外製藥股份有限公司 | A multiple specific antigen-binding molecule that replaces the function of Factor VIII in blood coagulation |
| US8790651B2 (en) * | 2011-07-21 | 2014-07-29 | Zoetis Llc | Interleukin-31 monoclonal antibody |
| WO2013088191A1 (en) | 2011-12-12 | 2013-06-20 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Antagonist of the fibroblast growth factor receptor 3 (fgfr3) for use in the treatment or the prevention of skeletal disorders linked with abnormal activation of fgfr3 |
| PL2824181T3 (pl) | 2012-03-08 | 2019-02-28 | Astellas Pharma Inc. | Nowa fuzja fgfr3 |
| UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
| US20150292030A1 (en) | 2012-11-27 | 2015-10-15 | Board Of Regents, The University Of Texas System | Methods of characterizing and treating molecular subset of muscle-invasive bladder cancer |
| WO2014161075A1 (en) | 2013-04-05 | 2014-10-09 | University Health Network | Methods and compositions for generating chondrocyte lineage cells and/or cartilage like tissue |
| TWI541022B (zh) | 2013-12-18 | 2016-07-11 | 應克隆公司 | 針對纖維母細胞生長因子受體－３（ｆｇｆｒ３）之化合物及治療方法 |
| BR112017017700A2 (pt) | 2015-02-19 | 2018-07-31 | Bioclin Therapeutics Inc | métodos, composições e kits para tratamento do câncer |
| SG11201906249PA (en) | 2017-02-06 | 2019-08-27 | Rainier Therapeutics Inc | Methods, compositions, and kits for treatment of cancer |
-
2021
- 2021-08-20 CA CA3189470A patent/CA3189470A1/en active Pending
- 2021-08-20 CN CN202180051281.1A patent/CN116323666A/zh active Pending
- 2021-08-20 TW TW110130895A patent/TW202229343A/zh unknown
- 2021-08-20 BR BR112023002455A patent/BR112023002455A2/pt unknown
- 2021-08-20 US US17/407,774 patent/US11505611B2/en active Active
- 2021-08-20 JP JP2023512280A patent/JP2023538098A/ja active Pending
- 2021-08-20 AU AU2021327387A patent/AU2021327387A1/en active Pending
- 2021-08-20 WO PCT/US2021/046958 patent/WO2022040560A1/en not_active Ceased
- 2021-08-20 KR KR1020237009493A patent/KR20230052963A/ko active Pending
- 2021-08-20 EP EP21770357.8A patent/EP4200019A1/en active Pending
- 2021-08-20 AR ARP210102356A patent/AR123306A1/es unknown
- 2021-08-20 IL IL300623A patent/IL300623A/en unknown
- 2021-08-20 MX MX2023002106A patent/MX2023002106A/es unknown
-
2022
- 2022-10-12 US US18/045,995 patent/US20230303704A1/en active Pending
-
2023
- 2023-02-14 CO CONC2023/0001559A patent/CO2023001559A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20230303704A1 (en) | 2023-09-28 |
| BR112023002455A2 (pt) | 2023-03-28 |
| EP4200019A1 (en) | 2023-06-28 |
| IL300623A (en) | 2023-04-01 |
| AU2021327387A1 (en) | 2023-05-04 |
| MX2023002106A (es) | 2023-03-15 |
| US20220056142A1 (en) | 2022-02-24 |
| CO2023001559A2 (es) | 2023-02-16 |
| AU2021327387A9 (en) | 2023-07-06 |
| WO2022040560A1 (en) | 2022-02-24 |
| TW202229343A (zh) | 2022-08-01 |
| KR20230052963A (ko) | 2023-04-20 |
| CN116323666A (zh) | 2023-06-23 |
| US11505611B2 (en) | 2022-11-22 |
| JP2023538098A (ja) | 2023-09-06 |
| CA3189470A1 (en) | 2022-02-24 |
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