AR121417A1 - Nuevos compuestos heterocíclicos - Google Patents

Nuevos compuestos heterocíclicos

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Publication number
AR121417A1
AR121417A1 ARP190100711A ARP190100711A AR121417A1 AR 121417 A1 AR121417 A1 AR 121417A1 AR P190100711 A ARP190100711 A AR P190100711A AR P190100711 A ARP190100711 A AR P190100711A AR 121417 A1 AR121417 A1 AR 121417A1
Authority
AR
Argentina
Prior art keywords
alkyl
alkoxy
cycloalkyl
haloalkyl
halogen
Prior art date
Application number
ARP190100711A
Other languages
English (en)
Inventor
Charles Bell
Joerg Benz
Luca Gobbi
Uwe Grether
Zbinden Katrin Groebke
Dennis Jul Hansen
Benoit Hornsperger
Buelent Kocer
Carsten Kroll
Bernd Kuhn
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR121417A1 publication Critical patent/AR121417A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Reivindicación 1: Compuesto de fórmula (1) o una sal farmacéuticamente aceptable del mismo, en la que: L se selecciona de -CR¹R²-(CH₂)ₚ-, -(CH₂)ₚ-CR¹R²-, -OCR³R⁴-, -CR³R⁴O- y un enlace covalente, m es 0, n es 0 ó 1 y X es CR²⁴, o m es 1, n es 1 ó 2 y X es CR²⁴, o N, p es 0, 1 ó 2, R¹ se selecciona de halógeno, alcoxi C₁₋₆, alquilo C₁₋₆, haloalquilo C₁₋₆, hidroxialquilo C₁₋₆, alcoxi C₁₋₆-alquilo C₁₋₆, haloalcoxi C₁₋₆, haloalcoxi C₁₋₆-alquilo C₁₋₆, ciano y un grupo de fórmula (2); y R² se selecciona de hidrógeno, halógeno e hidroxi, o R¹ y R², junto con el átomo de carbono al que se encuentran unidos, forman un cicloalquilo C₃₋₁₂ o un heterociclilo C₂₋₉, R³ se selecciona de alquilo C₁₋₆, haloalquilo C₁₋₆, cicloalquilo C₃₋₁₂ y arilo C₆₋₁₄, y R⁴ es hidrógeno, o R³ y R², junto con el átomo de carbono al que se encuentran unidos, forman un cicloalquilo C₃₋₁₂ o un heterociclilo C₂₋₉, R²⁰ es hidrógeno o alquilo C₁₋₆, R²¹, R²² y R²³ se seleccionan independientemente de hidrógeno, halógeno, ciano, hidroxi, alcoxi C₁₋₆, haloalcoxi C₁₋₆, amino-alcoxi C₁₋₆, alquilo C₁₋₆, haloalquilo C₁₋₆, hidroxialquilo C₁₋₆, (haloalquil C₁₋₆)-hidroxi-alquilo C₁₋₆, alcoxi C₁₋₆-carbonil-alquilo C₁₋₆, alcoxi C₁₋₆-carbonil-NH-alcoxi C₁₋₆, alcoxi C₁₋₆-carbonil-NH-(alcoxi C₁₋₆)₂-alquilo C₁₋₆-C(O)-NH-alcoxi C₁₋₆, alcoxi C₁₋₆-carbonil-NH-alcoxi C₁₋₆-alquil C₁₋₆-C(O)-NH-alcoxi C₁₋₆, SF₅, (alquil C₁₋₆)₃Si-O-alquilo C₁₋₆, un grupo de fórmula (3), y un grupo de fórmula (4), R²⁴ se selecciona de hidrógeno, halógeno, hidroxi y haloalquilo C₁₋₆, y alquilo C₁₋₆, R²⁵ y R²⁶ se seleccionan independientemente de hidrógeno, halógeno, alquilo C₁₋₆, alcoxi C₁₋₆, haloalquilo C₁₋₆, haloalcoxi C₁₋₆, alquil C₁₋₆-SO₂- y cicloalquilo C₃₋₁₂, R²⁷ y R²⁸ se seleccionan independientemente de hidrógeno, halógeno, alcoxi C₁₋₆, haloalcoxi C₁₋₆, alquilo C₁₋₆, haloalquilo C₁₋₆, hidroxialquilo C₁₋₆, halógeno, hidroxi, alquil C₁₋₆-sulfonilo, carbamoilo, ciano, cicloalquil C₁₋₆-alcoxi, alquil C₁₋₆-NH-C(O)- y cicloalquilo, A y B se seleccionan independientemente de arilo C₆₋₁₄, heteroarilo C₁₋₁₃, cicloalquilo C₃₋₁₂ y heterociclilo C₂₋₉, C¹ es cicloalquilo C₃₋₁₂ o heterociclilo C₂₋₉, C² es arilo C₆₋₁₄, L² se selecciona de un enlace covalente, -O-, -CH₂O-, -CH₂OCH₂- y -CH₂-, L³ se selecciona de un enlace covalente, -O-, -CH₂O-, -OCH₂-, -CH₂OCH₂- y -CH₂-, y L³ᵃ se selecciona de un enlace covalente, -CH₂O-, -OCH₂-, -CH₂OCH₂- y -CH₂-.
ARP190100711A 2018-03-22 2019-03-21 Nuevos compuestos heterocíclicos AR121417A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18163273 2018-03-22

Publications (1)

Publication Number Publication Date
AR121417A1 true AR121417A1 (es) 2022-06-08

Family

ID=61750011

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP190100711A AR121417A1 (es) 2018-03-22 2019-03-21 Nuevos compuestos heterocíclicos

Country Status (3)

Country Link
AR (1) AR121417A1 (es)
MA (1) MA52072B1 (es)
PT (1) PT3768684T (es)

Also Published As

Publication number Publication date
MA52072B1 (fr) 2023-04-28
MA52072A (fr) 2021-01-27
PT3768684T (pt) 2023-04-13

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