AR113696A1 - Anticuerpos específicos para el transcrito similar a la inmunoglobulina tipo 3 (ilt3) y sus usos - Google Patents
Anticuerpos específicos para el transcrito similar a la inmunoglobulina tipo 3 (ilt3) y sus usosInfo
- Publication number
- AR113696A1 AR113696A1 ARP180103343A ARP180103343A AR113696A1 AR 113696 A1 AR113696 A1 AR 113696A1 AR P180103343 A ARP180103343 A AR P180103343A AR P180103343 A ARP180103343 A AR P180103343A AR 113696 A1 AR113696 A1 AR 113696A1
- Authority
- AR
- Argentina
- Prior art keywords
- ilt3
- specific antibodies
- immunoglobulin type
- similar transcript
- immunoglobulin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se describen anticuerpos monoclonales no promiscuos humanizados específicos para el transcrito similar a la inmunoglobulina tipo 3 (ILT3), también conocido como receptor de tipo inmunoglobulina de leucocitos de la subfamilia B miembro 4 (LILRB4).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762587604P | 2017-11-17 | 2017-11-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR113696A1 true AR113696A1 (es) | 2020-06-03 |
Family
ID=64572590
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP180103343A AR113696A1 (es) | 2017-11-17 | 2018-11-15 | Anticuerpos específicos para el transcrito similar a la inmunoglobulina tipo 3 (ilt3) y sus usos |
Country Status (26)
Country | Link |
---|---|
US (6) | US11111297B2 (es) |
EP (1) | EP3710479A2 (es) |
JP (1) | JP7194481B2 (es) |
KR (1) | KR102478433B1 (es) |
CN (1) | CN111712518A (es) |
AR (1) | AR113696A1 (es) |
AU (1) | AU2018367524B2 (es) |
BR (1) | BR112020009759A8 (es) |
CA (1) | CA3082409A1 (es) |
CL (1) | CL2020001240A1 (es) |
CO (1) | CO2020006405A2 (es) |
CR (1) | CR20200204A (es) |
DO (1) | DOP2020000074A (es) |
EA (1) | EA202091228A1 (es) |
EC (1) | ECSP20032082A (es) |
GE (1) | GEP20237565B (es) |
IL (1) | IL274574A (es) |
JO (1) | JOP20200131A1 (es) |
MA (1) | MA50900A (es) |
MX (1) | MX2020005128A (es) |
NI (1) | NI202000036A (es) |
PE (1) | PE20210475A1 (es) |
PH (1) | PH12020550890A1 (es) |
SG (1) | SG11202004426SA (es) |
TW (1) | TWI816715B (es) |
WO (1) | WO2019099597A2 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101586617B1 (ko) | 2007-06-18 | 2016-01-20 | 머크 샤프 앤 도메 비.브이. | 사람 프로그램된 사멸 수용체 pd-1에 대한 항체 |
MX2022007288A (es) | 2019-12-19 | 2022-07-12 | Ngm Biopharmaceuticals Inc | Agentes de union a ilt3 y metodos de uso de los mismos. |
CA3212604A1 (en) * | 2021-03-19 | 2022-09-22 | Merck Sharp & Dohme Llc | Methods for treating cancer with anti-ilt3 antibodies |
WO2023140875A1 (en) * | 2022-01-19 | 2023-07-27 | Ngm Biopharmaceuticals, Inc. | Uses of ilt3-binding agents |
TW202346337A (zh) | 2022-03-29 | 2023-12-01 | 美商恩格姆生物製藥公司 | Ilt3及cd3結合劑以及其使用方法 |
WO2023209716A1 (en) | 2022-04-25 | 2023-11-02 | Biond Biologics Ltd. | Anti-ilt3 antibodies and use thereof |
WO2023235699A1 (en) | 2022-05-31 | 2023-12-07 | Jounce Therapeutics, Inc. | Antibodies to lilrb4 and uses thereof |
Family Cites Families (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
US4447224A (en) | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
US4741900A (en) | 1982-11-16 | 1988-05-03 | Cytogen Corporation | Antibody-metal ion complexes |
US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
DK1136556T3 (da) | 1991-11-25 | 2005-10-03 | Enzon Inc | Fremgangsmåde til fremstilling af multivalente antigen-bindende proteiner |
US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
US5885573A (en) | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
GB9818110D0 (en) | 1998-08-19 | 1998-10-14 | Weston Medical Ltd | Needleless injectors and other devices |
US6096002A (en) | 1998-11-18 | 2000-08-01 | Bioject, Inc. | NGAS powered self-resetting needle-less hypodermic jet injection apparatus and method |
EP1135415B1 (en) | 1998-12-01 | 2010-08-11 | Facet Biotech Corporation | Humanized antibodies to gamma-interferon |
WO2003000199A2 (en) * | 2001-06-25 | 2003-01-03 | The Trustees Of Columbia University In The City Of New York | Ilt3 and ilt4-related compositions and methods |
US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
CA2391438A1 (en) | 2002-05-01 | 2003-11-01 | Procyon Biopharma Inc. | Psp94 diagnostic reagents and assays |
ES2367430T3 (es) | 2002-12-23 | 2011-11-03 | Wyeth Llc | Anticuerpos contra pd-1 y sus usos. |
EP1799840A4 (en) * | 2004-09-03 | 2009-02-18 | Univ Columbia | ILT3-POLYPEPTIDES AND USES THEREOF |
CN101213297B (zh) | 2005-05-09 | 2013-02-13 | 小野药品工业株式会社 | 程序性死亡-1(pd-1)的人单克隆抗体及单独使用或与其它免疫治疗剂联合使用抗pd-1抗体来治疗癌症的方法 |
ES2547463T3 (es) | 2005-06-17 | 2015-10-06 | Merck Sharp & Dohme Corp. | Moléculas de unión a ILT3 y usos de las mismas |
KR101411165B1 (ko) | 2005-07-01 | 2014-06-25 | 메다렉스, 엘.엘.시. | 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날항체 |
RS52860B (en) * | 2005-12-20 | 2013-12-31 | Sbi Biotech Co. Ltd. | ANTI-ILT7 ANTITELO |
WO2007089945A2 (en) | 2006-02-02 | 2007-08-09 | The Trustees Of Columbia University In The City Of New York | Treating diseases by targeting silt3 |
EP2041180B8 (en) | 2006-06-19 | 2014-03-05 | Liquidating Trust | Ilt3 binding molecules and uses therefor |
GB0705775D0 (en) | 2007-03-26 | 2007-05-02 | Affitech As | Product |
KR101586617B1 (ko) | 2007-06-18 | 2016-01-20 | 머크 샤프 앤 도메 비.브이. | 사람 프로그램된 사멸 수용체 pd-1에 대한 항체 |
US8877688B2 (en) | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
US8691730B2 (en) | 2007-09-14 | 2014-04-08 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
HUE034465T2 (en) | 2008-02-11 | 2018-02-28 | Cure Tech Ltd | Monoclonal antibodies for tumor treatment |
EP2262837A4 (en) | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | PD-1 BINDING PROTEINS |
CN102203125A (zh) | 2008-08-25 | 2011-09-28 | 安普利穆尼股份有限公司 | Pd-1拮抗剂及其使用方法 |
NZ591130A (en) | 2008-08-25 | 2012-09-28 | Amplimmune Inc | Compositions comprising a PD-1 antagonists and cyclophosphamide and methods of use thereof |
PE20120341A1 (es) | 2008-12-09 | 2012-04-24 | Genentech Inc | Anticuerpos anti-pd-l1 y su uso para mejorar la funcion de celulas t |
EP3192811A1 (en) | 2009-02-09 | 2017-07-19 | Université d'Aix-Marseille | Pd-1 antibodies and pd-l1 antibodies and uses thereof |
CN101830978A (zh) * | 2009-03-09 | 2010-09-15 | 中国科学院微生物研究所 | 一种人免疫球蛋白样受体突变体及其应用 |
WO2011066342A2 (en) | 2009-11-24 | 2011-06-03 | Amplimmune, Inc. | Simultaneous inhibition of pd-l1/pd-l2 |
WO2011120134A1 (en) | 2010-03-29 | 2011-10-06 | Zymeworks, Inc. | Antibodies with enhanced or suppressed effector function |
CA2795078A1 (en) | 2010-04-16 | 2011-10-20 | Transbio Ltd | Proteins that bind pi16 and uses thereof |
KR20160044598A (ko) | 2011-03-29 | 2016-04-25 | 로슈 글리카트 아게 | 항체 Fc 변이체 |
WO2013033734A1 (en) * | 2011-09-02 | 2013-03-07 | The Trustees Of Columbia University In The City Of New York | Diagnosis and Treatment of Cancer Expressing ILT3 or ILT3 Ligand |
AU2013201121A1 (en) | 2011-09-20 | 2013-04-04 | Vical Incorporated | Synergistic anti-tumor efficacy using alloantigen combination immunotherapy |
WO2013181438A2 (en) | 2012-05-30 | 2013-12-05 | Icahn School Of Medicine At Mount Sinai | Compositions and methods for modulating pro-inflammatory immune response |
US20140242077A1 (en) | 2013-01-23 | 2014-08-28 | Abbvie, Inc. | Methods and compositions for modulating an immune response |
US9708406B2 (en) | 2013-05-20 | 2017-07-18 | Genentech, Inc. | Anti-transferrin receptor antibodies and methods of use |
JO3663B1 (ar) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
AU2015319809B2 (en) | 2014-09-28 | 2020-02-06 | The Regents Of The University Of California | Modulation of stimulatory and non-stimulatory myeloid cells |
WO2016127427A1 (zh) | 2015-02-15 | 2016-08-18 | 华为技术有限公司 | 电子设备外壳的加工方法、电子设备外壳及电子设备 |
KR102129107B1 (ko) | 2015-03-06 | 2020-07-02 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 항-lilrb 항체 및 암의 검출 및 치료를 위한 이의 용도 |
EP3325006A4 (en) | 2015-07-17 | 2019-03-06 | The Trustees of Columbia University in the City of New York | METHOD FOR TREATING CD166-EXPRESSIVE CANCER |
MX2018006245A (es) | 2015-11-18 | 2018-08-01 | Merck Sharp & Dohme | Proteinas de union a pd1 y/o lag3. |
US11249081B2 (en) * | 2016-08-31 | 2022-02-15 | Agency For Science, Technology And Research | Methods for the identification, targeting and isolation of human dendritic cell (DC) precursors “pre-DC” and their uses thereof |
WO2018089300A1 (en) | 2016-11-10 | 2018-05-17 | Merck Sharp & Dohme Corp. | Ilt3 ligand |
CA3053164A1 (en) | 2017-02-09 | 2018-08-16 | Bluefin Biomedicine, Inc. | Anti-ilt3 antibodies and antibody drug conjugates |
CA3212604A1 (en) * | 2021-03-19 | 2022-09-22 | Merck Sharp & Dohme Llc | Methods for treating cancer with anti-ilt3 antibodies |
AU2022318734A1 (en) * | 2021-07-28 | 2024-02-08 | Merck Sharp & Dohme Llc | Methods for treating acute myeloid leukemia with anti-ilt3 antibodies |
WO2023017525A1 (en) * | 2021-08-11 | 2023-02-16 | OncoHost Ltd. | Predicting patient response |
WO2023159152A2 (en) * | 2022-02-17 | 2023-08-24 | Immune-Onc Therapeutics, Inc. | Combination therapy of lilrb antagonist and pd-1/pd-l1 axis inhibitor |
WO2023235699A1 (en) * | 2022-05-31 | 2023-12-07 | Jounce Therapeutics, Inc. | Antibodies to lilrb4 and uses thereof |
WO2024026019A1 (en) * | 2022-07-28 | 2024-02-01 | Merck Sharp & Dohme Llc | Methods for treating chronic myelomonocytic leukemia with anti-ilt3 antibodies |
-
2018
- 2018-11-15 SG SG11202004426SA patent/SG11202004426SA/en unknown
- 2018-11-15 TW TW107140611A patent/TWI816715B/zh active
- 2018-11-15 JO JOP/2020/0131A patent/JOP20200131A1/ar unknown
- 2018-11-15 EA EA202091228A patent/EA202091228A1/ru unknown
- 2018-11-15 CR CR20200204A patent/CR20200204A/es unknown
- 2018-11-15 WO PCT/US2018/061165 patent/WO2019099597A2/en unknown
- 2018-11-15 CN CN201880086998.8A patent/CN111712518A/zh active Pending
- 2018-11-15 AR ARP180103343A patent/AR113696A1/es unknown
- 2018-11-15 US US16/191,485 patent/US11111297B2/en active Active
- 2018-11-15 GE GEAP201815366A patent/GEP20237565B/en unknown
- 2018-11-15 JP JP2020526543A patent/JP7194481B2/ja active Active
- 2018-11-15 BR BR112020009759A patent/BR112020009759A8/pt unknown
- 2018-11-15 EP EP18812561.1A patent/EP3710479A2/en active Pending
- 2018-11-15 AU AU2018367524A patent/AU2018367524B2/en active Active
- 2018-11-15 PE PE2020000691A patent/PE20210475A1/es unknown
- 2018-11-15 MA MA050900A patent/MA50900A/fr unknown
- 2018-11-15 CA CA3082409A patent/CA3082409A1/en active Pending
- 2018-11-15 MX MX2020005128A patent/MX2020005128A/es unknown
- 2018-11-15 KR KR1020207016922A patent/KR102478433B1/ko active IP Right Grant
-
2020
- 2020-05-06 DO DO2020000074A patent/DOP2020000074A/es unknown
- 2020-05-08 NI NI202000036A patent/NI202000036A/es unknown
- 2020-05-10 IL IL274574A patent/IL274574A/en unknown
- 2020-05-11 CL CL2020001240A patent/CL2020001240A1/es unknown
- 2020-05-27 CO CONC2020/0006405A patent/CO2020006405A2/es unknown
- 2020-06-12 EC ECSENADI202032082A patent/ECSP20032082A/es unknown
- 2020-06-15 PH PH12020550890A patent/PH12020550890A1/en unknown
-
2021
- 2021-07-16 US US17/377,924 patent/US20220025042A1/en active Pending
- 2021-07-16 US US17/378,030 patent/US20220025043A1/en active Pending
- 2021-07-16 US US17/378,070 patent/US20220010011A1/en active Pending
- 2021-07-16 US US17/378,000 patent/US20220033497A1/en active Pending
- 2021-07-16 US US17/378,050 patent/US20220010010A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ECSP20032082A (es) | Anticuerpos específicos para el transcrito similar a la inmunoglobulina tipo 3 (ilt3) y sus usos | |
BR112022010206A2 (pt) | Receptores de antígeno quiméricos e usos dos mesmos | |
CL2020000938A1 (es) | Anticuerpos anti-tigit, sus composiciones y uso. (divisional solicitud 201800744) | |
CY1125008T1 (el) | Χιμαιρικοι υποδοχεις αντιγονων που στοχευουν συζευγμενους με πρωτεϊνη g yποδοχεις και χρησεις αυτων | |
BR112017020894A2 (pt) | imunoreceptores específicos claudina-18.2 e epítopos de células t | |
ECSP17083779A (es) | Agentes de unión a inmunorreceptor de células t con dominios ig y motivo de inhibición basado en tirosina de inmunorreceptor (tigit) y usos de los mismos | |
CY1121539T1 (el) | Ειδικοι για κλαυδiνη-6 ανοσοϋποδοχεις και επιτοποι τ-κυτταρων | |
AR105767A1 (es) | Proteínas de fusión de unión a gitr multivalentes y multiespecíficas | |
CL2019000628A1 (es) | Anticuerpos anti-pd-1 y sus usos. | |
MX2018008308A (es) | Proteinas de fusion de union a 41bb multivalentes y multiespecificas. | |
CO2017006740A2 (es) | Anticuerpos anti–cd79b | |
CO2019011155A2 (es) | Anticuerpos anti-ilt4 y fragmentos de unión a antígeno | |
CO2018001405A2 (es) | Receptores de antígenos quiméricos basados en anticuerpos de dominio simple | |
CL2017003195A1 (es) | Anticuerpos madurados por afinidad y humanizados para fcrh5 y métodos para su uso. | |
CL2020002613A1 (es) | Receptores quiméricos de dll3 y métodos para su uso | |
UA116479C2 (uk) | БІСПЕЦИФІЧНЕ МОНОВАЛЕНТНЕ Fc-ДІАТІЛО, ЯКЕ ОДНОЧАСНО ЗВ'ЯЗУЄ CD32B I CD79b, ТА ЙОГО ЗАСТОСУВАННЯ | |
CY1123046T1 (el) | Ζωα εκτος του ανθρωπου που εχουν ανθρωποποιημενους υποδοχεις fc-γ | |
CL2018003515A1 (es) | Anticuerpos anti-gitr y sus usos. | |
CR20180141A (es) | Anticuerpos anti-cd 19 humano humanizados y métodos de utilización | |
CL2018002898A1 (es) | Nuevos anticuerpos anti-sirpa y sus aplicaciones terapéuticas. | |
UY36942A (es) | Proteínas de unión a antígeno que activan el receptor de leptina | |
NZ741067A (en) | Bispecific anti-human cd20/human transferrin receptor antibodies and methods of use | |
IL284091A (en) | Antibodies neutralize the type 2 immunoglobulin-like leukocyte receptor | |
BR112018006991A2 (pt) | receptores de antígeno quiméricos direcionados ao psca | |
CL2018002639A1 (es) | Inmunoglobulinas diseñadas por ingeniería genética con unión alterada al fcrn. |