NI202000036A - Anticuerpo específicos para el transcrito semillar a la inmunoglobulina tipo 3 (ilt3) y sus usos. - Google Patents

Anticuerpo específicos para el transcrito semillar a la inmunoglobulina tipo 3 (ilt3) y sus usos.

Info

Publication number
NI202000036A
NI202000036A NI202000036A NI202000036A NI202000036A NI 202000036 A NI202000036 A NI 202000036A NI 202000036 A NI202000036 A NI 202000036A NI 202000036 A NI202000036 A NI 202000036A NI 202000036 A NI202000036 A NI 202000036A
Authority
NI
Nicaragua
Prior art keywords
ilt3
transcript
seed
specific antibody
immunoglobulin type
Prior art date
Application number
NI202000036A
Other languages
English (en)
Inventor
A Meehl Michael
E Brandish Philip
Fayadat-Dilman Laurence
JUAN Veronica
Mieczkowski Carl
Singh Latika
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of NI202000036A publication Critical patent/NI202000036A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describen anticuerpos monoclonales no promiscuos humanizados específicos para el transcrito similar a la inmunoglobulina tipo 3 (ILT3), también conocido como receptor de tipo inmunoglobulina de leucocitos de la subfamilia B miembro 4 (LILRB4).
NI202000036A 2017-11-17 2020-05-08 Anticuerpo específicos para el transcrito semillar a la inmunoglobulina tipo 3 (ilt3) y sus usos. NI202000036A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762587604P 2017-11-17 2017-11-17

Publications (1)

Publication Number Publication Date
NI202000036A true NI202000036A (es) 2020-09-24

Family

ID=64572590

Family Applications (1)

Application Number Title Priority Date Filing Date
NI202000036A NI202000036A (es) 2017-11-17 2020-05-08 Anticuerpo específicos para el transcrito semillar a la inmunoglobulina tipo 3 (ilt3) y sus usos.

Country Status (26)

Country Link
US (6) US11111297B2 (es)
EP (1) EP3710479A2 (es)
JP (1) JP7194481B2 (es)
KR (1) KR102478433B1 (es)
CN (1) CN111712518A (es)
AR (1) AR113696A1 (es)
AU (1) AU2018367524B2 (es)
BR (1) BR112020009759A8 (es)
CA (1) CA3082409A1 (es)
CL (1) CL2020001240A1 (es)
CO (1) CO2020006405A2 (es)
CR (1) CR20200204A (es)
DO (1) DOP2020000074A (es)
EA (1) EA202091228A1 (es)
EC (1) ECSP20032082A (es)
GE (1) GEP20237565B (es)
IL (1) IL274574A (es)
JO (1) JOP20200131A1 (es)
MA (1) MA50900A (es)
MX (1) MX2020005128A (es)
NI (1) NI202000036A (es)
PE (1) PE20210475A1 (es)
PH (1) PH12020550890A1 (es)
SG (1) SG11202004426SA (es)
TW (1) TWI816715B (es)
WO (1) WO2019099597A2 (es)

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KR20220130671A (ko) 2019-12-19 2022-09-27 엔지엠 바이오파마슈티컬스, 아이엔씨. Ilt3-결합제 및 이의 사용 방법
AU2022239502A1 (en) * 2021-03-19 2023-10-05 Merck Sharp & Dohme Llc Methods for treating cancer with anti-ilt3 antibodies
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WO2023235699A1 (en) 2022-05-31 2023-12-07 Jounce Therapeutics, Inc. Antibodies to lilrb4 and uses thereof

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Also Published As

Publication number Publication date
CO2020006405A2 (es) 2020-06-09
PH12020550890A1 (en) 2021-04-12
KR102478433B1 (ko) 2022-12-15
US20220033497A1 (en) 2022-02-03
US20220025042A1 (en) 2022-01-27
MA50900A (fr) 2020-09-23
ECSP20032082A (es) 2020-08-31
BR112020009759A8 (pt) 2023-01-31
MX2020005128A (es) 2020-07-27
JOP20200131A1 (ar) 2020-05-28
US20220010011A1 (en) 2022-01-13
GEP20237565B (en) 2023-11-10
AR113696A1 (es) 2020-06-03
CA3082409A1 (en) 2019-05-23
AU2018367524B2 (en) 2022-09-15
KR20200083598A (ko) 2020-07-08
US20220025043A1 (en) 2022-01-27
WO2019099597A3 (en) 2019-06-13
PE20210475A1 (es) 2021-03-08
AU2018367524A1 (en) 2020-06-11
EA202091228A1 (ru) 2020-08-12
EP3710479A2 (en) 2020-09-23
CN111712518A (zh) 2020-09-25
WO2019099597A2 (en) 2019-05-23
CR20200204A (es) 2020-06-18
DOP2020000074A (es) 2020-08-31
IL274574A (en) 2020-06-30
CL2020001240A1 (es) 2020-12-18
JP7194481B2 (ja) 2022-12-22
US20190153093A1 (en) 2019-05-23
US11111297B2 (en) 2021-09-07
JP2021503280A (ja) 2021-02-12
BR112020009759A2 (pt) 2020-11-03
TWI816715B (zh) 2023-10-01
SG11202004426SA (en) 2020-06-29
US20220010010A1 (en) 2022-01-13
TW201922786A (zh) 2019-06-16

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