AR111224A1 - PROCESSES FOR THE PREPARATION OF FUNGICIDE COMPOUNDS OF TIENOPIRIMIDINE - Google Patents
PROCESSES FOR THE PREPARATION OF FUNGICIDE COMPOUNDS OF TIENOPIRIMIDINEInfo
- Publication number
- AR111224A1 AR111224A1 ARP180100490A ARP180100490A AR111224A1 AR 111224 A1 AR111224 A1 AR 111224A1 AR P180100490 A ARP180100490 A AR P180100490A AR P180100490 A ARP180100490 A AR P180100490A AR 111224 A1 AR111224 A1 AR 111224A1
- Authority
- AR
- Argentina
- Prior art keywords
- salt
- formula
- tienopirimidine
- processes
- preparation
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 230000000855 fungicidal effect Effects 0.000 title 1
- 239000000417 fungicide Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 3
- -1 2H-1,2,3-triazol-2-yl Chemical group 0.000 abstract 2
- 244000053095 fungal pathogen Species 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000002524 organometallic group Chemical group 0.000 abstract 1
- 239000000575 pesticide Substances 0.000 abstract 1
- 239000012429 reaction media Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/24—Coupling light guides
- G02B6/36—Mechanical coupling means
- G02B6/38—Mechanical coupling means having fibre to fibre mating means
- G02B6/3807—Dismountable connectors, i.e. comprising plugs
- G02B6/389—Dismountable connectors, i.e. comprising plugs characterised by the method of fastening connecting plugs and sockets, e.g. screw- or nut-lock, snap-in, bayonet type
- G02B6/3893—Push-pull type, e.g. snap-in, push-on
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/24—Coupling light guides
- G02B6/36—Mechanical coupling means
- G02B6/38—Mechanical coupling means having fibre to fibre mating means
- G02B6/3807—Dismountable connectors, i.e. comprising plugs
- G02B6/3897—Connectors fixed to housings, casing, frames or circuit boards
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/44—Mechanical structures for providing tensile strength and external protection for fibres, e.g. optical transmission cables
- G02B6/4439—Auxiliary devices
- G02B6/444—Systems or boxes with surplus lengths
- G02B6/4453—Cassettes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/44—Mechanical structures for providing tensile strength and external protection for fibres, e.g. optical transmission cables
- G02B6/4439—Auxiliary devices
- G02B6/4471—Terminating devices ; Cable clamps
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Los compuestos descriptos en este documento exhiben actividad como pesticidas y son útiles, por ejemplo, en métodos para el control de patógenos fúngicos y enfermedades causadas por patógenos fúngicos en plantas. Reivindicación 1: Un proceso para preparar un compuesto estereoméricamente enriquecido de fórmula (1) ó (2), o una sal del mismo, comprendiendo el proceso el contacto de un compuesto de fórmula (3) ó (4), o una sal del mismo, con una fuente de hidrógeno en presencia de un catalizador organometálico quiral en una zona de reducción asimétrica que comprende un medio de reacción, proporcionando de ese modo el compuesto o sal enriquecido estereoméricamente de fórmula (1) ó (2), respectivamente; donde: R¹ es 2H-1,2,3-triazol-2-ilo, 1-pirazolilo o -C(O)OCH₂CH₃; y R² es hidrógeno o F.The compounds described in this document exhibit activity as pesticides and are useful, for example, in methods for the control of fungal pathogens and diseases caused by fungal pathogens in plants. Claim 1: A process for preparing a stereomerically enriched compound of formula (1) or (2), or a salt thereof, the process comprising contacting a compound of formula (3) or (4), or a salt thereof , with a source of hydrogen in the presence of a chiral organometallic catalyst in an asymmetric reduction zone comprising a reaction medium, thereby providing the stereomerically enriched compound or salt of formula (1) or (2), respectively; where: R¹ is 2H-1,2,3-triazol-2-yl, 1-pyrazolyl or -C (O) OCH₂CH₃; and R² is hydrogen or F.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762466944P | 2017-03-03 | 2017-03-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR111224A1 true AR111224A1 (en) | 2019-06-19 |
Family
ID=61683933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180100490A AR111224A1 (en) | 2017-03-03 | 2018-03-02 | PROCESSES FOR THE PREPARATION OF FUNGICIDE COMPOUNDS OF TIENOPIRIMIDINE |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP3589635A1 (en) |
| JP (1) | JP2020509038A (en) |
| KR (1) | KR20190125359A (en) |
| CN (1) | CN110382504A (en) |
| AR (1) | AR111224A1 (en) |
| AU (1) | AU2018227575A1 (en) |
| BR (1) | BR112019017915A2 (en) |
| CA (1) | CA3054810A1 (en) |
| CO (1) | CO2019009579A2 (en) |
| EA (1) | EA201991880A1 (en) |
| WO (1) | WO2018161008A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018227588B2 (en) | 2017-03-03 | 2021-01-21 | Gilead Sciences, Inc. | Processes for preparing ACC inhibitors and solid forms thereof |
| WO2020092239A1 (en) * | 2018-10-29 | 2020-05-07 | Gilead Apollo, Llc | Processes for the preparation of fungicidal compounds |
| EP3669652A1 (en) | 2018-12-21 | 2020-06-24 | Bayer AG | Active compound combination |
| AR119594A1 (en) | 2019-08-09 | 2021-12-29 | Gilead Sciences Inc | THIENOPYRIMIDINE DERIVATIVES AS ACC INHIBITORS AND USES THEREOF |
| WO2021149771A1 (en) * | 2020-01-22 | 2021-07-29 | 日産化学株式会社 | Thienouracil compound and pest control agent |
| CN114539042A (en) * | 2022-02-23 | 2022-05-27 | 河南旭瑞新材料科技有限公司 | Novel synthesis process of 5-fluoro-2-hydroxyacetophenone |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX370976B (en) * | 2011-11-11 | 2020-01-10 | Gilead Apollo Llc | Acc inhibitors and uses thereof. |
| AR106472A1 (en) * | 2015-10-26 | 2018-01-17 | Gilead Apollo Llc | ACC INHIBITORS AND USES OF THE SAME |
| SI3380480T1 (en) * | 2015-11-25 | 2023-04-28 | Gilead Apollo, Llc | Pyrazole acc inhibitors and uses thereof |
| WO2017091602A1 (en) * | 2015-11-25 | 2017-06-01 | Gilead Apollo, Llc | Ester acc inhibitors and uses thereof |
| JP2019503338A (en) * | 2015-11-25 | 2019-02-07 | ギリアド アポロ， エルエルシー | Fungicidal composition comprising a derivative of 2,4-dioxo-1,4-dihydrothieno [2,3-d] pyrimidine |
| JP2018536661A (en) | 2015-11-25 | 2018-12-13 | ギリアド アポロ， エルエルシー | Triazole ACC inhibitors and uses thereof |
-
2018
- 2018-03-02 BR BR112019017915-1A patent/BR112019017915A2/en not_active IP Right Cessation
- 2018-03-02 AU AU2018227575A patent/AU2018227575A1/en not_active Abandoned
- 2018-03-02 JP JP2019547390A patent/JP2020509038A/en active Pending
- 2018-03-02 WO PCT/US2018/020728 patent/WO2018161008A1/en active Application Filing
- 2018-03-02 CA CA3054810A patent/CA3054810A1/en not_active Abandoned
- 2018-03-02 EA EA201991880A patent/EA201991880A1/en unknown
- 2018-03-02 AR ARP180100490A patent/AR111224A1/en unknown
- 2018-03-02 KR KR1020197027893A patent/KR20190125359A/en unknown
- 2018-03-02 EP EP18711772.6A patent/EP3589635A1/en not_active Withdrawn
- 2018-03-02 CN CN201880015391.0A patent/CN110382504A/en active Pending
-
2019
- 2019-09-03 CO CONC2019/0009579A patent/CO2019009579A2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018161008A1 (en) | 2018-09-07 |
| EP3589635A1 (en) | 2020-01-08 |
| KR20190125359A (en) | 2019-11-06 |
| CO2019009579A2 (en) | 2020-01-17 |
| JP2020509038A (en) | 2020-03-26 |
| CA3054810A1 (en) | 2018-09-07 |
| EA201991880A1 (en) | 2020-02-25 |
| BR112019017915A2 (en) | 2020-05-12 |
| CN110382504A (en) | 2019-10-25 |
| AU2018227575A1 (en) | 2019-09-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |