EA201991880A1 - METHODS FOR PRODUCING FUNGICIDIC COMPOUNDS - Google Patents

METHODS FOR PRODUCING FUNGICIDIC COMPOUNDS

Info

Publication number
EA201991880A1
EA201991880A1 EA201991880A EA201991880A EA201991880A1 EA 201991880 A1 EA201991880 A1 EA 201991880A1 EA 201991880 A EA201991880 A EA 201991880A EA 201991880 A EA201991880 A EA 201991880A EA 201991880 A1 EA201991880 A1 EA 201991880A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
compounds
fungicidic
producing
stereoisomer
Prior art date
Application number
EA201991880A
Other languages
Russian (ru)
Inventor
Джеральдин К. Харриман
Мэттью В. Лейти
Сильвана Марсель Лейт Де Морадей
Уилльям Х. Миллер
Тони-Джо Поэл
Хайнрих Дж. Шостарез
Ллойд Дж. Симонс
Урсула Дж. Сломчинска
Дэниел П. Уолкер
Шомир Гхош
Джон П. Лоусон
Original Assignee
Джилид Аполло, Ллс
Монсанто Текнолоджи Ллс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Джилид Аполло, Ллс, Монсанто Текнолоджи Ллс filed Critical Джилид Аполло, Ллс
Publication of EA201991880A1 publication Critical patent/EA201991880A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24—Coupling light guides
    • G02B6/36—Mechanical coupling means
    • G02B6/38—Mechanical coupling means having fibre to fibre mating means
    • G02B6/3807—Dismountable connectors, i.e. comprising plugs
    • G02B6/389—Dismountable connectors, i.e. comprising plugs characterised by the method of fastening connecting plugs and sockets, e.g. screw- or nut-lock, snap-in, bayonet type
    • G02B6/3893—Push-pull type, e.g. snap-in, push-on
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24—Coupling light guides
    • G02B6/36—Mechanical coupling means
    • G02B6/38—Mechanical coupling means having fibre to fibre mating means
    • G02B6/3807—Dismountable connectors, i.e. comprising plugs
    • G02B6/3897—Connectors fixed to housings, casing, frames or circuit boards
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/44—Mechanical structures for providing tensile strength and external protection for fibres, e.g. optical transmission cables
    • G02B6/4439—Auxiliary devices
    • G02B6/444—Systems or boxes with surplus lengths
    • G02B6/4453—Cassettes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/44—Mechanical structures for providing tensile strength and external protection for fibres, e.g. optical transmission cables
    • G02B6/4439—Auxiliary devices
    • G02B6/4471—Terminating devices ; Cable clamps

Abstract

В настоящей заявке предложены способы получения соединений, обогащенных одним стереоизомером, формул I-014, I-020, I-064, I-074, I-082, I-089, I-090, I-095, I-171, I-181, I-184, I-186, I-189, I-191, I-192, I-193, I-205, I-206, I-208, I-211, I-212, I-213, I-220, I-229, I-231, I-233, I-234, I-246, I-251, I-258, I-259, I-262, I-263, I-285, I-323 и I-400. Соединения, описанные в настоящей заявке, демонстрируют активность в качестве пестицидов и подходят для применения, например, в способах борьбы с патогенными грибами и заболеваниями, вызываемыми патогенными грибами, в растениях. Предпочтительный способ направлен на получение соединения формулы V-1 или V-2, обогащенного одним стереоизомером, за счет асимметрического восстановления в присутствии хирального металлоорганического катализатора.This application provides methods for preparing compounds enriched in one stereoisomer of formulas I-014, I-020, I-064, I-074, I-082, I-089, I-090, I-095, I-171, I -181, I-184, I-186, I-189, I-191, I-192, I-193, I-205, I-206, I-208, I-211, I-212, I-213 , I-220, I-229, I-231, I-233, I-234, I-246, I-251, I-258, I-259, I-262, I-263, I-285, I -323 and I-400. The compounds described in this application show activity as pesticides and are suitable for use, for example, in methods of controlling pathogenic fungi and diseases caused by pathogenic fungi in plants. A preferred method is directed to the preparation of a compound of formula V-1 or V-2 enriched in one stereoisomer by asymmetric reduction in the presence of a chiral organometallic catalyst.

EA201991880A 2017-03-03 2018-03-02 METHODS FOR PRODUCING FUNGICIDIC COMPOUNDS EA201991880A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762466944P 2017-03-03 2017-03-03
PCT/US2018/020728 WO2018161008A1 (en) 2017-03-03 2018-03-02 Processes for the preparation of fungicidal compounds

Publications (1)

Publication Number Publication Date
EA201991880A1 true EA201991880A1 (en) 2020-02-25

Family

ID=61683933

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201991880A EA201991880A1 (en) 2017-03-03 2018-03-02 METHODS FOR PRODUCING FUNGICIDIC COMPOUNDS

Country Status (11)

Country Link
EP (1) EP3589635A1 (en)
JP (1) JP2020509038A (en)
KR (1) KR20190125359A (en)
CN (1) CN110382504A (en)
AR (1) AR111224A1 (en)
AU (1) AU2018227575A1 (en)
BR (1) BR112019017915A2 (en)
CA (1) CA3054810A1 (en)
CO (1) CO2019009579A2 (en)
EA (1) EA201991880A1 (en)
WO (1) WO2018161008A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102308412B1 (en) 2017-03-03 2021-10-05 길리애드 사이언시즈, 인코포레이티드 Methods for preparing ACC inhibitors and solid forms thereof
WO2020092239A1 (en) * 2018-10-29 2020-05-07 Gilead Apollo, Llc Processes for the preparation of fungicidal compounds
EP3669652A1 (en) 2018-12-21 2020-06-24 Bayer AG Active compound combination
AR119594A1 (en) 2019-08-09 2021-12-29 Gilead Sciences Inc THIENOPYRIMIDINE DERIVATIVES AS ACC INHIBITORS AND USES THEREOF
WO2021149771A1 (en) * 2020-01-22 2021-07-29 日産化学株式会社 Thienouracil compound and pest control agent
CN114539042A (en) * 2022-02-23 2022-05-27 河南旭瑞新材料科技有限公司 Novel synthesis process of 5-fluoro-2-hydroxyacetophenone

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012335088B2 (en) * 2011-11-11 2017-08-24 Gilead Apollo, Llc ACC inhibitors and uses thereof
AR106472A1 (en) * 2015-10-26 2018-01-17 Gilead Apollo Llc ACC INHIBITORS AND USES OF THE SAME
PL3380479T3 (en) 2015-11-25 2023-05-08 Gilead Apollo, Llc Triazole acc inhibitors and uses thereof
KR20180086191A (en) * 2015-11-25 2018-07-30 길리어드 아폴로, 엘엘씨 A fungicidal composition containing a 2,4-dioxo-1,4-dihydrothieno [2,3-d] pyrimidine derivative
EA201890949A1 (en) * 2015-11-25 2018-12-28 Джилид Аполло, Ллс ESSENTIAL ETHERIC ACETYL-COA-CARBOXYLASE INHIBITORS AND THEIR OPTIONS
KR20180082556A (en) 2015-11-25 2018-07-18 길리어드 아폴로, 엘엘씨 Pyrazole ACC inhibitors and uses thereof

Also Published As

Publication number Publication date
BR112019017915A2 (en) 2020-05-12
WO2018161008A1 (en) 2018-09-07
CO2019009579A2 (en) 2020-01-17
KR20190125359A (en) 2019-11-06
JP2020509038A (en) 2020-03-26
CN110382504A (en) 2019-10-25
EP3589635A1 (en) 2020-01-08
CA3054810A1 (en) 2018-09-07
AR111224A1 (en) 2019-06-19
AU2018227575A1 (en) 2019-09-19

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