AR108461A1 - Compuestos imidazo[4,5-c]quinolin-2-ona y su uso en el tratamiento del cáncer - Google Patents

Compuestos imidazo[4,5-c]quinolin-2-ona y su uso en el tratamiento del cáncer

Info

Publication number
AR108461A1
AR108461A1 ARP170101261A ARP170101261A AR108461A1 AR 108461 A1 AR108461 A1 AR 108461A1 AR P170101261 A ARP170101261 A AR P170101261A AR P170101261 A ARP170101261 A AR P170101261A AR 108461 A1 AR108461 A1 AR 108461A1
Authority
AR
Argentina
Prior art keywords
compounds
pharmaceutically acceptable
acceptable salts
formula
quinolin
Prior art date
Application number
ARP170101261A
Other languages
English (en)
Spanish (es)
Inventor
Kurt Gordon Pike
Bernard Christophe Barlaam
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR108461A1 publication Critical patent/AR108461A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ARP170101261A 2016-05-11 2017-05-11 Compuestos imidazo[4,5-c]quinolin-2-ona y su uso en el tratamiento del cáncer AR108461A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1608227.3A GB201608227D0 (en) 2016-05-11 2016-05-11 Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer

Publications (1)

Publication Number Publication Date
AR108461A1 true AR108461A1 (es) 2018-08-22

Family

ID=56297492

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP170101261A AR108461A1 (es) 2016-05-11 2017-05-11 Compuestos imidazo[4,5-c]quinolin-2-ona y su uso en el tratamiento del cáncer

Country Status (4)

Country Link
AR (1) AR108461A1 (fr)
GB (1) GB201608227D0 (fr)
TW (1) TW201805284A (fr)
WO (1) WO2017194632A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110386932A (zh) * 2018-04-20 2019-10-29 艾科思莱德制药公司 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂
WO2019201283A1 (fr) * 2018-04-20 2019-10-24 Xrad Therapeutics, Inc. Inhibiteurs doubles d'atm et d'adn-pk pour une utilisation en thérapie antitumorale
AU2019339006B2 (en) * 2018-09-14 2024-03-14 Suzhou Zanrong Pharma Limited 1-isopropyl-3-methyl-8- (pyridin-3-yl) -1, 3-dihydro-2h-imidazo (4, 5-c) cinnolin-2-one as selective modulators of ataxia telangiectasia mutated (atm) kinase and uses thereof
EP3845532B1 (fr) * 2018-09-30 2022-12-21 Medshine Discovery Inc. Dérivé de quinolino-pyrrolidin-2-one et application associée
WO2021098734A1 (fr) * 2019-11-19 2021-05-27 南京明德新药研发有限公司 Composé de quinolinopyrrolidone substitué utilisé en tant qu'inhibiteur d'atm et son application
CN115003672A (zh) * 2020-01-09 2022-09-02 南京明德新药研发有限公司 喹啉并咪唑类化合物及其应用
WO2021197339A1 (fr) * 2020-03-30 2021-10-07 南京明德新药研发有限公司 Forme cristalline de composé de quinopyrrolidine-2-one servant d'inhibiteur d'atm et son utilisation
TW202216209A (zh) 2020-06-24 2022-05-01 英商阿斯特捷利康英國股份有限公司 抗體-藥物結合物及atm抑制劑之組合
EP3992191A1 (fr) 2020-11-03 2022-05-04 Deutsches Krebsforschungszentrum Dérivés d'imidazo[4,5-c]quinoline et leur utilisation en tant qu'inhibiteurs de kinase atm
CN118434736A (zh) * 2022-01-26 2024-08-02 正大天晴药业集团股份有限公司 含有肼基的化合物
CN115778962B (zh) * 2022-11-28 2024-09-17 中国医学科学院肿瘤医院 治疗男性食管癌患者的药物及其相关应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
PL194689B1 (pl) 1996-02-13 2007-06-29 Astrazeneca Uk Ltd Pochodne chinazoliny, ich kompozycje farmaceutyczne oraz ich zastosowania
NZ331191A (en) 1996-03-05 2000-03-27 Zeneca Ltd 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
CN102372711B (zh) 2010-08-18 2014-09-17 山东轩竹医药科技有限公司 咪唑并喹啉类PI3K和mTOR双重抑制剂
CN102399218A (zh) 2010-09-16 2012-04-04 和记黄埔医药（上海）有限公司 一类并合三杂环及其作为pi3k抑制剂的用途
NO2714752T3 (fr) * 2014-05-08 2018-04-21
GB201516504D0 (en) * 2015-09-17 2015-11-04 Astrazeneca Ab Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer

Also Published As

Publication number Publication date
GB201608227D0 (en) 2016-06-22
WO2017194632A1 (fr) 2017-11-16
TW201805284A (zh) 2018-02-16

Similar Documents

Publication Publication Date Title
AR108461A1 (es) Compuestos imidazo[4,5-c]quinolin-2-ona y su uso en el tratamiento del cáncer
CO2018003969A2 (es) Compuestos de imidazo[4,5-c]quinolin-2-ona
DOP2018000115A (es) Compuestos de imidazo[4,5-c]quinolin-2-ona y su uso en el tratamiento del cáncer
PE20191474A1 (es) Compuestos de amino-triazolopiridina y su uso en el tratamiento del cancer
DOP2016000281A (es) Compuestos de imidazo[4,5-c]quinolin-2-ona y su uso para tratar cáncer
DOP2018000065A (es) Derivados de 8-[6-[3-(amino)propoxi]-3-piridil]1-isopropilimidazo[4,5-c]quinolin-2-ona como moduladores selectivos de la cinasa de la ataxia telangiectasia mutada (atm) para el tratamiento del cáncer
CO2017002998A2 (es) Derivados de tetrahidronaftaleno que inhiben la proteína mcl-1
CO2017004525A2 (es) Dihidropirrolopiridinas inhibidoras de ror-gamma
CR20150628A (es) Derivados de la pirazolopirrolidina y su uso en el tratamiento de enfermedades
NI202000099A (es) Compuestos de purinona y su uso en el tratamiento del cáncer
AR102981A1 (es) Inhibidores de la necrosis celular y métodos de preparación de los mismos
ECSP19066134A (es) COMPUESTOS DE TIPO IMIDAZO[4,5-c]QUINOLIN-2-ONA DEUTERADOS Y SU USO EN EL TRATAMIENTO DEL CÁNCER
CR20160558A (es) Compuesto de 1, 3, 4 - tiadiazol y uso de los mismos para el tratamiento del cáncer
CO2018010951A2 (es) Compuestos de cinnolin-4-amina y su uso en el tratamiento del cáncer
CO2021001925A2 (es) Piridopirimidinas como inhibidores del receptor de histamina h4
AR120626A1 (es) Sales de un inhibidor de fgfr

Legal Events

Date Code Title Description
FB Suspension of granting procedure