AR106036A1 - Derivados de benzoacepina - Google Patents
Derivados de benzoacepinaInfo
- Publication number
- AR106036A1 AR106036A1 ARP160102815A ARP160102815A AR106036A1 AR 106036 A1 AR106036 A1 AR 106036A1 AR P160102815 A ARP160102815 A AR P160102815A AR P160102815 A ARP160102815 A AR P160102815A AR 106036 A1 AR106036 A1 AR 106036A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- cycloalkyl
- heterocycle
- aryl
- heteroaryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se divulgan compuestos de fórmula (1) y procedimientos de tratamiento de infecciones víricas con composiciones que comprenden dichos compuestos. Reivindicación 1: Un compuesto de fórmula (1), en la que: R¹ es alquilo C₁₋₆; R² es arilo C₅₋₁₄, cicloalquilo C₃₋₇, cicloalquenilo C₃₋₇, heterociclo C₃₋₉, o heteroarilo C₅₋₉, en la que cada grupo R² está opcionalmente sustituido con de uno a cuatro sustituyentes seleccionados de halo, alquilo C₁₋₆, heteroalquilo C₁₋₆ o alquileno C₁₋₆ o heteroalquileno C₁₋₆ en el que dicho alquileno C₁₋₆ o heteroalquileno C₁₋₆ están unidos a átomos de carbono adyacentes en dicho arilo C₅₋₁₄, cicloalquilo C₃₋₇, cicloalquenilo C₃₋₇, heterociclo C₃₋₉, o heteroarilo C₅₋₉ para formar un anillo condensado; L es un enlace, -CH₂(CO)-, -alquileno C₁₋₃-, -SO₂-, -C(O)-, -C(S)-, -C(NH)-, -C(O)NH-, -C(O)NHCH₂-, -C(O)N-, -C(O)OCH₂-, -C(O)O-, -C(O)C(O)-, SO₂-NH-, o -CH₂C(O)-; R³ es H, CN, alquilo C₁₋₆, arilo C₅₋₁₄, CH₂-arilo C₅₋₁₄, CH₂-cicloalquilo C₃₋₇, cicloalquilo C₃₋₇, espirocicloalquilo C₃₋₇, cicloalquenilo C₃₋₇, heterociclo C₃₋₉, o heteroarilo C₅₋₉, en la que cada grupo R³ está opcionalmente sustituido con de uno a cuatro sustituyentes seleccionados de halo, alquilo, C₁₋₆, heterociclo con puente C₂₋₈, cicloalquilo C₃₋₇, fluoroalquilo C₁₋₃, -O-alquilo C₁₋₆, -C(O)R⁴, -C(O)NR⁴,-C(O)NHR⁴, arilo C₅₋₁₄, heteroalquilo C₁₋₆, -B(OH)₂, heterociclo C₃₋₉, heteroarilo C₅₋₆, -C(O)O-alquilo C₁₋₆, o dos sustituyentes unidos a átomos adyacentes se pueden unir conjuntamente para formar un anillo condensado y ese anillo condensado puede estar opcionalmente sustituido con R⁴, en el que R⁴ es CN, halo, -O-alquilo C₁₋₆, alquilo C₁₋₆, cicloalquilo C₃₋₇, heterociclo C₃₋₉, o arilo C₅₋₁₄; cada R⁵ es independientemente H, halógeno, alquilo C₁₋₆, o cicloalquilo C₃₋₇, en el que cada alquilo C₁₋₆ y cicloalquilo C₃₋₇ puede estar opcionalmente sustituido con 1 - 3 átomos de halógeno; y en la que cada heterociclo, heteroarilo, heteroalquilo y heteroalquileno comprende de uno a tres heteroátomos seleccionados de S, N, B u O.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562219687P | 2015-09-17 | 2015-09-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR106036A1 true AR106036A1 (es) | 2017-12-06 |
Family
ID=56990680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160102815A AR106036A1 (es) | 2015-09-17 | 2016-09-15 | Derivados de benzoacepina |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10239840B2 (es) |
| EP (1) | EP3350174A1 (es) |
| JP (1) | JP2018527379A (es) |
| AR (1) | AR106036A1 (es) |
| TW (1) | TW201720798A (es) |
| WO (1) | WO2017046707A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9975906B2 (en) | 2014-05-16 | 2018-05-22 | Shionogi & Co., Ltd. | Tricyclic heterocycle derivatives having HIV replication inhibitory effect |
| CA2987384A1 (en) | 2015-05-29 | 2016-12-08 | Shionogi & Co., Ltd. | Nitrogen-containing tricyclic derivative having hiv replication inhibitory activity |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9006235B2 (en) * | 2012-03-06 | 2015-04-14 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| TW201441197A (zh) * | 2013-01-31 | 2014-11-01 | Shionogi & Co | Ｈｉｖ複製抑制劑 |
| ES2670010T3 (es) | 2014-02-20 | 2018-05-29 | VIIV Healthcare UK (No.5) Limited | Macrociclos de ácido piridin-3-il acético como inhibidores de replicación del virus de inmunodeficiencia humana |
| CR20170005A (es) | 2014-07-08 | 2017-05-08 | Viiv Healthcare Uk Ltd | Derivados de insoindolina |
-
2016
- 2016-09-13 TW TW105129707A patent/TW201720798A/zh unknown
- 2016-09-14 US US15/759,363 patent/US10239840B2/en not_active Expired - Fee Related
- 2016-09-14 EP EP16770562.3A patent/EP3350174A1/en not_active Withdrawn
- 2016-09-14 JP JP2018513841A patent/JP2018527379A/ja active Pending
- 2016-09-14 WO PCT/IB2016/055462 patent/WO2017046707A1/en active Application Filing
- 2016-09-15 AR ARP160102815A patent/AR106036A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018527379A (ja) | 2018-09-20 |
| WO2017046707A1 (en) | 2017-03-23 |
| EP3350174A1 (en) | 2018-07-25 |
| TW201720798A (zh) | 2017-06-16 |
| US10239840B2 (en) | 2019-03-26 |
| US20180179162A1 (en) | 2018-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |