AR105005A1 - Derivados de pirrolotriazinona como inhibidores de pi3k - Google Patents
Derivados de pirrolotriazinona como inhibidores de pi3kInfo
- Publication number
- AR105005A1 AR105005A1 ARP160101778A ARP160101778A AR105005A1 AR 105005 A1 AR105005 A1 AR 105005A1 AR P160101778 A ARP160101778 A AR P160101778A AR P160101778 A ARP160101778 A AR P160101778A AR 105005 A1 AR105005 A1 AR 105005A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- branched
- linear
- hydrogen atom
- independently represents
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describen derivados de pirrolotriazinona; así como procedimientos para su preparación, composiciones farmacéuticas que los comprenden y su uso en terapia como inhibidores de fosfoinositida-3-quinasas (PI3Ks). Reivindicación 1: Un compuesto de fórmula (1), o una de sus sales farmacéuticamente aceptables, o N-óxido, o derivado marcado con isótopo, en donde, n representa un número entero seleccionado de 1 ó 2; X e Y representa cada uno independientemente un átomo de nitrógeno o grupo CR³; R¹ y R² representa cada uno independientemente un átomo de hidrógeno o un grupo alquilo C₁₋₄ lineal o ramificado; R³ representa un átomo de hidrógeno, un átomo de halógeno, un hidroxilo, un grupo alquilo C₁₋₄ lineal o ramificado, un grupo C₁₋₄ alcoxi o un grupo halógenoalquilo C₁₋₄; Z representa un grupo -CH((CH₂)₀₋₁-NRᵃRᵇ)-, un grupo -NH- o un grupo -N(alquilo C₁₋₃)-; Rᵃ y Rᵇ representa cada uno independientemente un átomo de hidrógeno o un grupo alquilo C₁₋₄ lineal o ramificado; o Rᵃ y Rᵇ junto con el átomo de nitrógeno al que están unidos forman un grupo heterociclilo de 3 a 7 miembros, monocíclico, que contiene opcionalmente al menos un heteroátomo adicional seleccionado de O, S y N.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15382317 | 2015-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR105005A1 true AR105005A1 (es) | 2017-08-30 |
Family
ID=53496611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160101778A AR105005A1 (es) | 2015-06-16 | 2016-06-15 | Derivados de pirrolotriazinona como inhibidores de pi3k |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR105005A1 (es) |
| TW (1) | TW201710270A (es) |
| WO (1) | WO2016202800A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112028892B (zh) * | 2020-07-29 | 2022-12-16 | 天津全和诚科技有限责任公司 | 4-氨基-吡咯并三嗪衍生物在制备抗肺纤维化制剂中的应用 |
| CN112920203A (zh) * | 2021-01-26 | 2021-06-08 | 浙江永太科技股份有限公司 | 一种瑞德西韦有关物质及其制备方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT7920688V0 (it) | 1979-02-05 | 1979-02-05 | Chiesi Paolo Parma | Inalatore per sostanze medicamentose pulverulente, con combinata funzione di dosatore. |
| CY1492A (en) | 1981-07-08 | 1990-02-16 | Draco Ab | Powder inhalator |
| US4570630A (en) | 1983-08-03 | 1986-02-18 | Miles Laboratories, Inc. | Medicament inhalation device |
| FI69963C (fi) | 1984-10-04 | 1986-09-12 | Orion Yhtymae Oy | Doseringsanordning |
| DE3927170A1 (de) | 1989-08-17 | 1991-02-21 | Boehringer Ingelheim Kg | Inhalator |
| IT1237118B (it) | 1989-10-27 | 1993-05-18 | Miat Spa | Inalatore multidose per farmaci in polvere. |
| US5201308A (en) | 1990-02-14 | 1993-04-13 | Newhouse Michael T | Powder inhaler |
| GB9004781D0 (en) | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
| SG45171A1 (en) | 1990-03-21 | 1998-01-16 | Boehringer Ingelheim Int | Atomising devices and methods |
| GB9015522D0 (en) | 1990-07-13 | 1990-08-29 | Braithwaite Philip W | Inhaler |
| WO1992003175A1 (en) | 1990-08-11 | 1992-03-05 | Fisons Plc | Inhalation device |
| DE4027391A1 (de) | 1990-08-30 | 1992-03-12 | Boehringer Ingelheim Kg | Treibgasfreies inhalationsgeraet |
| DE69132850T2 (de) | 1990-09-26 | 2002-05-29 | Pharmachemie B.V., Haarlem | Wirbelkammer-Pulverinhalator |
| GB9026025D0 (en) | 1990-11-29 | 1991-01-16 | Boehringer Ingelheim Kg | Inhalation device |
| AU650953B2 (en) | 1991-03-21 | 1994-07-07 | Novartis Ag | Inhaler |
| DE4239402A1 (de) | 1992-11-24 | 1994-05-26 | Bayer Ag | Pulverinhalator |
| AU683036B2 (en) | 1992-12-18 | 1997-10-30 | Merck Sharp & Dohme Corp. | Inhaler for powdered medications |
| PL182198B1 (en) | 1995-06-21 | 2001-11-30 | Asta Medica Ag | Pharmaceutic powder holding container with integrated measuring device and powdered |
| DE19536902A1 (de) | 1995-10-04 | 1997-04-10 | Boehringer Ingelheim Int | Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung |
| DE10129703A1 (de) | 2001-06-22 | 2003-01-02 | Sofotec Gmbh & Co Kg | Zerstäubungssystem für eine Pulvermischung und Verfahren für Trockenpulverinhalatoren |
| CN1997418B (zh) | 2004-07-16 | 2010-08-11 | 奥米罗有限公司 | 用于粉状药物给药的吸入器，以及用于与该吸入器一起使用的药粉筒系统 |
| ES2319596B1 (es) | 2006-12-22 | 2010-02-08 | Laboratorios Almirall S.A. | Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico. |
| UY31272A1 (es) | 2007-08-10 | 2009-01-30 | Almirall Lab | Nuevos derivados de ácido azabifenilaminobenzoico |
| PE20150637A1 (es) | 2012-10-16 | 2015-05-08 | Almirall Sa | Derivados de pirrolotriazinona como inhibidores de pi3k |
-
2016
- 2016-06-14 WO PCT/EP2016/063635 patent/WO2016202800A1/en active Application Filing
- 2016-06-15 TW TW105118755A patent/TW201710270A/zh unknown
- 2016-06-15 AR ARP160101778A patent/AR105005A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016202800A1 (en) | 2016-12-22 |
| TW201710270A (zh) | 2017-03-16 |
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| FB | Suspension of granting procedure |