AR102550A1 - Planta transgénica que comprende un polinucleótido que codifica un dominio variable de anticuerpo de cadena pesada - Google Patents
Planta transgénica que comprende un polinucleótido que codifica un dominio variable de anticuerpo de cadena pesadaInfo
- Publication number
- AR102550A1 AR102550A1 ARP150103596A ARP150103596A AR102550A1 AR 102550 A1 AR102550 A1 AR 102550A1 AR P150103596 A ARP150103596 A AR P150103596A AR P150103596 A ARP150103596 A AR P150103596A AR 102550 A1 AR102550 A1 AR 102550A1
- Authority
- AR
- Argentina
- Prior art keywords
- plant
- tissue
- cell
- pathogen
- heavy chain
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8282—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for fungal resistance
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/14—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from fungi, algea or lichens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Cultivation Of Plants (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Reivindicación 1: Una planta o tejido vegetal o célula vegetal transgénico que comprende al menos un polinucleótido que comprende al menos una secuencia que codifica para un dominio variable de un anticuerpo de cadena pesada (VHH) que se une específicamente a un esfingolípido de un hongo, preferiblemente a una ceramida de un hongo, más preferiblemente a un glicoesfingolípido de un hongo, incluso más preferiblemente a un cerebrósido de un hongo, aún más preferiblemente a un glucocerebrósido de un hongo. Reivindicación 8: Partes cosechables y materiales de propagación de una planta o tejido vegetal o célula vegetal transgénico de acuerdo con una cualquiera de las reivindicaciones 1 a 7, que comprende al menos un polinucleótido como se lo define en una cualquiera de las reivindicaciones 1 a 7. Reivindicación 11: Un método para proteger al menos parte de una planta o tejido vegetal o célula vegetal de una infección con un patógeno de planta, para inhibir el crecimiento de un patógeno de planta en al menos parte de una planta o tejido vegetal o célula vegetal, y/o para incrementar la resistencia a patógenos de al menos parte de una planta o tejido vegetal o célula vegetal, que comprende expresar en al menos parte de la planta o tejido vegetal o célula vegetal al menos un polinucleótido que codifica un dominio variable de un anticuerpo de cadena pesada (VHH) que se une específicamente a un patógeno. Reivindicación 13: Uso de al menos un polinucleótido que codifica un dominio variable de un anticuerpo de cadena pesada (VHH) que se une específicamente a un patógeno, para proteger al menos parte de una planta o tejido vegetal o célula vegetal de una infección con un patógeno de planta, para inhibir el crecimiento de un patógeno de planta en al menos parte de una planta o tejido vegetal o célula vegetal, y/o para incrementar la resistencia a patógenos de al menos parte de una planta o tejido vegetal o célula vegetal, en donde el polinucleótido es expresado en al menos parte de la planta o tejido vegetal.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14191959 | 2014-11-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR102550A1 true AR102550A1 (es) | 2017-03-08 |
Family
ID=51845355
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP150103596A AR102550A1 (es) | 2014-11-05 | 2015-11-05 | Planta transgénica que comprende un polinucleótido que codifica un dominio variable de anticuerpo de cadena pesada |
Country Status (7)
Country | Link |
---|---|
US (2) | US10858666B2 (es) |
EP (1) | EP3215624B1 (es) |
JP (2) | JP7089877B2 (es) |
AR (1) | AR102550A1 (es) |
BR (1) | BR112017009330A2 (es) |
CA (1) | CA2966548A1 (es) |
WO (1) | WO2016071438A2 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20180222966A1 (en) * | 2013-04-29 | 2018-08-09 | Agrosavfe N.V. | Transgenic plant comprising a polynucleotide encoding a variable domain of heavy-chain antibody |
ES2703192T3 (es) | 2013-04-29 | 2019-03-07 | Agrosavfe Nv | Composiciones agroquímicas que contienen anticuerpos que se unen a esfingolípidos |
CA2966548A1 (en) | 2014-11-05 | 2016-05-12 | Agrosavfe Nv | Transgenic plant comprising a polynucleotide encoding a variable domain of heavy-chain antibody |
US10017560B1 (en) | 2017-11-16 | 2018-07-10 | King Saud University | Nanobody against begomoviruses |
WO2019161386A1 (en) * | 2018-02-19 | 2019-08-22 | New York University | Alpha-synuclein single domain antibodies |
MX2022012376A (es) | 2020-03-31 | 2023-02-15 | Biotalys NV | Polipeptidos antifungicos. |
CN113080114A (zh) * | 2021-04-12 | 2021-07-09 | 浙江大学 | 一种提高鱼类子代成活率的方法 |
WO2023057601A1 (en) * | 2021-10-06 | 2023-04-13 | Biotalys NV | Anti-fungal polypeptides |
EP4170039A1 (en) * | 2021-10-22 | 2023-04-26 | The Sainsbury Laboratory | Modifying the immune response in plants |
WO2024118831A1 (en) * | 2022-11-30 | 2024-06-06 | Velozbio Company | Compositions and methods for protein production |
WO2024145551A1 (en) * | 2022-12-29 | 2024-07-04 | Biotalys NV | Agrochemical compositions |
Family Cites Families (50)
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EP2192131A1 (en) | 1992-08-21 | 2010-06-02 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
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FR2708622B1 (fr) | 1993-08-02 | 1997-04-18 | Raymond Hamers | Vecteur recombinant contenant une séquence d'un gène de lipoprotéine de structure pour l'expression de séquences de nucléotides. |
EP0782626A1 (en) | 1994-09-19 | 1997-07-09 | Rijkslandbouwuniversiteit Wageningen | Gene constructs encoding crop-protecting agents, as well as transformed plants containing and expressing such constructs, and methods of controlling plague organisms and pathogens in crops |
EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
DK0937140T3 (da) | 1996-06-27 | 2008-01-28 | Vlaams Interuniv Inst Biotech | Antistofmolekyler, som interagerer specifikt med et målmolekyles aktive sted eller klöft |
AU3596599A (en) | 1998-01-26 | 1999-08-09 | Unilever Plc | Method for producing antibody fragments |
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EP1123398B1 (en) | 1998-10-16 | 2005-08-10 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Molecular pathogenicide mediated plant disease resistance |
AU3041100A (en) | 1999-01-05 | 2000-07-24 | Unilever Plc | Binding of antibody fragments to solid supports |
DE60013767T3 (de) | 1999-01-19 | 2009-07-09 | Unilever N.V. | Verfahren zur herstellung von antikörperfragmenten |
WO2000065057A1 (en) | 1999-04-22 | 2000-11-02 | Unilever Plc | Inhibition of viral infection using monovalent antigen-binding proteins |
CA2366104C (en) | 1999-07-22 | 2010-07-06 | Japan As Represented By Director General Of National Institute Of Agrobiological Resources, Ministry Of Agriculture, Forestry And Fisheries | Ultra-fast transformation technique for monocotyledons |
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AU1859201A (en) | 1999-11-29 | 2001-06-12 | Unilever Plc | Immobilisation of proteins |
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CA2795480C (en) | 2010-04-06 | 2021-10-26 | Vrije Universiteit Brussel | Specific delivery of agrochemicals |
WO2012011396A1 (ja) | 2010-07-20 | 2012-01-26 | 国立大学法人東京大学 | ナノ抗体を発現するトランスジェニックイネ |
US9380781B2 (en) | 2010-08-26 | 2016-07-05 | Agrosavfe N.V. | Compositions for seed treatment |
EP2609116A1 (en) | 2010-08-26 | 2013-07-03 | Agrosavfe N.V. | Insect binding antibodies |
CN103153044B (zh) * | 2010-10-08 | 2015-06-17 | 韩国生命工学研究院 | 源自巴西橡胶树的乳胶分泌组织特异性srpp启动子及其用途 |
US20150087517A1 (en) | 2011-10-06 | 2015-03-26 | Agrosavfe N.V. | Manufacturing of specifically targeting microcapsules |
ES2703192T3 (es) * | 2013-04-29 | 2019-03-07 | Agrosavfe Nv | Composiciones agroquímicas que contienen anticuerpos que se unen a esfingolípidos |
US20180222966A1 (en) * | 2013-04-29 | 2018-08-09 | Agrosavfe N.V. | Transgenic plant comprising a polynucleotide encoding a variable domain of heavy-chain antibody |
CA2966548A1 (en) | 2014-11-05 | 2016-05-12 | Agrosavfe Nv | Transgenic plant comprising a polynucleotide encoding a variable domain of heavy-chain antibody |
-
2015
- 2015-11-05 CA CA2966548A patent/CA2966548A1/en active Pending
- 2015-11-05 US US15/524,609 patent/US10858666B2/en active Active
- 2015-11-05 WO PCT/EP2015/075800 patent/WO2016071438A2/en active Application Filing
- 2015-11-05 AR ARP150103596A patent/AR102550A1/es unknown
- 2015-11-05 BR BR112017009330A patent/BR112017009330A2/pt not_active Application Discontinuation
- 2015-11-05 JP JP2017542328A patent/JP7089877B2/ja active Active
- 2015-11-05 EP EP15797886.7A patent/EP3215624B1/en active Active
-
2020
- 2020-12-07 US US17/113,552 patent/US20210340556A1/en not_active Abandoned
- 2020-12-18 JP JP2020209923A patent/JP2021061843A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US20180179551A1 (en) | 2018-06-28 |
JP7089877B2 (ja) | 2022-06-23 |
EP3215624C0 (en) | 2023-11-29 |
EP3215624B1 (en) | 2023-11-29 |
JP2017536134A (ja) | 2017-12-07 |
JP2021061843A (ja) | 2021-04-22 |
EP3215624A2 (en) | 2017-09-13 |
WO2016071438A3 (en) | 2016-06-23 |
BR112017009330A2 (pt) | 2017-12-19 |
WO2016071438A2 (en) | 2016-05-12 |
US10858666B2 (en) | 2020-12-08 |
US20210340556A1 (en) | 2021-11-04 |
CA2966548A1 (en) | 2016-05-12 |
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